Experimental Immunology

Every day we are attacked by a large number of different pathogens that our immune system tries to repel by using various strategies. To combat these, cells of the immune system have learnt to distinguish between harmless self structures and potentially dangerous foreign ones. Sometimes, however, immune cells are generated, which are falsely programmed and can attack structures in their own body. Learn more about the body`s protection against these cells and how we can use this mechanism in therapy.

Leader

Selected Publications

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J (2017) Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget 8: 35542-35557

Pasztoi M, Bonifacius A, Pezoldt J, Kulkarni D, Niemz J, Yang J, Teich R, Hajek J, Pisano F, Rohde M, Dersch P, Huehn J (2017) Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Cell Mol Life Sci 74: 2839-2850

Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J (2015) Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43: 1537-1548

Cording S, Wahl B, Kulkarni D, Chopra H, Pezoldt J, Buettner M, Dummer A, Hadis U, Heimesaat M, Bereswill S, Falk C, Bode U, Hamann A, Fleissner D, Huehn J*, Pabst O* (2014) The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunol 7: 359-368

Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S (2012) Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36: 262-275

Publikationen der Arbeitsgruppe

  • Authors: Zhang,B.; Zhang,Z.; Koeken,V.A.C.M.; Kumar,S.; Aillaud,M.; Tsay,H.C.; Liu,Z.; Kraft,A.R.M.; Soon,C.F.; Odak,I.; Bosnjak,B.; Vlot,A.; Swertz,M.A.; Ohler,U.; Geffers,R.; Illig,T.; Hühn,J.; Saliba,A.E.; Sander,L.E.; Förster,R.; Xu,C.J.; Cornberg,M.; Schulte,L.N.; Li,Y.; Deutsche,C.O.V.I.; ( Year: 2023). Title: Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19.DOI: 10.1016/j.xgen.2022.100232WEBURLS
  • Authors: Li,S.; Lu,C.W.; Diem,E.C.; Li,W.; Guderian,M.; Lindenberg,M.; Kruse,F.; Buettner,M.; Floess,S.; Winny,M.R.; Geffers,R.; Richnow,H.H.; Abraham,W.R.; Grassl,G.A.; Lochner,M.; ( Year: 2022). Title: Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function.Journal: Nature Communications Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-31725-2HZI repositoryPubMed
  • Authors: Pausder,A.; Mras,P.; Hoenicke,L.; Waldburg,N.; Lesker,T.R.; Schreiber,J.; Strowig,T.; Boehme,J.D.; Bruder,D.; ( Year: 2022). Title: Altered nasal microbiota in asthmatic patients is not related to changes in secretory immunity in the nasopharynx.DOI: 10.1111/cea.14200HZI repositoryPubMed
  • Authors: Song,M.H.; Gupta,A.; Sasidharan Nair,V.; Oh,K.; ( Year: 2022). Title: CD4+ T cells play an essential role in chronic MC903-induced skin inflammation.Journal: Biochem.Biophys.Res.Commun. Volume: 612, S-Page: 8- E-Page: 14 DOI: 10.1016/j.bbrc.2022.04.106HZI repositoryPubMed
  • Authors: Riese,P.; Trittel,S.; Akmatov,M.K.; May,M.; Prokein,J.; Illig,T.; Schindler,C.; Sawitzki,B.; Elfaki,Y.; Floess,S.; Huehn,J.; Blazejewski,A.J.; Strowig,T.; Hernandez-Vargas,E.A.; Geffers,R.; Zhang,B.; Li,Y.; Pessler,F.; Guzmán,C.A.; ( Year: 2022). Title: Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly.Journal: Nature Communications Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-34487-zHZI repositoryPubMed
