Vaccinology

Vaccination is the most efficient strategy to prevent infectious diseases. The art of the vaccine researcher lies in finding substances that prevent us from falling ill with diseases such as flu, viral hepatitis or HIV/AIDS. But what makes a vaccine successful and ensures effective protection? Our scientists study the reaction of the immune system to answer that question – and to develop better vaccination strategies.

Leader

Publications

  • Authors: Gottschick,C.; Raupach-Rosin,H.; Langer,S.; Hassan,L.; Horn,J.; Dorendorf,E.; Caputo,M.; Bittner,M.; Beier,L.; Rübsamen,N.; Schlinkmann,K.; Zoch,B.; Guzmán,C.A.; Hansen,G.; Heselich,V.; Holzapfel,E.; Hübner,J.; Pietschmann,T.; Pieper,D.H.; Pletz,M.; Riese,P.; Schmidt-Pokrzywniak,A.; Hartwig,S.; von,Kaisenberg C.; Aydogdu,M.; Buhles,M.; Dressler,F.; Eberl,W.; Haase,R.; Edler von,Koch F.; Feidicker,S.; Frambach,T.; Franz,H.G.B.; Guthmann,F.; Koch,H.G.; Seeger,S.; Oberhoff,C.; Pauker,W.; Petry,K.U.; Schild,R.L.; Tchirikov,M.; Röhrig,E.; Mikolajczyk,R.; ( Year: 2019). Title: Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood.Journal: Int.J.Epidemiol., S-Page: dyz001 / 1- E-Page: 10 DOI: 10.1093/ije/dyz001PubMed
  • Authors: Khera,T.; Behrendt,P.; Bankwitz,D.; Brown,R.J.P.; Todt,D.; Doepke,M.; Khan,A.G.; Schulze,K.; Law,J.; Logan,M.; Hockman,D.; Wong,J.A.J.-X.; Dold,L.; Gonzalez-Motos,V.; Spengler,U.; Viejo-Borbolla,A.; Ströh,L.; Krey,T.; Tarr,A.W.; Steinmann,E.; Manns,M.P.; Klein,F.; Guzmán,C.A.; Marcotrigiano,J.; Houghton,M.; Pietschmann,T.; ( Year: 2019). Title: Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.Journal: J.Hepatol. Volume: 70 Issue: 4, S-Page: 593- E-Page: 602 DOI: 10.1016/j.jhep.2018.11.003HZI repositoryPubMed
  • Authors: Ebensen,T.; Delandre,S.; Prochnow,B.; Guzmán,C.A.; Schulze,K.; ( Year: 2019). Title: The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization.Journal: Frontiers in Cellular and Infection Microbiology Volume: 9 Issue: February, S-Page: Article 31 DOI: 10.3389/fcimb.2019.00031HZI repositoryPubMed
  • Authors: Riehl,M.; Harms,M.; Lucas,H.; Ebensen,T.; Guzmán,C.A.; Mäder,K.; ( Year: 2018). Title: Dual dye in-vivo imaging of differentially charged PLGA carriers reveals antigen-depot effect, leading to improved immune responses in preclinical models.Journal: Eur.J.Pharm.Sci. Volume: 117, S-Page: 88- E-Page: 97 DOI: 10.1016/j.ejps.2018.01.040PubMed
  • Authors: Vashist,N.; Trittel,S.; Ebensen,T.; Chambers,B.J.; Guzmán,C.A.; Riese,P.; ( Year: 2018). Title: Influenza-activated ILC1s contribute to antiviral immunity partially influenced by differential GITR expression.Journal: Frontiers in Immunology Volume: 8 Issue: MAR, S-Page: no. 505 DOI: 10.3389/fimmu.2018.00505HZI repositoryPubMed
  • Authors: Eicke,D.; Baigger,A.; Schulze,K.; Latham,S.L.; Halloin,C.; Zweigerdt,R.; Guzmán,C.A.; Blasczyk,R.; Figueiredo,C.; ( Year: 2018). Title: Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.Journal: Sci.Rep. Volume: 8 Issue: 1, S-Page: Article number 10146 DOI: 10.1038/s41598-018-28459-xHZI repositoryPubMed
  • Authors: Zygmunt,B.M.; Wegrzyn,A.; Gajska,W.; Yevsa,T.; Chodaczek,G.; Guzmán,C.A.; ( Year: 2018). Title: Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-gamma Production.Journal: Journal of Immunology Volume: 201 Issue: 5, S-Page: 1400- E-Page: 1411 DOI: 10.4049/jimmunol.1700042PubMed
  • Authors: Lirussi,D.; Ebensen,T.; Schulze,K.; Reinhard,E.; Trittel,S.; Riese,P.; Prochnow,B.; Guzmán,C.A.; ( Year: 2018). Title: Rapid in vivo assessment of adjuvant's cytotoxic t lymphocytes generation capabilities for vaccine development.Journal: J.Visualized Exp. Volume: 2018 Issue: 136 DOI: 10.3791/57401HZI repositoryPubMed
  • Authors: Stegemann-Koniszewski,S.; Behrens,S.; Boehme,J.D.; Hochnadel,I.; Riese,P.; Guzmán,C.A.; Kröger,A.; Schreiber,J.; Gunzer,M.; Bruder,D.; ( Year: 2018). Title: Respiratory influenza A virus infection triggers local and systemic natural killer cell activation via toll-like receptor 7.Journal: Frontiers in Immunology Volume: 9 Issue: FEB, S-Page: Article 245 DOI: 10.3389/fimmu.2018.00245WEBURLS
  • Authors: Englezou,P.C.; Sapet,C.; D q moulins,T.; Milona,P.; Ebensen,T.; Schulze,K.; Guzmán,C.A.; Poulhes,F.; Zelphati,O.; Ruggli,N.; McCullough,K.C.; ( Year: 2018). Title: Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids.Journal: Mol.Ther.Nucl.Acids Volume: 12 Issue: September, S-Page: 118- E-Page: 134 DOI: 10.1016/j.omtn.2018.04.019HZI repositoryWEBURLS
  • Authors: Theobald,S.J.; Khailaie,S.; Meyer-Hermann,M.; Volk,V.; Olbrich,H.; Danisch,S.; Gerasch,L.; Schneider,A.; Sinzger,C.; Schaudien,D.; Lienenklaus,S.; Riese,P.; Guzmán,C.A.; Figueiredo,C.; Von Kaisenberg,C.; Spineli,L.M.; Glaesener,S.; Meyer-Bahlburg,A.; Ganser,A.; Schmitt,M.; MacH,M.; Messerle,M.; Stripecke,R.; ( Year: 2018). Title: Signatures of T and B cell development, functional responses and PD-1 upregulation after HCMV latent infections and reactivations in Nod.Rag.Gamma mice humanized with cord blood CD34+cells.Journal: Frontiers in Immunology Volume: 9 Issue: NOV, S-Page: 2734 DOI: 10.3389/fimmu.2018.02734HZI repositoryPubMed
  • Authors: Ziegler,A.; Soldner,C.; Lienenklaus,S.; Spanier,J.; Trittel,S.; Riese,P.; Kramps,T.; Weiss,S.; Heidenreich,R.; Jasny,E.; Guzmán,C.A.; Kallen,K.J.; Fotin-Mleczek,M.; Kalinke,U.; ( Year: 2017). Title: A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects.Journal: J Immunol. Volume: 198 Issue: 4, S-Page: 1595- E-Page: 1605 DOI: 10.4049/jimmunol.1601129 HZI repository PubMed
  • Authors: Akmatov,M.K.; Rober,N.; Ahrens,W.; Flesch-Janys,D.; Fricke,J.; Greiser,H.; Gunther,K.; Kaaks,R.; Kemmling,Y.; Krone,B.; Linseisen,J.; Meisinger,C.; Moebus,S.; Obi,N.; Guzmán,C.A.; Conrad,K.; Pessler,F.; ( Year: 2017). Title: Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study.Journal: Arthritis Res.Ther. Volume: 19 Issue: 1, S-Page: 127 DOI: 10.1186/s13075-017-1338-5HZI repositoryPubMed
  • Authors: Schulze,K.; Ebensen,T.; Chandrudu,S.; Skwarczynski,M.; Toth,I.; Olive,C.; Guzmán,C.A.; ( Year: 2017). Title: Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection.Journal: Nanomedicine. Volume: 13 Issue: 8, S-Page: 2463- E-Page: 2474 DOI: 10.1016/j.nano.2017.08.015HZI repositoryPubMed
  • Authors: Khanam,A.; TrehanPati,N.; Riese,P.; Rastogi,A.; Guzmán,C.A.; Sarin,S.K.; ( Year: 2017). Title: Blockade of Neutrophil's Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure.Journal: Front Immunol. Volume: 8, S-Page: 464 DOI: 10.3389/fimmu.2017.00464HZI repositoryPubMed
  • Authors: Chatterjea,A.; Lapointe,V.L.S.; Barradas,A.; Garritsen,H.; Yuan,H.; Renard,A.; Van Blitterswijk,C.A.; De Boer,J.; ( Year: 2017). Title: Cell aggregation enhances bone formation by human mesenchymal stromal cells.Journal: Eur.Cells and Mater. Volume: 33, S-Page: 121- E-Page: 129 DOI: 10.22203/eCM.v033a09HZI repositoryPubMed
  • Authors: Schulte,A.; Balzer,K.M.; Garritsen,H.; Legath,N.; Minol,J.-P.; Börgel,M.; Sixt,S.U.; ( Year: 2017). Title: Cryopreserved vascular grafts from human tissue.Journal: Gefässchirurgie Volume: 22 Issue: 6, S-Page: 428- E-Page: 436 DOI: 10.1007/s00772-017-0274-7PubMed
  • Authors: Rueckert,C.; Rand,U.; Roy,U.; Kasmapour,B.; Strowig,T.; Guzmán,C.A.; ( Year: 2017). Title: Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.Journal: FASEB J. Volume: 31 Issue: 7, S-Page: 3107- E-Page: 3115 DOI: 10.1096/fj.201601093RPubMed
  • Authors: Sanchez,Alberti A.; Bivona,A.E.; Cerny,N.; Schulze,K.; Weissmann,S.; Ebensen,T.; Morales,C.; Padilla,A.M.; Cazorla,S.I.; Tarleton,R.L.; Guzmán,C.A.; Malchiodi,E.L.; ( Year: 2017). Title: Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection.Journal: NPJ.Vaccines. Volume: 2 Issue: 1, S-Page: 9 DOI: 10.1038/s41541-017-0010-zHZI repositoryPubMed
  • Authors: Akmatov,M.K.; Riese,P.; May,M.; Jentsch,L.; Ahmed,M.W.; Werner,D.; Rosel,A.; Tyler,M.; Pessler,K.; Prokein,J.; Bernemann,I.; Klopp,N.; Prochnow,B.; Trittel,S.; Tallam,A.; Illig,T.; Schindler,C.; Guzmán,C.A.; Pessler,F.; ( Year: 2017). Title: Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.Journal: Hum.Vaccin.Immunother., S-Page: 1- E-Page: 10 DOI: 10.1080/21645515.2017.1299300HZI repositoryPubMed
  • Authors: Matos,M.N.; Cazorla,S.I.; Schulze,K.; Ebensen,T.; Guzmýan,C.A.; Malchiodi,E.L.; ( Year: 2017). Title: Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi.Journal: PLoS.Negl.Trop.Dis. Volume: 11 Issue: 2, S-Page: e0005300 DOI: 10.1371/journal.pntd.0005300HZI repositoryPubMed
  • Authors: Klingen,T.R.; Reimering,S.; Guzmán,C.A.; McHardy,A.C.; ( Year: 2017). Title: In Silico Vaccine Strain Prediction for Human Influenza Viruses.Journal: Trends Microbiol. Volume: 26 Issue: 2, S-Page: 119- E-Page: 131 DOI: 10.1016/j.tim.2017.09.001HZI repositoryPubMed
  • Authors: Schulze,K.; Ebensen,T.; Babiuk,L.A.; Gerdts,V.; Guzmán,C.A.; ( Year: 2017). Title: Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice.Journal: Nanomedicine. Volume: 13 Issue: 7, S-Page: 2169- E-Page: 2178 DOI: 10.1016/j.nano.2017.05.012HZI repositoryPubMed
  • Authors: Akmatov,M.K.; Jentsch,L.; Riese,P.; May,M.; Ahmed,M.W.; Werner,D.; Rösel,A.; Prokein,J.; Bernemann,I.; Klopp,N.; Prochnow,B.; Illig,T.; Schindler,C.; Guzmán,C.A.; Pessler,F.; ( Year: 2017). Title: Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination.Journal: BMC Med.Res.Methodol. Volume: 17 Issue: 1, S-Page: 1- E-Page: 9 DOI: 10.1186/s12874-017-0302-zHZI repositoryPubMed
  • Authors: Ebensen,T.; Debarry,J.; Pedersen,G.K.; Blazejewska,P.; Weissmann,S.; Schulze,K.; McCullough,K.C.; Cox,R.J.; Guzmán,C.A.; ( Year: 2017). Title: Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against Influenza H5N1 in Mice.Journal: Front Immunol. Volume: 8 Issue: Sep, S-Page: 1223 DOI: 10.3389/fimmu.2017.01223HZI repositoryPubMed
  • Authors: Riese,P.; Guzmán,C.A.; ( Year: 2017). Title: Roads to advanced vaccines: influenza case study.Journal: Microb.Biotechnol. Volume: 10 Issue: 5, S-Page: 1036- E-Page: 1040 DOI: 10.1111/1751-7915.12835HZI repositoryPubMed
