Microbial Immune Regulation

The microbiota encompasses a diverse population of microorganisms that colonize many body sites such as skin and intestine of multicellular hosts. The composition of the microbiota in humans is highly variable and is influenced by nutrition, immune competence, illness and use of medication (especially antibiotics). We are interested to enhance our understanding on how these microbial communities affect human infectious diseases and how they can be manipulated to treat diseases.

Leader

Selected Publications

Alpizar-Rodriguez D, Lesker TR, Gronow A, Gilbert B, Raemy E, Lamacchia C, Gabay C, Finckh A, Strowig T. Prevotella copri in individuals at risk for rheumatoid arthritis. Annals of the Rheumatic Diseases, 2019 78 5, 590-593

Roy U, Galvez EJC, Iljazovic A, Lesker T, Blazejewski A, Pils M, Heise U, Huber S, Flavell RA, Strowig T. Distinct microbial communities trigger colitis development upon damage to the intestinal barrier via innate or adaptive immune cells. Cell Reports. 2017 21(4):994-1008.

Thiemann S, Smit N, Roy U, Gálvez EJC, Helmecke J, Lesker T, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T. Enhancement of IFNγ production by distinct commensals ameliorates Salmonella induced disease. Cell Host & Microbe, 2017 21(6):682-694.e5.

Błażejewski AJ, Thiemann S, Schenk A, Pils M, Gálvez EJC, Heise U, de Zoete MR, Flavell RA, Strowig T. Microbiota normalization reveals that canonical Caspase-1 activation exacerbates chemically-induced intestinal inflammation. Cell Reports, 2017 19(11):2319-2330.   

Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011 145(5):745-57.

Publications

  • Authors: Fuchs,M.; Lamm-Schmidt,V.; Lence,T.; Sulzer,J.; Bublitz,A.; Wackenreuter,J.; Gerovac,M.; Strowig,T.; Faber,F.; ( Year: 2023). Title: A network of small RNAs regulates sporulation initiation in Clostridioides difficile.Journal: EMBO J DOI: 10.15252/embj.2022112858HZI repositoryPubMed
  • Authors: Li,D.; Bühler,M.; Runft,S.; Gerold,G.; Marek,K.; Baumgärtner,W.; Strowig,T.; Gerhauser,I.; ( Year: 2023). Title: ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler.Journal: Sci.Rep. Volume: 13 Issue: 1 DOI: 10.1038/s41598-023-38152-3HZI repositoryPubMed
  • Authors: Gilbert,B.T.P.; Lamacchia,C.; Amend,L.; Strowig,T.; Rodriguez,E.; Palmer,G.; Finckh,A.; ( Year: 2023). Title: Brief report: Assessment of mucosal barrier integrity using serological biomarkers in preclinical stages of rheumatoid arthritis.Journal: Frontiers in Immunology Volume: 14 DOI: 10.3389/fimmu.2023.1117742HZI repositoryPubMed
  • Authors: Amend,L.; Gilbert,B.T.P.; Pelczar,P.; Böttcher,M.; Huber,S.; Witte,T.; Finckh,A.; Strowig,T.; ( Year: 2023). Title: Characterization of serum biomarkers and antibody responses against Prevotella spp. in preclinical and new-onset phase of rheumatic diseases.Journal: Front.Cell.Infect.Microbiol. Volume: 12 DOI: 10.3389/fcimb.2022.1096211WEBURLS
  • Authors: Gui,W.; Hole,M.J.; Molinaro,A.; Edlund,K.; Jorgensen,K.K.; Su,H.; Begher-Tibbe,B.; Gaßler,N.; Schneider,C.V.; Muthukumarasamy,U.; Mohs,A.; Liao,L.; Jaeger,J.; Mertens,C.J.; Bergheim,I.; Strowig,T.; Hengstler,J.G.; Hov,J.R.; Marschall,H.U.; Trautwein,C.; Schneider,K.M.; ( Year: 2023). Title: Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis.Journal: Nature Communications Volume: 14 Issue: 1 DOI: 10.1038/s41467-023-38840-8HZI repositoryPubMed
  • Authors: Hamad,I.; Van Broeckhoven,J.; Cardilli,A.; Hellings,N.; Strowig,T.; Lemmens,S.; Hendrix,S.; Kleinewietfeld,M.; ( Year: 2023). Title: Effects of Recombinant IL-13 Treatment on Gut Microbiota Composition and Functional Recovery after Hemisection Spinal Cord Injury in Mice.Journal: Nutrients Volume: 15 Issue: 19 DOI: 10.3390/nu15194184HZI repositoryPubMed