  • Authors: Laubert,M.; Bonifacius,A.; Dragon,A.C.; Mangare,C.; Blasczyk,R.; Hühn,J.; Eiz-Vesper,B.; ( Year: 2022). Title: Enhancement of Antiviral T-Cell Responses by Vitamin C Suggests New Strategies to Improve Manufacturing of Virus-Specific T Cells for Adoptive Immunotherapy.Journal: Biology Volume: 11 Issue: 4, S-Page: Article number 536 DOI: 10.3390/biology11040536HZI repositoryPubMed
  • Authors: Shaikh,H.; Pezoldt,J.; Mokhtari,Z.; Gamboa,Vargas J.; Le,D.D.; Pena,Mosca J.; Arellano-Viera,E.; Kern,M.A.; Graf,C.; Beyersdorf,N.; Lutz,M.B.; Riedel,A.; Büttner-Herold,M.; Zernecke,A.; Einsele,H.; Saliba,A.E.; Ludewig,B.; Hühn,J.; Beilhack,A.; ( Year: 2022). Title: Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.DOI: 10.1172/jci.insight.154250PubMed
  • Authors: Nair,V.S.; Heredia,M.; Samsom,J.; Hühn,J.; ( Year: 2022). Title: Impact of gut microenvironment on epigenetic signatures of intestinal T helper cell subsets.Journal: Immunol.Lett. Volume: 246 Issue: June 2022, S-Page: 27- E-Page: 36 DOI: 10.1016/j.imlet.2022.04.006PubMed
  • Authors: Yang,J.; Zou,M.; Chu,X.; Floess,S.; Li,Y.; Delacher,M.; Hühn,J.; ( Year: 2022). Title: Inflammatory perturbations in early life long-lastingly shape the transcriptome and TCR repertoire of the first wave of regulatory T cells.Journal: Frontiers in Immunology Volume: 13 DOI: 10.3389/fimmu.2022.991671HZI repositoryPubMed
  • Authors: Wiechers,C.; Pezoldt,J.; Beckstette,M.; Berner,J.; Schraml,B.U.; Huehn,J.; ( Year: 2022). Title: Lymph node stromal cells support the maturation of pre-DCs into cDC-like cells via colony-stimulating factor 1.Journal: Immunology DOI: 10.1111/imm.13497HZI repositoryPubMed
  • Authors: Ataide,M.A.; Knöpper,K.; Cruz de,Casas P.; Ugur,M.; Eickhoff,S.; Zou,M.; Shaikh,H.; Trivedi,A.; Grafen,A.; Yang,T.; Prinz,I.; Ohlsen,K.; Gomez de,Agüero M.; Beilhack,A.; Hühn,J.; Gaya,M.; Saliba,A.E.; Gasteiger,G.; Kastenmüller,W.; ( Year: 2022). Title: Lymphatic migration of unconventional Tcells promotes site-specific immunity in distinct lymph nodes.DOI: 10.1016/j.immuni.2022.07.019PubMed
  • Authors: Pezoldt,J.; Wiechers,C.; Zou,M.; Litovchenko,M.; Biocanin,M.; Beckstette,M.; Sitnik,K.; Palatella,M.; van Mierlo,G.; Chen,W.; Gardeux,V.; Floess,S.; Ebel,M.; Russeil,J.; Arampatzi,P.; Vafardanejad,E.; Saliba,A.E.; Deplancke,B.; Hühn,J.; ( Year: 2022). Title: Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets.Journal: Nature Communications Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-34868-4HZI repositoryPubMed
  • Authors: Beckstette,M.; Lu,C.W.; Herppich,S.; Diem,E.C.; Ntalli,A.; Ochel,A.; Kruse,F.; Pietzsch,B.; Neumann,K.; Hühn,J.; Floess,S.; Lochner,M.; ( Year: 2022). Title: Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions.Journal: The Journal of experimental medicine Volume: 219 Issue: 10 DOI: 10.1084/jem.20210663HZI repositoryPubMed
