Viral Immune Modulation

Pathogens (germs) infiltrate our bodies daily but do not remain undetected. They encounter the strong defenses of our immune system, which recognizes invaders and promptly takes appropriate measures. However, many pathogens can produce life-long infections even with an intact immune system. The herpesvirus family is one such group of pathogens. Upon infection, herpesviruses establish a chronic infection and become lifelong companions. 

Leader

Selected Publications

Stempel M, Chan B, Juranić Lisnić V, Krmpotić A, Hartung J, Paludan SR, Füllbrunn N, Lemmermann NA, Brinkmann MM.
The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection.
EMBO J. 2019 Jan 29. pii: e100983. [Epub ahead of print] (DOI: 10.15252/embj.2018100983)

Bussey KA, Murthy S, Reimer E, Chan B, Hatesuer B, Schughart K, Glaunsinger B, Adler H, Brinkmann MM.
Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection.
J Virol. 2019 Jan 17;93(3). pii: e01173-18. Print 2019 Feb 1. (DOI: 10.1128/JVI.01173-18)

Bussey KA, Brinkmann MM.
Strategies for immune evasion by human tumor viruses.
Curr Opin Virol. 2018 Oct;32:30-39. Epub 2018 Sep 18. Review. (DOI: 10.1016/j.coviro.2018.08.015)

Bussey KA, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, Arnold C, Wissing J, Gad HH, Hartmann R, Brune W, Jänsch L, Whitehouse A, Brinkmann MM.
The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein.
PLoS Pathog. 2018 Mar 2;14(3):e1006937. eCollection 2018 Mar. (DOI: 10.1371/journal.ppat.1006937)

Chan B, Gonçalves Magalhães V, Lemmermann NAW, Juranić Lisnić V, Stempel M, Bussey KA, Reimer E, Podlech J, Lienenklaus S, Reddehase MJ, Jonjić S, Brinkmann MM. (2017)
The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
PLoS Pathog. 2017 May 25;13(5):e1006382. eCollection 2017 May. (DOI:10.1371/journal.ppat.1006382)

A complete list of publications can be found here.

News

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Follow us on Twitter

@BrinkmannLab

Contribution in the HZI staff magazine "InFact"

The Super Striker: How herpesviruses dribble out the immune system

If we imagine viruses and human immune cells as opposing soccer teams, we would observe a spectacular game: The viruses have barely gained possession of the ball and they are already storming down the field towards their goal. If the defence players and goalie of the opposing team, the human immune cells, do not reach their positions quickly enough the viruses’ goal cannot be prevented and a human is infected.

PrintSend per emailShare