Experimental Immunology

Every day we are attacked by a large number of different pathogens that our immune system tries to repel by using various strategies. To combat these, cells of the immune system have learnt to distinguish between harmless self structures and potentially dangerous foreign ones. Sometimes, however, immune cells are generated, which are falsely programmed and can attack structures in their own body. Learn more about the body`s protection against these cells and how we can use this mechanism in therapy.

Leader

Selected Publications

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J (2017) Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cellsOncotarget 8: 35542-35557

Pasztoi M, Bonifacius A, Pezoldt J, Kulkarni D, Niemz J, Yang J, Teich R, Hajek J, Pisano F, Rohde M, Dersch P, Huehn J (2017) Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Cell Mol Life Sci 74: 2839-2850

Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J (2015) Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43: 1537-1548

Cording S, Wahl B, Kulkarni D, Chopra H, Pezoldt J, Buettner M, Dummer A, Hadis U, Heimesaat M, Bereswill S, Falk C, Bode U, Hamann A, Fleissner D, Huehn J*, Pabst O* (2014) The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunol 7: 359-368

Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S (2012) Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cellsImmunity 36: 262-275

Publikationen der Arbeitsgruppe

  • Authors: Garg,G.; Muschaweckh,A.; Moreno,H.; Vasanthakumar,A.; Floess,S.; Lepennetier,G.; Oellinger,R.; Zhan,Y.; Regen,T.; Hiltensperger,M.; Peter,C.; Aly,L.; Knier,B.; Palam,L.R.; Kapur,R.; Kaplan,M.H.; Waisman,A.; Rad,R.; Schotta,G.; Hühn,J.; Kallies,A.; Korn,T.; ( Year: 2019). Title: Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.Journal: Cell Reports Volume: 26 Issue: 7, S-Page: 1854- E-Page: 1868 DOI: 10.1016/j.celrep.2019.01.070HZI repositoryPubMed
  • Authors: Schuster,M.; Plaza-Sirvent,C.; Visekruna,A.; Hühn,J.; Schmitz,I.; ( Year: 2019). Title: Generation of Foxp3+CD25- regulatory T-cell precursors requires c-rel and IkBNS.Journal: Frontiers in Immunology Volume: 10 Issue: JULY, S-Page: Article number 1583 DOI: 10.3389/fimmu.2019.01583HZI repositoryPubMed
  • Authors: Pandiyan,P.; Bhaskaran,N.; Zou,M.; Schneider,E.; Jayaraman,S.; Hühn,J.; ( Year: 2019). Title: Microbiome Dependent Regulation of T regs and Th17 Cells in Mucosa.Journal: Front Immunol Volume: 10, S-Page: 426 DOI: 10.3389/fimmu.2019.00426HZI repositoryPubMed
  • Authors: Lyszkiewicz,M.; Winter,S.J.; Witzlau,K.; Fohse,L.; Brownlie,R.; Puchalka,J.; Verheyden,N.A.; Kunze-Schumacher,H.; Imelmann,E.; Blume,J.; Raha,S.; Sekiya,T.; Yoshimura,A.; Frueh,J.T.; Ullrich,E.; Hühn,J.; Weiss,S.; Gutierrez,M.G.; Prinz,I.; Zamoyska,R.; Zietara,N.; Krueger,A.; ( Year: 2019). Title: miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.Journal: PLoS.Biol. Volume: 17 Issue: 3, S-Page: e2006716 DOI: 10.1371/journal.pbio.2006716HZI repositoryPubMed
  • Authors: Ludwig,R.; Hühn,J.; ( Year: 2018). Title: Already ENLIGHT-TENed? Equipping young immunologists with a combination of research-related and transferrable competencies.Journal: European Journal of Immunology Volume: 48 Issue: 12, S-Page: 1926- E-Page: 1928 DOI: 10.1002/eji.201870145PubMed
  • Authors: Schmidl,C.; Delacher,M.; Hühn,J.; Feuerer,M.; ( Year: 2018). Title: Epigenetic mechanisms regulating T-cell responses.Journal: J.Allergy Clin.Immunol. Volume: 142 Issue: 3, S-Page: 728- E-Page: 743 DOI: 10.1016/j.jaci.2018.07.014WEBURLS