  • Authors: Braband,K.L.; Kaufmann,T.; Floess,S.; Zou,M.; Hühn,J.; Delacher,M.; ( Year: 2022). Title: Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells.Journal: Frontiers in Immunology Volume: 13 DOI: 10.3389/fimmu.2022.1082055HZI repositoryPubMed
  • Authors: Palatella,M.; Guillaume,S.M.; Linterman,M.A.; Hühn,J.; ( Year: 2022). Title: The dark side of Tregs during aging.Volume: 13 DOI: 10.3389/fimmu.2022.940705HZI repositoryPubMed
  • Authors: Permanyer,M.; Bosnjak,B.; Glage,S.; Friedrichsen,M.; Floess,S.; Hühn,J.; Patzer,G.E.; Odak,I.; Eckert,N.; Zargari,R.; Ospina-Quintero,L.; Georgiev,H.; Förster,R.; ( Year: 2021). Title: Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.Journal: Cell Mol.Immunol Volume: 18 Issue: 2, S-Page: 398-- E-Page: 414 DOI: 10.1038/s41423-020-00599-zHZI repositoryPubMed
  • Authors: Zapatero-Belinchón,F.J.; Moeller,R.; Lasswitz,L.; Van Ham,M.; Becker,M.; Brogden,G.; Rosendal,E.; Bi,W.; Carriquí-Madronal,B.; Islam,K.; Lenman,A.; Gunesch,A.P.; Kirui,J.; Pietschmann,T.; Överby,A.K.; Jänsch,L.; Gerold,G.; ( Year: 2021). Title: Fluvastatin mitigates SARS-CoV-2 infection in human lung cells.Journal: iScience Volume: 24 Issue: 12 DOI: 10.1016/j.isci.2021.103469HZI repositoryPubMed
  • Authors: Floess,S.; Hühn,J.; ( Year: 2021). Title: Generation of Sequencing Libraries for Building Immune Cell Methylomes.Book Title: T-helper cells Editors: Annunziato,F.; Maggi,L.; Mazzoni,A.; (Ed.). Publisher: Springer, S-Page: 265- E-Page: 276 ISBN: 978-1-0716-1310-8 (ISBN)1940-6029 (ISBN)DOI: 10.1007/978-1-0716-1311-5_21HZI repositoryPubMed
  • Authors: Cossarizza,A.; Chang,H.D.; Radbruch,A.; Abrignani,S.; Addo,R.; Akdis,M.; Andr+ñ,I.; Andreata,F.; Annunziato,F.; Arranz,E.; Bacher,P.; Bari,S.; Barnaba,V.; Barros-Martins,J.; Baumjohann,D.; Beccaria,C.G.; Bernardo,D.; Boardman,D.A.; Borger,J.; B+Âttcher,C.; Brockmann,L.; Burns,M.; Busch,D.H.; Cameron,G.; Cammarata,I.; Cassotta,A.; Chang,Y.; Chirdo,F.G.; Christakou,E.; -îi-ìin,+; Cook,L.; Corbett,A.J.; Cornelis,R.; Cosmi,L.; Davey,M.S.; De Biasi,S.; De Simone,G.; Del Zotto,G.; Delacher,M.; Di Rosa,F.; Santo,J.D.; Diefenbach,A.; Dong,J.; D+Ârner,T.; Dress,R.J.; Dutertre,C.A.; Eckle,S.B.G.; Eede,P.; Evrard,M.; Falk,C.S.; Feuerer,M.; Fillatreau,S.; Fiz-Lopez,A.; Follo,M.; Foulds,G.A.; Fr+Âbel,J.; Gagliani,N.; Galletti,G.; Gangaev,A.; Garbi,N.; Garrote,J.A.; Geginat,J.; Gherardin,N.A.; Gibellini,L.; Ginhoux,F.; Godfrey,D.I.; Gruarin,P.; Haftmann,C.; Hansmann,L.; Harpur,C.M.; Hayday,A.C.; Heine,G.; Hern+índez,D.C.; Herrmann,M.; Hoelsken,O.; Huang,Q.; Huber,S.; Huber,J.E.; Hühn,J.; Hundemer,M.; Hwang,W.Y.K.; Iannacone,M.; Ivison,S.M.; J+ñck,H.M.; Jani,P.K.; Keller,B.; Kessler,N.; Ketelaars,S.; Knop,L.; Knopf,J.; Koay,H.F.; Kobow,K.; Kriegsmann,K.; Kristyanto,H.; Krueger,A.; Kuehne,J.F.; Kunze-Schumacher,H.; Kvistborg,P.; Kwok,I.; Latorre,D.; Lenz,D.; Levings,M.K.; Lino,A.C.; Liotta,F.; Long,H.M.; Lugli,E.; MacDonald,K.N.; Maggi,L.; Maini,M.K.; Mair,F.; Manta,C.; Manz,R.A.; Mashreghi,M.F.; Mazzoni,A.; McCluskey,J.; Mei,H.E.; Melchers,F.; Melzer,S.; Mielenz,D.; Monin,L.; Moretta,L.; Multhoff,G.; Mu+¦oz,L.E.; Mu+¦oz-Ruiz,M.; Muscate,F.; Natalini,A.; Neumann,K.; Ng,L.G.; Niedobitek,A.; Niemz,J.; Almeida,L.N.; Notarbartolo,S.; Ostendorf,L.; Pallett,L.J.; Patel,A.A.; Percin,G.I.; Peruzzi,G.; Pinti,M.; Pockley,A.G.; Pracht,K.; Prinz,I.; Pujol-Autonell,I.; Pulvirenti,N.; Quatrini,L.; Quinn,K.M.; Radbruch,H.; Rhys,H.; Rodrigo,M.B.; Romagnani,C.; Saggau,C.; Sakaguchi,S.; Sallusto,F.; Sanderink,L.; Sandrock,I.; Schauer,C.; Scheffold,A.; Scherer,H.U.; Schiemann,M.; Schildberg,F.A.; Schober,K.; Schoen,J.; Schuh,W.; ler,T.; Schulz,A.R.; Schulz,S.; Schulze,J.; Simonetti,S.; Singh,J.; Sitnik,K.M.; Stark,R.; Starossom,S.; Stehle,C.; Szelinski,F.; Tan,L.; Tarnok,A.; Tornack,J.; Tree,T.I.M.; van Beek,J.J.P.; van de Veen,W.; van Gisbergen,K.; Vasco,C.; Verheyden,N.A.; von Borstel,A.; Ward-Hartstonge,K.A.; Warnatz,K.; Waskow,C.; Wiedemann,A.; Wilharm,A.; Wing,J.; Wirz,O.; Wittner,J.; Yang,J.H.M.; Yang,J.; ( Year: 2021). Title: Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).Journal: European Journal of Immunology Volume: 51 Issue: 12, S-Page: 2708- E-Page: 3145 DOI: 10.1002/eji.202170126HZI repositoryPubMed
  • Authors: Elfaki,Y.; Robert,P.A.; Binz,C.; Falk,C.S.; Bruder,D.; Prinz,I.; Floess,S.; Meyer-Hermann,M.; Hühn,J.; ( Year: 2021). Title: Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice.Journal: European Journal of Immunology DOI: 10.1002/eji.202048981HZI repositoryPubMed
  • Authors: Saleh,R.; Nair,V.S.; Toor,S.M.; Elkord,E.; ( Year: 2021). Title: Intrinsic and acquired cancer immunotherapy resistance.Book Title: Cancer Immunology and Immunotherapy: Volume 1 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy City: London Publisher: Elsevier, S-Page: 463- E-Page: 497 ISBN: 9780128233979 (ISBN)DOI: 10.1016/B978-0-12-823397-9.00014-4HZI repositoryWEBURLS
  • Authors: Ruck,T.; Bock,S.; Pfeuffer,S.; Schroeter,C.B.; Cengiz,D.; Marciniak,P.; Lindner,M.; Herrmann,A.; Liebmann,M.; Kovac,S.; Gola,L.; Rolfes,L.; Pawlitzki,M.; Opel,N.; Hahn,T.; Dannlowski,U.; Pap,T.; Luessi,F.; Schreiber,J.A.; Wünsch,B.; Kuhlmann,T.; Seebohm,G.; Tackenberg,B.; Seja,P.; Döring,F.; Wischmeyer,E.; Chasan,A.I.; Roth,J.; Klotz,L.; Meyer Zu Hörste,G.; Wiendl,H.; Marschall,T.; Floess,S.; Hühn,J.; Budde,T.; Bopp,T.; Bittner,S.; Meuth,S.G.; ( Year: 2021). Title: K2P18.1 translates T cell receptor signals into thymic regulatory T cell development.Journal: Cell Research DOI: 10.1038/s41422-021-00580-zHZI repositoryPubMed
  • Authors: Zou,M.; Wiechers,C.; Hühn,J.; ( Year: 2021). Title: Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses.Journal: International Journal of Medical Microbiology Volume: 311 Issue: 3, S-Page: Article number 151492 DOI: 10.1016/j.ijmm.2021.151492HZI repositoryPubMed
  • Authors: Shaikh,H.; Vargas,J.G.; Mokhtari,Z.; Jarick,K.J.; Ulbrich,M.; Mosca,J.P.; Viera,E.A.; Graf,C.; Le,D.D.; Heinze,K.G.; Büttner-Herold,M.; Rosenwald,A.; Pezoldt,J.; Hühn,J.; Beilhack,A.; ( Year: 2021). Title: Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract.Journal: Frontiers in Immunology Volume: 12, S-Page: Article number 689896 DOI: 10.3389/fimmu.2021.689896HZI repositoryPubMed
