Systems Immunology

To see the immune system with the eyes of mathematics – that is the guiding principle of the department Systems Immunology. Mathematical models help to faster and better understand diseases that are associated with immune functions. Read here how scientists use mathematics to investigate chronic inflammatory diseases, the regulation of adaptive immune responses, and the interaction between the nervous, the endocrine and the immune system.


Selected Publications

Silva-Cayetano, A.; Fra-Bido, S.; Robert, P.A.; Innocentin, S.; Burton, A.R.; Watson, E.M.; Lee, J.L.; Webb, L.M.C.; Foster, W.S.; McKenzie, R.C.J.; Bignon, A.; Vanderleyden, I.; Alterauge, D.; Lemos, J.P.; Carr, E.J.; Hill, D.L.; Cinti, I.; Balabanian, K.; Baumjohann, D.; Espeli, M.; Meyer-Hermann, M.; Denton, A.E.; Linterman, M.A.; (2023). Spatial dysregulation of T follicular helper cells impairs vaccine responses in ageing. Nat Immunol 2023: in press.

Zhao, G.; Straub*, R.H.; Meyer-Hermann*, M.; (2022). The transition between acute and chronic infections in light of energy control: A mathematical model of energy flow in response to infection. J Roy Soc Interface 19:20220206. [* shared corresponding authors]. PubMed

Khailaie*, S.; Mitra*, T.; Bandyopadhyay§, A.; Schips§, M.; Mascheroni, P.; Vanella, P.; Lange, B.; Binder°, S.; Meyer-Hermann°, M.; (2021). Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures. BMC Med 19: 32 [*equal contribution, ° corresponding authors]. PubMed

Hernandez-Vargas, E. A. ; Wilk, E.; Canini, L; Toapanta , F.; Binder , S.; Uvarovskii , A.; Ross , T.; Guzman , C. A.; Perelson* , A. S.; Meyer-Hermann* , M.; (2014). Effects of aging on influenza virus infection dynamics. J. Virol. 88: 4123-4131 [*shared corresponding author]. PubMed

Zhang*,Y; Meyer-Hermann*, M; George, L.A.; Figge, M.T.; Khan, M.; Goodall, M.; Young, S.P.; Reynolds, A; Falciani, F; Waisman, A.; Notley, C.A.; Ehrenstein, M.R.; Kosco-Vilbois, M.; Toellner K.M.; (2013). Germinal center B cells govern their own fate via antibody feedback. J. Exp. Med. 210: 457-464. [*shared first authors]. PubMed




  • Silva-Cayetano, A.; Fra-Bido, S.; Robert, P.A.; Innocentin, S.; Burton, A.R.; Watson, E.M.; Lee, J.L.; Webb, L.M.C.; Foster, W.S.; McKenzie, R.C.J.; Bignon, A.; Vanderleyden, I.; Alterauge, D.; Lemos, J.P.; Carr, E.J.; Hill, D.L.; Cinti, I.; Balabanian, K.; Baumjohann, D.; Espeli, M.; Meyer-Hermann, M.; Denton, A.E.; Linterman, M.A.; (2023). Spatial dysregulation of T follicular helper cells impairs vaccine responses in ageing. Nat Immunol 2023: in press.
  • Gurwicz, N.; Stoler-Barak, L.; Schwan, N.; Bandyopadhyay, A.; Meyer-Hermann, M.; Shulman, Z.; (2023). Tingible body macrophages arise from lymph node resident precursors and uptake B cells by dendrites. J Exp Med 220:e20222173. PubMed
  • García-Valiente, R.; Merino Tejero, E.; Stratigopoulou, M.; Balashova, D.; Jongejan, A.; Lashgari, D.; Pélissier, A.; Caniels, T.G.; Claireaux, M.A.F.; Musters, A.; van Gils, M.J.; Rodríguez Martínez, M.; de Vries, N.; Meyer-Hermann, M.; Guikema, J.E.J.; Hoefsloot, H.; van Kampen, A.H.C.; (2023). Understanding repertoire sequencing data through a multiscale computational model of the germinal center. NPJ Syst Biol Appl 9:8. PubMed
  • Garg, A.K.; Mitra, T.; Schips, M.; Bandyopadyay, A.; Meyer-Hermann, M.; (2023). Amount of antigen, T follicular helper cells and quality of founder cells shape the diversity of germinal center B cells: A computational study. Front Immunol 14:1080853. PubMed
  • Grootveld, A.K.; Kyaw, W.; Panova, V.; Lau, A.W.Y.; Ashwin, E.; Seuzaret, G.; Dhenni, R.; Bhattacharyya, N.D.; Khoo, W.H.; Biro, M.; Mitra, T.; Meyer-Hermann, M.; Bertolino, P.; Tanaka, M.; Hume, D.A.; Croucher, P.I.; Brink, R.; Nguyen, A.; Bannard, O.; Phan, T.G.; (2023). Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell 186: 1144-1161. PubMed
  • Dorn*, R.; Khailaie*, S.; Stoeckli*, M.; Binder, S.C.; Mitra, T.; Lange, B.; Lautenbacher, S.; Peichl, A.; Vanella, P.; Wollmershäuser, T.; Fuest°, C.; Meyer-Hermann°, M.; (2023). The common interests of health protection and the economy: evidence from scenario calculations of COVID-19 containment policies. Eur J Health Econ 2023 Feb;24(1):67-74. [*shared first authors; °shared corresponding authors]. PubMed
  • Mlynarczyk, C.; Teater, M.; Pae, J.; Chin, C.R.; Wang, L.; Arulraj, T.; Barisic, D.; Papin, A.; Hoehn, K.B.; Kots, E.; Ersching, J.; Bandyopadhyay, A.; Barin, E.; Poh, H.X.; Evans, C.M.; Chadburn, A.; Chen, Z.; Shen, H.; Isles, H.M.; Pelzer, B.; Tsialta, I.; Doane, A.S.; Geng, H.; Rehman, M.H.; Melnick, J.; Morgan, W.; Nguyen, D.T.T.; Elemento, O.; Kharas, M.G.; Jaffrey, S.R.; Scott, D.W.; Khelashvili, G.; Meyer-Hermann, M.; Victora, G.D.; Melnick, A.; (2023). BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science 379:eabj7412. PubMed