  • Authors: Mazzuca,P.; Marsico,S.; Schulze,K.; Mitola,S.; Pils,M.C.; Giagulli,C.; Guzmán,C.A.; Caruso,A.; Caccuri,F.; ( Year: 2017). Title: Role of autophagy in the HIV-1 matrix protein p17-driven lymphangiogenesis.Journal: Journal of Virology Volume: 91 Issue: 16, S-Page: art. no. e00801-17 DOI: 10.1128/JVI.00801-17PubMed
  • Authors: Demoulins,T.; Englezou,P.C.; Milona,P.; Ruggli,N.; Tirelli,N.; Pichon,C.; Sapet,C.; Ebensen,T.; Guzmán,C.A.; McCullough,K.C.; ( Year: 2017). Title: Self-Replicating RNA Vaccine Delivery to Dendritic Cells.Journal: Methods in molecular biology (Clifton, N.J.) Volume: 1499, S-Page: 37- E-Page: 75 DOI: 10.1007/978-1-4939-6481-9_3 HZI repository PubMed
  • Authors: Demoulins,T.; Ebensen,T.; Schulze,K.; Englezou,P.C.; Milona,P.; Pelliccia,M.; Guzmán,C.A.; Ruggli,N.; McCullough,K.C.; ( Year: 2017). Title: Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure.Journal: J.Control Release Volume: 266, S-Page: 256- E-Page: 271 DOI: 10.1016/j.jconrel.2017.09.018PubMed
  • Authors: Landi,A.; Law,J.; Hockman,D.; Logan,M.; Crawford,K.; Chen,C.; Kundu,J.; Ebensen,T.; Guzmán,C.A.; Deschatelets,L.; Krishnan,L.; Tyrrell,D.L.J.; Houghton,M.; ( Year: 2017). Title: Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-di-AMP, a STING acitvator or archaeosomes.Journal: Vaccine Volume: 35 Issue: 50, S-Page: 6949- E-Page: 6956 DOI: 10.1016/j.vaccine.2017.10.072HZI repositoryPubMed
  • Authors: Volckmar,J.; Gereke,M.; Ebensen,T.; Riese,P.; Philipsen,L.; Lienenklaus,S.; Wohlleber,D.; Klopfleisch,R.; Stegemann-Koniszewski,S.; Muller,A.J.; Gruber,A.D.; Knolle,P.; Guzmán,C.A.; Bruder,D.; ( Year: 2017). Title: Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.Journal: Sci Rep. Volume: 7 Issue: Mar, S-Page: 43985 DOI: 10.1038/srep43985HZI repositoryPubMed
  • Authors: Lirussi,D.; Ebensen,T.; Schulze,K.; Trittel,S.; Duran,V.; Liebich,I.; Kalinke,U.; Guzmán,C.A.; ( Year: 2017). Title: Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway.Journal: EBioMedicine. Volume: 22, S-Page: 100- E-Page: 111 DOI: 10.1016/j.ebiom.2017.07.016HZI repositoryPubMed
  • Authors: Tomic,A.; Varanasi,P.R.; Golemac,M.; Malic,S.; Riese,P.; Borst,E.M.; Mischak-Weissinger,E.; Guzmán,C.A.; Krmpotic,A.; Jonjic,S.; Messerle,M.; ( Year: 2016). Title: Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.Journal: PLoS Pathogens Volume: 12 Issue: 12, S-Page: e1006015 DOI: 10.1371/journal.ppat.1006015HZI repositoryPubMed
  • Authors: Hatesuer,B.; Hoang,H.T.; Riese,P.; Trittel,S.; Gerhauser,I.; Elbahesh,H.; Geffers,R.; Wilk,E.; Schughart,K.; ( Year: 2016). Title: Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection.Journal: J Innate Immun. Volume: 9 Issue: 2, S-Page: 145- E-Page: 161 DOI: 10.1159/000450705HZI repositoryPubMed
  • Authors: Perin,P.M.; Haid,S.; Brown,R.J.; Doerrbecker,J.; Schulze,K.; Zeilinger,C.; von,Schaewen M.; Heller,B.; Vercauteren,K.; Luxenburger,E.; Baktash,Y.M.; Vondran,F.W.; Speerstra,S.; Awadh,A.; Mukhtarov,F.; Schang,L.M.; Kirschning,A.; Müller,R.; Guzmán,C.A.; Kaderali,L.; Randall,G.; Meuleman,P.; Ploss,A.; Pietschmann,T.; ( Year: 2016). Title: Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.Journal: Hepatology Volume: 63, S-Page: 49- E-Page: 62 DOI: 10.1002/hep.28111HZI repositoryPubMed
  • Authors: Yasar,H.; Gordon,S.; Loretz,B.; Schulze,K.; Guzmán,C.A.; Lehr,C.-M.; ( Year: 2016). Title: Follicular Drug Delivery: a Root to Success - delivering drugs through the skin without the use of needles has proven a significant challenge for the scientific community. But what about exploiting hair follicles?.Journal: The Medicine Maker Issue: 0816-601 DOI: -WEBURLS
  • Authors: Borger,A.K.; Eicke,D.; Wolf,C.; Gras,C.; Aufderbeck,S.; Schulze,K.; Engels,L.; Eiz-Vesper,B.; Schambach,A.; Guzmán,C.A.; Lachmann,N.; Moritz,T.; Martin,U.; Blasczyk,R.; Figueiredo,C.; ( Year: 2016). Title: Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions.Journal: Mol.Med. Volume: 22, S-Page: 274- E-Page: 285 DOI: 10.2119/molmed.2015.00235PubMed
  • Authors: Schulze,K.; Ebensen,T.; Riese,P.; Prochnow,B.; Lehr,C.M.; Guzmán,C.A.; ( Year: 2016). Title: New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy.Journal: Curr Top.Microbiol.Immunol. Volume: 398, S-Page: 207- E-Page: 234 DOI: 10.1007/82_2016_495PubMed
  • Authors: Vazquez,C.L.; Rodgers,A.; Herbst,S.; Coade,S.; Gronow,A.; Guzmán,C.A.; Wilson,M.S.; Kanzaki,M.; Nykjaer,A.; Gutierrez,M.G.; ( Year: 2016). Title: The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.Journal: Sci Rep. Volume: 6, S-Page: 29332 DOI: 10.1038/srep29332HZI repositoryPubMed
  • Authors: Riese,P.; Trittel,S.; May,T.; Cicin-Sain,L.; Chambers,B.J.; Guzmán,C.A.; ( Year: 2015). Title: Activated NKT cells imprint NK-cell differentiation, functionality and education.Journal: Eur.J Immunol. Volume: 45 Issue: 6, S-Page: 1794- E-Page: 1807 PubMed
  • Authors: Kaufmann,S.H.; Fletcher,H.A.; Guzmán,C.A.; Ottenhoff,T.H.; ( Year: 2015). Title: Big Data in Vaccinology: Introduction and section summaries.Journal: Vaccine Volume: 33 Issue: 40, S-Page: 5237- E-Page: 5240 PubMed
  • Authors: Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Guzman,C.A.; Abraham,W.R.; Höfle,M.G.; ( Year: 2015). Title: Cohort study of airway mycobiome in adult cystic fibrosis patients: Differences in community structure between fungi and bacteria reveal predominance of transient fungal elements.Journal: J.Clin.Microbiol. Volume: 53 Issue: 9, S-Page: 2900- E-Page: 2907 WEBURLS
  • Authors: Daenthanasanmak,A.; Salguero,G.; Sundarasetty,B.S.; Waskow,C.; Cosgun,K.N.; Guzmán,C.A.; Riese,P.; Gerasch,L.; Schneider,A.; Ingendoh,A.; Messerle,M.; Gabaev,I.; Woelk,B.; Ruggiero,E.; Schmidt,M.; von,Kalle C.; Figueiredo,C.; Eiz-Vesper,B.; von,Kaisenberg C.; Ganser,A.; Stripecke,R.; ( Year: 2015). Title: Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV.Journal: Mol.Ther.Methods Clin.Dev. Volume: 1, S-Page: 14060 DOI: 10.1038/mtm.2014.60HZI repositoryPubMed
  • Authors: Kügler,J.; Wilke,S.; Meier,D.; Tomszak,F.; Frenzel,A.; Schirrmann,T.; Dubel,S.; Garritsen,H.; Hock,B.; Toleikis,L.; Schutte,M.; Hust,M.; ( Year: 2015). Title: Generation and analysis of the improved human HAL9/10 antibody phage display libraries.Journal: BMC Biotechnol. Volume: 15 Issue: 1, S-Page: 10 DOI: 10.1186/s12896-015-0125-0HZI repositoryPubMed
  • Authors: Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Jauregui,R.; Brettar,I.; Guzmán,C.A.; Höfle,M.G.; ( Year: 2015). Title: High individuality of respiratory bacterial communities in a large cohort of adult cystic fibrosis patients under continuous antibiotic treatment.Journal: PLoS ONE Volume: 10 Issue: 2, S-Page: e0117436 DOI: 10.1371/journal.pone.0117436HZI repositoryPubMed
  • Authors: Schulze,K.; Mittal,A.; Hansen,S.; Ebensen,T.; Weißmann,S.; Guzmán,C.A.; Lehr,C.-M.; ( Year: 2015). Title: Impfung durch Eincremen: Transkutane Immunisierung mittels Nanopartikel.Journal: GIT - Laborfachzeitschrift Volume: 4, S-Page: 25- E-Page: 27
  • Authors: Stern,C.; Kasnitz,N.; Kocijancic,D.; Trittel,S.; Riese,P.; Guzmán,C.A.; Leschner,S.; Weiss,S.; ( Year: 2015). Title: Induction of CD4 and CD8 anti-tumor effector T cell responses by bacteria mediated tumor therapy.Journal: Int J Cancer Volume: 137 Issue: 8, S-Page: 2019- E-Page: 2028 DOI: 10.1002/ijc.29567HZI repositoryPubMed
  • Authors: Major,D.; Chichester,J.A.; Pathirana,R.D.; Guilfoyle,K.; Shoji,Y.; Guzmán,C.A.; Yusibov,V.; Cox,R.J.; ( Year: 2015). Title: Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge.Journal: Human Vaccines and Immunotherapeutics Volume: 11 Issue: 5, S-Page: 1235- E-Page: 1243 WEBURLS
  • Authors: Mittal,A.; Schulze,K.; Ebensen,T.; Weissmann,S.; Hansen,S.; Guzmán,C.A.; Lehr,C.M.; ( Year: 2015). Title: Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination.Journal: J.Control.Release Volume: 206, S-Page: 140- E-Page: 152 WEBURLS
  • Authors: Yang,R.; Lirussi,D.; Thornton,T.M.; Jelley-Gibbs,D.M.; Diehl,S.A.; Case,L.K.; Madesh,M.; Taatjes,D.J.; Teuscher,C.; Haynes,L.; Rincon,M.; ( Year: 2015). Title: Mitochondrial Ca and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.Journal: Elife. Volume: 4, S-Page: e0637622 DOI: 10.7554/eLife.06376.HZI repositoryPubMed
  • Authors: Boianelli,A.; Nguyen,V.K.; Ebensen,T.; Schulze,K.; Wilk,E.; Sharma,N.; Stegemann-Koniszewski,S.; Bruder,D.; Toapanta,F.R.; Guzm b n,C.A.; Meyer-Hermann,M.; Hernandez-Vargas,E.A.; ( Year: 2015). Title: Modeling influenza virus infection: A roadmap for influenza research.Journal: Viruses Volume: 7 Issue: 10, S-Page: 5274- E-Page: 5304 DOI: 10.3390/v7102875HZI repositoryPubMed
  • Authors: Gordon,S.; Daneshian,M.; Bouwstra,J.; Caloni,F.; Constant,S.; Davies,D.E.; Dandekar,G.; Guzmán,C.A.; Fabian,E.; Haltner,E.; Hartung,T.; Hasiwa,N.; Hayden,P.; Kandarova,H.; Khare,S.; Krug,H.F.; Kneuer,C.; Leist,M.; Lian,G.; Marx,U.; Metzger,M.; Ott,K.; Prieto,P.; Roberts,M.S.; Roggen,E.L.; Tralau,T.; van den,Braak C.; Walles,H.; Lehr,C.M.; ( Year: 2015). Title: Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.Journal: ALTEX. Volume: 32 Issue: 4, S-Page: 327- E-Page: 378 HZI repositoryPubMed
  • Authors: Demoulins,T.; Milona,P.; Englezou,P.C.; Ebensen,T.; Schulze,K.; Suter,R.; Pichon,C.; Midoux,P.; Guzmán,C.A.; Ruggli,N.; McCullough,K.C.; ( Year: 2015). Title: Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines.Journal: Nanomedicine Volume: 12, S-Page: 711- E-Page: 722 DOI: 10.1016/j.nano.2015.11.001PubMed
  • Authors: Riese,P.; Trittel,S.; Schulze,K.; Guzmán,C.A.; ( Year: 2015). Title: Rodents as pre-clinical models for predicting vaccine performance in humans.Journal: Expert Rev.Vaccines. Volume: 14 Issue: 9, S-Page: 1213- E-Page: 1225 HZI repositoryPubMed
  • Authors: Geels,M.J.; Thogersen,R.L.; Guzman,C.A.; Ho,M.M.; Verreck,F.; Collin,N.; Robertson,J.S.; McConkey,S.J.; Kaufmann,S.H.; Leroy,O.; ( Year: 2015). Title: TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development.Journal: Vaccine Volume: 33 Issue: 41, S-Page: 5481- E-Page: 5487 PubMed
  • Authors: Holzki,J.K.; Dag,F.; Dekhtiarenko,I.; Rand,U.; Casalegno-Garduno,R.; Trittel,S.; May,T.; Riese,P.; Cicin-Sain,L.; ( Year: 2015). Title: Type I IFN released by Myeloid Dendritic Cells reversibly impairs Cytomegalovirus replication by inhibiting immediate early gene expression.Journal: J Virol. Volume: 89, S-Page: 9886- E-Page: 9895 PubMed