  • Authors: Lipps,C.; Klein,F.; Wahlicht,T.; Seiffert,V.; Butueva,M.; Zauers,J.; Truschel,T.; Luckner,M.; Köster,M.; MacLeod,R.; Pezoldt,J.; Hühn,J.; Yuan,Q.; Muller,P.P.; Kempf,H.; Zweigerdt,R.; Dittrich-Breiholz,O.; Pufe,T.; Beckmann,R.; Drescher,W.; Riancho,J.; Sanudo,C.; Korff,T.; Opalka,B.; Rebmann,V.; Gothert,J.R.; Alves,P.M.; Ott,M.; Schucht,R.; Hauser,H.; Wirth,D.; May,T.; ( Year: 2018). Title: Expansion of functional personalized cells with specific transgene combinations.Journal: Nature Communications Volume: 9 Issue: 1, S-Page: 994 DOI: 10.1038/s41467-018-03408-4FulltextPubMed
  • Authors: Prajeeth,C.K.; Dittrich-Breiholz,O.; Talbot,S.R.; Robert,P.A.; Hühn,J.; Stangel,M.; ( Year: 2018). Title: IFN-Gamma producing Th1 cells induce different transcriptional profiles in microglia and astrocytes.Journal: Front.Cell.Neurosci. Volume: 12, S-Page: Article number 352 DOI: 10.3389/fncel.2018.00352HZI repositoryPubMed
  • Authors: Uhde,A.K.; Ciurkiewicz,M.; Herder,V.; Khan,M.A.; Hensel,N.; Claus,P.; Beckstette,M.; Teich,R.; Floess,S.; Baumgartner,W.; Jung,K.; Hühn,J.; Beineke,A.; ( Year: 2018). Title: Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice.Journal: Sci.Rep. Volume: 8 Issue: 1, S-Page: 6106 DOI: 10.1038/s41598-018-24378-zHZI repositoryPubMed
  • Authors: Pezoldt,J.; Yang,J.; Zou,M.; Hühn,J.; ( Year: 2018). Title: Microbiome and gut immunity: T cells.Book Title: The Gut Microbiome in Health and Disease Publisher: Springer International Publishing, S-Page: 119- E-Page: 140 ISBN: 9783319905457 (ISBN)9783319905440 (ISBN)DOI: 10.1007/978-3-319-90545-7_9WEBURLS
  • Authors: Pezoldt,J.; Pasztoi,M.; Zou,M.; Wiechers,C.; Beckstette,M.; Thierry,G.R.; Vafadarnejad,E.; Floess,S.; Arampatzi,P.; Buettner,M.; Schweer,J.; Fleissner,D.; Vital,M.; Pieper,D.H.; Basic,M.; Dersch,P.; Strowig,T.; Hornef,M.; Bleich,A.; Bode,U.; Pabst,O.; Bajenoff,M.; Saliba,A.E.; Huehn,J.; ( Year: 2018). Title: Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.Journal: Nature Communications Volume: 9 Issue: 1, S-Page: 3903 DOI: 10.1038/s41467-018-06423-7HZI repositoryPubMed
  • Authors: Schmoeckel,K.; Mrochen,D.M.; Hühn,J.; Pötschke,C.; Bröker,B.M.; ( Year: 2018). Title: Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree.Journal: PLoS ONE Volume: 13 Issue: 2, S-Page: Article number e0192197 DOI: 10.1371/journal.pone.0192197HZI repositoryPubMed
  • Authors: Prajeeth,C.K.; Hühn,J.; Stangel,M.; ( Year: 2018). Title: Regulation of neuroinflammatory properties of glial cells by T cell effector molecules.Journal: Neural Regen.Res. Volume: 13 Issue: 2, S-Page: 234- E-Page: 236 DOI: 10.4103/1673-5374.226385HZI repositoryPubMed
  • Authors: Yang,J.; Zou,M.; Pezoldt,J.; Zhou,X.; Hühn,J.; ( Year: 2018). Title: Thymus-derived Foxp3(+) regulatory T cells upregulate RORgammat expression under inflammatory conditions.Journal: J.Mol.Med.(Berl) Volume: 96 Issue: 12, S-Page: 1387- E-Page: 1394 DOI: 10.1007/s00109-018-1706-xPubMed
  • Authors: Kyburz,A.; Fallegger,A.; Zhang,X.; Altobelli,A.; Artola-Boran,M.; Borbet,T.; Urban,S.; Paul,P.; Münz,C.; Floess,S.; Hühn,J.; Cover,T.L.; Blaser,M.J.; Taube,C.; Müller,A.; ( Year: 2018). Title: Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells.Journal: J.Allergy Clin.Immunol. Volume: 143 Issue: 4, S-Page: 1496- E-Page: 1512 DOI: 10.1016/j.jaci.2018.07.046PubMed
  • Authors: Elfiky,A.; Bonifacius,A.; Pezoldt,J.; Pasztoi,M.; Chaoprasid,P.; Sadana,P.; El-Sherbeeny,N.; Hagras,M.; Scrima,A.; Dersch,P.; Hühn,J.; ( Year: 2018). Title: Yersinia Pseudotuberculosis Modulates Regulatory T Cell Stability via Injection of Yersinia Outer Proteins in a Type III Secretion System-Dependent Manner.Journal: Eur.J.Microbiol.Immunol.(Bp) Volume: 8 Issue: 4, S-Page: 101- E-Page: 106 DOI: 10.1556/1886.2018.00015HZI repositoryPubMed