  • Papaxenopoulou, L.A.; Zhao, G.; Khailaie, S.; Katsoulis-Dimitriou, K.; Schmitz, I.; Medina, E.; Hatzikirou, H.; Meyer-Hermann, M.; (2022). In silico predicted therapy against chronic Staphylococcus aureus infection leads to bacterial clearance in vivo. iScience 25:105522. PubMed
  • Arulraj, T.; Binder, S.C.; Meyer-Hermann, M.; (2022). Antibody mediated intercommunication of germinal centers. Cells 11:3680. PubMed
  • Arshad, H.; Siokis, A.; Franke, R.; Habib, A.; Alfonso, J.C.L.; Poliakova, Y.; Lücke, E.; Michaelis, K.; Brönstrup, M.; Meyer-Hermann, M.; Bilitewski, U.; Vila, J.; Abel, L.; Illig, T.; Schreiber, J.; Pessler, F.; (2022). Reprogramming of amino acid metabolism differs between Community-Acquired Pneumonia and infection-associated exacerbation of Chronic Obstructive Pulmonary Disease. Cells 11:2283. PubMed
  • Arulraj, T.; Binder, S.C.; Meyer-Hermann, M.; (2022). Investigating the Mechanism of Germinal Center Shutdown. Front Immunol 13:922318. PubMed
  • Bandyopadhyay°,*, A; Schips°,*, M.; Mitra, T.; Khailaie, S.; Binder, S.; Meyer-Hermann°, M.; (2022). Testing and isolation to prevent overloaded healthcare facilities and reduce death rates in the SARS-CoV-2 pandemic in Italy. Comms Med 2:75. [* shared first authors, ° shared corresponding authors]. PubMed
  • Zhao, G.; Straub*, R.H.; Meyer-Hermann*, M.; (2022). The transition between acute and chronic infections in light of energy control: A mathematical model of energy flow in response to infection. J Roy Soc Interface 19:20220206. [* shared corresponding authors]. PubMed
  • Lashgari, D.; Merino Tejero, E.; Meyer-Hermann, M.; Claireaux, M.A.F.; van Gils, M.J.; Hoefsloot, H.C.J.; van Kampen, A.H.C.; (2022). From affinity selection to kinetic selection in germinal centre modelling. PLoS Comput Biol 18:e1010168. PubMed
  • Koslow, W.; Kühn, M.J.; Binder, S.; Klitz, M.; Abele, D.; Basermann*, A.; Meyer-Hermann*, M.; (2022). Appropriate relaxation of non-pharmaceutical interventions minimizes the risk of a resurgence in SARS-CoV-2 infections in spite of the Delta variant. PLoS Comput Biol 2022 May 16; 18(5):e1010054 [*shared corresponding authors]. PubMed
  • Merino Tejero, E.; Mao, Q.; Lashgari, D.; Garcia-Valiente, R.; Robert, P.A.; Meyer-Hermann, M.; Martinez, M.R.; Guikema, J.E.; Hoefsloot, H.C.; van Kampen, A.H.; (2022). Multi-scale modeling recapitulates the effect of genetic alterations associated with diffuse large B-cell lymphoma in the germinal center dynamics. Front Sys Biol 2:864690. 
  • Kühn, M.J.; Abele, D.; Binder, S.; Rack, K.; Klitz, M.; Kleinert, J.; Gilg, J.; Spataro, L.; Koslow, W.; Siggel, M.; Meyer-Hermann*, M.; Basermann*, A.; (2022). Regional opening strategies with commuter testing and containment of new SARS-CoV-2 variants in Germany. BMC Infect Dis 2022 Apr 4; 22(1):333 [*shared corresponding authors]. PubMed
  • Long, Z.; Phillips, B.; Radtke, D.; Meyer-Hermann, M.; Bannard, O.; (2022). Competition for refueling rather than cyclic reentry initiation evident in germinal centers. Sci Immunol 7:eabm0775. PubMed
  • Schlicker*, L.; Zhao*, G.; Dudek, C.-A.; Boers, H.M.; Meyer-Hermann, M.; Jacobs, D.M.; Hiller, K.; (2022). Systemic lactate acts as a metabolic buffer in humans and prevents nutrient overflow in the postprandial phase. Front Nutr 9:785999. [*equal contribution]. PubMed


  • Formaglio*, P.; Alabdullah*, M.; Siokis, A.; Handschuh, J.; Sauerland, I.; Fu, Y.; Krone, A.; Gintschel, P.; Stettin, J.; Heyde, S.; Mohr, J.; Philipsen, L.; Schröder, A.; Robert, P.A.; Zhao, G.; Khailaie, S.; Dudeck, A.; Bertrand, J.; Spätz, G.F.; Kahlfuß, S.; Bousso, P.; Schraven, B.; Binder, S.; Meyer-Hermann, M.; Müller, A.J.; (2021). Nitric oxide controls intracellular pathogen proliferation by inhibiting the recruitment of permissive host cells. Immunity 54:1-16 [*equal contribution]. PubMed
  • Siokis, A.; Robert, P.A.; Demetriou, P.; Kvalvaag, A.; Valvo, S.; Mayya, V.; Dustin*, M.L.; Meyer-Hermann*, M.; (2021). Characterization of mechanisms positioning costimulatory complexes in immune synapses. iSicence 24:103100. [*corresponding authors].PubMed
  • Kühn, M.J.; Abele, D.; Mitra, T.; Koslow, W.; Abedi, M.; Rack, K.; Siggel, M.; Khailaie, S.; Klitz, M.; Binder, S.; Spataro, L.; Gilg, J.; Kleinert, J.; Häberle, M.; Plötzke, L.; Spinner, C.D.; Stecher, M.; Zhu, X.X.; Basermann*, A.; Meyer-Hermann*, M.; (2021). Assessment of effective mitigation and prediction of the spread of SARS-CoV-2 in Germany using demographic information and spatial resolution. Math Biosci 339:108648. [*corresponding authors]. PubMed
  • Merino Tejero, E.; Lashgari, D.; García-Valiente, R.; He, J.; Robert, P.A.; Meyer-Hermann, M.; Guikema, J.E.J.; Hoefsloot, H.; van Kampen, A.H.C.; (2021) Coupled antigen and BLIMP1 asymmetric division with a large segregation between daughter cells recapitulates the temporal transition from memory B cells to plasma cells and a DZ-to-LZ ratio in the germinal center. Front Immunol. 2021 Aug 17; 12:716240. PubMed
  • Meyer-Hermann, M.; (2021). A molecular theory of germinal center B cell selection and division. Cell Rep 36:109552. PubMed
  • Robert, P.A.; Arulraj, T.; Meyer-Hermann, M.; (2021). Ymir: A 3D structural affinity model for multi-epitope vaccine simulations. iScience 24: 102979. PubMed
  • Priesemann, V.; Meyer-Hermann, M.; Pigeot, I.; Schöbel, A.; (2021). The contribution of epidemiological models to the description of the outbreak of the COVID-19 pandemic. Bundesgesundheitsbl 64: 1058-1066. PubMed
  • Mascheroni, P.; Savvopoulos, S.; Alfonso, J.C.L.; Meyer-Hermann, M.; Hatzikirou, H.; (2021). Improving personalized tumor growth predictions using a Bayesian combination of mechanistic modeling and machine learning. Comms Med 1:19. PubMed
  • Arulraj, T.; Binder, S.C.; Meyer-Hermann, M.; (2021). In silico analysis of the longevity and timeline of individual germinal centre reactions in a primary immune response. Cells 10:1736. PubMed
  • Arulraj, T.; Binder, S.C.; Robert, P.A.; Meyer-Hermann, M.; (2021). Germinal centre shutdown. Front Immunol 12:705240. PubMed
  • Knabl*, L.; Mitra*, T.; Kimpel*, J.; Rössler, A.; Volland, A.; Walser, A.; Ulmer, H.; Pipperger, L.; Binder, S.C.; Riepler, L.; Bates, K.; Bandyopadhyay, A.; Schips, M.; Ranjan, M.; Falkensammer, B.; Borena*, W.; Meyer-Hermann*,°, M.; von Laer, D*,°; (2021) High SARS-CoV-2 seroprevalence in children and adults in the Austrian ski resort Ischgl. Comms Med 1:4 [*equal contribution; °corresponding authors]. PubMed
  • Elfaki*, Y.; Robert*, P.A.; Binz, C.; Falk, C.S.; Bruder, D.; Prinz, I.; Floess,  S.; Meyer-Hermann,  M.; Huehn, J.; (2021). Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice. Eur J Immunol 51: 1166-1181 [*equal contribution]. PubMed
  • Pae, J.; Ersching, J.; Castro, T.B.R.; Schips, M.; Mesin, L.; Allon, S.J.; Ordovas-Montanes, J.; Mlynarczyk, C.; Melnick, A.; Efeyan, A.; Shalek, A.K.; Meyer-Hermann, M.; Victora, G.D.; (2021). Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. J Exp Med 218:e20201699. PubMed
  • Arulraj, T.; Binder, S.C.; Meyer-Hermann, M.; (2021). Rate of immune complex cycling in follicular dendritic cell determines the extent of protecting antigen integrity and availability to germinal center B cells. J Immunol 206: 1436-1442. PubMed
  • Tretter, F.; Wolkenhauer, O.; Meyer-Hermann, M.; Dietrich, J.W.; Green, S.; Marcum, J.; Weckwerth, W.; (2021). The Quest for System-Theoretical Medicine in the COVID-19 Era. Front Med 8: 640974. PubMed
  • Merino Tejero, E.; Lashgari, D.; García-Valiente, R.; Gao, X.; Crauste, F.; Robert, P.A.; Meyer-Hermann, M.; Martínez, M.R.; van Ham, S.M.; Guikema, J.E.J.; Hoefsloot, H.; van Kampen, A.H.C.; (2021). Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help. Front Immunol 11: 620716. PubMed
  • Khailaie*, S.; Mitra*, T.; Bandyopadhyay§, A.; Schips§, M.; Mascheroni, P.; Vanella, P.; Lange, B.; Binder°, S.; Meyer-Hermann°, M.; (2021). Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures. BMC Med 19: 32 [*equal contribution, ° corresponding authors]. PubMed
  • Nakagawa, R.; Schips, M.; Young, G.; Bhaw-Rosun, L.; Toboso-Navasa, A.; Chakravarty, P.; Sesay, A.K.; Kassiotis, G.; Meyer-Hermann, M.; Calado, D.P.; (2020). Permissive selection followed by affinity-based proliferation of GC light zone B-cells dictates cell-fate and ensures clonad breadth. Proc Natl Acad Sci USA 118: e2016425118. PubMed
  • Volk, V.; Danisch, S.; Theobald, S.J.; Khailaie, S.; Meyer-Hermann, M.; Kalbarczyk, M.; Schneider, A.; Bialek-Waldmann, J.; Krönke, N.; Deng, Y.; Muenz, C.; Eiz-Vesper, B.; Dragon, A.C.; von Kaisenberg, C.; Lienenklaus, S.; Bleich, A.; Keck, J.; Hammerschmidt, W.; Delecluse, H.-J.; Feuerhake, F.; Stripecke, R.; (2021). PD-1 blockade aggravates EBV+ PTLD in humanized mice resulting in central nervous system involvement and CD4+ T cell dysregulations. Front Oncol 2020 10: 614876. PubMed
  • Wübbolding*, M.; Afonso*, J.C.L.; Lin, C.-Y.; Binder, S.; Falk, C.; Debarry, J.; Gineste, P.; Kraft, A.R.M.; Chien, R.-N.; Maasoumy, B.; Wedemeyer, H.; Jeng°, W.-J.; Meyer-Hermann°,  M.; Cornberg°, M.; zu Siederdissen°, C.H.; (2021). Pilot study using machine learning to identify immune profiles for the prediction of early virological relapse after stopping nucleos(t)ide analogues in HBeAg negative CHB. Hepatol Commun 5: 97-111. [*shared first author, °shared corresponding author]. PubMed


