Infection Immunology

An infection can be seen as a fight between a microbe and our body’s defence mechanisms. The microbe is trying to multiply and disseminate, while the different components of our immune system will work together trying to stop this process. This is not an easy mission for our body because microbes have learned how to hide, evade or even destroy some of the components of the immune system as well as how to resist antibiotic treatment. The focus of our research is to understand the battle between microbes and our immune defences. If we know the different tricks and mechanisms employed by the microbes to breach our defences we will be able to design new strategies to counteract and disarm the attacking microorganisms.

Leader

Selected Publications

von Köckritz-Blickwede M, Goldmann O, Thulin P, Heinemann K, Norrby-Teglund A, Rohde M, Medina E (2008) Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood 111:3070-3080

von Köckritz-Blickwede M, Rohde M, Oehmcke S, Miller LS, Cheung AL, Herwald H, Foster S, Medina E (2008) Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model. Am J Pathol 173:1657-1668

Tuchscherr L, Medina E, Hussain M, Völker W, Heitmann V, Niemann S, Holzinger D, Roth J, Proctor RA, Becker K, Peters G, Löffler B (2011) Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection. EMBO Mol Med 3:129-141

Ziegler C, Goldmann O, Hobeika E, Geffers R, Peters G, Medina E (2011) The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen reactivity to in vivo anergy. EMBO Mol Med 3:652-666

Horst SA, Hoerr V, Beineke A, Kreis C, Tuchscherr L, Kalinka J, Lehne S, Schleicher I, Köhler G, Fuchs T, Raschke MJ, Rohde M, Peters G, Faber C, Löffler B, Medina E (2012) A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis. Am J Pathol 181:1206-1214

Publications

  • Authors: Jayachandran,R.; Gumienny,A.; Bolinger,B.; Ruehl,S.; Lang,M.J.; Fucile,G.; Mazumder,S.; Tchang,V.; Woischnig,A.K.; Stiess,M.; Kunz,G.; Claudi,B.; Schmaler,M.; Siegmund,K.; Li,J.; Dertschnig,S.; Holländer,G.; Medina,E.; Karrer,U.; Moshous,D.; Bumann,D.; Khanna,N.; Rossi,S.W.; Pieters,J.; ( Year: 2019). Title: Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity.Journal: Immunity. Volume: 50 Issue: 1, S-Page: 152-165.e8- E-Page: 165.e8 DOI: 10.1016/j.immuni.2018.12.011HZI repositoryPubMed
  • Authors: Neumeier,B.L.; Khorenko,M.; Alves,F.; Goldmann,O.; Napp,J.; Schepers,U.; Reichardt,H.M.; Feldmann,C.; ( Year: 2019). Title: Fluorescent Inorganic-Organic Hybrid Nanoparticles.Journal: ChemNanoMat. Volume: 5 Issue: 1, S-Page: 24- E-Page: 45 DOI: 10.1002/cnma.201800310HZI repositoryWEBURLS
  • Authors: Nerlich,A.; Lapschies,A.M.; Kohler,T.P.; Cornax,I.; Eichhorn,I.; Goldmann,O.; Krienke,P.; Bergmann,S.; Nizet,V.; Hammerschmidt,S.; Rohde,M.; Fulde,M.; ( Year: 2019). Title: Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM.Journal: Virulence. Volume: 10 Issue: 1, S-Page: 194- E-Page: 206 DOI: 10.1080/21505594.2019.1589362HZI repositoryPubMed
  • Authors: Seiß,E.A.; Krone,A.; Formaglio,P.; Goldmann,O.; Engelmann,S.; Schraven,B.; Medina,E.; Müller,A.J.; ( Year: 2019). Title: Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils.Journal: Sci.Rep. Volume: 9 Issue: 1, S-Page: 5703 DOI: 10.1038/s41598-019-42129-6HZI repositoryPubMed
