Immune Regulation

Due to their physiological functions our mucosal surfaces are in direct contact to the environment and thus represent the major port of entry for pathogens. To protect the body from severe infections an effective mucosal immune system is indispensable. We are studying respiratory tract infections with the focus on influenza and pneumococci, which represent the most frequent viral and bacterial infectious agents for pneumonia in humans. A major focus of our research is to study molecular and cellular processes during coinfection with influenza and pneumococci and here in particular the immunological functions of the alveolar epithelium in host defense.

Leader

Selected Publications

Sharma-Chawla N, Stegemann-Koniszewski S, Christen H, Boehme JD, Kershaw O, Schreiber J, Guzmán CA, Bruder D*, Hernandez-Vargas EA*. In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection. Front Immunol. 2019 Aug 14;10:1864. *equal contribution.

Stegemann-Koniszewski S, Behrens S, Boehme JD, Hochnadel I, Riese P, Guzmán CA, Kröger A, Schreiber J, Gunzer M, Bruder D. Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7. Front Immunol. 2018 Feb 13;9:245.

Boehme JD, Stegemann-Koniszewski S, Autengruber A, Peters N, Wissing J, Jänsch L, Jeron A, Bruder D. Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance. Sci Rep. 2017 Jul 10;7(1):4972.

Sharma-Chawla N, Sender V, Kershaw O, Gruber AD, Volckmar J, Henriques-Normark B, Stegemann-Koniszewski S, Bruder D. Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation. Infect Immun. 2016 Nov 18;84(12):3445-3457.

Stegemann-Koniszewski S, Jeron A, Gereke M, Geffers R, Kröger A, Gunzer M, Bruder D. Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals. MBio. 2016 May 3;7(3).