  • Barua, A; Nava-Sedeno, J.M.; Meyer-Hermann, M.; Hatzikirou, H.; (2020). A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms. Sci Rep 10: 22371.PubMed
  • Barua, A.; Syga, S.; Mascheroni, P.; Kavallaris, N.; Meyer-Hermann, M.; Deutsch, A.; Hatzikirou*, H.; (2020). Entropy-driven cell-decision making predicts fluid-to-solid transition in multicellular systems. New J Phys: 22: 123034.
  • Rastogi, A.; Robert*, P.A.; Halle*, S.; Meyer-Hermann*, M.; (2020). Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments. PLoS Comput Biol: 16: e1008428. [*shared corresponding authors]. PubMed 
  • Linden, M.; Dehning, J.; Mohr, S.B.; Mohring, J.; Meyer-Hermann, M.; Pigeot, I.; Schöbel, A.; Priesemann, A.; (2020). Case numbers beyond contact tracing capacity are endangering the containment. Dtsch Arztebl Int 2020 Oct 28; 117: 790-791. Aerzteblatt German. PubMed
  • Demetriou, P.; Abu-Shah, E.; Valvo, S.; McCuaig, S.; Mayya, V.; Kvalvaag, A.; Starkey, T.; Korobchevskaya, K.; Lee, L.Y.W.; Friedrich, M.; Mann, E.; Kutuzov, M.A.; Morotti, M.; Wietek, N.; Rada, H.; Yusuf, S.; Afrose, J.; Siokism A,; Oxford IBD Cohort Investigators; Meyer-Hermann, M.; Ahmed, A.A.; Depoil, D.; Dustin, M.L.; (2020). A dynamic CD2 rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Nat Immunol 21:1232-1243. PubMed
  • Khailaie°,*, S.; Montaseri°, G.; Meyer-Hermann*, M.; (2020). An adaptive control scheme for Interleukin-2 therapy. iScience 23:101663. [*shared first author, °shared corresponding author] PubMed
  • Siokis, A.; Robert, P. A.; Meyer-Hermann, M.; (2020). Agent-based modeling of T cell receptor cooperativity. Int J Mol Sci 21: 6473. PubMed
  • Hoore, M.; Khailaie, S.; Montaseri, G.; Mitra, T.; Meyer-Hermann, M.; (2020). Mathematical model shows show sleep may affect amyloid β fibrillization. Biophys J 119: 862-872. PubMed
  • Reimer, D.; Meyer-Hermann, M.; Rakhymzhan, A.; Steinmetz, T.; Tripal, R.; Thomas, J.; Boettcher,  M.; Mougiakalos, D.; Schulz, S. R.; Urbanczyk, S.; Hauser, A. E.; Niesner, R. A.; Mielenz, D.; (2020). B cell speed and B-FDC contacts in germinal centers determine plasma cell output via Swiprosin-1/EFhd2. Cell Reports 32: 108030. PubMed
  • Theobald, S.J.; Kreer, C.; Khailaie, S.; Bonifacius, A.; Eiz-Vesper, B.; Figueiredo, C.; Mach, M.; Backovic, M.; Ballmaier, M.; Koenig, J.; Olbrich, H.; Schneider, A.; Volk, V.; Danisch, S.; Gieselmann, L.; Ercanoglu, M.S.; Messerle, M.; von Kaisenberg, C.; Witte, T.; Klawonn, F.; Meyer-Hermann, M.; Klein, F.; Stripecke, R.; (2020). Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV. PLoS Pathog 16: e1008560. PubMed 
  • Mascheroni, P.; Meyer-Hermann*, M.; Hatzikirou*, H.; (2020). Investigating the physical effects in bacterial therapies for avascular tumors. Front Microbiol 11: 1083. [*shared corresponding author] PubMed
  • Schaadt, N. S.; Schönmeyer, R.; Forestier, G.; Brieu, N.; Braubach, P.; Nekolla, K.; Meyer-Hermann,  M.; Feuerhake, F.; (2020). Graph-based description of tertiary lymphoid organs at single-cell level. PLoS Comput Biol; 16: e1007385. PubMed
  • Alfonso, J.C.L.; Papaxenopoulou, L. A.; Mascheroni, P.; Meyer-Hermann*, M.; Hatzikirou*, H.; (2020). On the immunological consequences of conventionally fractionated radiotherapy: in silico insights. iScience 23: 100897. [*shared corresponding author]. PubMed
  • Montaseri*, G.; Alfonso*, J. C. L.; Hatzikirou, H.; Meyer-Hermann, M.; (2020). A minimal modeling framework of radiation and immune system synergy to assist radiotherapy planning. J Theor Biol 486: 110099. [*shared first authors]. PubMed