  • Authors: Zhao,W.; Cross,A.R.; Crowe-McAuliffe,C.; Weigert-Munoz,A.; Csatary,E.E.; Solinski,A.E.; Krysiak,J.; Goldberg,J.B.; Wilson,D.N.; Medina,E.; Wuest,W.M.; Sieber,S.A.; ( Year: 2019). Title: The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.Journal: Angewandte Chemie - International Edition Volume: 58 Issue: 25, S-Page: 8581- E-Page: 8584 DOI: 10.1002/anie.201903472HZI repositoryPubMed
  • Authors: Strehlitz,A.; Goldmann,O.; Pils,M.C.; Pessler,F.; Medina,E.; ( Year: 2018). Title: An interferon signature discriminates pneumococcal from staphylococcal pneumonia.Journal: Frontiers in Immunology Volume: 9 Issue: JUN, S-Page: 1424 DOI: 10.3389/fimmu.2018.01424HZI repositoryPubMed
  • Authors: Ferrer-Navarro,M.; Strehlitz,A.; Medina,E.; Vila,J.; ( Year: 2018). Title: Changed expression of cytoskeleton proteins during lung injury in a mouse model of Streptococcus pneumoniae infection.Journal: Front.Microbiol. Volume: 9 Issue: MAY, S-Page: Article number 928 DOI: 10.3389/fmicb.2018.00928HZI repositoryPubMed
  • Authors: Medina,E.; Hartl,D.; ( Year: 2018). Title: Myeloid-Derived Suppressor Cells in Infection: A General Overview.Journal: J.Innate.Immun. Volume: 10 Issue: 5-6, S-Page: 407- E-Page: 413 DOI: 10.1159/000489830HZI repositoryPubMed
  • Authors: Heck,J.G.; Rox,K.; Lünsdorf,H.; Lückerath,T.; Klaassen,N.; Medina,E.; Goldmann,O.; Feldmann,C.; ( Year: 2018). Title: Zirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persisting Staphylococcus aureus.Journal: ACS Omega Volume: 3 Issue: 8, S-Page: 8589- E-Page: 8594 DOI: 10.1021/acsomega.8b00637HZI repositoryWEBURLS
  • Authors: Fetzer,C.; Korotkov,V.S.; Th S nert,R.; Lee,K.M.; Neuenschwander,M.; von Kries,J.P.; Medina,E.; Sieber,S.A.; ( Year: 2017). Title: A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.Journal: Angewandte Chemie - International Edition Volume: 56 Issue: 49, S-Page: 15746- E-Page: 15750 DOI: 10.1002/anie.201708454PubMed
  • Authors: Thänert,R.; Goldmann,O.; Beineke,A.; Medina,E.; ( Year: 2017). Title: Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection.Journal: Nature Communications Volume: 8, S-Page: 14268 DOI: 10.1038/ncomms14268HZI repositoryPubMed
  • Authors: Goldmann,O.; Beineke,A.; Medina,E.; ( Year: 2017). Title: Identification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils.Journal: The Journal of infectious diseases Volume: 216 Issue: 11, S-Page: 1444- E-Page: 1451 DOI: 10.1093/infdis/jix494HZI repositoryPubMed
  • Authors: Leech,J.M.; Lacey,K.A.; Mulcahy,M.E.; Medina,E.; McLoughlin,R.M.; ( Year: 2017). Title: IL-10 plays opposing roles during staphylococcus aureus systemic and localized infections.Journal: Journal of Immunology Volume: 198 Issue: 6, S-Page: 2352- E-Page: 2365 DOI: 10.4049/jimmunol.1601018HZI repositoryPubMed
  • Authors: Blaschke,U.; Beineke,A.; Klemens,J.; Medina,E.; Goldmann,O.; ( Year: 2017). Title: Induction of Cyclooxygenase 2 by Streptococcus pyogenes Is Mediated by Cytolysins.Journal: J.Innate.Immun. Volume: 9 Issue: 6, S-Page: 587- E-Page: 597 DOI: 10.1159/000479153PubMed
  • Authors: Goldmann,O.; Medina,E.; ( Year: 2017). Title: Staphylococcus aureus strategies to evade the host acquired immune response.Journal: International Journal of Medical Microbiology Issue: 9, S-Page: 1438 DOI: 10.1016/j.ijmm.2017.09.013PubMed
