Immunometabolism

The immunometabolism team headed by Prof. Karsten Hiller investigates the cellular and mitochondrial metabolism of immune cells.

Leader

Selected Publications

Nonnenmacher, Y. & Hiller, K. Biochemistry of proinflammatory macrophage activation. Cell. Mol. Life Sci. 75, 2093–2109 (2018).

Nonnenmacher, Y., Palorini, R., d’Herouël, A. F., Krämer, L., Neumann-Schaal, M., Chiaradonna, F., Skupin, A., Wegner, A. & Hiller, K. Analysis of mitochondrial metabolism in situ: Combining stable isotope labeling with selective permeabilization. Metabolic Engineering 43, 147–155 (2017).

Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld,C., Hao, Z., Brüstle, A., Itsumi, M., Jäger, C., Chen, Y., Pinkenburg, O., Camara, B.,Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P. A., Lohoff, M., Harris,I. S., Hiller, K. & Brenner, D. Glutathione Primes T Cell Metabolism for Inflammation. English. Immunity46, 675–689 (2017).

Meiser, J., Krämer, L., Sapcariu, S. C., Battello, N., Ghelfi, J., D’Herouel, A. F., Skupin,A. & Hiller, K. Pro-inflammatory Macrophages Sustain Pyruvate Oxidation throughPyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression. en. J. Biol. Chem. 291, 3932–3946 (2016).

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T.,Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C. L., Medina, E., Balling, R. & Hiller, K. Immune-responsive gene 1 protein links metabolism to immunity by catalyzingitaconic acid production. en. PNAS110, 7820–7825 (2013).

Publications

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2007

2006

2005

2004

2003

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