  • Authors: Barcia,R.N.; Santos,J.M.; Filipe,M.; Teixeira,M.; Martins,J.P.; Almeida,J.; Agua-Doce,A.; Varela,A.; Pohl,S.; Dittmar,K.E.; Calado,S.; Simoes,S.I.; Gaspar,M.M.; Cruz,M.E.; Lindenmaier,W.; Graca,L.; Cruz,H.; Cruz,P.E.; ( Year: 2015). Title: What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?.Journal: Stem Cells Int. Volume: 2015, S-Page: 583984 DOI: 10.1155/2015/583984HZI repositoryPubMed
  • Authors: Neuhaus,V.; Chichester,J.A.; Ebensen,Thomas; Schwarz,K.; Hartman,C.E.; Shoji,Y.; Guzmán,Carlos A.; Yusibov,V.; Sewald,K.; Braun,A.; ( Year: 2014). Title: A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung.Journal: Vaccine Volume: 32 Issue: 26, S-Page: 3216- E-Page: 3222 DOI: 10.1016/j.vaccine.2014.04.011HZI repositoryPubMed
  • Authors: Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Guzmán,Carlos A.; Höfle,Manfred G.; Abraham,Wolf-Rainer; ( Year: 2014). Title: A rapid method for breath analysis in cystic fibrosis patients.Journal: European Journal of Clinical Microbiology and Infectious Diseases Volume: 34, S-Page: 745- E-Page: 751 DOI: 10.1007/s10096-014-2286-5HZI repositoryPubMed
  • Authors: Skrnjug,I.; Guzmán,Carlos A.; Ruecker,C.; ( Year: 2014). Title: Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice.Journal: PLoS ONE Volume: 9 Issue: 10, S-Page: e110150 DOI: 10.1371/journal.pone.0110150HZI repositoryPubMed
  • Authors: Salguero,G.; Daenthanasanmak,A.; Münz,C.; Raykova,A.; Guzmán,Carlos A.; Riese,Peggy; Figueiredo,C.; Länger,F.; Schneider,A.; Macke,L.; Sundarasetty,B.S.; Witte,T.; Ganser,A.; Stripecke,R.; ( Year: 2014). Title: Dendritic cell-mediated immune humanization of mice: Implications for allogeneic and xenogeneic stem cell transplantation.Journal: Journal of Immunology Volume: 192 Issue: 10, S-Page: 4636- E-Page: 4647 WEBURLS
  • Authors: Mittal,A.; Schulze,Kai; Ebensen,Thomas; Weissmann,Sebastian; Hansen,Sonja; Lehr,Claus-Michael; Guzmán,Carlos A.; ( Year: 2014). Title: Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation.Journal: Nanomedicine Volume: 11, S-Page: 147- E-Page: 154 DOI: 10.1016/j.nano.2014.08.009HZI repositoryPubMed
  • Authors: Akmatov,M.K.; Kimani-Murage,E.; Pessler,F.; Guzmán,C.A.; Krause,G.; Kreienbrock,L.; Mikolajczyk,R.T.; ( Year: 2014). Title: Evaluation of invalid vaccine doses in 31 countries of the WHO African Region.Journal: Vaccine Volume: 33, S-Page: 892- E-Page: 901 PubMed
  • Authors: Flores,A.E.; Chhatwal,G.S.; Hillier,S.L.; Baker,C.J.; Ferrieri,P.; ( Year: 2014). Title: Expression of Group B Protective Surface Protein (BPS) by Invasive and Colonizing Isolates of Group B Streptococci.Journal: Current Microbiology Volume: 69 Issue: 6, S-Page: 894- E-Page: 898 WEBURLS
  • Authors: Becker,P.D.; Nörder,M.; Weissmann,S.; Ljapoci,R.; Erfle,V.; Drexler,I.; Guzmán,C.A.; ( Year: 2014). Title: Gene expression driven by a strong viral promoter in MVA increases vaccination efficiency by enhancing antibody responses and unmasking CD8+ t cell Epitopes.Journal: Vaccines Volume: 2 Issue: 3, S-Page: 581- E-Page: 600 DOI: 10.3390/vaccines2030581HZI repositoryPubMed
  • Authors: Caccuri,F.; Rueckert,C.; Giagulli,C.; Schulze,K.; Basta,D.; Zicari,S.; Marsico,S.; Cervi,E.; Fiorentini,S.; Slevin,M.; Guzmán,Carlos A.; Caruso,A.; ( Year: 2014). Title: HIV-1 matrix protein p17 promotes lymphangiogenesis and activates the endothelin-1/endothelin B receptor axis.Journal: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 34 Issue: 4, S-Page: 846- E-Page: 856 WEBURLS
  • Authors: Sanchez,M.V.; Ebensen,Thomas; Schulze,Kai; Cargnelutti,D.; Blazejewska,Paulina*; Scodeller,E.A.; Guzmán,Carlos A.; ( Year: 2014). Title: Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge.Journal: PLoS ONE Volume: 9 Issue: 8, S-Page: e104824 PubMed
  • Authors: Riese,Peggy; Sakthivel,Priya; Trittel,S.; Guzmán,Carlos A.; ( Year: 2014). Title: Intranasal formulations: promising strategy to deliver vaccines.Journal: Expert Opinion on Drug Delivery Volume: 11 Issue: 10, S-Page: 1619- E-Page: 1634 PubMed
  • Authors: Cazorla,S.I.; Matos,M.N.; Cerny,N.; Ramirez,C.; Alberti,A.S.; Bivona,A.E.; Morales,C.; Guzmán,Carlos A.; Malchiodi,E.L.; ( Year: 2014). Title: Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection against American Trypanosomiasis.Journal: Journal of Infectious Diseases Volume: 211, S-Page: 698- E-Page: 707 PubMed
  • Authors: Pandey,S.P.; Chandel,H.S.; Srivastava,S.; Selvaraj,S.; Jha,M.K.; Shukla,D.; Ebensen,Thomas; Guzmán,Carlos A.; Saha,B.; ( Year: 2014). Title: Pegylated Bisacycloxypropylcysteine, a Diacylated Lipopeptide Ligand of TLR6, Plays a Host-Protective Role against Experimental Leishmania major Infection.Journal: Journal of Immunology Volume: 193 Issue: 7, S-Page: 3632- E-Page: 3643 PubMed
  • Authors: Caccuri,F.; Giagulli,C.; Reichelt,J.; Martorelli,D.; Marsico,S.; Bugatti,A.; Barone,I.; Rusnati,M.; Guzmán,C.A.; Dolcetti,R.; Caruso,A.; ( Year: 2014). Title: Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate b cell growth.Journal: Journal of Virology Volume: 88 Issue: 10, S-Page: 5706- E-Page: 5717 DOI: ArticleWEBURLS
  • Authors: Matos,M.N.; Cazorla,S.I.; Bivona,A.E.; Morales,C.; Guzmán,Carlos A.; Malchiodi,E.L.; ( Year: 2014). Title: Tc52 Amino Terminal Domain DNA Carried by Attenuated Salmonella Induce Protection against a Trypanosoma cruzi Lethal Challenge.Journal: Infection and Immunity Volume: 82 Issue: 10, S-Page: 4265- E-Page: 4275 PubMed
  • Authors: Skrnjug,I.; Rueckert,C.; Libanova,R.; Lienenklaus,Stefan; Weiss,Siegfried; Guzmán,Carlos A.; ( Year: 2014). Title: The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages.Journal: PLoS ONE Volume: 9 Issue: 4, S-Page: e95728 DOI: 10.1371/journal.pone.0095728HZI repositoryPubMed
  • Authors: Dutruel,C.; Thole,J.; Geels,M.; Mollenkopf,H.J.; Ottenhoff,T.; Guzmán,Carlos A.; Fletcher,H.A.; Leroy,O.; Kaufmann,S.H.; ( Year: 2014). Title: TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'How can big data help?'.Journal: Vaccine Volume: 32 Issue: 35, S-Page: 4365- E-Page: 4368 DOI: 10.1016/j.vaccine.2014.06.014HZI repositoryPubMed
  • Authors: Retamal-Diaz,A.; Riquelme-Neira,R.; Saez,D.; Rivera,A.; Fernandez,P.; Cabrera,A.; Guzmán,Carlos A.; Onate,A.; ( Year: 2014). Title: Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol as adjuvant improved protective immunity associated with a DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus in mice.Journal: Clinical and Vaccine Immunology Volume: 21 Issue: 11, S-Page: 1474- E-Page: 1480 DOI: 10.1128/CVI.00554-14HZI repositoryPubMed
  • Authors: Svindland,S.C.; Pedersen,G.K.; Pathirana,R.D.; Bredholt,G.; Nostbakken,J.K.; Jul-Larsen,A.; Guzmán,Carlos A.; Montomoli,E.; Lapini,G.; Piccirella,S.; Jabbal-Gill,I.; Hinchcliffe,M.; Cox,R.J.; ( Year: 2013). Title: A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine1.Journal: Influenza and other Respiratory Viruses Volume: 7 Issue: 6, S-Page: 1181- E-Page: 1193 DOI: 10.1111/irv.12056HZI repositoryPubMed
  • Authors: Roy,B.; Agarwal,S.; Brennecke,A.-M.; Krey,M.; Pabst,O.; Düber,S.; Weiss,S.; ( Year: 2013). Title: B-1 cell subpopulations contribute differently to gut immunity.Journal: European Journal of Immunology Volume: 43 Issue: 8, S-Page: 2023- E-Page: 2032 DOI: 10.1002/eji.201243070HZI repositoryPubMed
  • Authors: Yevsa,Tatiana; Ebensen,T.; Fuchs,B.; Zygmunt,B.; Libanova,R.; Gross,R.; Schulze,K.; Guzmán,Carlos A.; ( Year: 2013). Title: Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology.Journal: Environmental Microbiology Volume: 15 Issue: 1, S-Page: 64- E-Page: 76 DOI: 10.1111/j.1462-2920.2012.02779.xHZI repositoryPubMed
  • Authors: Gismondi,M.I.; Díaz Carrasco,J.M.; Valva,P.; Becker,P.D.; Guzmán,C.A.; Campos,R.H.; Preciado,M.V.; ( Year: 2013). Title: Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children.Journal: Virology Volume: 447 Issue: 1-2, S-Page: 187- E-Page: 196 DOI: 10.1016/j.virol.2013.09.002HZI repositoryPubMed
  • Authors: Fiebig,A.; Pradella,S.; Petersen,J.; Päuker,O.; Michael,V.; Lünsdorf,H.; Göker,M.; Klenk,H.P.; Wagner-Döbler,I.; ( Year: 2013). Title: Genome of the R-body producing marine alphaproteobacterium Labrenzia alexandrii type strain (DFL-11T).Journal: Standards in Genomic Sciences Volume: 7 Issue: 3, S-Page: 413- E-Page: 426 DOI: 10.4056/sigs.3456959HZI repositoryPubMed
  • Authors: Gras,C.; Schulze,Kai; Goudeva,L.; Guzmán,Carlos A.; Blasczyk,R.; Figueiredo,C.; ( Year: 2013). Title: HLA-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model.Journal: Human gene therapy Volume: 24 Issue: 12, S-Page: 1018- E-Page: 1028 PubMed
  • Authors: Mittal,A.; Raber,A.S.; Schaefer,U.F.; Weissmann,S.; Ebensen,Thomas; Schulze,Kai; Guzmán,Carlos A.; Lehr,Claus-Michael; Hansen,S.; ( Year: 2013). Title: Non-invasive delivery of nanoparticles to hair follicles: A perspective for transcutaneous immunization.Journal: Vaccine Volume: 31 Issue: 34, S-Page: 3442- E-Page: 3451 PubMed
  • Authors: Gurramkonda,C.; Zahid,M.; Nemani,S.K.; Adnan,A.; Gudi,S.K.; Khanna,N.; Ebensen,T.; Lünsdorf,H.; Guzmán,C.A.; Rinas,U.; ( Year: 2013). Title: Purification of hepatitis B surface antigen virus-like particles from recombinant Pichia pastoris and in vivo analysis of their immunogenic properties.Journal: Journal of Chromatography B Volume: 940C, S-Page: 104- E-Page: 111 DOI: 10.1016/j.jchromb.2013.09.030HZI repositoryPubMed
  • Authors: Mittal,A.; Raber,A.S.; Schaefer,U.F.; Weissmann,S.; Ebensen,Thomas; Schulze,Kai; Guzmán,Carlos A.; Hansen,S.; Lehr,Claus-Michael; ( Year: 2013). Title: Transfollicular delivery of antigen using nanocarriers for non-invasive transcutaneous immunization.Journal: Controlled Release Society (CRS) Letters Volume: 30, S-Page: 16- E-Page: 17
  • Authors: Riese,Peggy; Schulze,Kai; Ebensen,Thomas; Prochnow,B.; Guzmán,Carlos A.; ( Year: 2013). Title: Vaccine Adjuvants: Key Tools For Innovative Vaccine Design.Journal: Current Topics in Medicinal Chemistry Volume: 13 Issue: 20, S-Page: 2562- E-Page: 2580 PubMed