  • Authors: Ranjan,S.; Goihl,A.; Kohli,S.; Gadi,I.; Pierau,M.; Shahzad,K.; Gupta,D.; Bock,F.; Wang,H.; Shaikh,H.; Kahne,T.; Reinhold,D.; Bank,U.; Zenclussen,A.C.; Niemz,J.; Schnoder,T.M.; Brunner-Weinzierl,M.; Fischer,T.; Kalinski,T.; Schraven,B.; Luft,T.; Hühn,J.; Naumann,M.; Heidel,F.H.; Isermann,B.; ( Year: 2017). Title: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.Journal: Nature Communications Volume: 8 Issue: 1, S-Page: 311 DOI: 10.1038/s41467-017-00169-4HZI repositoryPubMed
  • Authors: Nikolouli,E.; Hardtke-Wolenski,M.; Hapke,M.; Beckstette,M.; Geffers,R.; Floess,S.; Jaeckel,E.; Huehn,J.; ( Year: 2017). Title: Alloantigen-induced regulatory t cells generated in presence of vitamin c display enhanced stability of foxp3 expression and promote skin allograft acceptance.Journal: Frontiers in Immunology Volume: 8 Issue: 748 DOI: 10.3389/fimmu.2017.00748HZI repositoryPubMed
  • Authors: Schuster,M.; Plaza-Sirvent,C.; Matthies,A.M.; Heise,U.; Jeron,A.; Bruder,D.; Visekruna,A.; Hühn,J.; Schmitz,I.; ( Year: 2017). Title: c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.Journal: Journal of Immunology Volume: 199 Issue: 3, S-Page: 920- E-Page: 930 DOI: 10.4049/jimmunol.1600877PubMed
  • Authors: Ciurkiewicz,M.; Herder,V.; Khan,M.A.; Uhde,A.K.; Teich,R.; Floess,S.; Baumgartner,W.; Hühn,J.; Beineke,A.; ( Year: 2017). Title: Cytotoxic CD8+ T cells ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis.Journal: Brain Pathol. Volume: 28 Issue: 3, S-Page: 349- E-Page: 368 DOI: 10.1111/bpa.12518PubMed
  • Authors: Prajeeth,C.K.; Kronisch,J.; Khorooshi,R.; Knier,B.; Toft-Hansen,H.; Gudi,V.; Floess,S.; Hühn,J.; Owens,T.; Korn,T.; Stangel,M.; ( Year: 2017). Title: Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.Journal: J.Neuroinflammation. Volume: 14 Issue: 1, S-Page: 204 DOI: 10.1186/s12974-017-0978-3HZI repositoryPubMed
  • Authors: Beyer,M.; Hühn,J.; ( Year: 2017). Title: Epigenetic orchestration of thymic T reg cell development.Journal: Nat.Immunol. Volume: 18 Issue: 2, S-Page: 144- E-Page: 146 DOI: 10.1038/ni.3660HZI repositoryPubMed
  • Authors: Szilagyi,B.A.; Triebus,J.; Kressler,C.; de,Almeida M.; Tierling,S.; Durek,P.; Mardahl,M.; Szilagyi,A.; Floess,S.; Hühn,J.; Syrbe,U.; Walter,J.; Polansky,J.K.; Hamann,A.; ( Year: 2017). Title: Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells.Journal: Mucosal.Immunol. Volume: 10 Issue: 6, S-Page: 1443- E-Page: 1454 DOI: 10.1038/mi.2017.7HZI repositoryPubMed
  • Authors: Kyburz,A.; Urban,S.; Altobelli,A.; Floess,S.; Hühn,J.; Cover,T.L.; Muller,A.; ( Year: 2017). Title: Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.Journal: Clin.Exp.Allergy DOI: 10.1111/cea.12996HZI repositoryPubMed
  • Authors: Pezoldt,J.; Pisano,F.; Heine,W.; Pasztoi,M.; Rosenheinrich,M.; Nuss,A.M.; Pils,M.C.; Prinz,I.; Forster,R.; Hühn,J.; Dersch,P.; ( Year: 2017). Title: Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection.Journal: J Infect.Dis. Volume: 216 Issue: 6, S-Page: 752- E-Page: 760 DOI: 10.1093/infdis/jix037HZI repositoryPubMed
  • Authors: Pasztoi,M.; Pezoldt,J.; Beckstette,M.; Lipps,C.; Wirth,D.; Rohde,M.; Paloczi,K.; Buzas,E.I.; Hühn,J.; ( Year: 2017). Title: Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells.Journal: European Journal of Immunology Volume: 47 Issue: 12, S-Page: 2142- E-Page: 2152 DOI: 10.1002/eji.201746960HZI repositoryPubMed
  • Authors: Essig,K.; Hu,D.; Guimaraes,J.C.; Alterauge,D.; Edelmann,S.; Raj,T.; Kranich,J.; Behrens,G.; Heiseke,A.; Floess,S.; Klein,J.; Maiser,A.; Marschall,S.; Hrabe de Angelis,M.; Leonhardt,H.; Calkhoven,C.F.; Noessner,E.; Brocker,T.; Hühn,J.; Krug,A.B.; Zavolan,M.; Baumjohann,D.; Heissmeyer,V.; ( Year: 2017). Title: Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.Journal: Immunity Volume: 47 Issue: 6, S-Page: 1067- E-Page: 1082 DOI: 10.1016/j.immuni.2017.11.008PubMed