Publications

  • Authors: Frentzel,S.; Katsoulis-Dimitriou,K.; Jeron,A.; Schmitz,I.; Bruder,D.; ( Year: 2019). Title: Essential role of IkappaBNS for in vivo CD4(+) T cell activation, proliferation and Th1 cell differentiation during Listeria monocytogenes infection in mice.Journal: European Journal of Immunology Volume: 49 Issue: 9, S-Page: 1391- E-Page: 1398 DOI: 10.1002/eji.201847961HZI repositoryPubMed
  • Authors: Sharma-Chawla,N.; Stegemann-Koniszewski,S.; Christen,H.; Boehme,J.D.; Kershaw,O.; Schreiber,J.; Guzmán,C.A.; Bruder,D.; Hernandez-Vargas,E.A.; ( Year: 2019). Title: In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection.Journal: Front Immunol. Volume: 10, S-Page: 1864 DOI: 10.3389/fimmu.2019.01864HZI repositoryPubMed
  • Authors: Zheng,X.; Oduro,J.D.; Boehme,J.D.; Borkner,L.; Ebensen,T.; Heise,U.; Gereke,M.; Pils,M.C.; Krmpotic,A.; Guzmán,C.A.; Bruder,D.; Cicin-Sain,L.; ( Year: 2019). Title: Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge.Journal: PLoS Pathogens Volume: 15 Issue: 9, S-Page: e1008036 DOI: 10.1371/journal.ppat.1008036HZI repositoryPubMed
  • Authors: Volckmar,J.; Knop,L.; Stegemann-Koniszewski,S.; Schulze,K.; Ebensen,T.; Guzmán,C.A.; Bruder,D.; ( Year: 2019). Title: The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells.Journal: Vaccine Volume: 37 Issue: 35, S-Page: 4963- E-Page: 4974 DOI: 10.1016/j.vaccine.2019.07.019HZI repositoryPubMed
  • Authors: Schultz,K.; Grieger,C.; Li,Y.; Urb b nek,P.; Ruschel,A.; Minnich,K.; Bruder,D.; Gereke,M.; Sechi,A.; Herrlich,P.; ( Year: 2018). Title: Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.Journal: PLoS ONE Volume: 13 Issue: 12 DOI: 10.1371/journal.pone.0207358HZI repositoryPubMed
  • Authors: Liakopoulos,V.; Jeron,A.; Shah,A.; Bruder,D.; Mertens,P.R.; Gorny,X.; ( Year: 2018). Title: Hemodialysis-related changes in phenotypical features of monocytes.Journal: Sci.Rep. Volume: 8 Issue: 1, S-Page: Article number 13964 DOI: 10.1038/s41598-018-31889-2HZI repositoryPubMed
  • Authors: Veluswamy,P.; Bruder,D.; ( Year: 2018). Title: PD-1/PD-L1 pathway inhibition to restore effector functions in exhausted CD8+ T cells: Chances, limitations and potential risks.Journal: Transl.Cancer Res. Volume: 7 Issue: Supplement 4 (April), S-Page: S530- E-Page: S537 DOI: 10.21037/tcr.2018.04.04WEBURLS
  • Authors: Abdissa,K.; Nerlich,A.; Beineke,A.; Ruangkiattikul,N.; Pawar,V.; Heise,U.; Janze,N.; Falk,C.; Bruder,D.; Schleicher,U.; Bogdan,C.; Weiss,S.; Goethe,R.; ( Year: 2018). Title: Presence of infected Gr-1intCD11bhiCD11cintmonocytic myeloid derived suppressor cells subverts T cell response and is associated with impaired dendritic cell function in Mycobacterium avium-infected mice.Journal: Frontiers in Immunology Volume: 9 Issue: OCT DOI: 10.3389/fimmu.2018.02317HZI repositoryPubMed
  • Authors: Bulitta,B.; Zuschratter,W.; Bernal,I.; Bruder,D.; Klawonn,F.; von,Bergen M.; Garritsen,H.S.P.; Jänsch,L.; ( Year: 2018). Title: Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype.Journal: European Journal of Immunology Volume: 48 Issue: 8, S-Page: 1336- E-Page: 1349 DOI: 10.1002/eji.201747398PubMed
  • Authors: Jeron,A.; Boehme,J.D.; Volckmar,J.; Gereke,M.; Yevsa,T.; Geffers,R.; Guzmán,C.A.; Schreiber,J.; Stegemann-Koniszewski,S.; Bruder,D.; ( Year: 2018). Title: Respiratory bordetella bronchiseptica carriage is associated with broad phenotypic alterations of peripheral CD4+CD25+ T cells and differentially affects immune responses to secondary non-infectious and infectious stimuli in mice.Journal: International Journal of Molecular Sciences Volume: 19 Issue: 9, S-Page: Article number 2602 DOI: 10.3390/ijms19092602HZI repositoryPubMed
  • Authors: Stegemann-Koniszewski,S.; Behrens,S.; Boehme,J.D.; Hochnadel,I.; Riese,P.; Guzmán,C.A.; Kröger,A.; Schreiber,J.; Gunzer,M.; Bruder,D.; ( Year: 2018). Title: Respiratory influenza A virus infection triggers local and systemic natural killer cell activation via toll-like receptor 7.Journal: Frontiers in Immunology Volume: 9 Issue: FEB, S-Page: Article 245 DOI: 10.3389/fimmu.2018.00245WEBURLS