  • Authors: Koymans,K.J.; Goldmann,O.; Karlsson,C.A.Q.; Sital,W.; Th S nert,R.; Bisschop,A.; Vrieling,M.; Malmstr÷m,J.; van Kessel,K.P.M.; De Haas,C.J.C.; Van Strijp,J.A.G.; Medina,E.; ( Year: 2017). Title: The TLR2 Antagonist Staphylococcal Superantigen-Like Protein 3 Acts as a Virulence Factor to Promote Bacterial Pathogenicity in vivo.Journal: J.Innate Immun. Volume: 9 Issue: 6, S-Page: 561- E-Page: 573 DOI: 10.1159/000479100PubMed
  • Authors: Chaves-Moreno,D.; Wos-Oxley,M.L.; Jauregui,R.; Medina,E.; Oxley,A.P.; Pieper,D.H.; ( Year: 2016). Title: Exploring the transcriptome of Staphylococcus aureus in its natural niche.Journal: Sci Rep. Volume: 6, S-Page: 33174 DOI: 10.1038/srep33174HZI repositoryPubMed
  • Authors: Deicke,C.; Chakrakodi,B.; Pils,M.C.; Dickneite,G.; Johansson,L.; Medina,E.; Loof,T.G.; ( Year: 2016). Title: Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.Journal: Int.J Med.Microbiol. Volume: 306 Issue: 7, S-Page: 572- E-Page: 579 PubMed
  • Authors: Medina,E.; Pieper,D.H.; ( Year: 2016). Title: Tackling Threats and Future Problems of Multidrug-Resistant Bacteria.Journal: Curr Top.Microbiol.Immunol. Volume: 398, S-Page: 3- E-Page: 34 PubMed
  • Authors: Goldmann,O.; Tuchscherr,L.; Rohde,M.; Medina,E.; ( Year: 2015). Title: alpha-hemolysin enhances Staphylococcus aureus internalization and survival within mast cells by modulating the expression of beta1 integrin.Journal: Cell Microbiol. Volume: 18 Issue: 6, S-Page: 807- E-Page: 819 PubMed
  • Authors: Chaves-Moreno,D.; Wos-Oxley,M.L.; Jauregui,R.; Medina,E.; Oxley,A.P.; Pieper,D.H.; ( Year: 2015). Title: Application of a Novel "Pan-Genome"-Based Strategy for Assigning RNAseq Transcript Reads to Staphylococcus aureus Strains.Journal: PLoS ONE Volume: 10 Issue: 12, S-Page: e0145861 DOI: 10.1371/journal.pone.0145861HZI repositoryPubMed
  • Authors: Fiebig,A.; Loof,T.G.; Babbar,A.; Itzek,A.; Koehorst,J.J.; Schaap,P.J.; Nitsche-Schmitz,D.P.; ( Year: 2015). Title: Comparative Genomics of Streptococcus pyogenes M1 isolates differing in virulence and propensity to cause systemic infection in mice.Journal: International Journal of Medical Microbiology Volume: 305 Issue: 6, S-Page: 532- E-Page: 543 WEBURLS
  • Authors: Ben,Hania W.; Joseph,M.; Schumann,P.; Bunk,B.; Fiebig,A.; Sproer,C.; Klenk,H.P.; Fardeau,M.L.; Spring,S.; ( Year: 2015). Title: Complete genome sequence and description of Salinispira pacifica gen. nov., sp. nov., a novel spirochaete isolated form a hypersaline microbial mat.Journal: Stand.Genomic Sci Volume: 10, S-Page: 7 DOI: 10.1186/1944-3277-10-7HZI repositoryPubMed
  • Authors: Horst,S.A.; Itzek,A.; Klos,A.; Beineke,A.; Medina,E.; ( Year: 2015). Title: Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection.Journal: Pathogens Volume: 4 Issue: 4, S-Page: 722- E-Page: 738 DOI: 10.3390/pathogens4040722HZI repositoryPubMed
  • Authors: Lau,S.C.K.; Riedel,T.; Fiebig,A.; Han,J.; Huntemann,M.; Petersen,J.; Ivanova,N.N.; Markowitz,V.; Woyke,T.; Göker,M.; Kyrpides,N.C.; Klenk,H.P.; Qian,P.Y.; ( Year: 2015). Title: Genome sequence of the pink-pigmented marine bacterium Loktanella hongkongensis type strain (UST950701û009PT), a representative of the Roseobacter group.Journal: Standards in Genomic Sciences Volume: 10 Issue: AUGUST2015 DOI: 10.1186/s40793-015-0050-9HZI repositoryPubMed