  • Authors: Van Ham,M.; Teich,R.; Philipsen,L.; Niemz,J.; Amsberg,N.; Wissing,J.; Nimtz,M.; Grobe,L.; Kliche,S.; Thiel,N.; Klawonn,F.; Hubo,M.; Jonuleit,H.; Reichardt,P.; Muller,A.J.; Hühn,J.; Jänsch,L.; ( Year: 2017). Title: TCR signalling network organization at the immunological synapses of murine regulatory T cells.Journal: European Journal of Immunology Volume: 47 Issue: 12, S-Page: 2043- E-Page: 2058 DOI: 10.1002/eji.201747041HZI repositoryPubMed
  • Authors: Niemz,J.; Kliche,S.; Pils,M.C.; Morrison,E.; Manns,A.; Freund,C.; Crittenden,J.R.; Graybiel,A.M.; Galla,M.; Jänsch,L.; Hühn,J.; ( Year: 2017). Title: The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.Journal: Eur.J.Microbiol.Immunol.(Bp) Volume: 7 Issue: 2, S-Page: 112- E-Page: 126 DOI: 10.1556/1886.2017.00007HZI repositoryPubMed
  • Authors: Garg,G.; Nikolouli,E.; Hardtke-Wolenski,M.; Toker,A.; Ohkura,N.; Beckstette,M.; Miyao,T.; Geffers,R.; Floess,S.; Gerdes,N.; Lutgens,E.; Osterloh,A.; Hori,S.; Sakaguchi,S.; Jaeckel,E.; Hühn,J.; ( Year: 2017). Title: Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.Journal: Oncotarget. Volume: 8 Issue: 22, S-Page: 35542- E-Page: 35557 DOI: 10.18632/oncotarget.16221HZI repositoryPubMed
  • Authors: Pasztoi,M.; Bonifacius,A.; Pezoldt,J.; Kulkarni,D.; Niemz,J.; Yang,J.; Teich,R.; Hajek,J.; Pisano,F.; Rohde,M.; Dersch,P.; Hühn,J.; ( Year: 2017). Title: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.Journal: Cell Mol.Life Sci. Volume: 74 Issue: 15, S-Page: 2839- E-Page: 2850 DOI: 10.1007/s00018-017-2516-yHZI repositoryPubMed
  • Authors: Yang,B.H.; Hagemann,S.; Mamareli,P.; Lauer,U.; Hoffmann,U.; Beckstette,M.; Fohse,L.; Prinz,I.; Pezoldt,J.; Suerbaum,S.; Sparwasser,T.; Hamann,A.; Floess,S.; Hühn,J.; Lochner,M.; ( Year: 2016). Title: Foxp3+ T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.Journal: Mucosal.Immunol. Volume: 9, S-Page: 444- E-Page: 457 DOI: 10.1038/mi.2015.74HZI repositoryPubMed
  • Authors: Pink,M.; Ratsch,B.A.; Mardahl,M.; Durek,P.; Polansky,J.K.; Karl,M.; Baumgrass,R.; Wallner,S.; Cadenas,C.; Gianmoena,K.; Floess,S.; Chen,W.; Nordstroem,K.; Tierling,S.; Olek,S.; Walter,J.; Hamann,A.; Syrbe,U.; ( Year: 2016). Title: Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.Journal: J Immunol. Volume: 197, S-Page: 3406- E-Page: 3414 DOI: 10.4049/jimmunol.1502434PubMed
  • Authors: Goldstein,J.D.; Burlion,A.; Zaragoza,B.; Sendeyo,K.; Polansky,J.K.; Hühn,J.; Piaggio,E.; Salomon,B.L.; Marodon,G.; ( Year: 2016). Title: Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.Journal: PLoS ONE Volume: 11 Issue: 4, S-Page: e0153682 DOI: 10.1371/journal.pone.0153682HZI repositoryPubMed
  • Authors: Noyan,F.; Zimmermann,K.; Hardtke-Wolenski,M.; Knoefel,A.; Schulde,E.; Geffers,R.; Hust,M.; Hühn,J.; Galla,M.; Morgan,M.; Jokuszies,A.; Manns,M.P.; Jaeckel,E.; ( Year: 2016). Title: Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor.Journal: Am J Transplant. Volume: 17 Issue: 4, S-Page: 917- E-Page: 930 DOI: 10.1111/ajt.14175 HZI repository PubMed
  • Authors: Pezoldt,J.; Huehn,J.; ( Year: 2016). Title: Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation.Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 6 Issue: 3, S-Page: 219- E-Page: 226 DOI: 10.1556/1886.2016.00018PubMed
  • Authors: Uhde,A.K.; Herder,V.; Akram,Khan M.; Ciurkiewicz,M.; Schaudien,D.; Teich,R.; Floess,S.; Baumgartner,W.; Hühn,J.; Beineke,A.; ( Year: 2016). Title: Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.Journal: PLoS ONE Volume: 11 Issue: 9, S-Page: e0161883 DOI: 10.1371/journal.pone.0161883HZI repositoryPubMed
  • Authors: Milanez-Almeida,P.; Ulas,T.; Pasztoi,M.; Glage,S.; Schughart,K.; Lutz,M.B.; Schultze,J.L.; Hühn,J.; ( Year: 2015). Title: CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 5 Issue: 4, S-Page: 246- E-Page: 255 PubMed
  • Authors: Hühn,J.; Floess,S.; Ohkura,N.; Sakaguchi,S.; ( Year: 2015). Title: Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans".Journal: Journal of Immunology Volume: 194 Issue: 8, S-Page: 3533- E-Page: 3534 WEBURLS