  • Arshad*, H.; Alfonso*, J.C.L.; Franke, R.; Michaelis, K.; Araujo, L.; Habib, A.; Zboromyrska, Y.; Lücke, E.; Strungaru, E.; Akmatov, M.; Hatzikirou, H.; Meyer-Hermann, M.; Petermann, A.; Nauck,  M.; Brönstrup, M.; Bilitewski, U.; Abel, L.; Sievers, J.; Vila, J.; Illig, T.; Schreiber, J.; Pessler, F.; (2019). Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia. J Trans Med 17: 365. [*shared first author]. PubMed
  • Meyer-Hermann, M.; (2019). Injection of antibodies against immunodominant epitopes tunes germinal centers to generate broadly neutralizing antibodies. Cell Reports 29: 1066-1073. PubMed
  • Arulraj, T., Binder, S.C., Robert, P.A., and Meyer-Hermann, M. (2019). Synchronous germinal center onset impacts the efficiency of antibody responses. Front. Immunol. 10, 2116. PubMed
  • Roco, J.A., Mesin, L., Binder, S.C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P.F., Ellyard, J., Shen, Q., Robert, P.A., Cappello, J., et al. (2019). Class-Switch Recombination Occurs Infrequently in Germinal Centers. Immunity 51, 337-350.e7. PubMed
  • Cañete, P.F., Sweet, R.A., Gonzalez-Figueroa, P., Papa, I., Ohkura, N., Bolton, H., Roco, J.A., Cuenca, M., Bassett, K.J., Sayin, I., et al. (2019). Regulatory roles of IL-10-producing human follicular T cells. J. Exp. Med. 216, 1843–1856. PubMed
  • Enderling, H., Alfonso, J.C.L., Moros, E., Caudell, J.J., and Harrison, L.B. (2019). Integrating Mathematical Modeling into the Roadmap for Personalized Adaptive Radiation Therapy. Trends Cancer 5, 467–474. PubMed
  • Alfonso, J.C.L., and Berk, L. (2019). Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy. Radiat. Oncol. 14, 88. PubMed
  • Mascheroni, P., López Alfonso, J.C., Kalli, M., Stylianopoulos, T., Meyer-Hermann, M., and Hatzikirou, H. (2019). On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas. Cancers (Basel) 11. PubMed
  • Schlicker, L., Boers, H.M., Dudek, C.-A., Zhao, G., Barua, A., Trezzi, J.-P., Meyer-Hermann, M., Jacobs, D.M., and Hiller, K. (2019). Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans. Metabolites 9. PubMed
  • López Alfonso, J.C., Poleszczuk, J., Walker, R., Kim, S., Pilon-Thomas, S., Conejo-Garcia, J.J., Soliman, H., Czerniecki, B., Harrison, L.B., and Enderling, H. (2019). Immunologic consequences of sequencing cancer radiotherapy and surgery. JCO Clin. Cancer Inform. 3, 1–16. PubMed


  • Theobald, S.J.; Khailaie, S.; Meyer-Hermann, M.; Volk, V.; Olbrich, H.; Danisch, , S.; Gerasch, L.; Schneider, A.; Sinzger, C.; Schaudien, D.; Lienenklaus, S.; Riese, P.; Guzman, C.A.; Figueiredo, C.; von Kaisenberg, C.; Spineli, L.M.; Glaesener, S.; Meyer-Bahlburg, A.; Ganser, A.; Schmitt, M.; Mach, M.; Messerle, M.; Stripecke, R.; (2018). Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells. Front. Immunol. 22:2734. PubMed
  • Spöring, I.; Martinez, V.A.; Hotz, C.; Schwarz-Linek, J.; Grady, K.L.; Nava-Sedeño, J.M.; Vissers, T.; Singer, H.M.; Rohde, M.; Bourquin, C.; Hatzikirou, H.; Poon, W.C.K.; Dufour, Y.S.; Erhardt, M.; (2018). Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle. PLoS Biol. 16: e2006989. PubMed
  • Meyer-Hermann, M.; (2018). Estimation of the cancer risk induced by therapies targeting stem cell replication and treatment recommendations. Sci. Rep. 28: 11776. PubMed
  • Meyer-Hermann*, M.; Binder, S.C.; Mesin, L.; Victora, G.D.; (2018). Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers. Front. Immunol. 9: 2020. [*first and corresponding author]. PubMed
  • Khailaie, S.; Rowshanravan, B.; Robert, P. A.; Waters, E.; Halliday, N.; Badillo Herrera, J. D.; Walker, L. S. K.; Sansom°, D. M.; Meyer-Hermann°, M.; (2018). Characterization of CTLA4 trafficking and implications for its function. Biophys. J. 115: 1330-1343 [°shared corresponding author]. PubMed
  • Montaseri, G.; Boianelli, A.; Hernandez-Vargas°, E. A.; Meyer-Hermann°, M.; (2018). PK/PD-based adaptive tailoring of oseltamivir doses to treat within-host influenza viral infections. Prog. Biophys. Mol. Biol. 139:31-42 [°shared corresponding author]. PubMed
  • Siokis, A.; Robert, P. A.; Demetriou, P.; Dustin, M. L.; Meyer-Hermann, M.; (2018). F-Actin-Driven CD28-CD80 Localization in the Immune Synapse. Cell Rep. 24: 1151-1162. [*shared corresponding author]. PubMed
  • López Alfonso, J. C.; Parsai, S.; Joshi, N.; Godley, A.; Shah, C.; Koyfman, S. A.; Caudell, J. J.; Fuller, C. D.; Enderling, H.; Scott, J. G.; (2018). Temporally feathered intensity-modulated radiation therapy: A planning technique to reduce normal tissue toxicity. Med. Phys. 45: 3466-3474. PubMed
  • Robert, P. A.; Marschall, A.; Meyer-Hermann, M.; (2018). Induction of broadly neutralizing antibodies in Germinal Centre simulations. Curr. Opin. Biotech. 51: 137-145. PubMed