  • Authors: Riedel,T.; Spring,S.; Fiebig,A.; Scheuner,C.; Petersen,J.; Goker,M.; Klenk,H.P.; ( Year: 2015). Title: Genome sequence of the Roseovarius mucosus type strain (DSM 17069(T)), a bacteriochlorophyll a-containing representative of the marine Roseobacter group isolated from the dinoflagellate Alexandrium ostenfeldii.Journal: Stand.Genomic Sci Volume: 10, S-Page: 17 DOI: 10.1186/1944-3277-10-17HZI repositoryPubMed
  • Authors: Ruiz-Cruz,S.; Espinosa,M.; Goldmann,O.; Bravo,A.; ( Year: 2015). Title: Global Regulation of Gene Expression by the MafR Protein of Enterococcus faecalis.Journal: Front Microbiol. Volume: 6, S-Page: 1521 DOI: 10.3389/fmicb.2015.01521HZI repositoryPubMed
  • Authors: Tsatsaronis,J.A.; Ly,D.; Pupovac,A.; Goldmann,O.; Rohde,M.; Taylor,J.M.; Walker,M.J.; Medina,E.; Sanderson-Smith,M.L.; ( Year: 2015). Title: Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses.Journal: J.Innate Immun. Volume: 7 Issue: 6, S-Page: 612- E-Page: 622 WEBURLS
  • Authors: Tuchscherr,L.; Kreis,C.A.; Hoerr,V.; Flint,L.; Hachmeister,M.; Geraci,J.; Bremer-Streck,S.; Kiehntopf,M.; Medina,E.; Kribus,M.; Raschke,M.; Pletz,M.; Peters,G.; Loffler,B.; ( Year: 2015). Title: Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis.Journal: J Antimicrob.Chemother. Volume: 71, S-Page: 438- E-Page: 448 PubMed
  • Authors: Loof,T.G.; Goldmann,O.; Naudin,C.; Mörgelin,M.; Neumann,Y.; Pils,M.C.; Foster,S.J.; Medina,E.; Herwald,H.; ( Year: 2015). Title: Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network.Journal: Microbiology Volume: 161 Issue: 3, S-Page: 621- E-Page: 627 WEBURLS
  • Authors: Tebartz,C.; Horst,Sarah A.; Sparwasser,Tim; Hühn,Jochen; Beineke,A.; Peters,G.; Medina,Eva; ( Year: 2014). Title: A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection.Journal: Journal of Immunology Volume: 194 Issue: 3, S-Page: 1100- E-Page: 1111 PubMed
  • Authors: Szafranska,A.K.; Oxley,A.P.A.; Chaves-Moreno,D.; Horst,S.A.; Roßlenbroich,S.; Peters,G.; Goldmann,O.; Rohd,M.; Sinha,B.; Pieper,D.H.; Löffler,B.; Jauregui,R.; Wos-Oxley,M.L.; Medina,E.; ( Year: 2014). Title: High-resolution transcriptomic analysis of the adaptive response of staphylococcus aureus during acute and chronic phases of osteomyelitis.Journal: MBio Volume: 5 Issue: 6, S-Page: e01775 DOI: 10.1128/mBio.01775-14HZI repositoryPubMed
  • Authors: Mehraj,J.; Akmatov,M.K.; Strömpl,J.; Gatzemeier,A.; Layer,F.; Werner,G.; Pieper,D.H.; Medina,E.; Witte,W.; Pessler,F.; Krause,G.; ( Year: 2014). Title: Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Nasal Carriage in a Random Sample of Non-Hospitalized Adult Population in Northern Germany.Journal: PLoS ONE Volume: 9 Issue: 9, S-Page: e107937 DOI: 10.1371/journal.pone.0107937HZI repositoryPubMed
  • Authors: Scheb-Wetzel,Matthias; Rohde,Manfred; Bravo,A.; Goldmann,Oliver; ( Year: 2014). Title: New insights into the antimicrobial effect of mast cells against Enterococcus faecalis.Journal: Infection and Immunity Volume: 82 Issue: 11, S-Page: 4496- E-Page: 4507 DOI: 10.1128/IAI.02114-14HZI repositoryPubMed
  • Authors: Yuan,D.; Zhu,Z.; Tan,X.; Liang,J.; Zeng,C.; Zhang,J.; Chen,J.; Ma,L.; Dogan,A.; Brockmann,G.; Goldmann,Oliver; Medina,Eva; Rice,A.D.; Moyer,R.W.; Man,X.; Yi,K.; Li,Y.; Lu,Q.; Huang,Y.; Huang,S.; ( Year: 2014). Title: Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms.Journal: Science China Life Sciences Volume: 57, S-Page: 876- E-Page: 888 PubMed