  • Authors: Yang,B.H.; Flöß,Stefan; Hagemann,S.; Deyneko,Igor V.; Gröbe,Lothar; Pezoldt,J.; Sparwasser,Tim; Lochner,M.; Hühn,Jochen; ( Year: 2015). Title: Development of a unique epigenetic signature during in vivo Th17 differentiation.Journal: Nucleic Acids Res Volume: 43 Issue: 3, S-Page: 1537- E-Page: 1548 DOI: 10.1093/nar/gkv014HZI repositoryPubMed
  • Authors: Hühn,J.; Beyer,M.; ( Year: 2015). Title: Epigenetic and transcriptional control of Foxp3 regulatory T cells.Journal: Semin.Immunol. Volume: 27 Issue: 1, S-Page: 10- E-Page: 18 DOI: 10.1016/j.smim.2015.02.002PubMed
  • Authors: Roesner,L.M.; Flöß,S.; Witte,T.; Olek,S.; Hühn,J.; Werfel,T.; ( Year: 2015). Title: Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients.Journal: Allergy: European Journal of Allergy and Clinical Immunology Volume: 70 Issue: 12, S-Page: 1656- E-Page: 1660 PubMed
  • Authors: Klysz,D.; Tai,X.; Robert,P.A.; Craveiro,M.; Cretenet,G.; Oburoglu,L.; Mongellaz,C.; Flöß,S.; Fritz,V.; Matias,M.I.; Yong,C.; Surh,N.; Marie,J.C.; Hühn,J.; Zimmermann,V.; Kinet,S.; Dardalhon,V.; Taylor,N.; ( Year: 2015). Title: Glutamine-dependent alpha-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation.Journal: Sci Signal Volume: 8 Issue: 396, S-Page: ra97 PubMed
  • Authors: Braun,A.; Dewert,N.; Brunnert,F.; Schnabel,V.; Hardenberg,J.H.; Richter,B.; Zachmann,K.; Cording,S.; Classen,A.; Brans,R.; Hamann,A.; Hühn,J.; Schon,M.P.; ( Year: 2015). Title: Integrin alpha(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity.Journal: J Invest Dermatol. PubMed
  • Authors: Pasztoi,M.; Pezoldt,J.; Hühn,J.; ( Year: 2015). Title: Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells.Journal: Prog.Mol.Biol.Transl.Sci Volume: 136, S-Page: 35- E-Page: 56 DOI: 10.1016/bs.pmbts.2015.07.012PubMed
  • Authors: Walter,F.R.; Veszelka,S.; Pasztoi,M.; Peterfi,Z.A.; Toth,A.; Rakhely,G.; Cervenak,L.; Abraham,C.S.; Deli,M.A.; ( Year: 2015). Title: Tesmilifene modifies brain endothelial functions and opens the blood-brain/blood-glioma barrier.Journal: J Neurochem. Volume: 134 Issue: 6, S-Page: 1040- E-Page: 1054 PubMed
  • Authors: Tebartz,C.; Horst,Sarah A.; Sparwasser,Tim; Hühn,Jochen; Beineke,A.; Peters,G.; Medina,Eva; ( Year: 2014). Title: A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection.Journal: Journal of Immunology Volume: 194 Issue: 3, S-Page: 1100- E-Page: 1111 PubMed
  • Authors: Khailaie,S.; Robert,P.A.; Toker,A.; Hühn,J.; Meyer-Hermann,M.; ( Year: 2014). Title: A signal integration model of thymic selection and natural regulatory T cell commitment.Journal: Journal of Immunology Volume: 193 Issue: 12, S-Page: 5983- E-Page: 5996 PubMed
  • Authors: Mayer,Christian T.; Lahl,K.; Milanez-Almeida,P.; Watts,D.; Dittmer,U.; Fyhrquist,N.; Hühn,Jochen; Kopf,M.; Kretschmer,K.; Rouse,B.; Sparwasser,Tim; ( Year: 2014). Title: Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.Journal: Immunity, Inflammation and Disease Volume: 2 Issue: 3, S-Page: 162- E-Page: 165 DOI: 10.1002/iid3.33HZI repositoryPubMed
  • Authors: Berod,L.; Friedrich,C.; Nandan,A.; Freitag,J.; Hagemann,S.; Harmrolfs,K.; Sandouk,A.; Hesse,C.; Castro,C.N.; Bahre,H.; Tschirner,S.K.; Gorinski,N.; Gohmert,M.; Mayer,C.T.; Hühn,Jochen; Ponimaskin,E.; Abraham,Wolf-Rainer; Müller,Rolf; Lochner,M.; Sparwasser,Tim; ( Year: 2014). Title: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.Journal: Nature medicine Volume: 20, S-Page: 1327- E-Page: 1333 PubMed
  • Authors: Milanez-Almeida,P.; Klawonn,F.; Meyer-Hermann,M.; Hühn,J.; ( Year: 2014). Title: Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 4 Issue: 3, S-Page: 147- E-Page: 155 PubMed