  • Authors: Blanco-Miguez,A.; Galvez,E.J.C.; Pasolli,E.; De Filippis,F.; Amend,L.; Huang,K.D.; Manghi,P.; Lesker,T.R.; Riedel,T.; Cova,L.; Puncoochar,M.; Thomas,A.M.; Valles-Colomer,M.; Schober,I.; Hitch,T.C.A.; Clavel,T.; Berry,S.E.; Davies,R.; Wolf,J.; Spector,T.D.; Overmann,J.; Tett,A.; Ercolini,D.; Segata,N.; Strowig,T.; ( Year: 2023). Title: Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions.Journal: Cell Host.Microbe Volume: 31 Issue: 11 DOI: 10.1016/j.chom.2023.09.013HZI repositoryPubMed
  • Authors: Zhao,B.; Osbelt,L.; Lesker,T.R.; Wende,M.; Galvez,E.J.C.; Hönicke,L.; Bublitz,A.; Greweling-Pils,M.C.; Grassl,G.A.; Neumann-Schaal,M.; Strowig,T.; ( Year: 2023). Title: Helicobacter spp. are prevalent in wild mice and protect from lethal Citrobacterrodentium infection in the absence of adaptive immunity.Journal: Cell Reports Volume: 42 Issue: 6 DOI: 10.1016/j.celrep.2023.112549HZI repositoryPubMed
  • Authors: Ma,J.; Urgard,E.; Runge,S.; Classon,C.H.; Math+ñ,L.; Stark,J.M.; Cheng,L.; +ülvarez,J.A.; von Zedtwitz,S.; Baleviciute,A.; Martinez Hoyer,S.; Li,M.; Gernand,A.M.; Osbelt,L.; Bielecka,A.A.; Lesker,T.R.; Huang,H.J.; Vrtala,S.; Boon,L.; Beyaert,R.; Adner,M.; Martinez Gonzalez,I.; Strowig,T.; Du,J.; Nyl+®n,S.; Rosshart,S.P.; Coquet,J.M.; ( Year: 2023). Title: Laboratory mice with a wild microbiota generate strong allergic immune responses.Journal: Sci Immunol Volume: 8 Issue: 87 DOI: 10.1126/sciimmunol.adf7702HZI repositoryPubMed
  • Authors: Su,H.; Haque,M.; Becker,S.; Edlund,K.; Duda,J.; Wang,Q.; Rei+; ¦; ing,J.; Marschall,H.U.; Candels,L.S.; Mohamed,M.; Sj+Âland,W.; Liao,L.; Drexler,S.A.; Strowig,T.; Rahnenführer,J.; Hengstler,J.G.; Hatting,M.; ; Trautwein,C.; ( Year: 2023). Title: Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals.Journal: Liver International DOI: 10.1111/liv.15587HZI repositoryPubMed
  • Authors: Manghi,P.; Blanco-Miguez,A.; Manara,S.; NabiNejad,A.; Cumbo,F.; Beghini,F.; Armanini,F.; Golzato,D.; Huang,K.D.; Thomas,A.M.; Piccinno,G.; Puncochar,M.; Zolfo,M.; Lesker,T.R.; Bredon,M.; Planchais,J.; Glodt,J.; Valles-Colomer,M.; Koren,O.; Pasolli,E.; Asnicar,F.; Strowig,T.; Sokol,H.; Segata,N.; ( Year: 2023). Title: MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice.Journal: Cell Reports Volume: 42 Issue: 5 DOI: 10.1016/j.celrep.2023.112464HZI repositoryPubMed
  • Authors: Tintelnot,J.; Xu,Y.; Lesker,T.R.; Schönlein,M.; Konczalla,L.; Giannou,A.D.; Pelczar,P.; Kylies,D.; Puelles,V.G.; Bielecka,A.A.; Peschka,M.; Cortesi,F.; Riecken,K.; Jung,M.; Amend,L.; Bröring,T.S.; Trajkovic-Arsic,M.; Siveke,J.T.; Renné,T.; Zhang,D.; Boeck,S.; Strowig,T.; Uzunoglu,F.G.; Güngör,C.; Stein,A.; Izbicki,J.R.; Bokemeyer,C.; Sinn,M.; Kimmelman,A.C.; Huber,S.; Gagliani,N.; ( Year: 2023). Title: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.Journal: Nature DOI: 10.1038/s41586-023-05728-yHZI repositoryPubMed
  • Authors: Lourenco,M.; Osbelt,L.; Passet,V.; Gravey,F.; Megrian,D.; Strowig,T.; Rodrigues,C.; Brisse,S.; ( Year: 2023). Title: Phages against Noncapsulated Klebsiella pneumoniae: Broader Host range, Slower Resistance.Journal: Microbiol.Spectr. DOI: 10.1128/spectrum.04812-22HZI repositoryPubMed
  • Authors: Liu,X.; Khalil,A.E.M.M.; Muthukumarasamy,U.; Onogi,Y.; Yan,X.; Singh,I.; Lopez-Gonzales,E.; Israel,A.; Serrano,A.C.; Strowig,T.; Ussar,S.; ( Year: 2023). Title: Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice.Journal: BMC Biol. Volume: 21 Issue: 1 DOI: 10.1186/s12915-023-01629-8HZI repositoryPubMed