  • Authors: Mracsko,E.; Stegemann-Koniszewski,S.; Na,S.Y.; Dalpke,A.; Bruder,D.; Lasitschka,F.; Veltkamp,R.; ( Year: 2017). Title: A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae.Journal: Cerebrovasc.Dis. Volume: 43 Issue: 3-4, S-Page: 99- E-Page: 109 DOI: 10.1159/000452136PubMed
  • Authors: Boehme,J.D.; Stegemann-Koniszewski,S.; Autengruber,A.; Peters,N.; Wissing,J.; Jänsch,L.; Jeron,A.; Bruder,D.; ( Year: 2017). Title: Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance.Journal: Sci.Rep. Volume: 7 Issue: 1, S-Page: 4972 DOI: 10.1038/s41598-017-05212-4PubMed
  • Authors: Boehme,J.D.; Bruder,D.; ( Year: 2017). Title: IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity.Journal: Cell Mol.Immunol. Volume: 14 Issue: 11, S-Page: 875- E-Page: 877 DOI: 10.1038/cmi.2017.53HZI repositoryPubMed
  • Authors: Frede,A.; Neuhaus,B.; Knuschke,T.; Wadwa,M.; Kollenda,S.; Klopfleisch,R.; Hansen,W.; Buer,J.; Bruder,D.; Epple,M.; Westendorf,A.M.; ( Year: 2017). Title: Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation.Journal: Nanomedicine. Volume: 13 Issue: 8, S-Page: 2395- E-Page: 2403 DOI: 10.1016/j.nano.2017.08.001PubMed
  • Authors: Volckmar,J.; Gereke,M.; Ebensen,T.; Riese,P.; Philipsen,L.; Lienenklaus,S.; Wohlleber,D.; Klopfleisch,R.; Stegemann-Koniszewski,S.; Muller,A.J.; Gruber,A.D.; Knolle,P.; Guzmán,C.A.; Bruder,D.; ( Year: 2017). Title: Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.Journal: Sci Rep. Volume: 7 Issue: Mar, S-Page: 43985 DOI: 10.1038/srep43985HZI repositoryPubMed
  • Authors: Pieler,M.M.; Frentzel,S.; Bruder,D.; Wolff,M.W.; Reichl,U.; ( Year: 2016). Title: A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection.Journal: Vaccine Volume: 34 Issue: 50, S-Page: 6367- E-Page: 6374 DOI: 10.1016/j.vaccine.2016.10.041HZI repositoryPubMed
  • Authors: Sakthivel,P.; Sharma,N.; Klahn,P.; Gereke,M.; Bruder,D.; ( Year: 2016). Title: Abscisic acid: A phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications.Journal: Curr.Med.Chem. Volume: 23 Issue: 15, S-Page: 1549- E-Page: 1570 DOI: 10.2174/0929867323666160405113129WEBURLS
  • Authors: Parzmair,G.P.; Gereke,M.; Haberkorn,O.; Annemann,M.; Podlasly,L.; Kliche,S.; Reinhold,A.; Schraven,B.; Bruder,D.; ( Year: 2016). Title: ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.Journal: J Leukoc.Biol. Volume: 101 Issue: 2, S-Page: 407- E-Page: 419 DOI: 10.1189/jlb.1A0216-090RRPubMed
  • Authors: Stegemann-Koniszewski,S.; Jeron,A.; Gereke,M.; Geffers,R.; Kroger,A.; Gunzer,M.; Bruder,D.; ( Year: 2016). Title: Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals.Journal: MBio. Volume: 7 Issue: 3 DOI: 10.1128/mBio.00276-16HZI repositoryPubMed
  • Authors: Duvigneau,S.; Sharma-Chawla,N.; Boianelli,A.; Stegemann-Koniszewski,S.; Nguyen,V.K.; Bruder,D.; Hernandez-Vargas,E.A.; ( Year: 2016). Title: Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection.Journal: Sci Rep. Volume: 6, S-Page: 37045 DOI: 10.1038/srep37045HZI repositoryPubMed
  • Authors: Rolle,A.M.; Hasenberg,M.; Thornton,C.R.; Solouk-Saran,D.; M S nn,L.; Weski,J.; Maurer,A.; Fischer,E.; Spycher,P.R.; Schibli,R.; Boschetti,F.; Stegemann-Koniszewski,S.; Bruder,D.; Severin,G.W.; Autenrieth,S.E.; Krappmann,S.; Davies,G.; Pichler,B.J.; Gunzer,M.; Wiehr,S.; ( Year: 2016). Title: ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 113 Issue: 8, S-Page: E1026- E-Page: E1033 DOI: 10.1073/pnas.1518836113HZI repositoryPubMed
  • Authors: Sharma-Chawla,N.; Sender,V.; Kershaw,O.; Gruber,A.D.; Volckmar,J.; Henriques-Normark,B.; Stegemann-Koniszewski,S.; Bruder,D.; ( Year: 2016). Title: Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific manifestation.Journal: Infection and Immunity Volume: 84 Issue: 12, S-Page: 3445- E-Page: 3457 DOI: 10.1128/IAI.00422-16HZI repositoryPubMed
  • Authors: Sakthivel,P.; Bruder,D.; ( Year: 2016). Title: Mechanism of granuloma formation in sarcoidosis.Journal: Curr Opin.Hematol. Volume: 24 Issue: 1, S-Page: 59- E-Page: 65 PubMed