  • Nava-Sedeño, J. M.; Hatzikirou, H.; Klages, R.; Deutsch, A.; (2017). Cellular automaton models for time-correlated random walks: derivation and analysis. Sci. Rep. 7: 16952. PubMed
  • Volk*, V.; Reppas*, A. I.; Robert, P. A.; Spineli, L. M.; Sundarasetty, B. S.; Theobald, S. J.; Schneider, A.; Gerasch, L.; Deves-Roth, C.; Klöß, S.; Koehl, U.; von Kaisenberg, C.; Figueiredo, C.; Hatzikirou°, H.; Meyer-Hermann°, M.; Stripecke°, R.; (2017). Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization. Front. Immunol. 8: 1709. [*shared first author and °shared corresponding author]. PubMed
  • Zhao, G.; Wirth, D.; Schmitz, I.; Meyer-Hermann, M.; (2017). A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance. Nat. Commun. 8: 1362. PubMed
  • Alfonso, J. C. L.; Talkenberger, K.; Seifert, M.; Klink, B.; Hawkins-Daarud, A.; Swanson, K. R.; Hatzikirou, H., Deutsch, A.; (2017). The biology and mathematical modelling of glioma invasion: a review. J. R. Soc. Interface 14: 20170490. PubMed
  • Papa, I.; Saliba, D.; Ponzoni, M.; Bustamante, S.; Canete, P.F.; Gonzalez-Figueroa, P.; McNamara, H.A.; Valvo, S.; Grimbaldeston, M.; Sweet, R.A.; Vohra, H.; Cockburn, I.A.; Meyer-Hermann, M.; Dustin, M.L.; Doglioni, C.;Vinuesa, C.G.; (2017). TFH-derived dopamine accelerates productive synapses in germinal centres. Nature 7663: 318-323. PubMed
  • Marschall, A.L.; Zhang, C.; Dübel, S.; (2017). Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells. Methods Mol. Biol. 1513:201-208. PubMed
  • Schaadt, N.S.; Alfonso, J.C.L.; Schönmeyer, R.; Grote, A.; Forestier, G.; Wemmert, C.; Krönke, N.; Stoeckelhuber, M.; Kreipe, H.H.; Hatzikirou, H.; Feuerhake, F.; (2017). Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis. Breast Cancer Res. Treat. 164: 305-315. PubMed
  • Robert, P.A.; Rastogi, A.; Binder, S.; Meyer-Hermann, M.; (2017). How to simulate a germinal centre. Methods Mol. Biol. 1623: 303-334. PubMed
  • Siokis, A.; Robert, P.A.; Meyer-Hermann M.; (2017). Mathematical Modeling of Synaptic Patterns. Methods Mol. Biol. 1584: 171-182. PubMed
  • Hatzikirou, H.; López Alfonso, J. C.; Leschner, S.; Weiss, S.; Meyer-Hermann, M.; (2017). Therapeutic Potential of Bacteria against Solid Tumors. Cancer Res. 77:1553-1563. PubMed
  • Nava-Sedeno*, J. M.; Hatzikirou*, H.; Peruani, F.; Deutsch, A.; (2017). Extracting cellular automaton rules from physical Langevin equation models for single and collective cell migration. J. Math. Biol. 75: 1075-1100. [*shared first author]. PubMed


  • Marschall, A.L.; Dübel, S.; (2016). Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm? Comput. Struct. Biotechnol. J.: 14:304-308. PubMed
  • Binder, S.C.; Meyer-Hermann, M.; (2016). Implications of intravital imaging of murine germinal centers on the control of B cell selection and division. Front. Immunol. 7: 593.
  • Montaseri, G; Meyer-Hermann, M.; (2016). Diversity of coupled oscillators can enhance their synchronization. Phys. Rev. E 94: 042213. PubMed
  • Duvigneau, S.; Sharma-Chawla, N.; Boianelli, A.; Stegemann-Koniszewski, S.; Nguyen, V.K.; Bruder, D.; Hernandez-Vargas, E.A.; (2016). Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection. Sci. Rep. 6: 37045. PubMed
  • Nguyen, V.K.; Klawonn, F.; Mikolajczyk, R.; Hernandez-Vargas, E.A.; (2016). Analysis of practical identifiability of a viral infection model. PLoS ONE. 11: e0167568. PubMed
  • Alfonso, J. C. L.; Schaadt, N. S.; Schönmeyer, R.; Brieu, N.; Forestier, G.; Wemmert, C.; Feuerhake, F.; Hatzikirou, H.; (2016). In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium. Sci. Rep. 6: 33322. PubMed
  • Alfonso, J.C.L.; Kohn-Luque, A.; Stylianopoulos, T.; Feuerhake, F.; Deutsch, A.; Hatzikirou, H.; (2016). Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights. Sci. Rep. 6: 37283. PubMed
  • Ghanbari, A.; Dehghany, J.; Schwebs, T; Müsken, M.; Häussler, S.; Meyer-Hermann, M.; (2016). Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms. Sci. Rep. 6: 32097. PubMed
  • Boianelli, A.; Sharma-Chawla, N.; Bruder, D.; Hernandez-Vargas, E.A.; (2016). Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection. Front. Cell. Infect. Microbiol. 6: 60. PubMed
  • Mziaut, H.; Mulligan, B.; Hoboth, P.; Otto, O.; Ivanova, A.; Herbig, M.; Schumann, D.; Hildebrandt, T.; Dehghany, J.; Sönmez, A.; Münster, C.; Meyer-Hermann, M.; Guck, J.; Kalaidzidis, Y.; Solimena, M.; (2016). The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol. Metab. 5: 656–668. PubMed
  • Marschall, A.L.J.; Dübel, S.; Böldicke, T.; (2016). Recent Advances with ER Targeted Intrabodies. Protein Targeting Compounds. Prediction, Selection and Activity of Specific Inhibitors. Springer International Publishing, ISBN 9783319224725: 77-93.
  • Dübel, S.; Marschall, A.L.J.; (2016). Proteinfunktionsanalyse in vivo - Neue Impulse für den Protein-Knock-down mit intrabodies. BIOspektrum 22: 33-36.
  • Binder*, S.C.; Eckweiler*, D.; Schulz, S.; Bielecka, A.; Nicolai, T.; Franke, R.; Häussler*, S.; Meyer-Hermann*, M.; (2016). Functional modules of sigma factor regulons guarantee adaptability and evolvability. Sci. Rep. 6: 22212. [*shared first and shared corresponding author]. PubMed
  • Tas, J.M.J.; Mesin, L; Pasqual, G.; Targ, S.; Jacobsen, J.T.; Mano, Y.M.; Chen, C.S.; Weill, J.C.; Reynaud, C.A.; Browne, E.P.; Meyer-Hermann, M.; Victora, G.D.; (2016). Visualizing antibody affinity maturation in germinal centers. Science 351: 1048-1054. PubMed
  • Halle, S.; Keyser, K.A.; Stahl, F.R.; Busche, A.; Marquardt, A.; Zheng, X.; Galla, M.; Heissmeyer, V.; Heller, K.; Boelter, J; Wagner, K.; Bischoff, Y.; Martens, R.; Braun, A.; Werth, K.; Uvarovskii, A.; Kempf, H.; Meyer-Hermann, M.; Arens, R.; Kremer, M.; Sutter, G.; Messerle, M.; Förster, R.; (2016). In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity 44: 233-245. PubMed
  • Nakagawa, R.; Leyland, R.; Meyer-Hermann, M.; Lu, D.; Turner, M.; Arbore, G.; Phan, T.G.; Brink, R.; Vigorito, E.; (2016). MicroRNA-155 controls affinity-based selection by protecting c-Myc+ B cells from apoptosis. J. Clin. Invest. 126: 377-388. PubMed