  • Authors: Loof,Torsten G.; Deicke,Christin; Medina,Eva; ( Year: 2014). Title: The role of coagulation/fibrinolysis during Streptococcus pyogenes infection.Journal: Frontiers in Cellular and Infection Microbiology Volume: 4, S-Page: 128 DOI: 10.3389/fcimb.2014.00128HZI repositoryPubMed
  • Authors: Michelucci,A.; Cordes,T.; Ghelfi,J.; Pailot,A.; Reiling,N.; Goldmann,O.; Binz,T.; Wegner,A.; Tallam,A.; Rausell,A.; Buttini,M.; Linster,C.L.; Medina,Eva; Balling,R.; Hiller,K.; ( Year: 2013). Title: Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.Journal: Proceedings of the National Academy of Sciences USA Volume: 110 Issue: 19, S-Page: 7820- E-Page: 7825 DOI: 10.1073/pnas.1218599110HZI repositoryPubMed
  • Authors: Rosendahl,A.; Bergmann,Silke; Hammerschmidt,S.; Goldmann,O.; Medina,E.; ( Year: 2013). Title: Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia.Journal: Frontiers in Cellular and Infection Microbiology Volume: 3, S-Page: 21 DOI: 10.3389/fcimb.2013.00021HZI repositoryPubMed
  • Authors: Ko,Y.P.; Freitag,C.M.; Kuipers,A.; Jongerius,I.; Medina,Eva; van Rooijen,W.J.; Spaan,A.N.; van Kessel,K.P.M.; Höök,M.; Rooijkkers,S.H.M.; ( Year: 2013). Title: Phagocytosis escape by a bacterial protein that connects complement and coagulation proteins at the bacterial surface.Journal: PLoS Pathogens Volume: 9 Issue: 12, S-Page: e1003816 DOI: 10.1371/journal.ppat.1003816HZI repositoryPubMed
  • Authors: Horst,Sarah A.; Linner,A.; Beineke,A.; Lehne,Sabine; Höltje,Claudia; Hecht,A.; Norrby-Teglund,A.; Medina,Eva; Goldmann,Oliver; ( Year: 2013). Title: Prognostic Value and Therapeutic Potential of TREM-1 in Streptococcus pyogenes- Induced Sepsis.Journal: Journal of Innate Immunology Volume: 5 Issue: 6, S-Page: 581- E-Page: 590 DOI: 10.1159/000348283HZI repositoryPubMed
  • Authors: Horst,S.A.; Hoerr,V.; Beineke,A.; Kreis,C.; Tuchscherr,L.; Kalinka,J.; Lehne,S.; Schleicher,I.; Kohler,G.; Fuchs,T.; Raschke,M.J.; Rohde,Manfred*; Peters,G.; Faber,C.; Loffler,B.; Medina,Eva*; ( Year: 2012). Title: A Novel Mouse Model of Staphylococcus aureus Chronic Osteomyelitis That Closely Mimics the Human Infection: An Integrated View of Disease Pathogenesis.Journal: American Journal of Pathology Volume: 181 Issue: 4, S-Page: 1206- E-Page: 1214 DOI: 10.1016/j.ajpath.2012.07.005PubMed
  • Authors: Niemann,S.; Ehrhardt,C.; Medina,Eva*; Warnking,K.; Tuchscherr,L.; Heitmann,V.; Ludwig,S.; Peters,G.; Loffler,B.; ( Year: 2012). Title: Combined Action of Influenza Virus and Staphylococcus aureus Panton-Valentine Leukocidin Provokes Severe Lung Epithelium Damage.Journal: Journal of Infectious Diseases Volume: 206 Issue: 7, S-Page: 1138- E-Page: 1148 PubMed
  • Authors: Wos-Oxley,M.; Bleich,A.; Oxley,A.P.; Kahl,S.; Janus,L.; Smoczek,A.; Nahrstedt,H.; Pils,M.; Taudien,S.; Platzer,M.; Hedrich,H.J.; Medina,Eva*; Pieper,Dietmar*; ( Year: 2012). Title: Comparative evaluation of establishing a human gut microbial community within rodent models.Journal: Gut Microbes Volume: 3 Issue: 3 PubMed
  • Authors: Schindler,D.; Gutierrez,Maximiliano G.; Beineke,A.; Rauter,Y.; Rohde,Manfred; Foster,S.; Goldmann,O.; Medina,Eva; ( Year: 2012). Title: Dendritic Cells Are Central Coordinators of the Host Immune Response to Staphylococcus aureus Bloodstream Infection.Journal: American Journal of Pathology Volume: 181 Issue: 4, S-Page: 1327- E-Page: 1337 PubMed