  • Authors: Boianelli,A.; Sharma-Chawla,N.; Bruder,D.; Hernandez-Vargas,E.A.; ( Year: 2016). Title: Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection.Journal: Front Cell Infect.Microbiol. Volume: 6, S-Page: 60 DOI: 10.3389/fcimb.2016.00060HZI repositoryPubMed
  • Authors: Sakthivel,P.; Breithaupt,A.; Gereke,M.; Copland,D.A.; Schulz,C.; Gruber,A.D.; Dick,A.D.; Schreiber,J.; Bruder,D.; ( Year: 2016). Title: Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course.Journal: Lung Volume: 159, S-Page: 59- E-Page: 68 DOI: 10.1007/s00408-016-9962-4 HZI repository PubMed
  • Authors: Boehme,J.D.; Pietkiewicz,S.; Lavrik,I.; Jeron,A.; Bruder,D.; ( Year: 2015). Title: Erratum to: Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease.Journal: Lung Volume: 193, S-Page: 955 PubMed
  • Authors: Yeruva,S.; Chodisetti,G.; Luo,M.; Chen,M.; Cinar,A.; Ludolph,L.; Lünnemann,M.; Goldstein,J.; Singh,A.K.; Riederer,B.; Bachmann,O.; Bleich,A.; Gereke,M.; Bruder,D.; Hagen,S.; He,P.; Yun,C.; Seidler,U.; ( Year: 2015). Title: Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis.Journal: Pflug.Arch.Eur.J.Physiol. Volume: 467 Issue: 8, S-Page: 1795- E-Page: 1807 DOI: 10.1007/s00424-014-1608-xHZI repositoryPubMed
  • Authors: Tschernig,T.; Hartwig,C.; Jeron,A.; Dinh,Q.T.; Gereke,M.; Bruder,D.; ( Year: 2015). Title: First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma.Journal: Int.J Genomics Volume: 2015, S-Page: 638032 DOI: 10.1155/2015/638032HZI repositoryPubMed
  • Authors: Biswas,A.; Bruder,D.; Wolf,S.A.; Jeron,A.; Mack,M.; Heimesaat,M.M.; Dunay,I.R.; ( Year: 2015). Title: Ly6Chigh monocytes control cerebral toxoplasmosis.Journal: Journal of Immunology Volume: 194 Issue: 7, S-Page: 3223- E-Page: 3235 WEBURLS
  • Authors: Boianelli,A.; Nguyen,V.K.; Ebensen,T.; Schulze,K.; Wilk,E.; Sharma,N.; Stegemann-Koniszewski,S.; Bruder,D.; Toapanta,F.R.; Guzm b n,C.A.; Meyer-Hermann,M.; Hernandez-Vargas,E.A.; ( Year: 2015). Title: Modeling influenza virus infection: A roadmap for influenza research.Journal: Viruses Volume: 7 Issue: 10, S-Page: 5274- E-Page: 5304 DOI: 10.3390/v7102875HZI repositoryPubMed
  • Authors: Désiréé Boehme,J.; Pietkiewicz,S.; Lavrik,I.; Jeron,A.; Bruder,D.; ( Year: 2015). Title: Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease.Journal: Lung Volume: 193 Issue: 6, S-Page: 947- E-Page: 953 DOI: 10.1007/s00408-015-9797-4HZI repositoryPubMed
  • Authors: Sakthivel,P.; Grunewald,J.; Eklund,A.; Bruder,D.; Wahlstrom,J.; ( Year: 2015). Title: Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and resolution.Journal: Clin.Exp.Immunol. Volume: 183, S-Page: 294- E-Page: 306 PubMed
  • Authors: Sakthivel,P.; Gereke,M.; Breithaupt,A.; Fuchs,D.; Gigliotti,L.; Gruber,A.D.; Dianzani,U.; Bruder,D.; ( Year: 2014). Title: Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells.Journal: PLoS ONE Volume: 9 Issue: 7, S-Page: e100970 DOI: 10.1371/journal.pone.0100970HZI repositoryPubMed
  • Authors: Petzold,C.; Steinbronn,N.; Gereke,M.; Strasser,R.H.; Sparwasser,T.; Bruder,D.; Geffers,R.; Schallenberg,S.; Kretschmer,K.; ( Year: 2014). Title: Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin.Journal: European Journal of Immunology Volume: 44 Issue: 12, S-Page: 3632- E-Page: 3645 DOI: ArticleWEBURLS
  • Authors: Kominsky,D.J.; Campbell,E.L.; Ehrentraut,S.F.; Wilson,K.E.; Kelly,C.J.; Glover,L.E.; Collins,C.B.; Bayless,A.J.; Saeedi,B.; Dobrinskikh,E.; Bowers,B.E.; Macmanus,C.F.; Muller,W.; Colgan,S.P.; Bruder,Dunja; ( Year: 2014). Title: IFN-gamma-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia.Journal: Journal of Immunology Volume: 192 Issue: 3, S-Page: 1267- E-Page: 1276 DOI: 10.4049/jimmunol.1301757HZI repositoryPubMed
  • Authors: Nair,Sharmila; Michaelsen-Preusse,K.; Finsterbusch,Katja; Stegemann-Koniszewski,Sabine; Bruder,Dunja; Grashoff,Martina; Korte,Martin; Köster,Mario; Kalinke,Ulrich; Hauser,Hansjörg; Kröger,Andrea; ( Year: 2014). Title: Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons.Journal: PLoS Pathogens Volume: 10 Issue: 3, S-Page: e1003999 DOI: 10.1371/journal.ppat.1003999HZI repositoryPubMed