  • Klysz, D.; Tai, X.; Robert, P.A.; Craveiro, M.; Cretenet, G.; Oburoglu, L.; Mongellaz, C.; Floess, S.; Fritz, V.; Matias, M.I.; Yong, C.; Surh, N.; Marie, J.C.; Huehn, J.; Zimmermann, V.; Kinet, S.; Dardalhon, V.; Taylor, N.; (2015). Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation. Sci. Signal 8: ra97. PubMed
  • Robert, P.A.; (2015). Commentary: "Can selective MHC downregulation explain the specificity and genetic diversity of NK cell receptors?". Front. Immunol. 6: 444. PubMed
  • Kempf, H.; Bleicher, M.; Meyer-Hermann, M.; (2015). Spatio-temporal dynamics of hypoxia during radiotherapy. PLoS ONE 10: e0133357. PubMed
  • Hatzikirou, H.; Alfonso, J.C.; Mühle, S.; Stern, C.; Weiss, S.; Meyer-Hermann, M.; (2015). Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions. J. R. Soc. Interface 12: 20150439. PubMed
  • Boianelli, A.; Nguyen, V. K.; Ebensen, T.; Schulze, K.; Wilk, E.; Sharma, N.; Stegemann-Koniszewski, S.; Bruder, D.; Toapanta, F.R.; Guzmán, C.A.; Meyer Hermann, M.; Hernandez-Vargas, E.A.; (2015). Modeling Influenza Virus Infection: A Roadmap for Influenza Research. Viruses 7: 5274-5304. PubMed
  • Sukhorukov, V. M.; Meyer-Hermann, M.; (2015). Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton. Sci. Rep. 5: 13924. PubMed
  • Marschall, A; Dübel, S; Böldicke, T.; (2015). Specific in vivo knockdown of protein function by intrabodies. mAbs 7: 1-26. PubMed
  • Boianelli, A.; Pettini, E.; Prota, G.; Medaglini, D.; Vicino, A.; (2015). A Stochastic model for CD4+ T cell proliferation and dissemination network in primary immune response. PLoS ONE 10: e0135787. PubMed
  • Dehghany, J.; Hoboth, P.; Ivanova, A.; Mziaut, H.; Müller, A.; Kalaidzidis,  Y.; Solimena, M.; Meyer-Hermann, M.; (2015). A spatial model of insulin-granule dynamics in pancreatic β-cells. Traffic 16: 797-813. PubMed
  • Zehner, M.; Marschall, A. L.; Bos, E.; Fehrenschild, D.; Limmer, A.; Ossendorp, F.; Cresswell, P.; Koster, A.J.; Dübel, S.; Burgdorf, S.; (2015). The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells. Immunity 42: 850-863. PubMed
  • Nguyen, V.K.; Binder, S.C.; Boianelli, A.; Meyer-Hermann°, M.; Hernandez-Vargas°, E.A.; (2015). Ebola virus infection modeling and identifiability problems. Front. Microbiol. 6: 257 [°shared corresponding author]. PubMed
  • Hoboth, P.; Müller, A.; Ivanova, A.; Mziaut, H.; Dehghany, J.; Sonmez, A.; Lachnit, M.; Meyer-Hermann, M.; Kalaidzidis, Y.; Solimena, M.; (2015). Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. PNAS 112: E667-E676. PubMed
  • Montaseri, G.; Yazdanpanah, M. J.; Bahrami, F.; (2015). Designing a deep brain stimulator to suppress pathological neuronal synchrony. Neural Networks 63: 282-292. PubMed
  • Binder, S. C.; Hernandez-Vargas, E. A.; Meyer-Hermann, M.; (2015). Reducing complexity: An iterative strategy for parameter determination in biological networks. Comput. Phys. Commun. 190: 15-22.
  • Milanez-Almeida*, P.; Meyer-Hermann*°, M.; Toker, A.; Khailaie, S; Huehn°, J.; (2015). Foxp3+ regulatory T cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen. Eur. J. Immunol. 45: 153-166 [*shared first and °shared corresponding author]. PubMed


  • Montaseri, G.; Adhami-mirhosseini, A.; Yazdanpanah, M.J.; (2014). Desynchronization of coupled limit-cycle oscillators through nonlinear output regulation. Systems & Control Letters 71: 38-43.
  • Khailaie, S.; Robert, P.A.; Toker, A.; Huehn, J.; Meyer-Hermann, M.; (2014). A signal integration model of thymic selection and natural regulatory T cell commitment. J. Immunol. 193: 5983-5996. PubMed
  • Meyer-Hermann, M.; (2014). Overcoming the dichotomy of quantity and quality in antibody responses. J. Immunol. 193: 5414-5419. PubMed
  • Jaafoura, S.; de Goër de Herve, M. G.; Hernandez-Vargas, E. A.; Hendel-Chavez, H.; Abdoh, M.; Mateo, M.C.; Krzysiek, R.; Merad, M.; Seng, R.; Tardieu, M.; Delfraissy, J. F.; Goujard, C.; Taoufik, Y.; (2014). Progressive Contraction of the Latent HIV Reservoir around a Core of Less-Differentiated CD4+ Memory T-Cells. Nat. Commun. 5: 5407. PubMed
  • Milanez-Almeida, P.; Klawonn, F.; Meyer-Hermann, M.; Huehn, J.; (2014). Differential control of immune cell homeostasis by Foxp3+ regulatory T cells in murine peripheral lymph nodes and spleen. Eur. J. Microbiol. Immunol. 4: 147-155. PubMed
  • Haering, M.; Hördt, A.; Meyer-Hermann, M.; Hernandez-Vargas, E. A.; (2014). Computational study to determine when to Initiate and alternate therapy in HIV infection. BioMed Res. Int.: 472869. PubMed
  • Zhao, G; Dharmadhikari, G.; Maedler, K; Meyer-Hermann, M.; (2014). Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies. PLoS Comput. Biol. 10: e1003798. PubMed
  • Jiao, Y.; Lau, T.; Hatzikirou, H.; Meyer-Hermann, M.; Corbo, J. C.; Torquato, S.; (2014). Avian photoreceptor patterns represent a disordered hyperuniform solution to a multi-scale packing problem. Phys. Rev. E 89: 022721. PubMed
  • Hernandez-Vargas, E. A. ; Wilk, E.; Canini, L; Toapanta , F.; Binder , S.; Uvarovskii , A.; Ross , T.; Guzman , C. A.; Perelson* , A. S.; Meyer-Hermann* , M.; (2014). Effects of aging on influenza virus infection dynamics. J. Virol. 88: 4123-4131 [*shared corresponding author]. PubMed
  • Jain, H.V.; Richardson, A.; Meyer-Hermann, M.; Byrne, H.M.; (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PLoS ONE 9: e81582. PubMed
  • Alanisa, A. Y.; Hernandez-Gonzalezb, M.; Hernandez-Vargas, E. A.; (2014). Observers for biological systems. Appl. Soft Comput. 24: 1175-1182.


  • Khailaie, S.; Bahrami, F.; Janahmadi, M.; Milanez-Almeida, P.; Huehn, J.; Meyer-Hermann, M.; (2013). A mathematical model of immune activation with a unified self-nonself concept. Front. Immunol. 4: 474. PubMed
  • He, J. S.; Meyer-Hermann, M.; Xiangying, D.; Zuan, L.Y.; Jones, L.A.; Ramakrishna, L.; de Vries, V.C.; Dolpady, J.; Aina, H.; Joseph, S.; Narayanan, S.; Subramaniam, S.; Puthia, M.; Wong, G.; Xiong, H.; Poidinger, M.; Urban, J.F.; Lafaille, J.J.; Curotto de Lafaille, M.A.; (2013). The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J. Exp. Med. 210: 2755-2771. PubMed
  • Ghanbari, A.; Rahimi, M.; Dehghany, J.; (2013). Influence of Surface Grafted Polymers on the Polymer Dynamics in a Silica-Polystyrene Nanocomposite: A Coarse-Grained Molecular Dynamics Investigation. J. Phys. Chem. C 117: 25069-25076.
  • Kempf, H.; Hatzikirou, H.; Bleicher, M.; Meyer-Hermann, M.; (2013). In Silico Analysis of Cell Cycle Synchronisation Effects in Radiotherapy of Tumour Spheroids. PLoS Comput. Biol. 9: e1003295. PubMed
  • Schmeitz, C.; Hernandez-Vargas, E.A.; Fliegert, R.; Guse, A.H.; Meyer-Hermann, M.; (2013). A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties. Front. Immunol. 3: 277. PubMed
  • Hernandez-Vargas, E.A.; Colaneri, P.; Middleton, R.; (2013). Switching strategies to mitigate HIV mutation. IEEE T. on Contr. Syst. T. 22: 1623-1628.
  • Hernandez-Vargas, E.A.; Colaneri, P.; Middleton, R.; (2013). Optimal therapy scheduling for a simplified HIV infection model. Automatica 49 : 2874-2880.
  • Zhang*,Y; Meyer-Hermann*, M; George, L.A.; Figge, M.T.; Khan, M.; Goodall, M.; Young, S.P.; Reynolds, A; Falciani, F; Waisman, A.; Notley, C.A.; Ehrenstein, M.R.; Kosco-Vilbois, M.; Toellner K.M.; (2013). Germinal center B cells govern their own fate via antibody feedback. J. Exp. Med. 210: 457-464. [*shared first authors]. PubMed
  • Hernandez-Vargas, E.A.; Middleton, R.H.; (2013). Modeling the three stages in HIV infectionJ. Theor. Biol. 320: 33-40. PubMed