  • Authors: Goldmann,O.; Medina,Eva*; ( Year: 2012). Title: The expanding world of extracellular traps: not only neutrophils but much more.Journal: Frontiers in Immunology Volume: 3, S-Page: 420 DOI: 10.3389/fimmu.2012.00420HZI repositoryPubMed
  • Authors: Medina,Eva*; Goldmann,O.; ( Year: 2011). Title: In vivo and ex vivo protocols for measuring the killing of extracellular pathogens by macrophages.Journal: Current Protocols in Immunology Volume: Chapter 14, S-Page: Unit14.19 PubMed
  • Authors: Abel,J.; Goldmann,O.; Ziegler,C.; Höltje,C.; Smeltzer,M.S.; Cheung,A.L.; Bruhn,D.; Rohde,Manfred*; Medina,Eva*; ( Year: 2011). Title: Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake.Journal: Journal of Innate Immunity Volume: 3 Issue: 5, S-Page: 495- E-Page: 507 DOI: 10.1159/000327714HZI repositoryPubMed
  • Authors: Tuchscherr,L.; Medina,Eva*; Hussain,M.; Volker,W.; Heitmann,V.; Niemann,S.; Holzinger,D.; Roth,J.; Proctor,R.A.; Becker,K.; Peters,G.; Loffler,B.; ( Year: 2011). Title: Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection.Journal: EMBO Molecular Medicine Volume: 3 Issue: 3, S-Page: 129- E-Page: 141 DOI: 10.1002/emmm.201000115HZI repositoryPubMed
  • Authors: Nippe,N.; Varga,G.; Holzinger,D.; Loffler,B.; Medina,Eva*; Becker,K.; Roth,J.; Ehrchen,J.M.; Sunderkotter,C.; ( Year: 2011). Title: Subcutaneous Infection with S. aureus in Mice Reveals Association of Resistance with Influx of Neutrophils and Th2 Response.Journal: Journal of Investigative Dermatology Volume: 131 Issue: 1, S-Page: 125- E-Page: 132 DOI: 10.1038/jid.2010.282HZI repositoryPubMed
  • Authors: Ziegler,C.; Goldmann,O.; Hobeika,E.; Geffers,Robert*; Peters,G.; Medina,Eva*; ( Year: 2011). Title: The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy.Journal: EMBO Molecular Medicine Volume: 3 Issue: 11, S-Page: 652- E-Page: 666 PubMed
  • Authors: Loof,T.G.; Goldmann,O.; Gessner,A.; Herwald,H.; Medina,Eva*; ( Year: 2010). Title: Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88.Journal: American Journal of Pathology Volume: 176 Issue: 2, S-Page: 754- E-Page: 763 PubMed
  • Authors: Goldmann,O.; Lehne,S.; Medina,Eva*; ( Year: 2010). Title: Age-related susceptibility to Streptococcus pyogenes infection in mice: underlying immune dysfunction and strategy to enhance immunity.Journal: Journal of Pathology Volume: 220 Issue: 5, S-Page: 521- E-Page: 529 DOI: 10.1002/path.2664HZI repositoryPubMed
  • Authors: Goldmann,O.; Hertzen,E.; Hecht,A.; Schmidt,H.; Lehne,S.; Norrby-Teglund,A.; Medina,Eva*; ( Year: 2010). Title: Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes.Journal: Journal of Immunology Volume: 185 Issue: 4, S-Page: 2372- E-Page: 2381 PubMed
  • Authors: Medina,Eva*; ( Year: 2010). Title: Murine model of cutaneous infection with Streptococcus pyogenes.Journal: Methods in Molecular Biology Volume: 602, S-Page: 395- E-Page: 403 PubMed
  • Authors: Medina,Eva*; ( Year: 2010). Title: Murine model of pneumococcal pneumonia.Journal: Methods in Molecular Biology Volume: 602, S-Page: 405- E-Page: 410
  • Authors: Medina,Eva*; ( Year: 2010). Title: Murine model of polymicrobial septic peritonitis using cecal ligation and puncture (CLP).Journal: Methods in Molecular Biology Volume: 602, S-Page: 411- E-Page: 415
  • Authors: Medina,Eva*; ( Year: 2009). Title: Beyond the NETs.Journal: Journal of Innate Immunity Volume: 1, S-Page: 175