  • Authors: Hasenberg,M.; Stegemann-Koniszewski,S.; Gunzer,Matthias*; ( Year: 2013). Title: Cellular immune reactions in the lung.Journal: Immunological Reviews Volume: 251 Issue: 1, S-Page: 189- E-Page: 214 DOI: 10.1111/imr.12020HZI repositoryPubMed
  • Authors: Telieps,T.; Ewald,F.; Gereke,M.; Annemann,M.; Rauter,Y.; Schuster,M.; Ueffing,N.; von,Smolinski D.; Gruber,A.D.; Bruder,D.; Schmitz,I.; ( Year: 2013). Title: Cellular-FLIP, Raji isoform (c-FLIPR) modulates cell death induction upon T-cell activation and infection.Journal: European Journal of Immunology Volume: 43 Issue: 6, S-Page: 1499- E-Page: 1510 WEBURLS
  • Authors: Martinez,J.P.; Perez-Vilaro,G.; Muthukumar,Y.; Scheller,N.; Hirsch,Tatjana; Diestel,R.; Steinmetz,Heinrich; Jansen,Rolf; Frank,Ronald; Sasse,Florenz; Meyerhans,A.; Diez,J.; ( Year: 2013). Title: Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.Journal: RNA Biology Volume: 10 Issue: 11, S-Page: 1661- E-Page: 1669 Fulltext
  • Authors: Tosiek,M.J.; Bader,S.R.; Gruber,A.D.; Buer,J.; Gereke,M.; Bruder,Dunja; ( Year: 2012). Title: CD8+ T Cells Responding to Alveolar Self-Antigen Lack CD25 Expression and Fail to Precipitate Autoimmunity.Journal: American Journal of Respiratory Cell and Molecular Biology Volume: 47 Issue: 6, S-Page: 869- E-Page: 878 DOI: 10.1165/rcmb.2011-0387OCPubMed
  • Authors: Jeron,A.; Hansen,W.; Ewert,F.; Buer,J.; Geffers,R.; Bruder,D.; ( Year: 2012). Title: ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells.Journal: BMC GENOMICS Volume: 13 Issue: 1, S-Page: 705 DOI: 10.1186/1471-2164-13-705HZI repositoryPubMed
  • Authors: König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; ( Year: 2012). Title: First insight into the kinome of human regulatory T cells.Journal: PLoS ONE Volume: 7 Issue: 7, S-Page: e40896 DOI: 10.1371/journal.pone.0040896HZI repositoryPubMed
  • Authors: Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; ( Year: 2012). Title: Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies.Journal: Journal of Visualized Experiments: JoVE Issue: 70 DOI: 4322.WEBURLS
  • Authors: Albrecht,M.; Arnhold,M.; Lingner,S.; Mahapatra,S.; Bruder,Dunja; Hansen,G.; Dittrich,A.M.; ( Year: 2012). Title: IL-4 Attenuates Pulmonary Epithelial Cell-Mediated Suppression of T Cell Priming.Journal: PLoS ONE Volume: 7 Issue: 9, S-Page: e45916 DOI: 10.1371/journal.pone.0045916PubMed
  • Authors: Autengruber,Andrea; Gereke,Marcus; Hansen,G.; Hennig,C.; Bruder,Dunja; ( Year: 2012). Title: Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.Journal: European Journal of Microbiology and Immunology Volume: 2 Issue: 2, S-Page: 112- E-Page: 120 DOI: 10.1556/EuJMI.2.2012.2.3
  • Authors: Sakthivel,Priya; Gereke,Marcus; Bruder,Dunja; ( Year: 2012). Title: Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction.Journal: Review on Recent Clinical Trials Volume: 7 Issue: 1, S-Page: 10- E-Page: 23 PubMed
  • Authors: Stegemann-Koniszewski,S.; Gereke,M.; Orrskog,S.; Lienenklaus,S.; Pasche,B.; Bader,S.R.; Gruber,A.D.; Akira,S.; Weiss,Siegfried; Henriques-Normark,B.; Bruder,Dunja; Gunzer,M.; ( Year: 2012). Title: TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection.Journal: Journal of Innate Immunity Volume: 5 Issue: 1, S-Page: 84- E-Page: 96 DOI: 10.1159/000345112HZI repositoryPubMed
  • Authors: Tosiek,M.J.; Gruber,A.D.; Bader,S.; Hoymann,H.G.; Mauel,S.; Tschwernig,T.; Buer,J.; Gereke,M.; Bruder,Dunja*; ( Year: 2011). Title: CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung inflammation.Journal: Journal of Immunology Volume: 186 Issue: 11, S-Page: 6106- E-Page: 6118
  • Authors: Hasenberg,M.; Köhler,A.; Jeron,A.; Bonifatius,S.; Gunzer,M.; ( Year: 2011). Title: Direct observation of phagocytosis and NET formation by neutrophils in infected lungs using 2-photon microscopy3332.Journal: Journal of Visualized Experiments Volume: 52 Issue: art. no. e2659 DOI: 10.3791/2659