  • Authors: Formaglio,P.; Alabdullah,M.; Siokis,A.; Handschuh,J.; Sauerland,I.; Fu,Y.; Krone,A.; Gintschel,P.; Stettin,J.; Heyde,S.; Mohr,J.; Philipsen,L.; Schröder,A.; Robert,P.A.; Zhao,G.; Khailaie,S.; Dudeck,A.; Bertrand,J.; Späth,G.F.; Kahlfuß,S.; Bousso,P.; Schraven,B.; Hühn,J.; Binder,S.; Meyer-Hermann,M.; Müller,A.J.; ( Year: 2021). Title: Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.Journal: Immunity DOI: 10.1016/j.immuni.2021.09.021HZI repositoryPubMed
  • Authors: Haftmann,C.; Zwicky,P.; Ingelfinger,F.; Mair,F.; Floess,S.; Riedel,R.; Durek,P.; Spalinger,M.R.; Friebel,E.; Leung,B.P.; Lutz,M.; Puertas,N.; Amorim,A.; Schürli,S.; Becher,B.; Kisielow,J.; Waisman,A.; Mashreghi,M.F.; Hühn,J.; Becher,B.; ( Year: 2021). Title: Protection against autoimmunity is driven by thymic epithelial cell.Journal: Science Immunology Volume: 6 Issue: 65, S-Page: eabf3111 DOI: 10.1126/sciimmunol.abf3111HZI repositoryPubMed
  • Authors: Nikolouli,E.; Elfaki,Y.; Herppich,S.; Schelmbauer,C.; Delacher,M.; Falk,C.; Mufazalov,I.A.; Waisman,A.; Feuerer,M.; Hühn,J.; ( Year: 2021). Title: Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions.Journal: Cell.Mol.Immunol Volume: 18 Issue: 1, S-Page: 182- E-Page: 193 DOI: 10.1038/s41423-019-0352-8HZI repositoryPubMed
  • Authors: Delacher,M.; Simon,M.; Sanderink,L.; Hotz-Wagenblatt,A.; Wuttke,M.; Schambeck,K.; Schmidleithner,L.; Bittner,S.; Pant,A.; Ritter,U.; Hehlgans,T.; Riegel,D.; Schneider,V.; Groeber-Becker,F.K.; Eigenberger,A.; Gebhard,C.; Strieder,N.; Fischer,A.; Rehli,M.; Hoffmann,P.; Edinger,M.; Strowig,T.; Hühn,J.; Schmidl,C.; Werner,J.M.; Prantl,L.; Brors,B.; Imbusch,C.D.; Feuerer,M.; ( Year: 2021). Title: Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells.Journal: Immunity Volume: 54 Issue: 4, S-Page: 702-- E-Page: 720.e17 DOI: 10.1016/j.immuni.2021.03.007HZI repositoryPubMed
  • Authors: Pezoldt,J.; Wiechers,C.; Erhard,F.; Rand,U.; Bulat,T.; Beckstette,M.; Brendolan,A.; Hühn,J.; Kalinke,U.; Mueller,M.; Strobl,B.; Deplancke,B.; Cicin-Sain,L.; Sitnik,K.M.; ( Year: 2021). Title: Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection.Journal: Commun.Biolog. Volume: 4 Issue: 1, S-Page: Article number 1355 DOI: 10.1038/s42003-021-02882-9HZI repositoryPubMed
  • Authors: Elfaki,Y.; Yang,J.; Boehme,J.; Schultz,K.; Bruder,D.; Falk,C.S.; Hühn,J.; Floess,S.; ( Year: 2021). Title: Tbx21 and foxp3 are epigenetically stabilized in t-bet+ tregs that transiently accumulate in influenza a virus-infected lungs.Journal: International Journal of Molecular Sciences Volume: 22 Issue: 14, S-Page: Article number 7522 DOI: 10.3390/ijms22147522HZI repositoryPubMed
  • Authors: Herppich,S.; Beckstette,M.; Hühn,J.; ( Year: 2021). Title: The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells.Journal: Immunity, Inflammation and Disease DOI: 10.1002/iid3.559HZI repositoryPubMed
  • Authors: Ciurkiewicz,M.; Floess,S.; Beckstette,M.; Kummerfeld,M.; Baumgärtner,W.; Hühn,J.; Beineke,A.; ( Year: 2021). Title: Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination.Journal: Brain Pathology DOI: 10.1111/bpa.13000HZI repositoryPubMed