  • Meyer-Hermann, M.; Beyer, T.; (2012). Models of cell migration. Encyclopedia of Molecular Cell Biology and Molecular Medicine (EMCBMM) - Systems Biology: 423-467.
  • Hernandez-Gonzalez, M.; Alanis, A.; Hernandez-Vargas, E.A.; (2012). Decentralized Discrete-Time Neural Control for a Quanser 2-DOF Helicopter. Appl. Soft Comput. 12: 2462-2469.
  • Meyer-Hermann, M.; Mohr, E.; Pelletier, N.; Zhang, Y.; Victora, G.D.; Toellner, K.M.; (2012). A theory of germinal center B cell selection, division, and exit. Cell Rep. 2: 162-174. PubMed
  • Dustin, M.L., Meyer-Hermann, M.; (2012). Antigen feast or famine. Science 335: 408-409. PubMed
  • Figge, M.T.; Reichert, A.S.; Meyer-Hermann, M.; Osiewacz,H.D.; (2012). Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PLoS Comput. Biol. 8: e1002576. HZI-Repositorium PubMed
  • Sukhorukov, V.M.; Dikov, D.; Reichert, A.S.; Meyer-Hermann, M.; (2012). Emergence of the mitochondrial reticulum from fission and fusion dynamics. PLoS Comput. Biol. 8: e1002745. HZI-Repositorium PubMed
  • Fava, E.; Dehghany, J.; Ouwendijk, J.; Muller, A.; Niederlein, A.; Verkade, P.; Meyer-Hermann, M.; Solimena, M.; (2012). Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia 55: 1013-1023. HZI-Repositorium PubMed
  • Binder, S.C.; Telschow, A.; Meyer-Hermann, M.; (2012). Population Dynamics of Borrelia burgdorferi in Lyme Disease. Front. Microbiol. 3: 104. PubMed


  • Kobayashi, Y.; Achaz, G.; Telschow, A.; (2011). Effect of parasitic sex-ratio distorters on host gene frequencies in a mainland-island context. J. Evol. Biol. 24: 1695-1705. PubMed
  • Grise, G.; Meyer-Hermann, M.; (2011). Surface reconstruction using Delaunay triangulation for applications in life sciences. Comput. Phys. Commun. 182: 967-977.
  • Kobayashi, Y.; Telschow, A.; (2011). The concept of effective recombination rate and its application in speciation theory. Evolution 65: 617-628. PubMed
  • Jain, H.; Meyer-Hermann, M.; (2011). The molecular basis of synergism between carboplatin and ABT-737 therapy targeting ovarian carcinomas. Cancer Res. 71: 705-715. PubMed


  • Meyer-Hermann, M.; Benninger, R.K.P.; (2010). A mathematical model of betacells in an islet of Langerhans sensing a glucose gradient. HFSP 4: 61-71. PubMed
  • Kobayashi, Y.; Telschow, A.; (2010). Cytoplasmic feminizing elements in a two-population model: infection dynamics, gene flow modification, and the spread of autosomal suppressors. J. Evol. Biol. 23: 2558-2568. PubMed
  • Victora, G.D.; Schwickert, T.A.; Fooksman, D.R.; Meyer-Hermann, M.; Dustin, M.L.; Nussenzweig, M.C.; (2010). Germinal center selection mechanism revealed by multiphoton microscopy using a photoactivatable fluorescent reporter. Cell 143: 592-605. PubMed
  • Fatehi, H.; Meyer-Hermann, M.; Figge, M.T; (2010). Modeling cellular aggregation induced by chemotaxis and phototaxis. Math. Med. Biol. 27: 373-384. PubMed
  • Kempf, H.; Bleicher, M.; Meyer-Hermann, M; (2010). Spatio-temporal cell dynamics in tumour spheroid irradiation. Eur. Phys. J. D 60: 177-193.
  • Garin*, A.; Meyer-Hermann*, M.; Contie, M.; Figge, M.T.; Buatois, V.; Gunzer, M.; Toellner, K.-M.; Elson, G.; Kosco-Vilbois, M.H.*; (2010). Toll-Like Receptor 4 signaling by Follicular Dendritic Cells is pivotal for germinal center onset and affinity maturation. Immunity 33: 84-95 [*shared first author]. PubMed
  • Grise, G.; Meyer-Hermann, M.; (2010). Towards sub-cellular modeling with Delaunay triangulation. Math. Model. Nat. Phenom. 5: 224-238.


  • Meyer-Hermann, M.; Figge, M.T.; Toellner, K.M.; (2009). Germinal centres seen through the mathematical eye: B cell models on the catwalk. Trends Immunol. 30: 157-164. PubMed
  • Meyer-Hermann, M.; Figge, M.T.; Straub, R.; (2009). Mathematical modeling of the circadian rhythm of key neuroendocrine immune players in rheumatoid arthritis: A systems biology approach. Arthritis & Rheumatism 60: 2585-2594. PubMed
  • Figge, M.T.; Meyer-Hermann, M.; (2009). Modeling receptor-ligand binding kinetics in immunological synapse formation. Eur. Phys. J. D 51: 153-160.
  • Savin, C.; Triesch, J.; Meyer-Hermann, M.; (2009). Epileptogenesis due to glia-mediated synaptic scaling. J. Roy. Soc. Interface 6: 655-668.
  • Kosco-Vilbois, M.; Meyer-Hermann, M.; (2009). The 16th international conference on lymphatic tissues and germinal centres in immune responses. Eur. J. Immunol. 39: 2311-2312. PubMed


  • Beyer, T.; Meyer-Hermann, M.; (2008). Cell transmembrane receptors determine tissue pattern stability. Phys. Rev. Lett. 101: 148102. PubMed
  • Meyer-Hermann, M.; (2008). Delaunay-Object-Dynamics: Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation. Curr. Top. Dev. Biol. 81: 373-399. PubMed
  • Figge, M.T.; Garin, A.; Gunzer, M.; Kosco-Vilbois, M.; Toellner, K.-M.; Meyer-Hermann, M.; (2008). Deriving a germinal center lymphocyte migration model from two-photon data. J. Exp. Med. 205: 3019-3029. PubMed
  • Beyer, T.; Meyer-Hermann, M.; (2008). Mechanisms of organogenesis of primary lymphoid follicles. Int. Immunol. 20: 615-623. PubMed