  • Authors: Alberts,R.; Chen,H.; Pommerenke,C.; Smit,A.B.; Spijker,S.; Williams,R.W.; Geffers,Robert*; Bruder,Dunja*; Schughart,Klaus*; ( Year: 2011). Title: Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease1.Journal: BMC GENOMICS Volume: 12, S-Page: 610 DOI: 10.1186/1471-2164-12-610HZI repositoryPubMed
  • Authors: Ukena,S.N.; Velaga,S.; Geffers,Robert*; Grosse,J.; Baron,U.; Buchholz,S.; Stadler,M.; Bruder,Dunja*; Ganser,A.; Franzke,A.; ( Year: 2011). Title: Human regulatory T cells in allogeneic stem cell transplantation.Journal: Blood Volume: 118 Issue: 13, S-Page: e82- E-Page: e92 PubMed
  • Authors: Liesz,A.; Zhou,W.; Mracskó,E.; Karcher,S.; Doerr,H.; Schwarting,S.; Sun,L.; Bruder,Dunja*; Stegemann,S.; Cerwenka,A.; Sommer,C.; Dalpke,A.; Veltkamp,R.; ( Year: 2011). Title: Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.Journal: Brain Volume: 134 Issue: 3, S-Page: 704- E-Page: 720
  • Authors: Cappuccini,F.; Eldh,T.; Bruder,Dunja*; Gereke,M.; Jastrow,H.; Schulze-Osthoff,K.; Fischer,U.; Kohler,D.; Stuschke,M.; Jendrossek,V.; ( Year: 2011). Title: New insights into the molecular pathology of radiation-induced pneumopathy.Journal: Radiotherapy and Oncology Volume: 101 Issue: 1, S-Page: 86- E-Page: 92 DOI: 10.1016/j.radonc.2011.05.064HZI repositoryPubMed
  • Authors: Kang,T.W.; Yevsa,T.; Woller,N.; Hoenicke,L.; Wuestefeld,T.; Dauch,D.; Hohmeyer,A.; Gereke,M.; Rudalska,R.; Potapova,A.; Iken,M.; Vucur,M.; Weiss,Siegfried*; Heikenwalder,M.; Khan,S.; Gil,J.; Bruder,Dunja*; Manns,M.; Schirmacher,P.; Tacke,F.; Ott,M.; Luedde,T.; Longerich,T.; Kubicka,S.; Zender,Lars*; ( Year: 2011). Title: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.Journal: Nature Volume: 479 Issue: 7374, S-Page: 547- E-Page: 551 PubMed
  • Authors: Bar-On,L.; Birnberg,T.; Lewis,K.L.; Edelson,B.T.; Bruder,Dunja*; Hildner,K.; Buer,J.; Murphy,K.M.; Reizis,B.; Jung,S.; ( Year: 2010). Title: CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells.Journal: Proceedings of the National Acadamy of Sciences of the United States of America Volume: 107 Issue: 33, S-Page: 14745- E-Page: 14750 DOI: 10.1073/pnas.1001562107HZI repositoryPubMed
  • Authors: Bruns,S.; Kniemeyer,O.; Hasenberg,M.; Aimanianda,V.; Nietzsche,S.; Thywissen,A.; Jeron,A.; Latge,J.P.; Brakhage,A.A.; Gunzer,M.; ( Year: 2010). Title: Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA.Journal: PLoS Pathogens Volume: 6 Issue: 4, S-Page: e1000873 DOI: 10.1371/journal.ppat.1000873HZI repositoryPubMed
  • Authors: Gereke,M.; Jung,S.; Buer,J.; Bruder,Dunja*; ( Year: 2009). Title: Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells.Journal: American Journal of Respiratory and Critical Care Medicine Volume: 179 Issue: 5, S-Page: 344- E-Page: 355 PubMed
  • Authors: De Buhr,M.F.; Hedrich,H.J.; Westendorf,Astrid M.*; Obermeier,F.; Hofmann,C.; Zschemisch,N.H.; Buer,J.; Bumann,D.; Goyert,S.M.; Bleich,A.; ( Year: 2009). Title: Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice.Journal: Inflammatory Bowel Diseases Volume: 15 Issue: 12, S-Page: 1824- E-Page: 1836 DOI: 10.1002/ibd.21030HZI repositoryPubMed
  • Authors: Westendorf,A.M.; Fleissner,D.; Gröbe,Lothar*; Jung,S.; Gruber,A.D.; Hansen,W.; Buer,J.; ( Year: 2009). Title: CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells.Journal: GUT Volume: 58 Issue: 2, S-Page: 211- E-Page: 219 PubMed
  • Authors: Jeron,A.; Pfoertner,S.; Bruder,Dunja*; Geffers,Robert*; Hammerer,P.; Hofmann,R.; Buer,J.; Schrader,A.J.; ( Year: 2009). Title: Frequency and Gene Expression Profile of Regulatory T Cells in Renal Cell Carcinoma.Journal: Tumor Biology Volume: 30 Issue: 3, S-Page: 160- E-Page: 170 PubMed
  • Authors: Probst-Kepper,M.; Geffers,R.; Kroger,A.; Viegas,N.; Erck,C.; Hecht,H.-J.; Lünsdorf,H.; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,A.; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,R.; Hauser,H.; Buer,J.; Weiss,S.; ( Year: 2009). Title: GARP: a key receptor controlling FOXP3 in human regulatory T cells.Journal: Journal of Cellular and Molecular Medicine Volume: 13 Issue: 9, S-Page: 3343- E-Page: 3357 PubMed