  • Authors: Prajeeth,C.K.; Lohr,K.; Flöß,Stefan; Zimmermann,J.; Ulrich,R.; Gudi,V.; Beineke,A.; Baumgartner,W.; Muller,M.; Hühn,Jochen; Stangel,M.; ( Year: 2014). Title: Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia.Journal: Brain, Behavior, and Immunity Volume: 37, S-Page: 248- E-Page: 259 DOI: 10.1016/j.bbi.2014.01.001HZI repositoryPubMed
  • Authors: Milanez-Almeida,P.; Meyer-Hermann,M.; Toker,A.; Khailaie,S.; Hühn,J.; ( Year: 2014). Title: Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen.Journal: European Journal of Immunology Volume: 45, S-Page: 153- E-Page: 166 PubMed
  • Authors: Prajeeth,C.K.; Beineke,A.; Iskandar,C.; Gudi,V.; Herder,V.; Gerhauser,I.; Haist,V.; Teich,R.; Hühn,J.; Baumgartner,W.; Stangel,M.; ( Year: 2014). Title: Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.Journal: J Neuroinflammation. Volume: 11 Issue: 1, S-Page: 180 DOI: 10.1186/s12974-014-0180-9HZI repositoryPubMed
  • Authors: Franckaert,D.; Dooley,J.; Roos,E.; Flöß,Stefan; Hühn,Jochen; Luche,H.; Fehling,H.J.; Liston,A.; Linterman,M.A.; Schlenner,S.M.; ( Year: 2014). Title: Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells.Journal: Immunology and Cell Biology Volume: 93 Issue: 4, S-Page: 417- E-Page: 423 DOI: 10.1038/icb.2014.108HZI repositoryPubMed
  • Authors: Cording,S.; Wahl,B.; Kulkarni,D.; Chopra,H.; Pezoldt,Jörn; Buettner,M.; Dummer,A.; Hadis,U.; Heimesaat,M.; Bereswill,S.; Falk,C.; Bode,U.; Hamann,A.; Fleissner,D.; Hühn,Jochen; Pabst,O.; ( Year: 2014). Title: The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes.Journal: Mucosal Immunology Volume: 7 Issue: 2, S-Page: 359- E-Page: 368 DOI: 10.1038/mi.2013.54PubMed
  • Authors: Schreiber,L.; Pietzsch,Beate; Flöß,Stefan; Farah,Carla; Jänsch,Lothar; Schmitz,Ingo; Hühn,Jochen; ( Year: 2014). Title: The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling.Journal: PLoS ONE Volume: 9 Issue: 2, S-Page: e88318 DOI: 10.1371/journal.pone.0088318HZI repositoryPubMed
  • Authors: Delacher,M.; Schreiber,L.; Richards,D.M.; Farah,C.; Feuerer,M.; Hühn,J.; ( Year: 2014). Title: Transcriptional control of regulatory T cells.Journal: Curr Top.Microbiol.Immunol. Volume: 381, S-Page: 83- E-Page: 124 PubMed
  • Authors: Khailaie,Sahamoddin; Bahrami,F.; Janahmadi,M.; Milanez-Almeida,P.; Hühn,J.; Meyer-Hermann,M.; ( Year: 2013). Title: A mathematical model of immune activation with a unified self-nonself concept.Journal: Frontiers in Immunology Volume: 4, S-Page: 474 DOI: 10.3389/fimmu.2013.00474HZI repositoryPubMed
  • Authors: Toker,A.; Engelbert,D.; Garg,G.; Polansky,J.K.; Floess,S.; Miyao,T.; Baron,U.; Düber,S.; Geffers,R.; Giehr,P.; Schallenberg,S.; Kretschmer,K.; Olek,S.; Walter,J.; Weiss,S.; Hori,S.; Hamann,A.; Hühn,J.; ( Year: 2013). Title: Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.Journal: Journal of Immunology Volume: 190 Issue: 7, S-Page: 3180- E-Page: 3188 WEBURLS
  • Authors: Cording,S.; Fleißner,Diana; Heimesaat,M.M.; Bereswill,S.; Loddenkemper,C.; Uematsu,S.; Akira,S.; Hamann,A.; Hühn,Jochen; ( Year: 2013). Title: Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches.Journal: European Journal of Microbiology and Immunology Volume: 3 Issue: 1, S-Page: 1- E-Page: 10 PubMed
  • Authors: Kühlhorn,F.; Rath,M.; Schmoeckel,K.; Cziupka,K.; Nguyen,H.H.; Hildebrandt,P.; Hünig,T.; Sparwasser,Tim; Hühn,Jochen; Pötschke,C.; Bröker,B.M.; ( Year: 2013). Title: Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis.Journal: PLoS ONE Volume: 8 Issue: 5, S-Page: e65109 DOI: 10.1371/journal.pone.0065109HZI repositoryPubMed
  • Authors: Huang,Yi-Ju; Haist,V.; Baumgartner,W.; Fohse,L.; Prinz,I.; Suerbaum,S.; Floess,Stefan; Hühn,Jochen; ( Year: 2013). Title: Induced and thymus-derived Foxp3 regulatory T cells share a common niche.Journal: European Journal of Immunology Volume: 44 Issue: 2, S-Page: 460- E-Page: 468 DOI: 10.1002/eji.201343463PubMed