  • Meyer-Hermann, M.; (2007). Are T cells at the origin of B cell lymphomas?. Theor. Biol. 244: 656-669. PubMed
  • Meyer-Hermann, M.; (2007). B cell selection mechanisms revisited: A concerted action. Adv. Compl. Sys. 10: 557-580.
  • Schaller, G.; Meyer-Hermann, M.; (2007). A modelling approach towards epidermal homoeostasis control. J. Theor. Biol. 247: 554-573. PubMed
  • Caliceti, E.; Meyer-Hermann, M.; Ribeca, P.; Surzhykov, A.; Jentschura, U.D.; (2007). From useful algorithms for slowly convergent series to physical predictions based on divergent perturbative expansions. Phys. Rep. 446: 1-96.
  • Beyer, T.; Meyer-Hermann, M.; (2007). Modeling emergent tissue organization involving high-speed migrating cells in a flow equilibrium. Phys. Rev. E 76: 1-13. PubMed
  • Meyer-Hermann, M.; (2007). The electrophysiology of the beta-cell based on single transmembrane protein characteristics. Biophys. J. 93: 2952-2968. PubMed


  • Meyer-Hermann, M.; Maini, P.K.; Iber, D.; (2006). An analysis of B cell selection mechanisms in germinal centers. Math. Med. Biol. 23: 255-277. PubMed
  • Schaller, G.; Meyer-Hermann, M.; (2006). Continuum versus discrete model: a comparison for multicellular tumour spheroids. Philos. Trans. Roy. Soc. A 364: 1443-1464. PubMed
  • Figge, M.T.; Meyer-Hermann, M.; (2006). Geometrically repatterned immunological synapses uncover formation mechanisms. PLoS Comput. Biol. 2: e171. PubMed


  • Graupner, M.; Erler, F.; Meyer-Hermann, M.; (2005). A theory of Plasma Membrane Calcium Pump stimulation and activity. J. Biol. Phys. 31: 183-206. PubMed
  • Meyer-Hermann, M.; Maini, P.K.; (2005). Cutting edge: Back to "one-way" germinal centers. J. Immunol. 174: 2489-2493. PubMed
  • Krafft, C.; Salzer, R.; Soff, G.; Meyer-Hermann, M.; (2005). Identification of B- and T-cells in human spleen samples by infrared microspectroscopic imaging. Cytometry A 64: 53-61. PubMed
  • Meyer-Hermann, M.; Maini, P.K.; (2005). Interpreting two-photon imaging data of lymphocyte motility. Phys. Rev. E 71: 061912. PubMed
  • Schaller, G.; Meyer-Hermann, M.; (2005). Multicellular tumor spheroid in an off-lattice Voronoi/Delaunay cell model. Phys. Rev. E 71: 051910. PubMed
  • Beyer, T.; Schaller, G.; Deutsch, A.; Meyer-Hermann, M.; (2005). Parallel dynamic and kinetic regular triangulation in three dimensions. Comput. Phys. Commun. 172: 86-108.


  • Erler, F.; Meyer-Hermann, M.; Soff, G.; (2004). A quantitative model for presynaptic free calcium dynamics during different stimulation protocols. Neurocomp. 61: 169-191.
  • Schaller, G.; Meyer-Hermann, M.; (2004). Kinetic and dynamic Delaunay tetrahedralizations in three dimensions. Comput. Phys. Commun. 162: 9-23.
  • Meyer-Hermann, M.; Beyer, T.; (2004). The type of seeder cells determines the efficiency of germinal center reactions. Bull. Math. Biol. 66: 125-141. PubMed


  • Meyer-Hermann, M.; (2002). A mathematical model for the germinal center morphology and affinity maturation. J. Theor. Biol. 216: 273-300. PubMed
  • Beyer, T.; Meyer-Hermann, M.; Soff, G.; (2002). A possible role of chemotaxis in germinal center formation. Int. Immunol. 14: 1369-1381. PubMed
  • Meyer-Hermann, M.; Beyer, T.; (2002). Conclusions from two model concepts on germinal center dynamics and morphology. Dev. Immunol. 9: 203-214. PubMed
  • Meyer-Hermann, M.; (2002). Does Recycling in Germinal Centers exist?. Immunol. Cell Biol. 80: 30-35. PubMed
  • Knauf, A.; Meyer-Hermann, M.; Soff, G.; (2002). Estimating the small-x exponent of the structure function g1NS from the Bjorken Sum Rule. Phys. Lett. B 549: 109-114.


  • Meyer-Hermann, M.; Kuhn, R.; Schützhold, R.; (2001). On the anomalous dimension for the transversity distribution. Phys. Rev. D 63: 116001.
  • Meyer-Hermann, M.; Deutsch, A.; Or-Guil, M.; (2001). Recycling probability and dynamical properties of germinal center reactions. J. Theor. Biol. 210: 265-285. PubMed


  • Meyer-Hermann, M., Schäfer, A.; (1999). The Mass of a Quark-Squark Bound State from QCD Sum Rules. Int. J. Mod. Phys. A 14: 4763-4780.
  • Meyer-Hermann, M.; Schäfer, A.; (1999). The renormalon contribution to the current product j5 jS. Eur. Phys. J. A 5: 91-95.


  • Meyer-Hermann, M.; Maul, M.; Mankiewicz, L.; Stein, E.; Schäfer, A.; (1996). IR Renormalon Contribution to the Polarized Structure Function g1. Phys. Lett. B 383: 463-469.
  • Stein, E., Meyer-Hermann, M., Mankiewicz, L., Schäfer, A.; (1996). IR-Renormalon Contribution to the Longitudinal Structure Function FL. Phys. Lett. B 376: 177-185.


  • Meyer-Hermann, M.; Schäfer, A.; Greiner, W.; (1995). QCD sum rules with finite masses. Z. Phys. A 351: 345-351.

Project leader

  • Dr David Christian Kerkmann

    Project Leader Epidemiological Modelling


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  • How is the HZI contributing to the management of the coronavirus pandemic?

    Since the beginning of the SARS-CoV-2 pandemic, the Helmholtz Centre for Infection Research (HZI) in Braunschweig has focused its research activities on the novel coronavirus. Representative for the diverse research projects at HZI, three scientists present their contributions to coping with the pandemic. Prof Michael Meyer-Hermann is developing mathematical models for the course of the pandemic. Prof Melanie Brinkmann has investigated transmission pathways in a large coronavirus outbreak and shown that the pathogen can be spread via aerosols. Prof Gérard Krause is leading an antibody study to monitor the development of the pandemic and is developing digital tools such as the SORMAS system to support the public health service in pandemic response.

Audio Podcast

  • BRICS – Rechnen für die InfektionsforschungDie Mischung macht es – im richtigen Leben ebenso wie in der Infektionsforschung. Systembiologen am HZI und an der Technischen Universität Braunschweig mischen Laborerkenntnisse mit Computermodellen. Begleiten Sie Michael Meyer-Hermann virtuell an das BRICS und hören Sie weshalb es so sinnvoll ist, Biologie mit System zu betreiben.
  • Rechnen für die Gesundheit – Systembiologie bringt System in die Arthritis-Therapie Infektionsforscher arbeiten mit Zellkulturen, Krankheitserregern, nehmen Proben, messen und werten die Messergebnisse aus. Allerdings reicht das in der modernen Wissenschaft häufig nicht mehr aus – gerade wenn es um so komplexe Systeme wie uns Menschen geht. Hier kommen Computer ins Spiel: die Systembiologie. Hören Sie Michael Meyer-Hermann zu, wie er am Rechner die Jahrzehnte alte Therapie gegen Rheumatoide Arthritis auf den Kopf stellt...
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