  • Authors: Stegemann,S.; Dahlberg,S.; Kroger,A.; Gereke,M.; Bruder,Dunja*; Henriques-Normark,B.; Gunzer,Matthias*; ( Year: 2009). Title: Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia.Journal: PLoS ONE Volume: 4 Issue: 3, S-Page: e4840 DOI: 10.1371/journal.pone.0004840HZI repositoryPubMed
  • Authors: Lienenklaus,S.; Cornitescu,M.; Zietara,N.; Lyszkiewicz,M.; Gekara,N.; Jablonska,J.; Edenhofer,F.; Rajewsky,K.; Bruder,Dunja*; Hafner,M.; Staeheli,P.; Weiss,Siegfried*; ( Year: 2009). Title: Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.Journal: Journal of Immunology Volume: 183 Issue: 5, S-Page: 3229- E-Page: 3236 PubMed
  • Authors: Barth,K.; Weinhold,K.; Guenther,A.; Linge,A.; Gereke,Marcus*; Kasper,M.; ( Year: 2008). Title: Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells.Journal: International Journal of Biochemistry and Cell Biology Volume: 40 Issue: 10, S-Page: 2230- E-Page: 2239 DOI: 10.1016/j.biocel.2008.03.001PubMed
  • Authors: Hansen,W.; Westendorf,A.M.; Reinwald,S.; Bruder,Dunja*; Deppenmeier,S.; Gröbe,Lothar*; Probst-Kepper,Michael*; Gruber,A.D.; Geffers,Robert*; Buer,Jan*; ( Year: 2007). Title: Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 - CD25 - regulatory T cells 1.Journal: Journal of Immunology Volume: 179, S-Page: 8059- E-Page: 8068
  • Authors: Gereke,M.; Gröbe,L.; Prettin,S.; Kasper,M.; Deppenmeier,S.; Gruber,A.D.; Enelow,R.I.; Buer,J.; Bruder,D.; ( Year: 2007). Title: Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation.Journal: Respiratory research Volume: 8, S-Page: 47 DOI: 10.1186/1465-9921-8-47HZI repositoryPubMed
  • Authors: Ukena,S.N.; Singh,A.; Dringenberg,U.; Engelhardt,R.; Seidler,U.; Hansen,W.; Bleich,A.; Bruder,Dunja*; Franzke,A.; Rogler,G.; Suerbaum,S.; Buer,Jan*; Gunzer,F.; Westendorf,Astrid .M.*; ( Year: 2007). Title: Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity.Journal: PLoS ONE Volume: 2 Issue: 12, S-Page: e1308 DOI: 10.1371/journal.pone.0001308HZI repositoryPubMed
  • Authors: Westendorf,A.M.; Fleissner,D.; Deppenmeier,S.; Gruber,A.D.; Bruder,D.; Hansen,H.; Liblau,R.; Buer,J.; ( Year: 2006). Title: Autoimmune-mediated intestinal inflammation - impact and regulation of antigen specific CD8+ T cells.Journal: Gastroenterology Volume: 131 Issue: 2, S-Page: 510- E-Page: 524
  • Authors: Bruder,Dunja*; Srikiatkhachorn,A.; Enelow,R.I.; ( Year: 2006). Title: Cellular immunity and lung injury in respiratory virus infection.Journal: Viral Immunology Volume: 26, S-Page: 318- E-Page: 327
  • Authors: Hansen,W.; Loser,K.; Westendorf,Astrid M.*; Bruder,Dunja*; Pförtner,S.; Siewert,C.; Huehn,J.; Beissert,S.; Buer,Jan*; ( Year: 2006). Title: GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.Journal: Journal of Immunology Volume: 177, S-Page: 209- E-Page: 215
  • Authors: Westendorf,A.M.; Bruder,D.; Hansen,W.; Buer,J.; ( Year: 2006). Title: Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model.Journal: Annals of the New York Academy of Sciences Volume: 1072, S-Page: 401- E-Page: 406
  • Authors: Ramana,C.V.; Chintapalli,J.; Xu,L.; Alia,C.; Bruder,Dunja*; Enelow,R.I.; ( Year: 2006). Title: Lung epithelial Stat1 and NF- B signalling in response to CD8+ T cell antigen recognition.Journal: Journal of Interferon and Cytokine Research Volume: 26, S-Page: 318- E-Page: 327
  • Authors: Bruder,Dunja*; Nussbaum,A.K.; Gakamsky,D.M.; Schirle,M.; Stevanovic,S.; Singh-Jasuja,H.; Darji,A.; Chakraborty,T.; Schild,H.; Pecht,I.; Weiss,Siegfried*; ( Year: 2006). Title: Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O.Journal: International immunology Volume: 18, S-Page: 89- E-Page: 100 DOI: 10.1093/intimm/dxh352HZI repositoryPubMed
  • Authors: Pfoertner,Susanne*; Jeron,A.; Probst-Kepper,M.; Guzmán,Carlos A.*; Hansen,W.; Westendorf,A.M.; Toepfer,T.; Schrader,A.J.; Franzke,A.; Buer,Jan*; Geffers,Robert*; ( Year: 2006). Title: Signatures of human regulatory T cells: an encounter with old friends and new players.Journal: Genome Biology Volume: 7, S-Page: R54 DOI: 10.1186/gb-2006-7-7-r54HZI repositoryPubMed