  • Authors: Brettar,I.; Christen,R.; Höfle,Manfred G.; ( Year: 2012). Title: Analysis of bacterial core communities in the central Baltic by comparative RNA-DNA-based fingerprinting provides links to structure-function relationships.Journal: ISME Journal Volume: 6 Issue: 1, S-Page: 195- E-Page: 212 DOI: 10.10038/ismej.2011.80PubMed
  • Authors: Henne,K.; Kahlisch,L.; Brettar,I.; Höfle,Manfred G.; ( Year: 2012). Title: Analysis of structure and composition of bacterial core communities in mature drinking water biofilms and bulk water of a citywide network in Germany.Journal: Applied and Environmental Microbiology Volume: 78 Issue: 10, S-Page: 3530- E-Page: 3538 DOI: 10.1128/AEM.06373-11HZI repositoryPubMed
  • Authors: Ebermann,L.; Ruzsics,Z.; Guzmán,Carlos A.; Van,Rooijen N.; Casalegno-Garduno,R.; Koszinowski,U.; Cicin-Sain,Luka; ( Year: 2012). Title: Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient host.Journal: PLoS Pathogens Volume: 8 Issue: 12, S-Page: e1003062 DOI: 10.1371/journal.ppat.1003062HZI repositoryPubMed
  • Authors: Fiege,K.; Lünsdorf,H.; Atarijabarzadeh,S.; Mischnick,P.; ( Year: 2012). Title: Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles.Journal: Beilstein Journal of Organic Chemistry Volume: 8, S-Page: 551- E-Page: 566 DOI: 10.3762/bjoc.8.63HZI repositoryPubMed
  • Authors: Libanova,R.; Becker,P.D.; Guzmán,Carlos A.; ( Year: 2012). Title: Cyclic di-nucleotides: new era for small molecules as adjuvants.Journal: Microbial Biotechnology Volume: 5 Issue: 2, S-Page: 168- E-Page: 176 DOI: 10.1111/j.1751-7915.2011.00306.xHZI repositoryPubMed
  • Authors: Waern,J.M.; Yuan,Q.; Rudrich,U.; Becker,P.D.; Schulze,K.; Strick-Marchand,H.; Huntington,N.D.; Zacher,B.J.; Wursthorn,K.; DiSanto,J.P.; Guzmán,Carlos A.; Manns,M.P.; Ott,M.; Bock,M.; ( Year: 2012). Title: Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice.Journal: Hepatology Volume: 56 Issue: 4, S-Page: 1479- E-Page: 1488 DOI: 10.1002/hep.25816HZI repositoryPubMed
  • Authors: Caro-Quintero,A.; Auchtung,J.; Deng,J.; Brettar,I.; Höfle,Manfred; Tiedje,J.M.; Konstantinidis,K.T.; ( Year: 2012). Title: Genome sequencing of five Shewanella baltica strains recovered from the oxic-anoxic interface of the Baltic Sea.Journal: Journal of Bacteriology Volume: 194 Issue: 5, S-Page: 1236 PubMed
  • Authors: Caccuri,F.; Giagulli,C.; Bugatti,A.; Benetti,A.; Alessandri,G.; Ribatti,D.; Marsico,S.; Apostoli,P.; Slevin,M.A.; Rusnati,M.; Guzman,Carlos A.; Fiorentini,S.; Caruso,A.; ( Year: 2012). Title: HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.Journal: Proceedings of the National Academy of Sciences USA Volume: 109 Issue: 36, S-Page: 14580- E-Page: 14585 PubMed
  • Authors: Krawczyk-Bärsch,E.; Lünsdorf,H.; Pedersen,K.; Arnold,T.; Bok,F.; Steudtner,R.; Lehtinen,A.; Brendler,V.; ( Year: 2012). Title: Immobilization of uranium in biofilm microorganisms exposed to groundwater seeps over granitic rock tunnel walls in Olkiluoto, Finland.Journal: Geochimica et Cosmochimica Acta Volume: 96, S-Page: 94- E-Page: 104
  • Authors: Vezzulli,L.; Brettar,I.; Pezzati,E.; Reid,P.C.; Colwell,R.R.; Höfle,Manfred G.; Pruzzo,C.; ( Year: 2012). Title: Long-term effects of ocean warming on the prokaryotic community: evidence from the vibrios.Journal: ISME Journal Volume: 6 Issue: 1, S-Page: 21- E-Page: 30 DOI: 10.1038/ismej.2011.89HZI repositoryPubMed
  • Authors: Nörder,M.; Gutierrez,M.G.; Zicari,S.; Cervi,E.; Caruso,A.; Guzmán,Carlos A.; ( Year: 2012). Title: Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation.Journal: FASEB journal Volume: 26 Issue: 7, S-Page: 2835- E-Page: 2846 PubMed
  • Authors: Garcia,K.; Gavilan,R.G.; Höfle,Manfred G.; Martinez-Urtaza,J.; Espejo,R.T.; ( Year: 2012). Title: Microevolution of Pandemic Vibrio parahaemolyticus Assessed by the Number of Repeat Units in Short Sequence Tandem Repeat Regions.Journal: PLoS ONE Volume: 7 Issue: 1, S-Page: e30823 DOI: 10.1371/journal.pone.0030823HZI repositoryPubMed
  • Authors: Zygmunt,B.M.; Weissmann,S.F.; Guzmán,Carlos A.; ( Year: 2012). Title: NKT Cell Stimulation with alpha-Galactosylceramide Results in a Block of Th17 Differentiation after Intranasal Immunization in Mice.Journal: PLoS ONE Volume: 7 Issue: 1, S-Page: e30382 DOI: 10.1371/journal.pone.0030382HZI repositoryPubMed
  • Authors: Mehner,D.; Osadnik,H.; Lünsdorf,H.; Bruser,T.; ( Year: 2012). Title: The Tat System for Membrane Translocation of Folded Proteins Recruits the Membrane-stabilizing Psp Machinery in Escherichia coli.Journal: Journal of Biological Chemistry Volume: 287 Issue: 33, S-Page: 27834- E-Page: 27842 PubMed
  • Authors: Krishnaswamy,J.K.; Jirmo,A.C.; Baru,A.M.; Ebensen,T.; Guzmán,Carlos A.; Sparwasser,Tim; Behrens,G.M.; ( Year: 2012). Title: Toll-like receptor-2 agonist-allergen coupling efficiently redirects th2 cell responses and inhibits allergic airway eosinophilia.Journal: American Journal of Respiratory Cell and Molecular Biology Volume: 47 Issue: 6, S-Page: 852- E-Page: 863 DOI: 10.1165/rcmb.2011-0414OCPubMed
  • Authors: Rueckert,C.; Guzmán,Carlos A.; ( Year: 2012). Title: Vaccines: from empirical development to rational design.Journal: PLoS Pathogens Volume: 8 Issue: 11, S-Page: e1003001 DOI: 10.1371/journal.ppat.1003001HZI repositoryPubMed
  • Authors: Danilov,S.M.; Gordon,K.; Nesterovitch,A.B.; Lünsdorf,H.; Chen,Z.; Castellon,M.; Popova,I.A.; Kalinin,S.; Mendonca,E.; Petukhov,P.A.; Schwartz,D.E.; Minshall,R.D.; Sturrock,E.D.; ( Year: 2011). Title: An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding.Journal: PLoS ONE Volume: 6 Issue: 10, S-Page: e25952 PubMed
  • Authors: Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Brettar,I.; Höfle,Manfred G.*; ( Year: 2011). Title: Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526.Journal: Microbial Ecology Volume: 63 Issue: 2, S-Page: 383- E-Page: 397 DOI: 10.1007/s00248-011-9918-4PubMed
  • Authors: Ebensen,T.; Libanova,R.; Schulze,K.; Yevsa,T.; Morr,M.; Guzmán,Carlos A.*; ( Year: 2011). Title: Bis-(3',5')-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant.Journal: Vaccine Volume: 29 Issue: 32, S-Page: 5210- E-Page: 5220 PubMed
  • Authors: Pedersen,G.K.; Ebensen,T.; Gjeraker,I.H.; Svindland,S.; Bredholt,G.; Guzmán,Carlos A.*; Cox,R.J.; ( Year: 2011). Title: Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP.Journal: PLoS ONE Volume: 6 Issue: 11, S-Page: e26973 DOI: 10.1371/journal.pone.0026973HZI repositoryPubMed
  • Authors: TrehanPati,N.; Sukriti,S.; Geffers,Robert*; Hissar,S.; Riese,P.; Toepfer,T.; Guzmán,Carlos A.*; Sarin,S.K.; ( Year: 2011). Title: Gene expression profiles of T cells from hepatitis E virus infected patients in acute and resolving phase.Journal: Journal of Clinical Immunology Volume: 31 Issue: 3, S-Page: 498- E-Page: 508 DOI: 10.1007/s10875-010-9506-210.1007/s10875-010-9506-2HZI repositoryPubMed
  • Authors: Duarte,M.; Ferreira-da-Silva,F.; Lünsdorf,H.; Junca,H.; Gales,L.; Pieper,D.H.; Nunes,O.C.; ( Year: 2011). Title: Gulosibacter molinativorax ON4T molinate hydrolase, a novel cobalt-dependent amidohydrolase.Journal: Journal of Bacteriology Volume: 193 Issue: 20, S-Page: 5810- E-Page: 5816 DOI: 10.1128/JB.05054-11HZI repositoryPubMed
  • Authors: Huntington,N.D.; Alves,N.L.; Legrand,N.; Lim,A.; Strick-Marchand,H.; Mention,J.J.; Plet,A.; Weijer,K.; Jacques,Y.; Becker,P.D.; Guzmán,Carlos*; Soussan,P.; Kremsdorf,D.; Spits,H.; Di Santo,J.P.; ( Year: 2011). Title: IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.Journal: Proceeding of the National Academy of Sciences USA Volume: 108 Issue: 15, S-Page: 6217- E-Page: 6222 PubMed
  • Authors: Madhun,A.S.; Haaheim,L.R.; Nostbakken,J.K.; Ebensen,T.; Chichester,J.; Yusibov,V.; Guzmán,Carlos A.*; Cox,R.J.; ( Year: 2011). Title: Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4(+) cells and strong mucosal and systemic antibody responses in mice.Journal: Vaccine Volume: 29 Issue: 31, S-Page: 4973- E-Page: 4982 PubMed
  • Authors: Knothe,S.; Mutschler,V.; Rochlitzer,S.; Winkler,C.; Ebensen,T.; Guzmán,Carlos A.*; Hohlfeld,J.; Braun,A.; Muller,M.; ( Year: 2011). Title: Local treatment with BPPcysMPEG reduces allergic airway inflammation in sensitized mice.Journal: Immunobiology Volume: 216 Issue: 1-2, S-Page: 110- E-Page: 117 DOI: 10.1016/j.imbio.2010.05.003HZI repositoryPubMed
  • Authors: Leidinger,P.; Popescu,R.; Gerthsen,D.; Lünsdorf,H.; Feldmann,C.; ( Year: 2011). Title: Nanoscale copper sulfide hollow spheres with phase-engineered composition: covellite (CuS), digenite (Cu1.8S), chalcocite (Cu2S).Journal: Nanoscale Volume: 3 Issue: 6, S-Page: 2544- E-Page: 2551 PubMed
  • Authors: Zygmunt,B.M.; Gröbe,Lothar*; Guzmán,Carlos A.*; ( Year: 2011). Title: Peritoneal cavity is dominated by IFNgamma-secreting CXCR3+ Th1 cells.Journal: PLoS ONE Volume: 6 Issue: 7, S-Page: e18032 DOI: 10.1371/journal.pone.0018032HZI repositoryPubMed
  • Authors: Hedrich,S.; Lünsdorf,H.; Kleeberg,R.; Heide,G.; Seifert,J.; Schlomann,M.; ( Year: 2011). Title: Schwertmannite Formation Adjacent to Bacterial Cells in a Mine Water Treatment Plant and in Pure Cultures of Ferrovum myxofaciens.Journal: Environmental Science and Technology Volume: 45 Issue: 18, S-Page: 7685- E-Page: 7692 PubMed
  • Authors: Krawczyk-Barsch,E.; Lünsdorf,H.; Arnold,T.; Brendler,V.; Eisbein,E.; Jenk,U.; Zimmermann,U.; ( Year: 2011). Title: The influence of biofilms on the migration of uranium in acid mine drainage (AMD) waters.Journal: Science of the Total Environment Volume: 409 Issue: 16, S-Page: 3059- E-Page: 3065 PubMed
  • Authors: Knothe,S.; Mutschler,V.; Rochlitzer,S.; Winkler,C.; Ebensen,T.; Guzmán,Carlos A.*; Hohlfeld,J.; Braun,A.; Muller,M.; ( Year: 2011). Title: The NKT cell ligand alphagalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response.Journal: Vaccine Volume: 29 Issue: 25, S-Page: 4249- E-Page: 4255 DOI: 10.1016/j.vaccine.2011.03.068HZI repositoryPubMed
  • Authors: Guzmán,C.A.; Timmis,Kenneth N.*; ( Year: 2011). Title: Towards intelligent vaccines: the VAC-CHIP..Journal: Microbial Biotechnology Volume: 4 Issue: 2 DOI: 10.1111/j.1751-7915.2010.00245.xPubMed