  • Authors: Goldmann,O.; Rohde,Manfred*; Medina,Eva*; ( Year: 2009). Title: Infection biology: Streptococcus pyogenes - Lethal for macrophages.Journal: Biospektrum Volume: 15 Issue: 4, S-Page: 380- E-Page: 182
  • Authors: Medina,Eva*; ( Year: 2009). Title: Neutrophil Extracellular Traps: a strategic tactic to defeat pahtogens with potential consequences for the host.Journal: Journal of Innate Immunity Volume: 1, S-Page: 176- E-Page: 180
  • Authors: von Kockritz-Blickwede,M.; Konrad,S.; Foster,S.; Gessner,J.E.; Medina,Eva*; ( Year: 2009). Title: Protective role of complement C5a in an experimental model of Staphylococcus aureus bacteremia.Journal: Journal of Innate Immunity Volume: 2 Issue: 1, S-Page: 87- E-Page: 92 PubMed
  • Authors: Goldmann,O.; Sastalla,I.; Wos-Oxley,M.; Rohde,Manfred*; Medina,Eva*; ( Year: 2009). Title: Streptococcus pyogenes induces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway.Journal: Cellular Microbiology Volume: 11 Issue: 1, S-Page: 138- E-Page: 155 PubMed
  • Authors: Oehmcke,S.; Shannon,O.; von Kockritz-Blickwede,Maren*; Morgelin,M.; Linder,A.; Olin,A.I.; Bjorck,L.; Herwald,H.; ( Year: 2009). Title: Treatment of invasive streptococcal infection with a peptide derived from human high molecular weight kininogen.Journal: Blood Volume: 114 Issue: 2, S-Page: 444- E-Page: 451 PubMed
  • Authors: Loof,T.G.; Goldmann,O.; Medina,Eva*; ( Year: 2008). Title: Immune recognition of Streptococcus pyogenes by dendritic cells.Journal: Infection and Immunity Volume: 76 Issue: 6, S-Page: 2785- E-Page: 2792 DOI: 10.1128/IAI.01680-07HZI repositoryPubMed
  • Authors: von Kockritz-Blickwede,M.; Rohde,Manfred*; Oehmcke,S.; Miller,L.S.; Cheung,A.L.; Herwald,H.; Foster,S.; Medina,Eva*; ( Year: 2008). Title: Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model.Journal: American Journal of Pathology Volume: 173 Issue: 6, S-Page: 1657- E-Page: 1668 PubMed
  • Authors: Von Köckritz-Blickwede,M.; Goldmann,O.; Thulin,P.; Heinemann,K.; Norrby-Teglund,A.; Rohde,Manfred*; Medina,Eva*; ( Year: 2008). Title: Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation.Journal: Blood, S-Page: doi: 10.1182/blood-2007-07-104018 DOI: 10.1182/blood-2007-07-104018HZI repositoryPubMed
  • Authors: Schulze,K.; Goldmann,Oliver*; Medina,Eva*; Guzmán,Carlos A.*; ( Year: 2008). Title: The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells.Journal: International Journal of Medical Microbiology Volume: 298 Issue: 1-2, S-Page: 3- E-Page: 10
  • Authors: Klein,C.; Medina,Eva*; Sander,L.; Roskams,T.; Müller,Werner*; Trautwein,C.; Goldmann,O.; ( Year: 2007). Title: Contribution of IL-6/gp130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes.Journal: Journal of Infectious Diseases Volume: 196 Issue: 5, S-Page: 755- E-Page: 762 DOI: 10.1086/520090HZI repositoryPubMed
  • Authors: Luthje,P.; von Kockritz-Blickwede,Maren*; Schwarz,S.; ( Year: 2007). Title: Identification and characterization of nine novel types of small staphylococcal plasmids carrying the lincosamide nucleotidyltransferase gene lnu(A).Journal: Journal of Antimicrobial Chemotherapy Volume: 59 Issue: 4, S-Page: 600- E-Page: 606 PubMed
  • Authors: Loof,T.G.; Rohde,Manfred*; Chhatwal,Gursharan S.*; Jung,S.; Medina,Eva*; ( Year: 2007). Title: The contribution of dendritic cells to host defenses against Streptococcus pyogenes.Journal: Journal of Infectious Diseases Volume: 196, S-Page: 1794- E-Page: 1803