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Video

  • Impfung gegen Diabetes

    Diabetes mellitus ist inzwischen eine Volkskrankheit an der jährlich mehr junge Menschen erkranken. Lebenslang müssen die Betroffenen strenge Diät halten und Insulin spritzen, da ihre Bauchspeicheldrüse das Hormon nicht produziert und dadurch der Zucker im Blut nicht von den Zellen aufgenommen werden kann. Diabetes ist eine Krankheit, bei der das Immunsystem selbst für die Krankheit verantwortlich ist. Forscher am HZI versuchen die Krankheit zu verstehen und haben in Mäusen einen Weg gefunden das Immunsystem auszutricksen: Sie programmieren es um. Der erste Schritt zu einer völlig neuen Therapie.
    Länge: 06:08

Audio Podcast

  • Raucherhusten-COPDWenn der Husten ständig quält und die Luft dauerhaft knapp wird, zerstört die Autoimmunkrankheit Raucherhusten - Fachname COPD - die Lunge. Dunja Bruder und Marcus Gereke sind den Ursachen dieser Volkskrankheit auf der Spur und nehmen Sie mit auf Forschungsreise ins Labor...

Video

HZI researchers are working on a vaccine against influenza that has a longer lasting effect and is also to be absorbed via the mucous membranes using a nasal spray. The research project is presented in the NDR programme "Hallo Niedersachsen".

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