Enzymes of tetrapyrrole biosynthesis
Recent examples are the structures of coproporphyrinogen IX oxidase and aminolevulinic acid synthase.
Finally we have solved and analyzed the crystal structure of aminolevulinic acid synthase, the first enzyme of tetrapyrrole biosynthesis in mammals and yeast, in complex with both substrates. Mutations in this enzyme lead to rare blood disorders and other diseases. With the structure of aminolevulinic acid synthase the structures of all enzymes of heme biosynthesis have finally been determined. (Astner et al, 2005).
Future research will focus on the catalytic mechanism and substrate binding of selected enzymes.
University of Hannover
Technical University Braunschweig
- Structure and Function of Proteins - Prof. Wulf Blankenfeldt