  • Authors: Siracusa,F.; Schaltenberg,N.; Kumar,Y.; Lesker,T.R.; Steglich,B.; Liwinski,T.; Cortesi,F.; Frommann,L.; Diercks,B.P.; B+Ânisch,F.; Fischer,A.W.; Scognamiglio,P.; Pauly,M.J.; Casar,C.; Cohen,Y.; Pelczar,P.; Agalioti,T.; Delfs,F.; Worthmann,A.; Wahib,R.; Jagemann,B.; Mittr++cker,H.W.; Kretz,O.; Guse,A.H.; Izbicki,J.R.; Lassen,K.G.; Strowig,T.; Schweizer,M.; Villablanca,E.J.; Elinav,E.; Huber,S.; Heeren,J.; Gagliani,N.; ( Year: 2023). Title: Short-term dietary changes can result in mucosal and systemic immune depression.Journal: Nat.Immunol. Volume: 24 Issue: 9 DOI: 10.1038/s41590-023-01587-xHZI repositoryPubMed
  • Authors: Harnack,C.; Berger,H.; Liu,L.; Mollenkopf,H.J.; Strowig,T.; Sigal,M.; ( Year: 2023). Title: Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.Journal: Gut Microbes Volume: 15 Issue: 1 DOI: 10.1080/19490976.2023.2233689HZI repositoryPubMed
  • Authors: Saleh,D.O.; Horstmann,J.A.; Giralt-Zuniga,M.; Weber,W.; Kaganovitch,E.; Durairaj,A.C.; Klotzsch,E.; Strowig,T.; Erhardt,M.; ( Year: 2023). Title: SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner.Journal: PLoS.Pathog. Volume: 19 Issue: 6 DOI: 10.1371/journal.ppat.1011451HZI repositoryPubMed
  • Authors: Essex,M.; Rios Rodriguez,V; Rademacher,J.; Proft,F.; Löber,U.; Marko,L.; Pleyer,U.; Strowig,T.; Marchand,J.; Kirwan,J.A.; Siegmund,B.; Forslund,S.K.; Poddubnyy,D.; ( Year: 2023). Title: Spondyloarthritis, acute anterior uveitis, and Crohn's disease have both shared and distinct gut microbiota.Journal: Arthritis Rheumatol. DOI: 10.1002/art.42658PubMed
  • Authors: Collias,D.; Vialetto,E.; Yu,J.; Co,K.; Almási,È.; Rüttiger,A.S.; Achmedov,T.; Strowig,T.; Beisel,C.L.; ( Year: 2023). Title: Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria.Journal: Nature Communications Volume: 14 Issue: 1 DOI: 10.1038/s41467-023-36283-9HZI repositoryPubMed
  • Authors: Paschold,L.; Gottschick,C.; Langer,S.; Klee,B.; Diexer,S.; Aksentijevich,I.; Schultheiß,C.; Purschke,O.; Riese,P.; Trittel,S.; Haase,R.; Dressler,F.; Eberl,W.; Hübner,J.; Strowig,T.; Guzman,C.A.; Mikolajczyk,R.; Binder,M.; ( Year: 2023). Title: T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.Journal: Sci.Rep. Volume: 13 Issue: 1 DOI: 10.1038/s41598-023-36144-xHZI repositoryWEBURLS
  • Authors: Bublitz,A.; Brauer,M.; Wagner,S.; Hofer,W.; Müsken,M.; Deschner,F.; Lesker,T.R.; Neumann-Schaal,M.; Paul,L.; Nübel,U.; Bartel,J.; Kany,A.M.; Zühlke,D.; Bernecker,S.; Jansen,R.; Sievers,S.; Riedel,K.; Herrmann,J.; Müller,R.; Fuchs,T.M.; Strowig,T.; ( Year: 2023). Title: The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection.Journal: Cell Host.Microbe DOI: 10.1016/j.chom.2023.04.003HZI repositoryPubMed
  • Authors: Giannou,A.D.; Kempski,J.; Shiri,A.M.; Lücke,J.; Zhang,T.; Zhao,L.; Zazara,D.E.; Cortesi,F.; Riecken,K.; Amezcua Vesely,M.C.; Low,J.S.; Xu,H.; Kaffe,E.; Garcia-Perez,L.; Agalioti,T.; Yamada,Y.; Jungraithmayr,W.; Zigmond,E.; Karstens,K.F.; Steglich,B.; Wagner,J.; Konczalla,L.; Carambia,A.; Schulze,K.; von Felden,J.; May,P.; Briukhovetska,D.; Bedke,T.; Brockmann,L.; Starzonek,S.; Lange,T.; Koch,C.; Riethdorf,S.; Pelczar,P.; Böttcher,M.; Sabihi,M.; Huber,F.J.; Reeh,M.; Grass,J.K.; Wahib,R.; Seese,H.; Stüben,B.O.; Fard-Aghaie,M.; Duprée,A.; Scognamiglio,P.; Plitzko,G.; Meiners,J.; Soukou,S.; Wittek,A.; Manthey,C.; Maroulis,I.C.; Arck,P.C.; Perez,D.; Gao,B.; Zarogiannis,S.G.; Strowig,T.; Pasqualini,R.; Arap,W.; Gosálvez,J.S.; Kobold,S.; Prinz,I.; Guse,A.H.; Tachezy,M.; Ghadban,T.; Heumann,A.; Li,J.; Melling,N.; Mann,O.; Izbicki,J.R.; Pantel,K.; Schumacher,U.; Lohse,A.W.; Flavell,R.A.; Gagliani,N.; Huber,S.; ( Year: 2023). Title: Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.Journal: Immunity Volume: 56 Issue: 1 DOI: 10.1016/j.immuni.2022.12.014PubMed