  • Authors: Kreutzfeldt,M.; Bergthaler,A.; Fernandez,M.; Brück,W.; Steinbach,K.; Vorm,M.; Coras,R.; Blümcke,I.; Bonilla,W.V.; Fleige,A.; Forman,R.; Müller,W.; Becher,B.; Misgeld,T.; Kerschensteiner,M.; Pinschewer,D.D.; Merkler,D.; ( Year: 2013). Title: Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss.Journal: Journal of Experimental Medicine Volume: 210 Issue: 10, S-Page: 2087- E-Page: 2103 DOI: 10.1084/jem.20122143HZI repositoryPubMed
  • Authors: Sledzinska,A.; Hemmers,S.; Mair,F.; Gorka,O.; Ruland,J.; Fairbairn,L.; Nissler,A.; Müller,W.; Waisman,A.; Becher,B.; Buch,T.; ( Year: 2013). Title: TGF-beta Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function.Journal: PLoS Biology Volume: 11 Issue: 10, S-Page: e1001674 DOI: 10.1371/journal.pbio.1001674HZI repositoryPubMed
  • Authors: Schweer,J.; Kulkarni,D.; Kochut,A.; Pezoldt,J.; Pisano,F.; Pils,M.C.; Genth,H.; Hühn,J.; Dersch,P.; ( Year: 2013). Title: The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases.Journal: PLoS Pathogens Volume: 9 Issue: 11, S-Page: e1003746 DOI: 10.1371/journal.ppat.1003746HZI repositoryPubMed
  • Authors: Patzelt,D.; Wang,H.; Buchholz,I.; Rohde,M.; Gröbe,L.; Pradella,S.; Neumann,A.; Schulz,S.; Heyber,S.; Munch,K.; Munch,R.; Jahn,D.; Wagner-Döbler,I.; Tomasch,J.; ( Year: 2013). Title: You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae.Journal: ISME Journal Volume: 7 Issue: 12, S-Page: 2274- E-Page: 2286 DOI: 10.1038/ismej.2013.107PubMed
  • Authors: Hinz,D.; Bauer,M.; Roder,S.; Olek,S.; Hühn,Jochen; Sack,U.; Borte,M.; Simon,J.C.; Lehmann,I.; Herberth,G.; ( Year: 2012). Title: Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year.Journal: Allerg: European Journal of Allergy and Clinical Immunology Volume: 67 Issue: 3, S-Page: 380- E-Page: 389 PubMed
  • Authors: Brand,S.; Kesper,D.A.; Teich,R.; Kilic-Niebergall,E.; Pinkenburg,O.; Bothur,E.; Lohoff,M.; Garn,H.; Pfefferle,P.I.; Renz,H.; ( Year: 2012). Title: DNA methylation of T H1/T H2 cytokine genes affects sensitization and progress of experimental asthma.Journal: Journal of Allergy and Clinical Immunology Volume: 129 Issue: 6, S-Page: 1602- E-Page: 1610
  • Authors: König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; ( Year: 2012). Title: First insight into the kinome of human regulatory T cells.Journal: PLoS ONE Volume: 7 Issue: 7, S-Page: e40896 DOI: 10.1371/journal.pone.0040896HZI repositoryPubMed
  • Authors: Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; ( Year: 2012). Title: Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies.Journal: Journal of Visualized Experiments: JoVE Issue: 70 DOI: 4322.WEBURLS
  • Authors: O'Connor,R.A.; Floess,S.; Hühn,Jochen; Jones,S.A.; Anderton,S.M.; ( Year: 2012). Title: Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.Journal: European Journal of Immunology Volume: 42 Issue: 5, S-Page: 1174- E-Page: 1179 PubMed
  • Authors: Koenecke,C.; Lee,C.W.; Thamm,K.; Fohse,L.; Schafferus,M.; Mittrucker,H.W.; Floess,S.; Hühn,Jochen; Ganser,A.; Forster,R.; Prinz,I.; ( Year: 2012). Title: IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease.Journal: Journal of Immunology Volume: 189 Issue: 6, S-Page: 2890- E-Page: 2896 PubMed
  • Authors: Schuster,M.; Glauben,R.; Plaza-Sirvent,C.; Schreiber,L.; Annemann,M.; Floess,S.; Kuhl,A.A.; Clayton,L.K.; Sparwasser,Tim; Schulze-Osthoff,K.; Pfeffer,K.; Hühn,Jochen; Siegmund,B.; Schmitz,Ingo; ( Year: 2012). Title: IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor.Journal: Immunity Volume: 37 Issue: 6, S-Page: 998- E-Page: 1008 DOI: 10.1016/j.immuni.2012.08.023HZI repositoryPubMed
  • Authors: Herder,V.; Gerhauser,I.; Klein,S.K.; Almeida,P.; Kummerfeld,M.; Ulrich,R.; Seehusen,F.; Rohn,K.; Schaudien,D.; Baumgartner,W.; Hühn,Jochen; Beineke,A.; ( Year: 2012). Title: Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis.Journal: Journal of Neuroimmunology Volume: 249 Issue: 1-2, S-Page: 27- E-Page: 39 PubMed
