Viral Immune Modulation

Pathogens (germs) infiltrate our bodies daily but do not remain undetected. They encounter the strong defenses of our immune system, which recognizes invaders and promptly takes appropriate measures. However, many pathogens can produce life-long infections even with an intact immune system. The herpesvirus family is one such group of pathogens. Upon infection, herpesviruses establish a chronic infection and become lifelong companions. 
The investigation into the spread of SARS-CoV-2 in a meat processing plant can be found here.

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  • Chronic Infections: Microbial Persistence and its Control: CRC900
  • Die Rolle der Proteintyrosinphosphatase PTP1B für die Funktion der Toll-like Rezeptoren TLR7 und TLR9: DFG BR3432/3-1

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  • How to stop the coronavirus with the Cheesemodel

    Virologist Prof Melanie Brinkmann compares measures against the coronavirus with swiss cheese. No measure is perfect but many measures together could be the key to success.

  • How is the HZI contributing to the management of the coronavirus pandemic?

    Since the beginning of the SARS-CoV-2 pandemic, the Helmholtz Centre for Infection Research (HZI) in Braunschweig has focused its research activities on the novel coronavirus. Representative for the diverse research projects at HZI, three scientists present their contributions to coping with the pandemic. Prof Michael Meyer-Hermann is developing mathematical models for the course of the pandemic. Prof Melanie Brinkmann has investigated transmission pathways in a large coronavirus outbreak and shown that the pathogen can be spread via aerosols. Prof Gérard Krause is leading an antibody study to monitor the development of the pandemic and is developing digital tools such as the SORMAS system to support the public health service in pandemic response.

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Contribution in the HZI staff magazine "InFact"

The Super Striker: How herpesviruses dribble out the immune system

If we imagine viruses and human immune cells as opposing soccer teams, we would observe a spectacular game: The viruses have barely gained possession of the ball and they are already storming down the field towards their goal. If the defence players and goalie of the opposing team, the human immune cells, do not reach their positions quickly enough the viruses’ goal cannot be prevented and a human is infected.

You can read the article here

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