  • Authors: Hitch,T.C.A.; Bisdorf,K.; Afrizal,A.; Riedel,T.; Overmann,J.; Strowig,T.; Clavel,T.; ( Year: 2022). Title: A taxonomic note on the genus Prevotella: Description of four novel genera and emended description of the genera Hallella and Xylanibacter.Journal: Syst.Appl.Microbiol. Volume: 45 Issue: 6 DOI: 10.1016/j.syapm.2022.126354HZI repositoryPubMed
  • Authors: Pausder,A.; Mras,P.; Hoenicke,L.; Waldburg,N.; Lesker,T.R.; Schreiber,J.; Strowig,T.; Boehme,J.D.; Bruder,D.; ( Year: 2022). Title: Altered nasal microbiota in asthmatic patients is not related to changes in secretory immunity in the nasopharynx.Journal: Clin.Exp.Allergy DOI: 10.1111/cea.14200HZI repositoryPubMed
  • Authors: Thriene,K.; Stanislas,V.; Amend,L.; Strowig,T.; Michels,K.B.; ( Year: 2022). Title: Assessment of the Gut Microbiota during Juice Fasting with and without Inulin Supplementation: A Feasibility Study in Healthy Volunteers.Journal: Foods Volume: 11 Issue: 22 DOI: 10.3390/foods11223673WEBURLS
  • Authors: Melcher,C.; Yu,J.; Duong,V.H.H.; Westphal,K.; Helmi Siasi Farimany,N.; Shaverskyi,A.; Zhao,B.; Strowig,T.; Glage,S.; Brand,K.; Chan,A.C.; Föger,N.; Lee,K.H.; ( Year: 2022). Title: B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation.Journal: Cell Reports Volume: 40 Issue: 2 DOI: 10.1016/j.celrep.2022.111051HZI repositoryPubMed
  • Authors: Riese,P.; Trittel,S.; Akmatov,M.K.; May,M.; Prokein,J.; Illig,T.; Schindler,C.; Sawitzki,B.; Elfaki,Y.; Floess,S.; Huehn,J.; Blazejewski,A.J.; Strowig,T.; Hernandez-Vargas,E.A.; Geffers,R.; Zhang,B.; Li,Y.; Pessler,F.; Guzmán,C.A.; ( Year: 2022). Title: Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly.Journal: Nature Communications Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-34487-zHZI repositoryPubMed
  • Authors: Afrizal,A.; Jennings,S.A.V.; Hitch,T.C.A.; Riedel,T.; Basic,M.; Panyot,A.; Treichel,N.; Hager,F.T.; Wong,E.O.; Wolter,B.; Viehof,A.; von,Strempel A.; Eberl,C.; Buhl,E.M.; Abt,B.; Bleich,A.; Tolba,R.; Blank,L.M.; Navarre,W.W.; Kiessling,F.; Horz,H.P.; Torow,N.; Cerovic,V.; Stecher,B.; Strowig,T.; Overmann,J.; Clavel,T.; ( Year: 2022). Title: Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities.Journal: Cell Host.Microbe DOI: 10.1016/j.chom.2022.09.011HZI repositoryPubMed
  • Authors: Lucassen,A.; Hankel,J.; Finkler-Schade,C.; Osbelt,L.; Strowig,T.; Visscher,C.; Schuberth,H.J.; ( Year: 2022). Title: Feeding a Saccharomyces cerevisiae Fermentation Product (Olimond BB) Does Not Alter the Fecal Microbiota of Thoroughbred Racehorses.Journal: Animals.(Basel) Volume: 12 Issue: 12, S-Page: 1496 DOI: 10.3390/ani12121496HZI repositoryPubMed
  • Authors: Hankel,J.; Chuppava,B.; Wilke,V.; Hartung,C.B.; Muthukumarasamy,U.; Strowig,T.; Bach Knudsen,K.E.; Kamphues,J.; Visscher,C.; ( Year: 2022). Title: High Dietary Intake of Rye Affects Porcine Gut Microbiota in a Salmonella Typhimurium Infection Study.Journal: Plants Volume: 11 Issue: 17 DOI: 10.3390/plants11172232HZI repositoryPubMed
  • Authors: Schneider,K.M.; Mohs,A.; Gui,W.; Galvez,E.J.C.; Candels,L.S.; Hoenicke,L.; Muthukumarasamy,U.; Holland,C.H.; Elfers,C.; Kilic,K.; Schneider,C.V.; Schierwagen,R.; Strnad,P.; Wirtz,T.H.; Marschall,H.U.; Latz,E.; Lelouvier,B.; Saez-Rodriguez,J.; de Vos,W.; Strowig,T.; Trebicka,J.; Trautwein,C.; ( Year: 2022). Title: Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.Journal: Nature Communications Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-31312-5HZI repositoryPubMed
  • Authors: Hankel,J.; Kittler,S.; Chuppava,B.; Galvez,E.; Strowig,T.; Becker,A.; Von Köckritz-Blickwede,M.; Plötz,M.; Visscher,C.; ( Year: 2022). Title: Luminal and mucosa-associated caecal microbiota of chickens after experimental Campylobacter jejuni infection in the absence of Campylobacter-specific phages of group II and III.Journal: Microb.Genomics Volume: 8 Issue: 10 DOI: 10.1099/mgen.0.000874HZI repositoryPubMed
  • Authors: Hankel,J.; Sander,S.; Muthukumarasamy,U.; Strowig,T.; Kamphues,J.; Jung,K.; Visscher,C.; ( Year: 2022). Title: Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection.Journal: Front.Vet.Sci. Volume: 9 DOI: 10.3389/fvets.2022.1004506HZI repositoryPubMed
  • Authors: French,T.; Steffen,J.; Glas,A.; Osbelt,L.; Strowig,T.; Schott,B.H.; Schüler,T.; Dunay,I.R.; ( Year: 2022). Title: Persisting Microbiota and Neuronal Imbalance Following T. gondii Infection Reliant on the Infection Route.Journal: Frontiers in Immunology Volume: 13 DOI: 10.3389/fimmu.2022.920658HZI repositoryPubMed
  • Authors: Kini,A.; Zhao,B.; Basic,M.; Roy,U.; Iljazovic,A.; Odak,I.; Ye,Z.; Riederer,B.; Di Stefano,G.; Römermann,D.; Koenecke,C.; Bleich,A.; Strowig,T.; Seidler,U.; ( Year: 2022). Title: Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect.Journal: Gut Microbes Volume: 14 Issue: 1, S-Page: 2041943 DOI: 10.1080/19490976.2022.2041943HZI repositoryPubMed
  • Authors: Plaza-Sirvent,C.; Zhao,B.; Bronietzki,A.W.; Pils,M.C.; Tafrishi,N.; Schuster,M.; Strowig,T.; Schmitz,I.; ( Year: 2021). Title: A Central Role for Atg5 in Microbiota-Dependent Foxp3(+) RORγt(+) Treg Cell Preservation to Maintain Intestinal Immune Homeostasis.Journal: Front Immunol. Volume: 12, S-Page: Art. no. 705436 DOI: 10.3389/fimmu.2021.705436HZI repositoryPubMed
  • Authors: Li,J.; Gálvez,E.J.C.; Amend,L.; Almasi,A.; Iljazovic,A.; Lesker,T.R.; Bielecka,A.A.; Schorr,E.M.; Strowig,T.; ( Year: 2021). Title: A versatile genetic toolbox for Prevotella copri enables studying polysaccharide utilization systems.Journal: Embo Journal Volume: 40 Issue: 23, S-Page: e108287 DOI: 10.15252/embj.2021108287HZI repositoryPubMed
  • Authors: Muschaweck,M.; Kopplin,L.; Ticconi,F.; Schippers,A.; Iljazovic,A.; Galvez,E.J.C.; Abdallah,A.T.; Wagner,N.; Costa,I.G.; Strowig,T.; Pabst,O.; ( Year: 2021). Title: Cognate recognition of microbial antigens defines constricted CD4+ T cell receptor repertoires in the inflamed colon.Journal: Immunity. DOI: 10.1016/j.immuni.2021.08.014HZI repositoryPubMed
  • Authors: Song,Y.; Shan,L.; Gbyli,R.; Liu,W.; Strowig,T.; Patel,A.; Fu,X.; Wang,X.; Xu,M.L.; Gao,Y.; Qin,A.; Bruscia,E.M.; Tebaldi,T.; Biancon,G.; Mamillapalli,P.; Urbonas,D.; Eynon,E.; Gonzalez,D.G.; Chen,J.; Krause,D.S.; Alderman,J.; Halene,S.; Flavell,R.A.; ( Year: 2021). Title: Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.Journal: Science Volume: 371 Issue: 6533, S-Page: 1019- E-Page: 1025 DOI: 10.1126/science.abe2485HZI repositoryPubMed
  • Authors: Hankel,J.; Bodmann,B.; Todte,M.; Galvez,E.; Strowig,T.; Radko,D.; Antakli,A.; Visscher,C.; ( Year: 2021). Title: Comparison of Chicken Cecal Microbiota after Metaphylactic Treatment or Following Administration of Feed Additives in a Broiler Farm with Enterococcal Spondylitis History.Journal: Pathogens. Volume: 10 Issue: 8, S-Page: Art. no. 1068 DOI: 10.3390/pathogens10081068HZI repositoryPubMed
  • Authors: Koeninger,L.; Osbelt,L.; Berscheid,A.; Wendler,J.; Berger,J.; Hipp,K.; Lesker,T.R.; Pils,M.C.; Malek,N.P.; Jensen,B.A.H.; Brötz-Oesterhelt,H.; Strowig,T.; Wehkamp,J.; ( Year: 2021). Title: Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota.Journal: Commun.Biolog. Volume: 4 Issue: 1, S-Page: Article number 47 DOI: 10.1038/s42003-020-01582-0HZI repositoryPubMed
  • Authors: Pausder,A.; Fricke,J.; Schughart,K.; Schreiber,J.; Strowig,T.; Bruder,D.; Boehme,J.D.; ( Year: 2021). Title: Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract.Journal: Lung DOI: 10.1007/s00408-021-00498-8HZI repositoryPubMed
  • Authors: Maifeld,A.; Bartolomaeus,H.; Löber,U.; Avery,E.G.; Steckhan,N.; Markó,L.; Wilck,N.; Hamad,I.; Susnjar,U.; Mähler,A.; Hohmann,C.; Chen,C.Y.; Cramer,H.; Dobos,G.; Lesker,T.R.; Strowig,T.; Dechend,R.; Bzdok,D.; Kleinewietfeld,M.; Michalsen,A.; Müller,D.N.; Forslund,S.K.; ( Year: 2021). Title: Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.Journal: Nat Commun. Volume: 12 Issue: 1, S-Page: 1970 DOI: 10.1038/s41467-021-22097-0HZI repositoryPubMed
  • Authors: Schneider,K.M.; Candels,L.S.; Hov,J.R.; Myllys,M.; Hassan,R.; Schneider,C.V.; Wahlström,A.; Mohs,A.; Zühlke,S.; Liao,L.; Elfers,C.; Kilic,K.; Henricsson,M.; Molinaro,A.; Hatting,M.; Zaza,A.; Drasdo,D.; Frissen,M.; Devlin,A.S.; Gálvez,E.J.C.; Strowig,T.; Karlsen,T.H.; Hengstler,J.G.; Marschall,H.U.; Ghallab,A.; Trautwein,C.; ( Year: 2021). Title: Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling.Journal: Nature Metabolism Volume: 3 Issue: 9, S-Page: 1228- E-Page: 1241 DOI: 10.1038/s42255-021-00452-1PubMed
  • Authors: Regen,T.; Isaac,S.; Amorim,A.; Nunez,N.G.; Hauptmann,J.; Shanmugavadivu,A.; Klein,M.; Sankowski,R.; Mufazalov,I.A.; Yogev,N.; Huppert,J.; Wanke,F.; Witting,M.; Grill,A.; Gálvez,E.J.C.; Nikolaev,A.; Blanfeld,M.; Prinz,I.; Schmitt-Kopplin,P.; Strowig,T.; Reinhardt,C.; Prinz,M.; Bopp,T.; Becher,B.; Ubeda,C.; Waisman,A.; ( Year: 2021). Title: IL-17 controls central nervous system autoimmunity through the intestinal microbiome.Journal: Science Immunology Volume: 6 Issue: 56, S-Page: eaaz6563 DOI: 10.1126/sciimmunol.aaz6563HZI repositoryPubMed
  • Authors: Roy,U.; de Oliveira,R.S.; Galvez,E.J.C.; Gronow,A.; Basic,M.; Perez,L.G.; Gagliani,N.; Bleich,A.; Huber,S.; Strowig,T.; ( Year: 2021). Title: Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells.Journal: Frontiers in Immunology Volume: 12, S-Page: 671331 DOI: 10.3389/fimmu.2021.671331HZI repositoryPubMed
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  • Authors: Bunte,S.; Grone,R.; Keller,B.; Keller,C.; Galvez,E.; Strowig,T.; Kamphues,J.; Hankel,J.; ( Year: 2020). Title: Intestinal microbiota of fattening pigs offered non-fermented and fermented liquid feed with and without the supplementation of non-fermented coarse cereals.Journal: Microorg. Volume: 8 Issue: 5, S-Page: Article number 638 DOI: 10.3390/microorganisms8050638HZI repositoryPubMed
  • Authors: Roje,B.; Elek,A.; Palada,V.; Bom,J.; Iljazovic,A.; Simic,A.; Susak,L.; Vilovic,K.; Strowig,T.; Vlahovicek,K.; Terzic,J.; ( Year: 2020). Title: Microbiota Alters Urinary Bladder Weight and Gene Expression.Journal: Microorganisms. Volume: 8 Issue: 3, S-Page: 421 DOI: 10.3390/microorganisms8030421HZI repositoryPubMed
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  • Authors: Strowig,T.; Thiemann,S.; Diefenbach,A.; ( Year: 2018). Title: Microbiome and gut immunity: Innate immune cells.Book Title: The Gut Microbiome in Health and Disease Publisher: Springer, S-Page: 103- E-Page: 118 ISBN: 9783319905457 (ISBN)9783319905440 (ISBN)DOI: 10.1007/978-3-319-90545-7_8PubMed
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  • Authors: Yu,H.; Borsotti,C.; Schickel,J.N.; Zhu,S.; Strowig,T.; Eynon,E.E.; Frleta,D.; Gurer,C.; Murphy,A.J.; Yancopoulos,G.D.; Meffre,E.; Manz,M.G.; Flavell,R.A.; ( Year: 2017). Title: A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production.Journal: Blood Volume: 129 Issue: 8, S-Page: 959- E-Page: 969 DOI: 10.1182/blood-2016-04-709584Fulltext HZI repository PubMed
  • Authors: Rueckert,C.; Rand,U.; Roy,U.; Kasmapour,B.; Strowig,T.; Guzmán,C.A.; ( Year: 2017). Title: Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.Journal: FASEB J. Volume: 31 Issue: 7, S-Page: 3107- E-Page: 3115 DOI: 10.1096/fj.201601093RPubMed
  • Authors: Roy,U.; Gàlvez,E.J.C.; Iljazovic,A.; Lesker,T.R.; Blazejewski,A.J.; Pils,M.C.; Heise,U.; Huber,S.; Flavell,R.A.; Strowig,T.; ( Year: 2017). Title: Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells.Journal: Cell Reports Volume: 21 Issue: 4, S-Page: 994- E-Page: 1008 DOI: 10.1016/j.celrep.2017.09.097HZI repositoryPubMed
  • Authors: Thiemann,S.; Smit,N.; Roy,U.; Lesker,T.R.; Galvez,E.J.C.; Helmecke,J.; Basic,M.; Bleich,A.; Goodman,A.L.; Kalinke,U.; Flavell,R.A.; Erhardt,M.; Strowig,T.; ( Year: 2017). Title: Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease.Journal: Cell Host.Microbe Volume: 21 Issue: 6, S-Page: 682- E-Page: 694 DOI: 10.1016/j.chom.2017.05.005PubMed
  • Authors: Horstmann,J.A.; Zschieschang,E.; Truschel,T.; de,Diego J.; Lunelli,M.; Rohde,M.; May,T.; Strowig,T.; Stradal,T.; Kolbe,M.; Erhardt,M.; ( Year: 2017). Title: Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonization.Journal: Cell Microbiol. Volume: 19 Issue: 8 DOI: 10.1111/cmi.12739 HZI repository PubMed
  • Authors: Herndler-Brandstetter,D.; Shan,L.; Yao,Y.; Stecher,C.; Plajer,V.; Lietzenmayer,M.; Strowig,T.; de Zoete,M.R.; Palm,N.W.; Chen,J.; Blish,C.A.; Frleta,D.; Gurer,C.; Macdonald,L.E.; Murphy,A.J.; Yancopoulos,G.D.; Montgomery,R.R.; Flavell,R.A.; ( Year: 2017). Title: Humanized mouse model supports development, function, and tissue residency of human natural killer cells.Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 114 Issue: 45, S-Page: E9626- E-Page: E9634 DOI: 10.1073/pnas.1705301114HZI repositoryPubMed
  • Authors: Blazejewski,A.J.; Thiemann,S.; Schenk,A.; Pils,M.C.; Galvez,E.J.C.; Roy,U.; Heise,U.; de Zoete,M.R.; Flavell,R.A.; Strowig,T.; ( Year: 2017). Title: Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation.Journal: Cell Reports Volume: 19 Issue: 11, S-Page: 2319- E-Page: 2330 DOI: 10.1016/j.celrep.2017.05.058HZI repositoryPubMed
  • Authors: Friedrich,C.; Mamareli,P.; Thiemann,S.; Kruse,F.; Wang,Z.; Holzmann,B.; Strowig,T.; Sparwasser,T.; Lochner,M.; ( Year: 2017). Title: MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.Journal: PLoS Pathogens Volume: 13 Issue: 5, S-Page: e1006357 DOI: 10.1371/journal.ppat.1006357HZI repositoryPubMed
  • Authors: Galvez,E.J.C.; Iljazovic,A.; Gronow,A.; Flavell,R.; Strowig,T.; ( Year: 2017). Title: Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure.Journal: Cell Reports Volume: 21 Issue: 13, S-Page: 3914- E-Page: 3926 DOI: 10.1016/j.celrep.2017.12.027HZI repositoryPubMed
  • Authors: Pelczar,P.; Witkowski,M.; Perez,L.G.; Kempski,J.; Hammel,A.G.; Brockmann,L.; Kleinschmidt,D.; Wende,S.; Haueis,C.; Bedke,T.; Witkowski,M.; Krasemann,S.; Steurer,S.; Booth,C.J.; Busch,P.; König,A.; Rauch,U.; Benten,D.; Izbicki,J.R.; Rösch,T.; Lohse,A.W.; Strowig,T.; Gagliani,N.; Flavell,R.A.; Huber,S.; ( Year: 2016). Title: A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.Journal: Science Volume: 354 Issue: 6310, S-Page: 358- E-Page: 362 DOI: 10.1126/science.aah5903PubMed
  • Authors: Rausch,P.; Basic,M.; Batra,A.; Bischoff,S.C.; Blaut,M.; Clavel,T.; Glasner,J.; Gopalakrishnan,S.; Grassl,G.A.; Gunther,C.; Haller,D.; Hirose,M.; Ibrahim,S.; Loh,G.; Mattner,J.; Nagel,S.; Pabst,O.; Schmidt,F.; Siegmund,B.; Strowig,T.; Volynets,V.; Wirtz,S.; Zeissig,S.; Zeissig,Y.; Bleich,A.; Baines,J.F.; ( Year: 2016). Title: Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities.Journal: Int.J Med.Microbiol. Volume: 306 Issue: 5, S-Page: 343- E-Page: 355 DOI: 10.1016/j.ijmm.2016.03.004HZI repositoryPubMed
  • Authors: Thiemann,S.; Smit,N.; Strowig,T.; ( Year: 2016). Title: Antibiotics and the Intestinal Microbiome : Individual Responses, Resilience of the Ecosystem, and the Susceptibility to Infections.Book Title: How to Overcome the Antibiotic Crisis Publisher: Springer, S-Page: 123- E-Page: 146 DOI: 10.1007/82_2016_504PubMed
  • Authors: Hu,B.; Jin,C.; Li,H.B.; Tong,J.; Ouyang,X.; Cetinbas,N.M.; Zhu,S.; Strowig,T.; Lam,F.C.; Zhao,C.; Henao-Mejia,J.; Yilmaz,O.; Fitzgerald,K.A.; Eisenbarth,S.C.; Elinav,E.; Flavell,R.A.; ( Year: 2016). Title: The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.Journal: Science Volume: 354 Issue: 6313, S-Page: 765- E-Page: 768 DOI: 10.1126/science.aaf7532HZI repositoryPubMed
  • Authors: Pessi,I.S.; Osorio-Forero,C.; G; b; lvez,E.J.; Simões,F.L.; ; S; imões,J.C.; Junca,H.; ; ; M; a; cedo,A.J.; ( Year: 2015). Title: Distinct composition signatures of archaeal and bacterial phylotypes in the Wanda Glacier forefield, Antarctic Peninsula.Journal: Fems Microbiology Ecology Volume: 91 Issue: 1, S-Page: Article number fiu005 WEBURLS
  • Authors: Finethy,R.; Jorgensen,I.; Haldar,A.K.; de Zoete,M.R.; Strowig,T.; Flavell,R.A.; Yamamoto,M.; Nagarajan,U.M.; Miao,E.A.; Coers,J.; ( Year: 2015). Title: Guanylate Binding Proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.Journal: Infection and Immunity Volume: 83, S-Page: 4740- E-Page: 4749 PubMed
  • Authors: Vazquez,C.L.; Lerner,T.R.; Kasmapour,B.; Pei,G.; Gronow,Achim; Bianco,M.V.; Blanco,F.C.; Bleck,C.K.; Geffers,Robert; Bigi,F.; Abraham,Wolf-Rainer; Gutierrez,Maximiliano G.; ( Year: 2014). Title: Experimental selection of long-term intracellular mycobacteria.Journal: Cell Microbiology Volume: 16, S-Page: 1425- E-Page: 1440 DOI: 10.1111/cmi.12303HZI repositoryPubMed
  • Authors: Wynosky-Dolfi,M.A.; Snyder,A.G.; Philip,N.H.; Doonan,P.J.; Poffenberger,M.C.; Avizonis,D.; Zwack,E.E.; Riblett,A.M.; Hu,B.; Strowig,Till; Flavell,R.A.; Jones,R.G.; Freedman,B.D.; Brodsky,I.E.; ( Year: 2014). Title: Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.Journal: Journal of Experimental Medicine Volume: 211 Issue: 4, S-Page: 653- E-Page: 668 PubMed
  • Authors: Bronietzki,Marc; Kasmapour,Bahram; Gutierrez,Maximiliano; ( Year: 2014). Title: Study of phagolysosome biogenesis in live macrophages.Journal: Journal of Visualized Experiments: JoVE Issue: 85 DOI: 10.3791/51201.WEBURLS

Audio Podcast

  • Mit Mäusekot gegen Morbus Crohn – neue Wege gegen chronisch-entzündliche DarmerkrankungenEntzündliche Darmerkrankungen bedeuten großes Leid für die Patienten, sind kaum behandelbar und bisher wissen weder Ärzte noch Forscher, wie es dazu kommt, dass allein in Deutschland etwa 300.000 Menschen an Krankheiten wie Morbus Crohn und Colitis Ulcerosa leiden. Wissenschaftler am HZI suchen in den Bakteriengemeinschaften, die im Darm leben nach Antworten. Begleiten Sie Till Strowig ins Labor und hören Sie zu, wie er ein Probenröhrchen voll Mäusekot für die Forschung homogenisiert…
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