  • Authors: Sabirova,J.S.; Becker,A.; Lünsdorf,H.; Nicaud,J.M.; Timmis,K.N.; Golyshin,P.N.; ( Year: 2011). Title: Transcriptional profiling of the marine oil-degrading bacterium Alcanivorax borkumensis during growth on n-alkanes.Journal: Fems Microbiology Letters Volume: 319 Issue: 2, S-Page: 160- E-Page: 168 DOI: 10.1111/j.1574-6968.2011.02279.xHZI repositoryPubMed
  • Authors: Lünsdorf,H.; Gurramkonda,C.; Adnan,A.; Khanna,N.; Rinas,U.; ( Year: 2011). Title: Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen.Journal: Microbial Cell Factories Volume: 10, S-Page: 48 DOI: 10.1186/1475-2859-10-48HZI repositoryPubMed
  • Authors: Becker,P.D.; Royo,J.L.; Guzmán,Carlos A.*; ( Year: 2010). Title: Based on the salicylate-dependent control circuit encompassing nahR/Psal::xylS2 for biotechnological applications.Journal: Bioengineered Bugs Volume: 1 Issue: 4, S-Page: 244- E-Page: 251
  • Authors: Wang,X.; Lünsdorf,H.; Ehren,I.; Brauner,A.; Romling,U.; ( Year: 2010). Title: Characteristics of Biofilms from Urinary Tract Catheters and Presence of Biofilm-Related Components in Escherichia coli.Journal: Current Microbiology Volume: 60, S-Page: 446- E-Page: 453 PubMed
  • Authors: Libanova,R.; Ebensen,T.; Schulze,K.; Bruhn,D.; Nörder,M.; Yevsa,T.; Morr,M.; Guzmán,Carlos A.*; ( Year: 2010). Title: Corrigendum to "The member of the cyclic di-nucleotide family bis- (3',5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant [Vaccine 28 (2010) 2249-2258].Journal: Vaccine Volume: 28 Issue: 20, S-Page: 3625
  • Authors: Becker,P.D.; Royo,J.L.; Guzmán,Carlos A.*; ( Year: 2010). Title: Exploitation of prokaryotic expression systems based on the salicylate-dependent control circuit encompassing nahRPsal::xylS2 for biotechnological applications.Journal: Bioengineered Bugs Volume: 1, S-Page: 246- E-Page: 253 DOI: 10.4161/bbug.1.4.11247FulltextPubMed
  • Authors: Bjorkstrom,N.K.; Riese,P.; Heuts,F.; Andersson,S.; Fauriat,C.; Ivarsson,M.A.; Bjorklund,A.T.; Flodstrom-Tullberg,M.; Michaelsson,J.; Rottenberg,M.E.; Guzmán,Carlos A.*; Ljunggren,H.G.; Malmberg,K.J.; ( Year: 2010). Title: Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.Journal: Blood Volume: 116 Issue: 19, S-Page: 3853- E-Page: 3864 PubMed
  • Authors: Becker,P.D.; Legrand,N.; van Geelen,C.M.; Noerder,M.; Huntington,N.D.; Lim,A.; Yasuda,E.; Diehl,S.A.; Scheeren,F.A.; Ott,M.; Weijer,K.; Wedemeyer,H.; Di Santo,J.P.; Beaumont,T.; Guzmán,Carlos A.*; Spits,H.; ( Year: 2010). Title: Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.Journal: PLoS ONE Volume: 5 Issue: 10 DOI: 10.1371/journal.pone.0013137HZI repositoryPubMed
  • Authors: Kahlisch,L.; Henne,K.; Draheim,J.; Brettar,I.; Höfle,Manfred G.*; ( Year: 2010). Title: High-resolution in situ genotyping of Legionella pneumophila populations in drinking water by multiple-locus variable-number tandem-repeat analysis using environmental DNA.Journal: Applied in Environmental Microbiology Volume: 76 Issue: 18, S-Page: 6186- E-Page: 6195 DOI: 10.1128/AEM.00416-10HZI repositoryPubMed
  • Authors: Stegmann,K.A.; Björkström,N.K.; Liermann,H.; Ciesek,S.; Riese,P.; Wiegand,J.; Hadem,J.; Suneetha,P.V.; Jaroszewicz,J.; Wang,C.; Schlaphoff,V.; Fytili,P.; Cornberg,M.; Manns,M.P.; Geffers,Robert*; Pietschmann,Thomas*; Guzmán,Carlos A.*; Ljunggren,H.-G.; Wedemeyer,H.; ( Year: 2010). Title: IFN alpha-induced TRAIL on human NK cells is associated with control of hepatitis C virus infection.Journal: Gastroenterology Volume: 138 Issue: 5, S-Page: 1885- E-Page: 1897
  • Authors: Nörder,M.; Becker,P.D.; Drexler,I.; Link,C.; Erfle,V.; Guzmán,Carlos A.*; ( Year: 2010). Title: Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.Journal: PLoS ONE Volume: 5 Issue: 6, S-Page: e11400 DOI: 10.1371/journal.pone.0011400HZI repositoryPubMed
  • Authors: Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Draheim,J.; Höfle,Manfred G.*; Brettar,I.; ( Year: 2010). Title: Molecular analysis of the bacterial drinking water community with respect to live/dead status.Journal: Water Science and Technology Volume: 61 Issue: 1, S-Page: 9- E-Page: 14 DOI: 10.2166/wst.2010.773PubMed
  • Authors: Switalla,S.; Lauenstein,L.; Prenzler,F.; Knothe,S.; Forster,C.; Fieguth,H.G.; Pfennig,O.; Schaumann,F.; Martin,C.; Guzmán,Carlos A.*; Ebensen,T.; Muller,M.; Hohlfeld,J.M.; Krug,N.; Braun,A.; Sewald,K.; ( Year: 2010). Title: Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices.Journal: Toxicology and Applied Pharmacology Volume: 246 Issue: 3, S-Page: 107- E-Page: 115 DOI: 10.1016/j.taap.2010.04.010PubMed
  • Authors: Fritzer,A.; Senn,B.M.; Minh,D.B.; Hanner,M.; Gelbmann,D.; Noiges,B.; Henics,T.; Schulze,K.; Guzmán,Carlos A.*; Goodacre,J.; von,Gabain A.; Nagy,E.; Meinke,A.L.; ( Year: 2010). Title: Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine.Journal: Infection and Immunity Volume: 78 Issue: 9, S-Page: 4051- E-Page: 4067 PubMed
  • Authors: Hahn,M.W.; Lang,E.; Brandt,U.; Lünsdorf,H.; Wu,Q.L.; Stackebrandt,E.; ( Year: 2010). Title: Polynucleobacter cosmopolitanus sp. nov., free-living planktonic bacteria inhabiting freshwater lakes and rivers.Journal: International Journal of Systematic and Evolutionary Microbiology Volume: 60 Issue: Pt 1, S-Page: 166- E-Page: 173 PubMed
  • Authors: Chen,H.L.; Lünsdorf,H.; Hecht,H.J.; Tsai,H.; ( Year: 2010). Title: Porcine pulmonary angiotensin I-converting enzyme-Biochemical characterization and spatial arrangement of the N- and C-domains by three-dimensional electron microscopic reconstruction.Journal: Micron Volume: 41 Issue: 6, S-Page: 674- E-Page: 685 DOI: 10.1016/j.micron.2010.01.005HZI repositoryPubMed
  • Authors: Cazorla,S.I.; Frank,F.M.; Becker,P.D.; Arnaiz,M.; Mirkin,G.A.; Corral,R.S.; Guzmán,Carlos A.*; Malchiodi,E.L.; ( Year: 2010). Title: Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection.Journal: Journal of Infectious Diseases Volume: 202 Issue: 1, S-Page: 136- E-Page: 144 DOI: 10.1086/652872HZI repositoryPubMed
  • Authors: Libanova,R.; Ebensen,T.; Schulze,K.; Bruhn,D.; Norder,M.; Yevsa,T.; Morr,M.; Guzmán,Carlos A.*; ( Year: 2010). Title: The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant.Journal: Vaccine Volume: 28 Issue: 10, S-Page: 2249- E-Page: 2258 PubMed
  • Authors: Prajeeth,C.K.; Jirmo,A.C.; Krishnaswamy,J.K.; Ebensen,T.; Guzmán,Carlos A.*; Weiss,Siegfried*; Constabel,H.; Schmidt,R.E.; Behrens,G.M.; ( Year: 2010). Title: The synthetic TLR2 agonist BPPcysMPEG leads to efficient cross-priming against co-administered and linked antigens.Journal: European Journal of Immunology Volume: 40 Issue: 5, S-Page: 1272- E-Page: 1283 PubMed
  • Authors: Caro-Quintero,A.; Deng,J.; Auchtung,J.; Brettar,I.; Höfle,Manfred G.*; Klappenbach,J.; Konstantinidis,K.T.; ( Year: 2010). Title: Unprecedented levels of horizontal gene transfer among spatially co-occurring Shewanella bacteria from the Baltic Sea.Journal: ISME Journal Volume: 5 Issue: 131, S-Page: 140 PubMed
  • Authors: Roming,M.; Lünsdorf,H.; Dittmar,K.E.; Feldmann,C.; ( Year: 2010). Title: ZrO(HPO(4))(1-x)(FMN)(x): quick and easy synthesis of a nanoscale luminescent biomarker.Journal: Angewandte Chemie International Edition Volume: 49 Issue: 3, S-Page: 632- E-Page: 637 PubMed
  • Authors: Osanjo,G.O.; Muthike,E.W.; Tsuma,L.; Okoth,M.W.; Bulimo,W.D.; Lünsdorf,H.; Abraham,W.-R.; Dion,M.; Timmis,K.N.; Golyshin,P.N.; Mulaa,F.J.; ( Year: 2009). Title: A salt lake extremophile, Paracoccus bogoriensis sp. nov., efficiently produces xanthophyll carotenoids.Journal: African Journal of Microbiology Research Volume: 3 Issue: 8, S-Page: 426- E-Page: 433
  • Authors: Fuchs,B.; Knothe,S.; Rochlitzer,S.; Nassimi,M.; Greweling,M.; Lauenstein,H.D.; Nassenstein,C.; Muller,M.; Ebensen,T.; Dittrich,A.M.; Krug,N.; Guzman,Carlos A.*; Braun,A.; ( Year: 2009). Title: A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens.Journal: International Archives of Allergy and Immunology Volume: 152 Issue: 2, S-Page: 131- E-Page: 139 DOI: 10.1159/000265534PubMed
  • Authors: Golyshina,O.V.; Yakimov,M.M.; Lünsdorf,H.; Ferrer,M.; Nimtz,M.; Timmis,K.N.; Wray,V.; Tindall,B.J.; Golyshin,P.N.; ( Year: 2009). Title: Acidiplasma aeolicum gen. nov., sp. nov., a euryarchaeon of the family Ferroplasmaceae isolated from a hydrothermal pool, and transfer of Ferroplasma cupricumulans to Acidiplasma cupricumulans comb. nov.Journal: International Journal of Systematic and Evolutionary Microbiology Volume: 59 Issue: Pt 11, S-Page: 2815- E-Page: 2823 DOI: 10.1099/ijs.0.009639-0HZI repositoryPubMed
  • Authors: Gismondi,M.I.; Becker,P.D.; az Carrasco,J.M.; Guzmán,Carlos A.*; Campos,R.H.; Preciado,M.V.; ( Year: 2009). Title: Evolution of hepatitis C virus hypervariable region 1 in immunocompetent children born to HCV-infected mothers.Journal: Journal of Viral Hepatitis Volume: 16 Issue: 5, S-Page: 332- E-Page: 339 DOI: 10.1111/j.1365-2893.2009.01071.xHZI repositoryPubMed
  • Authors: Probst-Kepper,M.; Geffers,R.; Kroger,A.; Viegas,N.; Erck,C.; Hecht,H.-J.; Lünsdorf,H.; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,A.; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,R.; Hauser,H.; Buer,J.; Weiss,S.; ( Year: 2009). Title: GARP: a key receptor controlling FOXP3 in human regulatory T cells.Journal: Journal of Cellular and Molecular Medicine Volume: 13 Issue: 9, S-Page: 3343- E-Page: 3357 PubMed
  • Authors: Pati,N.T.; Geffers,Robert*; Sukriti,Hissar S.; Riese,P.; Toepfer,T.; Buer,J.; Guzmán,Carlos A.*; Sarin,S.K.; ( Year: 2009). Title: Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B viral infection.Journal: Hepatology Volume: 49 Issue: 3, S-Page: 781- E-Page: 790
  • Authors: Valva,P.; Becker,P.; Streitemberger,P.; Garcia,Lombardi M.; Rey,G.; Guzmán,Carlos A.*; Preciado,M.V.; ( Year: 2009). Title: Germline TP53 mutations and single nucleotide polymorphisms in children.Journal: Medicina (B Aires) Volume: 69 Issue: 1/2, S-Page: 143- E-Page: 147 PubMed
  • Authors: Wurdemann,D.; Tindall,B.J.; Pukall,R.; Lünsdorf,H.; Strompl,C.; Namuth,T.; Nahrstedt,H.; Wos-Oxley,M.; Ott,S.; Schreiber,S.; Timmis,K.N.; Oxley,A.P.; ( Year: 2009). Title: Gordonibacter pamelaeae gen. nov., sp. nov., a new member of the Coriobacteriaceae isolated from a patient with Crohn's disease, and reclassification of Eggerthella hongkongensis Lau et al. 2006 as Paraeggerthella hongkongensis gen. nov., comb. nov.Journal: International Journal of Systematic and Evolutionary Microbiology Volume: 59 Issue: Pt 6, S-Page: 1405- E-Page: 1415 PubMed