  • Authors: Bettini,M.L.; Pan,F.; Bettini,M.; Finkelstein,D.; Rehg,J.E.; Floess,S.; Bell,B.D.; Ziegler,S.F.; Hühn,Jochen; Pardoll,D.M.; Vignali,D.A.; ( Year: 2012). Title: Loss of epigenetic modification driven by the foxp3 transcription factor leads to regulatory T cell insufficiency.Journal: Immunity Volume: 36 Issue: 5, S-Page: 717- E-Page: 730 PubMed
  • Authors: Weiss,J.M.; Bilate,A.M.; Gobert,M.; Ding,Y.; de Lafaille,M.A.C.; Parkhurst,C.N.; Xiong,H.; Dolpady,J.; Frey,A.B.; Ruocco,M.G.; Yang,Y.; Flöss,Stefan; Hühn,Jochen; Oh,S.; Li,M.O.; Niec,R.E.; Rudensky,A.Y.; Dustin,M.L.; Littman,D.R.; Lafaille,J.J.; ( Year: 2012). Title: Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosagenerated induced Foxp3+ T reg cells.Journal: Journal of Experimental Medicine Volume: 209 Issue: 10, S-Page: 1723- E-Page: 1742 DOI: 10.1084/jem.20120914HZI repositoryPubMed
  • Authors: Miyao,T.; Floess,S.; Setoguchi,R.; Luche,H.; Fehling,H.J.; Waldmann,H.; Hühn,Jochen; Hori,S.; ( Year: 2012). Title: Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.Journal: Immunity Volume: 36 Issue: 2, S-Page: 262- E-Page: 275 PubMed
  • Authors: Ohkura,N.; Hamaguchi,M.; Morikawa,H.; Sugimura,K.; Tanaka,A.; Ito,Y.; Osaki,M.; Tanaka,Y.; Yamashita,R.; Nakano,N.; Hühn,Jochen; Fehling,H.J.; Sparwasser,Tim*; Nakai,K.; Sakaguchi,S.; ( Year: 2012). Title: T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development.Journal: Immunity Volume: 37 Issue: 5, S-Page: 785- E-Page: 799 DOI: 10.1016/j.immuni.2012.09.010HZI repositoryPubMed
  • Authors: Berod,L.; Puttur,F.; Hühn,Jochen; Sparwasser,Tim*; ( Year: 2012). Title: Tregs in infection and vaccinology: heroes or traitors?.Journal: Microbial Biotechnology Volume: 5 Issue: 2, S-Page: 260- E-Page: 269 PubMed
  • Authors: Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Brettar,I.; Höfle,Manfred G.*; ( Year: 2011). Title: Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526.Journal: Microbial Ecology Volume: 63 Issue: 2, S-Page: 383- E-Page: 397 DOI: 10.1007/s00248-011-9918-4PubMed
  • Authors: Mayer,C.T.; Floess,S.; Baru,A.M.; Lahl,K.; Hühn,Jochen*; Sparwasser,T.; ( Year: 2011). Title: CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity.Journal: European Journal of Immunology Volume: 41 Issue: 3, S-Page: 716- E-Page: 725 DOI: 10.1002/eji.201040913HZI repositoryPubMed
  • Authors: Steinfelder,S.; Floess,S.; Engelbert,D.; Haeringer,B.; Baron,U.; Rivino,L.; Steckel,B.; Gruetzkau,A.; Olek,S.; Geginat,J.; Hühn,Jochen*; Hamann,A.; ( Year: 2011). Title: Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.Journal: Blood Volume: 117 Issue: 10, S-Page: 2839- E-Page: 2846 DOI: 10.1182/blood-2010-06-293027HZI repositoryPubMed
  • Authors: Brand,S.; Teich,René*; Dicke,T.; Harb,H.; Yildirim,A.O.; Tost,J.; Schneider-Stock,R.; Waterland,R.A.; Bauer,U.M.; von,Mutius E.; Garn,H.; Pfefferle,P.I.; Renz,H.; ( Year: 2011). Title: Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes.Journal: Journal of Allergy and Clinical Immunology Volume: 128 Issue: 3, S-Page: 618- E-Page: 625.e7 PubMed
  • Authors: Blankenhaus,B.; Klemm,U.; Eschbach,M.L.; Sparwasser,T.; Hühn,Jochen*; Kuhl,A.A.; Loddenkemper,C.; Jacobs,T.; Breloer,M.; ( Year: 2011). Title: Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.Journal: Journal of Immunology Volume: 186 Issue: 7, S-Page: 4295- E-Page: 4305 PubMed
  • Authors: Toker,A.; Hühn,Jochen*; ( Year: 2011). Title: To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms.Journal: Science Signaling Volume: 4 Issue: 158, S-Page: e4 DOI: 10.1126/scisignal.2001783HZI repositoryPubMed
  • Authors: Hubert,S.; Rissiek,B.; Klages,K.; Hühn,Jochen*; Sparwasser,T.; Haag,F.; Koch-Nolte,F.; Boyer,O.; Seman,M.; Adriouch,S.; ( