Innate Immunity and Infection

The moment a pathogen, which has successfully entered the body, is recognized, the body quickly mobilizes its defenses. Interferons are molecules that are counted among the body’s first line of defense. They prevent proliferation and the spread of viruses in the body and serve to alert the immune system. Read here about the different ways we use to try and decode this system, all in an effort to find new approaches to infectious disease prevention and therapy.


Prof Dr Andrea Kröger

A pathogen’s initial contact with the host is crucial for the outcome of an infection. The host’s initial reactions will decide whether the host is able to assert itself or whether it will lead to a chronic infection and more serious illness.

Prof Dr Andrea Kröger

Andrea Kröger received her initial training in Biology during her studies of Biology at the Technical University of Braunschweig. 1995, she joined group of Dr. Hansjörg Hauser at the Department of Gene Regulation and Differentiation of the Helmholtz Centre for Infection Research. During her doctoral studies, she worked on the characterization of suppressive effects of the transcription factor IRF-1 in mouse tumor models and the development of screening cell lines for the identification of small molecules for IRF-1 induction.

During her postdoctoral studies in Dr. Hansjörg Hauser´s group, her research focuses on stimulation of the immune response. Since 2010, as principal investigator of the “Interferons in Immune Defense and Immunity“ project, Andrea Kröger is searching for the mechanisms used by the interferon system to fight infections and influence protective immune responses.

Since 2012Andrea Kröger leads the research group “Innate Immunity and Infection” at the HZI. In December 2014 she completed her habilitation thesis for cell biology at the Technical University Braunschweig. Since June 2015 Andrea Kröger has a professorship for molecular Microbiology at the Otto-von-Guericke-University in Magdeburg.

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