  • Authors: Bosch,V.; Pfeiffer,T.; Devitt,G.; Allespach,I.; Ebensen,T.; Emerson,V.; Guzmán,C.A.; Keppler,O.T.; ( Year: 2009). Title: HIV pseudovirion vaccine exposing Env "fusion intermediates"-Response to immunisation in human CD4/CCR5-transgenic rats.Journal: Vaccine Volume: 27 Issue: 16, S-Page: 2202- E-Page: 2212
  • Authors: Legrand,N.; Ploss,A.; Balling,Rudi*; Becker,P.D.; Borsotti,C.; Brezillon,N.; Debarry,J.; de,Jong Y.; Deng,H.; Di Santo,J.P.; Eisenbarth,S.; Eynon,E.; Flavell,R.A.; Guzmán,Carlos A.*; Huntington,N.D.; Kremsdorf,D.; Manns,M.P.; Manz,M.G.; Mention,J.J.; Ott,M.; Rathinam,C.; Rice,C.M.; Rongvaux,A.; Stevens,S.; Spits,H.; Strick-Marchand,H.; Takizawa,H.; van Lent,A.U.; Wang,C.; Weijer,K.; Willinger,T.; Ziegler,P.; ( Year: 2009). Title: Humanized mice for modeling human infectious disease: challenges, progress, and outlook.Journal: Cell Host and Microbe Volume: 6 Issue: 1, S-Page: 5- E-Page: 9 DOI: 10.1016/j.chom.2009.06.006HZI repositoryPubMed
  • Authors: Ebensen,T.; Guzmán,C.A.; ( Year: 2009). Title: Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.Journal: Advances in Experimental Medicine and Biology Volume: 655, S-Page: 171- E-Page: 188 PubMed
  • Authors: Zygmunt,B.M.; Rharbaoui,F.; Gröbe,Lothar*; Guzman,Carlos A.*; ( Year: 2009). Title: Intranasal immunization promotes th17 immune responses.Journal: Journal of Immunology Volume: 183 Issue: 11, S-Page: 6933- E-Page: 6938 PubMed
  • Authors: Zharkouskay,A.; Lünsdorf,H.; Feldmann,C.; ( Year: 2009). Title: Ionic liquid-based synthesis of luminescent YVO4:Eu and YVO4:Eu@YF3 nanocrystals.Journal: Journal of Materials Science Volume: 44 Issue: 15, S-Page: 39361- E-Page: 39427
  • Authors: Harth-Chu,E.; Espejo,R.T.; Christen,R.; Guzmán,Carlos A.*; Höfle,Manfred G.*; ( Year: 2009). Title: Multiple-locus variable-number tandem-repeat analysis for clonal identification of Vibrio parahaemolyticus isolates by using capillary electrophoresis.Journal: Applied in Environmental Microbiology Volume: 75 Issue: 12, S-Page: 4079- E-Page: 4088 PubMed
  • Authors: Guzmán,Carlos A.*; ( Year: 2009). Title: Optimizing rational vaccine design.Journal: Microbial Biotechnology Volume: 2 Issue: 2 spec. iss., S-Page: 136- E-Page: 138
  • Authors: Giagulli,C.; Noerder,M.; Avolio,M.; Becker,P.D.; Fiorentini,S.; Guzmán,Carlos A.*; Caruso,A.; ( Year: 2009). Title: Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.Journal: International Immunopharmacology Volume: 9 Issue: 12, S-Page: 1366- E-Page: 1373 DOI: 10.1016/j.intimp.2009.08.010HZI repositoryPubMed
  • Authors: Haridass,D.; Yuan,Q.; Becker,P.D.; Cantz,T.; Iken,M.; Rothe,M.; Narain,N.; Bock,M.; Norder,M.; Legrand,N.; Wedemeyer,H.; Weijer,K.; Spits,H.; Manns,M.P.; Cai,J.; Deng,H.; Di Santo,J.P.; Guzman,Carlos A.*; Ott,M.; ( Year: 2009). Title: Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.Journal: American Journal of Pathology Volume: 175 Issue: 4, S-Page: 1483- E-Page: 1492 PubMed
  • Authors: Gurramkonda,C.; Adnan,A.; Gabel,T.; Lünsdorf,H.; Ross,A.; Nemani,S.K.; Swaminathan,S.; Khanna,N.; Rinas,U.; ( Year: 2009). Title: Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen.Journal: Microbial Cell Factories Volume: 8, S-Page: 13 DOI: 10.1186/1475-2859-8-13HZI repositoryPubMed
  • Authors: Spring,S.; Lünsdorf,H.; Fuchs,B.M.; Tindall,B.J.; ( Year: 2009). Title: The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.Journal: PLoS ONE Volume: 4 Issue: 3, S-Page: e4866 DOI: 10.1371/journal.pone.0004866HZI repositoryPubMed
  • Authors: Palma,C.; Iona,E.; Ebensen,T.; Guzmán,Carlos A.*; Cassone,A.; ( Year: 2009). Title: The toll-like receptor 2/6 ligand MALP-2 reduces the viability of Mycobacterium tuberculosis in murine macrophages.Journal: Open Microbiology Journal Volume: 3, S-Page: 47- E-Page: 52
  • Authors: Schulze,K.; Staib,C.; Schatzl,H.M.; Ebensen,Thomas*; Erfle,V.; Guzmán,Carlos A.*; ( Year: 2008). Title: A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus.Journal: Vaccine Volume: 26 Issue: 51, S-Page: 6678- E-Page: 6684 DOI: 10.1016/j.vaccine.2008.09.006HZI repositoryPubMed
  • Authors: Vezzulli,L.; Guzmán,Carlos A.*; Colwell,R.R.; Pruzzo,C.; ( Year: 2008). Title: Dual role colonization factors connecting Vibrio cholerae's lifestyles in human and aquatic environments open new perspectives for combating infectious diseases.Journal: Current Opinion in Biotechnology Volume: 19 Issue: 3, S-Page: 254- E-Page: 259 PubMed
  • Authors: Jordao,L.; Lengeling,Andreas*; Bordat,Y.; Boudou,F.; Gicquel,B.; Neyrolles,O.; Becker,P.D.; Guzmán,Carlos .A.*; Griffiths,G.; Anes,E.; ( Year: 2008). Title: Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice.Journal: Microbes and Infection Volume: 10 Issue: 12-13, S-Page: 1379- E-Page: 1386 PubMed
  • Authors: Cataldi,A.; Yevsa,T.; Vilte,D.A.; Schulze,K.; Castro-Parodi,M.; Larzabal,M.; Ibarra,C.; Mercado,E.C.; Guzmán,Carlos A.*; ( Year: 2008). Title: Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant.Journal: Vaccine Volume: 26 Issue: 44, S-Page: 5662- E-Page: 5667 DOI: 10.1016/j.vaccine.2008.07.027FulltextHZI repositoryPubMed
  • Authors: Becker,P.D.; Nörder,Miriam*; Guzmán,Carlos.A.*; ( Year: 2008). Title: Genetic immunization: Bacteria as DNA vaccine delivery vehicles.Journal: Human Vaccines Volume: 4 Issue: 3, S-Page: 189- E-Page: 202 Fulltext
  • Authors: Marini,E.; Tiberio,L.; Fiorentini,S.; Caracciolo,S.; Tosti,G.; Guzmán,Carlos A.*; Schiaffonati,L.; Fiorentini,S.; Caruso,A.; ( Year: 2008). Title: HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of the transcriptional factor AP-1.Journal: Cellular Microbiology Volume: 10 Issue: 3, S-Page: 655- E-Page: 666
  • Authors: Fiorentini,S.; Riboldi,E.; Facchetti,F.; Avolio,M.; Fabbri,M.; Tosti,G.; Becker,P.D.; Guzmán,Carlos A.*; Sozzani,S.; Caruso,A.; ( Year: 2008). Title: HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype.Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 105 Issue: 10, S-Page: 3867- E-Page: 3872 PubMed
  • Authors: Ebensen,Thomas*; Guzmán,Carlos.A.*; ( Year: 2008). Title: Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.Journal: Human Vaccines Volume: 4 Issue: 1, S-Page: 13- E-Page: 22 HZI repositoryPubMed
  • Authors: Mastini,C.; Becker,P.D.; Iezzi,M.; Curcio,C.; Musiani,P.; Forni,G.; Cavallo,F.; Guzmán,Carlos A.*; ( Year: 2008). Title: Intramammary application of non-methylated-CpG oligodeoxynucleotides (CpG) inhibits both local and systemic mammary carcinogenesis in female BALB/c Her-2/neu transgenic mice.Journal: Current Cancer Drug Targets Volume: 8 Issue: 3, S-Page: 230- E-Page: 242 HZI repositoryPubMed
  • Authors: Gobert,A.P.; Coste,A.; Guzmán,Carlos A.*; Hindré,T.; Girardeau,P.; Martin,C.; ( Year: 2008). Title: Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origin and serotypes.Journal: Microbes and Infection Volume: 10 Issue: 2, S-Page: 159- E-Page: 165 DOI: 10.1016/j.micinf.2007.10.018HZI repositoryPubMed
  • Authors: Brettar,Ingrid*; Höfle,Manfred G.*; ( Year: 2008). Title: Molecular assessment of bacterial pathogens-a contribution to drinking water safety.Journal: Current Opinion in Biotechnology Volume: 19 Issue: 3, S-Page: 274- E-Page: 280 PubMed
  • Authors: Höfle,Manfred G.*; Kirchman,D.L.; Christen,R.; Brettar,Ingrid*; ( Year: 2008). Title: Molecular diversity of bacterioplankton: Link to a predictive biogeochemistry of pelagic ecosystems.Journal: Aquatic Microbial Ecology Volume: 53 Issue: 1, S-Page: 39- E-Page: 58
  • Authors: Gillen,C.M.; Courtney,H.S.; Schulze,K.; Rohde,Manfred*; Wilson,M.R.; Timmer,A.M.; Guzmán,Carlos A.*; Nizet,V.; Chhatwal,Gursharan S.*; Walker,M.J.; ( Year: 2008). Title: Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.Journal: Journal of Biological Chemistry Volume: 283, S-Page: 6359- E-Page: 6366
  • Authors: Cazorla,S.I.; Becker,P.D.; Frank,F.M.; Ebensen,T.; Sartori,M.J.; Corral,R.S.; Malchiodi,E.L.; Guzmán,Carlos A.*; ( Year: 2008). Title: Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi.Journal: Infection and Immunity Volume: 76 Issue: 1, S-Page: 324- E-Page: 333 DOI: 10.1128/IAI.01163-07HZI repositoryPubMed
  • Authors: Hegermann,J.; Lünsdorf,H.; Overbeck,J.; Schrempf,H.; ( Year: 2008). Title: Polyphosphate at the Streptomyces lividans cytoplasmic membrane is enhanced in the presence of the potassium channel KcsA.Journal: Journal of Microscopy Volume: 229 Issue: Pt 1, S-Page: 174- E-Page: 182 PubMed
  • Authors: Henne,K.; Kahlisch,L.; Draheim,J.; Brettar,Ingrid*; Höfle,Manfred*; ( Year: 2008). Title: Polyvalent fingerprint based molecular surveillance methods for drinking water supply systems.Journal: Water Science and Technology: Water Supply Volume: 8 Issue: 5, S-Page: 527- E-Page: 532
  • Authors: Cazorla,S.I.; Frank,F.M.; Becker,P.D.; Corral,R.S.; Guzmán,Carlos A.*; Malchiodi,E.L.; ( Year: 2008). Title: Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury an experimental Trypanosoma cruzi infection model.Journal: Vaccine Volume: 26, S-Page: 1999- E-Page: 2009 DOI: 10.1016/j.vaccine.2008.02.011HZI repositoryPubMed
  • Authors: Becker,P.D.; Royo,J.L.; ( Year: 2008). Title: Prokaryotic gene regulation: Aspirin as a regulator of the gene expression.Journal: Biospektrum Volume: 14 Issue: 5, S-Page: 506- E-Page: 507 DOI: ArticleWEBURLS
  • Authors: Standar,K.; Mehner,D.; Osadnik,H.; Berthelmann,F.; Hause,G.; Lünsdorf,H.; Bruser,T.; ( Year: 2008). Title: PspA can form large scaffolds in Escherichia coli.Journal: Febs Letters Volume: 582 Issue: 25-26, S-Page: 3585- E-Page: 3589 DOI: 10.1016/j.febslet.2008.09.002HZI repositoryPubMed
  • Authors: Fiorentini,S.; Marsico,S.; Becker,P.D.; Iaria,M.L.; Bruno,R.; Guzmán,Carlos A.*; Caruso,A.; ( Year: 2008). Title: Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17.Journal: Vaccine Volume: 26 Issue: 36, S-Page: 4758- E-Page: 4765 PubMed