  • Authors: Zou,M.; Yang,J.; Wiechers,C.; Hühn,J.; ( Year: 2020). Title: Acute neonatal Listeria monocytogenes infection causes long-term, organ-specific changes in immune cell subset composition.Journal: Eur.J.Microbiol.Immunol.(Bp) DOI: 10.1556/1886.2020.00007HZI repositoryPubMed
  • Authors: Matthias,J.; Heink,S.; Picard,F.S.; Zeiträg,J.; Kolz,A.; Chao,Y.Y.; Soll,D.; de Almeida,G.P.; Glasmacher,E.; Jacobsen,I.D.; Riedel,T.; Peters,A.; Floess,S.; Hühn,J.; Baumjohann,D.; Huber,M.; Korn,T.; Zielinski,C.E.; ( Year: 2020). Title: Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments.Journal: J.Clin.Invest Volume: 130 Issue: 9, S-Page: 4587- E-Page: 4600 DOI: 10.1172/JCI137786HZI repositoryPubMed
  • Authors: Bonifacius,A.; Goldmann,O.; Floess,S.; Holtfreter,S.; Robert,P.A.; Nordengrün,M.; Kruse,F.; Lochner,M.; Falk,C.S.; Schmitz,I.; Bröker,B.M.; Medina,E.; Hühn,J.; ( Year: 2020). Title: Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses.Journal: Front Immunol. Volume: 11, S-Page: 1579 DOI: 10.3389/fimmu.2020.01579HZI repositoryPubMed
  • Authors: Kouakanou,L.; Peters,C.; Sun,Q.; Floess,S.; Bhat,J.; Hühn,J.; Kabelitz,D.; ( Year: 2020). Title: Vitamin C supports conversion of human.Journal: Sci.Rep. Volume: 10 Issue: 1, S-Page: 6550 DOI: 10.1038/s41598-020-63572-wHZI repositoryPubMed
  • Authors: Garg,G.; Muschaweckh,A.; Moreno,H.; Vasanthakumar,A.; Floess,S.; Lepennetier,G.; Oellinger,R.; Zhan,Y.; Regen,T.; Hiltensperger,M.; Peter,C.; Aly,L.; Knier,B.; Palam,L.R.; Kapur,R.; Kaplan,M.H.; Waisman,A.; Rad,R.; Schotta,G.; Hühn,J.; Kallies,A.; Korn,T.; ( Year: 2019). Title: Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.Journal: Cell Reports Volume: 26 Issue: 7, S-Page: 1854- E-Page: 1868 DOI: 10.1016/j.celrep.2019.01.070HZI repositoryPubMed
  • Authors: Maluski,M.; Ghosh,A.; Herbst,J.; Scholl,V.; Baumann,R.; Hühn,J.; Geffers,R.; Meyer,J.; Maul,H.; Eiz-Vesper,B.; Krueger,A.; Schambach,A.; van den Brink,M.R.M.; Sauer,M.G.; ( Year: 2019). Title: Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development.Journal: Journal of Clinical Investigation Volume: 129 Issue: 12, S-Page: 5108- E-Page: 5122 DOI: 10.1172/JCI126350HZI repositoryPubMed
  • Authors: Herppich,S.; Toker,A.; Pietzsch,B.; Kitagawa,Y.; Ohkura,N.; Miyao,T.; Floess,S.; Hori,S.; Sakaguchi,S.; Hühn,J.; ( Year: 2019). Title: Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells.Journal: Frontiers in Immunology Volume: 10, S-Page: Article number 2382 DOI: 10.3389/fimmu.2019.02382HZI repositoryPubMed
  • Authors: Schuster,M.; Plaza-Sirvent,C.; Visekruna,A.; Hühn,J.; Schmitz,I.; ( Year: 2019). Title: Generation of Foxp3+CD25- regulatory T-cell precursors requires c-rel and IkBNS.Journal: Frontiers in Immunology Volume: 10 Issue: JULY, S-Page: Article number 1583 DOI: 10.3389/fimmu.2019.01583HZI repositoryPubMed
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  • Authors: Pezoldt,J.; Yang,J.; Zou,M.; Hühn,J.; ( Year: 2018). Title: Microbiome and gut immunity: T cells.Book Title: The Gut Microbiome in Health and Disease Publisher: Springer, S-Page: 119- E-Page: 140 ISBN: 9783319905457 (ISBN)9783319905440 (ISBN)DOI: 10.1007/978-3-319-90545-7_9PubMed
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