  • Authors: Goldmann,O.; von Kockritz-Blickwede,M.; Holtje,C.; Chhatwal,Gursharan S*.; Geffers,Robert*; Medina,Eva*; ( Year: 2007). Title: Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program.Journal: Infection and Immunity Volume: 75 Issue: 8, S-Page: 4148- E-Page: 4157 DOI: 10.1128/IAI.00181.07HZI repositoryPubMed
  • Authors: Dinkla,Kathrin*; Sastalla,I.; Godehardt,A.W.; Janze,N.; Chhatwal,Gursharan S*.; Rohde,Manfred*; Medina,Eva*; ( Year: 2007). Title: Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related ?2-macroglobulin-binding protein GRAB located on the bacterial surface.Journal: Microbes and Infection Volume: 9 Issue: 8, S-Page: 922- E-Page: 931
  • Authors: Schulze,K.; Medina,Eva*; Guzmán,Carlos A.*; ( Year: 2006). Title: Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes fails to protect mice against lethal mucosal challenge with a heterologous strain.Journal: Vaccine Volume: 24, S-Page: 1446- E-Page: 1450 DOI: 10.1016/j.vaccine.2005.06.039
  • Authors: Medina,E.; ( Year: 2006). Title: Streptococcus pyogenes and host'genetics.Journal: Mod.Asp.Immunobiol. Volume: 18, S-Page: 13 DOI: NoteWEBURLS
  • Authors: Medina,Eva*; Ryan,L.; LaCourse,R.; North,R.J.; ( Year: 2006). Title: Superior virulence of Mycobacterium bovis over Mycobacterium tuberculosis (Mtb) for Mtb-resistant and Mtb-susceptible mice is manifest as an ability to cause extrapulmonary disease.Journal: Tuberculosis Volume: 86 Issue: 1, S-Page: 20- E-Page: 27
  • Authors: Siegert,J.; Sastalla,I.; Chhatwal,Gursharan S*.; Medina,Eva*; ( Year: 2006). Title: Vaccination equally enables both genetically susceptible and resistant mice to control infection with group A streptococci.Journal: Microbes and Infection Volume: 8 Issue: 2, S-Page: 347- E-Page: 353 DOI: 10.1016/j.micinf.2005.06.024HZI repositoryPubMed
  • Authors: Goldmann,O.; Chhatwal,G.S.; Medina,E.; ( Year: 2005). Title: Contribution of NK cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice.Journal: Journal of Infectious Diseases Volume: 191, S-Page: 1280- E-Page: 1286
  • Authors: Medina,E.; Lengeling,A.; ( Year: 2005). Title: Genetic regulation of host responses to Group A Streptococcus in mice.Journal: Briefings in Functional Genomics & Proteomics Volume: 4, S-Page: 248- E-Page: 257
  • Authors: Schulze,K.; Goldmann,O.; Toppel,A.; Medina,E.; Guzmán,C.A.; ( Year: 2005). Title: The FAI protein of group C streptococci targets B cells and exhibits adjuvant activity.Journal: Vaccine Volume: 23, S-Page: 1408- E-Page: 1413
  • Authors: Medina,Eva*; ( Year: 2004). Title: Models of group A streptococcal diseases: a review of current status.Journal: Drug Discovery Today: Disease Models Volume: 1, S-Page: 65- E-Page: 71

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  • Dem alternden Immunsystem auf die Sprünge helfen Wir werden älter und mit dem Alter wird unser Immunsystem schwächer. Infektionskrankheiten haben ein leichtes Spiel in einem gealterten Körper – vor allem schwere Infektionen mit Bakterien häufen sich jenseits der 60 und können leicht lebensbedrohlich werden. Nur woran liegt das? Und lässt sich wirklich nichts dagegen unternehmen? Eva Medina und Oliver Goldmann hatten eine Idee. Wie sie dem Immunsystem auf die Sprünge helfen wollen, hören Sie hier...
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