  • Authors: Schulze,K.; Goldmann,Oliver*; Medina,Eva*; Guzmán,Carlos A.*; ( Year: 2008). Title: The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells.Journal: International Journal of Medical Microbiology Volume: 298 Issue: 1-2, S-Page: 3- E-Page: 10
  • Authors: Gross,R.; Guzmán,Carlos A.*; Sebaihia,M.; Martins dos Santos,Vitor A.P.M.*; Pieper,Dietmar H.*; Koebnik,R.; Lechner,M.; Bartels,D.; Buhrmester,J.; Choudhuri,J.V.; Ebensen,T.; Gaigalat,L.; Herrmann,S.; Khachane,A.N.; Larisch,C.; Link,S.; Linke,B.; Meyer,F.; Mormann,S.; Nakunst,D.; Ruckert,C.; Schneiker-Bekel,S.; Schulze,K.; Vorholter,F.J.; Yevsa,T.; Engle,J.T.; Goldman,W.E.; Puhler,A.; Gobel,U.B.; Goesmann,A.; Blöcker,Helmut*; Kaiser,O.; Martinez-Arias,R.; ( Year: 2008). Title: The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.Journal: BMC GENOMICS Volume: 9, S-Page: 449 DOI: 10.1186/1471-2164-9-449HZI repositoryPubMed
  • Authors: Ebensen,T.; Link,C.; Riese,P.; Schulze,K.; Morr,M.; Guzmán,Carlos A.*; ( Year: 2007). Title: A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties.Journal: Journal of Immunology (Baltimore, Md.: 1950) Volume: 179 Issue: 4, S-Page: 2065- E-Page: 2073
  • Authors: Brettar,I.; Christen,R.; Bötel,J.; Lünsdorf,H.; Höfle,M.; ( Year: 2007). Title: Anderseniella baltica gen. nov., sp. nov., a novel marine bacterium of the Alphaproteobacteria isolated from sediment in the central Baltic Sea.Journal: International Journal of Systematic and Evolutionary Microbiology Volume: 57 Issue: 10, S-Page: 2399- E-Page: 2405
  • Authors: Höfle,Manfred G.*; Brettar,Ingrid*; ( Year: 2007). Title: Ein molekularbiologischer Blick in unser Trinkwasser - Mikrobielle Diagnostik für Umweltproben.Journal: Bioforum Volume: 3 Issue: 2, S-Page: 4
  • Authors: Olive,C.; Schulze,K.; Kuo Sun,H.; Ebensen,Thomas*; Horváth,A.; Toth,I.; Guzmán,Carlos A.*; ( Year: 2007). Title: Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/Sfbl lipid core peptide vaccine formulation.Journal: Vaccine Volume: 25 Issue: 10, S-Page: 1789- E-Page: 1797
  • Authors: Brettar,Ingrid*; Guzmán,Carlos A.*; Höfle,Manfred G.*; ( Year: 2007). Title: Human pathogenic micro-organisms in the marine environment - an ecological perspective.Journal: CIESM Reports Volume: 31
  • Authors: Becker,P.D.; Nörder,Miriam*; Guzmán,Carlos A.*; Grinstein,S.; ( Year: 2007). Title: Immune modulator adamantylamide dipeptide stimulates efficient Major Histocompatibility complex class I-restricted responses in mice.Journal: Clinical and Vaccine Immunology Volume: 14, S-Page: 538- E-Page: 543 DOI: 10.1128/CVI.00316-06HZI repositoryPubMed
  • Authors: Royo,J.L.; Becker,P.D.; Camacho,E.M.; Cebolla,A.; Link,C.; Santero,E.; Guzmán,Carlos A.*; ( Year: 2007). Title: In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit.Journal: Nature Methods Volume: 4 Issue: 11, S-Page: 937- E-Page: 942 DOI: 10.1038/nmeth1107HZI repositoryPubMed
  • Authors: Becker,P.D.; Bertot,G.M.; Souss,D.; Ebensen,T.; Guzmán,Carlos A.*; Grinstein,S.; ( Year: 2007). Title: Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model.Journal: Infection and Immunity Volume: 75 Issue: 4, S-Page: 1778- E-Page: 1784 DOI: 10.1128/IAI.01081-06HZI repositoryPubMed
  • Authors: Fiorentini,S.; Marconi,P.; Avolio,M.; Marini,E.; Garrafa,E.; Caracciolo,S.; Rossi,D.; Bozac,A.; Becker,P.D.; Gentili,F.; Facchetti,F.; Guzmán,Carlos A.*; Manservigi,R.; Caruso,A.; ( Year: 2007). Title: Replication-deficient mutant Herpes Simplex Virus-1 targets professional antigen presenting cells and induces efficient CD4+ T helper responses.Journal: Microbes and Infection Volume: 9 Issue: 8, S-Page: 988- E-Page: 996 DOI: 10.1016/j.micinf.2007.04.001HZI repositoryPubMed
  • Authors: Ebensen,Thomas*; Schulze,Kai*; Riese,Peggy*; Morr,Michael*; Guzmán,Carlos A.*; ( Year: 2007). Title: The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant.Journal: Clinical and Vaccine Immunology Volume: 14 Issue: 8, S-Page: 952- E-Page: 958 DOI: 10.1128/CVI.00119-07HZI repositoryPubMed
  • Authors: Ebensen,T.; Schulze,K.; Riese,P.; Link,C.; Morr,M.; Guzmán,C.A.; ( Year: 2007). Title: The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties.Journal: Vaccine Volume: 25 Issue: 8, S-Page: 1464- E-Page: 1469 DOI: 10.1128/CVI.00119-07
  • Authors: Gattinger,A.; Höfle,Manfred G.*; Schloter,M.; Embacher,A.; Böhme,F.; Munch,J.C.; Labrenz,M.; ( Year: 2007). Title: Traditional cattle manure application determines abundance, diversity and activity of methanogenic Archaea in an arable European soil.Journal: Environmental Microbiology Volume: 9 Issue: 3, S-Page: 612- E-Page: 624 DOI: 10.1111/j.1462-2920.2006.01181.xHZI repositoryPubMed
  • Authors: Link,C.; Ebensen,Thomas*; Ständner,L.; Déjosez,M.; Reinhard,E.; Rharbaoui,F.; Guzmán,Carlos A.*; ( Year: 2006). Title: An SopB-mediated immune escape mechanism of Salmonella enterica can be subverted to optimise the performance of live attenuated vaccine carrier strains.Journal: Microbes and Infection Volume: 8, S-Page: 2262- E-Page: 2269 DOI: 10.1016/j.micinf.2006.04.013HZI repositoryPubMed
  • Authors: De Buhr,M.; Mähler,M.; Geffers,Robert*; Hansen,W.; Westendorf,Astrid M.*; Lauber,J.; Buer,Jan*; Akira,S.; Schlegelberger,B.; Hedrich,H.J.; Bleich,A.; ( Year: 2006). Title: Cd14, Gbp1, and Pla2g2a: 3 major candidate genes for experimental IBD identified by combining QTL and microarray analyses.Journal: Physiological Genomics Volume: 25, S-Page: 426- E-Page: 434 DOI: 10.1152/physiolgenomics.00022.2005FulltextPubMed
  • Authors: Borsutzky,S.; Ebensen,T.; Link,C.; Becker,P.D.; Fiorelli,V.; Cafaro,A.; Ensoli,B.; Guzmán,C.A.; ( Year: 2006). Title: Efficient systemic and mucosal responses against the HIV-1 Tat protein by Prime/Boost vaccination using the lipopeptide MALP-2 as adjuvant.Journal: Vaccine Volume: 24, S-Page: 2049- E-Page: 2056 DOI: 10.1016./j.vaccine.2005.11.025
  • Authors: Garbe,A.I.; Vermeer,B.; Gamrekelashivili,J.; von Wasielewski,R.; Greten,F.R.; Westendorf,Astrid M.*; Buer,Jan*; Schmid,R.M.; Manns,M.P.; Korangy,F.; Greten,T.F.; ( Year: 2006). Title: Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses.Journal: Cancer Research Volume: 66, S-Page: 508- E-Page: 516
  • Authors: Hansen,W.; Loser,K.; Westendorf,Astrid M.*; Bruder,Dunja*; Pförtner,S.; Siewert,C.; Huehn,J.; Beissert,S.; Buer,Jan*; ( Year: 2006). Title: GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.Journal: Journal of Immunology Volume: 177, S-Page: 209- E-Page: 215
  • Authors: Fiorentini,S.; Becker,P.D.; Marini,E.; Marconi,P.; Avolio,M.; Tosti,G.; Link,C.; Manservigi,R.; Guzmán,Carlos A.*; Caruso,A.; ( Year: 2006). Title: HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens.Journal: Viral Immunology Volume: 19, S-Page: 177- E-Page: 188
  • Authors: Veldman,C.; Pahl,A.; Beissert,S.; Hansen,W.; Buer,Jan*; Dieckmann,D.; Schuler,G.; Hertl,M.; ( Year: 2006). Title: Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th 2-like cells.Journal: Journal of Immunology Volume: 176, S-Page: 3215- E-Page: 3222
  • Authors: Schulze,K.; Medina,Eva*; Guzmán,Carlos A.*; ( Year: 2006). Title: Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes fails to protect mice against lethal mucosal challenge with a heterologous strain.Journal: Vaccine Volume: 24, S-Page: 1446- E-Page: 1450 DOI: 10.1016/j.vaccine.2005.06.039
  • Authors: Schulze,K.; Olive,C.; Ebensen,T.; Guzmán,C.A.; ( Year: 2006). Title: Intranasal vaccination with Sfbl or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with S. pyogenes.Journal: Vaccine Volume: 24, S-Page: 6088- E-Page: 6095
  • Authors: Gismondi,M.I.; Becker,P.D.; Valva,P.; Guzmán,Carlos A.*; Preciado,M.V.; ( Year: 2006). Title: Phylogenetic analysis of previously non-typeable hepatitis C virus isolates from Argentina.Journal: Journal of Clinical Microbiology Volume: 44, S-Page: 2229- E-Page: 2232 DOI: 10.1128/JCM.02569-05HZI repositoryPubMed
  • Authors: Pfoertner,Susanne*; Jeron,A.; Probst-Kepper,M.; Guzmán,Carlos A.*; Hansen,W.; Westendorf,A.M.; Toepfer,T.; Schrader,A.J.; Franzke,A.; Buer,Jan*; Geffers,Robert*; ( Year: 2006). Title: Signatures of human regulatory T cells: an encounter with old friends and new players.Journal: Genome Biology Volume: 7, S-Page: R54 DOI: 10.1186/gb-2006-7-7-r54HZI repositoryPubMed
  • Authors: Becker,P.D.; Fiorentini,S.; Link,C.; Tosti,G.; Ebensen,T.; Caruso,A.; Guzmán,C.A.; ( Year: 2006). Title: The HIV-1 matrix protein p17 can be efficiently delivered by intranasal route in mice using the TLR 1/6 agonist MALP-2 as mucosal adjuvant.Journal: Vaccine Volume: 24, S-Page: 5269- E-Page: 5276 DOI: 10.1016/j.vaccine.2005.11.008
  • Authors: Ocklenburg,F.; Moharregh-Khiabani,D.; Geffers,Robert*; Janke,V.; Pfoertner,S.; Garritsen,H.; Groebe,L.; Klempnauer,J.; Dittmar,Kurt E.J.*; Weiss,Siegfried*; Buer,Jan*; Probst-Kepper,M.; ( Year: 2006). Title: UBD, a down-stream element of Foxp3, leads to the identification of LGALS3, a new marker of human regulatory T cells.Journal: Laboratory Investigation Volume: 86, S-Page: 724- E-Page: 737
  • Authors: Guzmán,Carlos A.*; Borsutzky,S.; Griot-Wenk,M.; Metcalfe,I.C.; Pearman,J.; Collioud,A.; Favre,D.; Dietrich,G.; ( Year: 2006). Title: Vaccines against Typhoid fever.Journal: Vaccine Volume: 24, S-Page: 3804- E-Page: 3811 DOI: 10.1016/J.vaccine.2005.07.111HZI repositoryPubMed
  • Authors: González-Escalona,N.; Romero,J.; Guzmán,Carlos A.*; Espejo,R.T.; ( Year: 2006). Title: Variation in the 16S-23S rRNA intergenic spacer regions in Vibrio parahaemolyticus strains are due to indels nearby their tRNA Glu.Journal: Fems Microbiology Letters Volume: 256, S-Page: 38- E-Page: 43
  • Authors: Rharbaoui,F.; Bruder,D.; Vidakovic,M.; Ebensen,T.; Buer,J.; Guzmán,C.A.; ( Year: 2005). Title: Characterization of a B220+ lymphoid cell subpopulation with immune modulatory functions.Journal: Journal of Immunology Volume: 174, S-Page: 1317- E-Page: 1324
  • Authors: Schulze,K.; Ebensen,T.; Link,C.; Guzmán,C.A.; ( Year: 2005). Title: Mukosale versus systemische Vakzinierung: Neue Strategien zur Entwicklung effizienterer Impfstoffe.Journal: Deutsche Industrievereinigung Biotechnologie (DIB)
  • Authors: Rharbaoui,F.; Guzmán,C.A.; ( Year: 2005). Title: New generation of immune modulators based on toll-like receptor signaling.Journal: Current Immunology Review Volume: 1 Issue: 2, S-Page: 107- E-Page: 118
  • Authors: Guzmán,C.A.; Cebolla,A.; Beltrametti,F.; Staendner,L.H.; de Lorenzo,V.; ( Year: 2005). Title: Physiological stress of intracellular Shigella flexneri visualized with a metabolic sensor fused to a surface-reporter system.Journal: Febs Letters Volume: 579 Issue: 3, S-Page: 813- E-Page: 818
  • Authors: Schulze,K.; Goldmann,O.; Toppel,A.; Medina,E.; Guzmán,C.A.; ( Year: 2005). Title: The FAI protein of group C streptococci targets B cells and exhibits adjuvant activity.Journal: Vaccine Volume: 23, S-Page: 1408- E-Page: 1413
  • Authors: Borsutzky,S.; Kretschmer,K.; Becker,P.D.; Mühlradt,P.F.; Kirschning,C.J.; Weiss,S.; Guzmán,C.A.; ( Year: 2005). Title: The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.Journal: Journal of Immunology Volume: 174 Issue: 10, S-Page: 6308- E-Page: 6313 DOI: 10.4049/jimmunol.174.10.6308HZI repositoryPubMed
  • Authors: Erfle,V.; Goebel,F.D.; Guzmán,C.A.; Le Grand,R.; ( Year: 2005). Title: Vaccines based on Nef and on Nef/delta V2 Env.Journal: Microbes and Infection Volume: 7, S-Page: 1400- E-Page: 1404
  • Authors: Ebensen,Thomas; Paukner,S.; Link,C.; Kudela,P.; de Domenico,C.; Lubitz,W.; Guzmán,C.A.; ( Year: 2004). Title: Bacterial ghosts are an efficient delivery system for DNA vaccines.Journal: Journal of Immunology Volume: 172, S-Page: 6858- E-Page: 6865
  • Authors: Fey,A.; Eichler,S.; Flavier,S.; Christen,R.; Höfle,M.G.; Guzmán,C.A.; ( Year: 2004). Title: Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water, using Salmonella as a model organism.Journal: Applied and Environmental Microbiology Volume: 70 Issue: 6, S-Page: 3618- E-Page: 3623 DOI: 10.1128/AEM.70.6.3618-3623.2004HZI repositoryPubMed
  • Authors: Gismondi,M.I.; Staendner,L.H.; Grinstein,S.; Guzmán,C.A.; Preciado,M.V.; ( Year: 2004). Title: Hepatitis C virus isolates from Argentina disclose a novel genotype 1-associated restriction pattern.Journal: Journal of Clinical Microbiology Volume: 42 Issue: 3, S-Page: 1298- E-Page: 1301 DOI: 10.1128/JCM.42.3.1298-1301.2004HZI repositoryPubMed
  • Authors: McArthur,J.; Schulze,K.; Chin,J.; Currie,B.J.; Sriprakash,K.S.; Talay,S.R.; Chhatwal,G.S.; ,Guzmán C.A.; ( Year: 2004). Title: Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice.Journal: Indian Journal of Medical Research Volume: 119 Issue: Suppl., S-Page: 113- E-Page: 118
  • Authors: Bertot,G.M.; Becker,P.D.; Guzmán,C.A.; Grinstein,S.; ( Year: 2004). Title: Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against Otitis media and lung infection by nontypeable Haemophilus influenzae.Journal: Journal of Infectious Diseases Volume: 189 Issue: 7, S-Page: 1304- E-Page: 1312 DOI: 10.1086/382508FulltextHZI repository
  • Authors: Guzmán,C.A.; Feuerstein,G.; ( Year: 2004). Title: Pharmaceutical Biotechnology - Editorial Overview.Journal: Current Opinion in Biotechnology Volume: 15, S-Page: 503- E-Page: 505
  • Authors: Becker,P.D.; Guzmán,C.A.; ( Year: 2004). Title: Rational design of vaccination strategies to promote antigen entry into the MHC class I-restricted presentation pathway.Journal: Transfusion Medicine and Hemotherapy Volume: 31, S-Page: 398- E-Page: 411 DOI: 10.1159/000082484)FulltextPubMed
  • Authors: Ebensen,Thomas; Guzmán,C.A.; Schulze,K.; ( Year: 2004). Title: Salmonellen - Feind, aber auch Freund.Journal: Labor Praxis Volume: Oktober, S-Page: 30.33
  • Authors: Borsutzky,S.; Cazac,B.B.; Roes,J.; Guzmán,C.A.; ( Year: 2004). Title: TGF-ß receptor signaling is critical for mucosal IgA responses.Journal: Journal of Immunology Volume: 173, S-Page: 3305- E-Page: 3309
  • Authors: Rharbaoui,F.; Westendorf,A.; Link,C.; Felk,S.; Buer,J.; Gunzer,M.; Guzmán,C.A.; ( Year: 2004). Title: The mycoplasma-derived lipopeptide MALP-2 triggers a global immune activation on nasal associated lymphoid tissues.Journal: Infection and Immunity Volume: 72, S-Page: 6978- E-Page: 6986
  • Authors: Link,C.; Gavioli,R.; Ebensen,T.; Canella,A.; Reinhard,E.; Guzmán,C.A.; ( Year: 2004). Title: The toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity.Journal: European Journal of Immunology Volume: 34 Issue: 3, S-Page: 899- E-Page: 907
  • Authors: Guzmán,C.A.; Borsutzky,S.; Favre,D.; Dietrich,G.; ( Year: 2004). Title: Vaccines against infections caused by Salmonella, Shigella, and pathogenic Escherichia coli.Journal: EcoSal Plus Volume: 1 Issue: 1 DOI: ArticleWEBURLS
  • Authors: Mcarthur,J.D.; West,N.P.; Cole,J.N.; Jungnitz,H.; Guzmán,C.A.; Chin,J.; Lehrbach,P.R.; Djordjevic,S.P.; Walker,M.J.; ( Year: 2003). Title: An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection.Journal: Fems Microbiology Letters Volume: 221, S-Page: 7- E-Page: 16
  • Authors: Dietrich,G.; Spreng,S.; Favre,D.; Viret,J.-F.; Guzmán,C.A.; ( Year: 2003). Title: Delivery of cancer DNA vaccines by live attenuated bacteria..Journal: Enhancer-immunotherapy of cancer Volume: 1, S-Page: 16- E-Page: 18
  • Authors: Noguera-Obenza,M.; Ochoa,T.J.; Gomez,H.F.; Guerrero,M.L.; Herrera-Insua,I.; Morrow,A.L.; Ruiz-Palacios,G.; Pickering,L.K.; Guzmán,C.A.; Cleary,T.G.; ( Year: 2003). Title: Human milk secretory antibodies against attching and effacing Escherchia coli antigens..Journal: Emerging Infectious Diseases Volume: 9, S-Page: 545- E-Page: 551
  • Authors: Schulze,K.; Medina,E.; Chhatwal,G.S.; Guzmán,C.A.; ( Year: 2003). Title: Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes.Journal: Infection and Immunity Volume: 71 Issue: 12, S-Page: 7197- E-Page: 7201
  • Authors: Schulze,K.; Guzmán,C.A.; ( Year: 2003). Title: Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity.Journal: Fems Immunology and Medical Microbiology Volume: 37, S-Page: 173- E-Page: 177
  • Authors: Ochoa,T.J.; Noguera-Obenza,M.; Ebel,F.; Guzmán,C.A.; Gomez,H.F.; Cleary,T.G.; ( Year: 2003). Title: Lactoferrin impairs Type III secretory system function in enteropathogenic Escherichia coli.Journal: Infection and Immunity Volume: 71, S-Page: 5149- E-Page: 5155
  • Authors: Dietrich,G.; Spreng,S.; Favre,D.; Viret,J.-F.; Guzmán,C.A.; ( Year: 2003). Title: Live attenuated bacteria as vectors to deliver plasmid DNA vaccines.Journal: Current opinion in molecular therapeutics Volume: 5, S-Page: 10- E-Page: 19
  • Authors: Buttó,S.; Fiorelli,V.; Tripiciano,A.; Ruiz-Alverez,M.J.; Scoglio,A.; Ensoli,F.; Ciccozzi,M.; Collacchi,B.; Sabbatucci,M.; Cafaro,A.; Guzmán,C.A.; Borsetti,A.; Caputo,A.; Vardas,E.; Colvin,M.; Lukwija,M.; Rezza,G.; Ensoli,B.; and the Tat Multicentric Study Group; ( Year: 2003). Title: Sequence conservation and antibody cross-recognition of the Clade B HIV-1 Tat protein vaccine candidate in HIV-1-infected Italian, Ugandan and South African individuals..Journal: Journal of Infectious Diseases. Volume: 188, S-Page: 1171- E-Page: 1180
  • Authors: Schulze,K.; Medina,E.; Chhatwal,G.S.; Guzmán,C.A.; ( Year: 2003). Title: Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein..Journal: Vaccine Volume: 21 Issue: 17-18, S-Page: 1958- E-Page: 1964

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  • Schnupfimpfung

    Impfen ohne Spritze. Darauf warten nicht nur Spritzen-Phobiker. Nasensprays sollen in Zukunft das Impfen revolutionieren. Doch es gibt ein großes Problem: Der Impfstoff muss zuerst durch die wehrhafte Schleimhaut, um zu seinem Ziel zu gelangen. Der Lösung dieses Problems hat sich ein Forscherteam des Helmholtz-Zentrums für Infektionsforschung mit großem Erfolg verschrieben. Länge: 05:59

  • KrankheitsErregend - Impfung

    Noch vor wenigen Jahrzehnten waren die Pocken eine weit verbreitete, oft tödliche Seuche. Heute gelten sie weltweit als ausgerottet. Diese Erfolgsgeschichte geht auf eine der wirksamsten vorbeugenden Maßnahmen der Medizin zurück: die Impfung. Diese befähigen das Immunsystem, Krankheitserreger zu eliminieren, noch bevor es zu einem Krankheitsausbruch kommt. Im ersten Teil der Vortragsreihe „KrankheitsErregend – Meilensteine der Medizin“ beleuchteten Marion Hulverscheidt, Carlos A. Guzmán und Hans Georg Koch das Thema aus verschiedenen Blickwinkeln.

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  • Ein neuer Impfstoff gegen Tuberkulose – die Infektion Nr. 1 in der WeltAlle 15 Sekunden stirbt ein Mensch an Tuberkulose. Bislang gibt es keinen ausreichend wirksamen Impfstoff gegen das Mycobacterium tuberkulosis, lediglich einen, der Säuglinge in den ersten zwei Lebensjahren schützt. Jetzt kristallisiert sich in klinischen Studien ein vielversprechender neuer Impfstoff heraus, den die Vakzine Projekt Management GmbH auf ihrem Weg zur Zulassung begleitet. Bernd Eisele und Leander Grode stellen Ihnen den Impfstoff vor und berichten von ihren Hoffnungen und Erwartungen…
  • Turbo für die Impfung – neue Hilfsstoffe ermöglichen neue Impfmethoden Sie habe einen schlechten Ruf, aber ohne sie geht nichts: Impfverstärker. Seit es Impfungen gibt, brauchen Impfstoff die Unterstützung kleiner Moleküle. Thomas Ebensen und Rimma Libanova haben einen vielversprechenden Impfturbo entdeckt – der ganz nebenbei die gesamte Impftechnik revolutionieren könnte. Kommen Sie mit...
  • Influenza zwischen Schwein und Mensch - die Experten Klaus Schughart und Carlos Guzman im Gespräch Die Influenzawelle rollt, aber die Informationen über Schweinegrippe, saisonale Grippe und die verschiedenen Impfstoffe sind verwirrend - teilweise beängstigend. Soll ich mich impfen lassen? Sind die Impfstoffe sicher? Mein Nachbar kennt aber jemanden... Die Grippe ist doch gar nicht so schlimm... Sind Sie ebenfalls unsicher? Dann lassen Sie sich die wichtigsten Fragen von unseren Experten des Helmholtz-Zentrums für Infektionsforschung für Influenza Klaus Schughart und Carlos Guzman beantworten...
  • SchnupfimpfungImpfen ohne Spritze. Darauf warten nicht nur Spritzen-Phobiker. Nasensprays sollen in Zukunft das Impfen revolutionieren. Doch es gibt ein großes Problem: Der Impfstoff muss zuerst durch die wehrhafte Schleimhaut, um zu seinem Ziel zu gelangen.
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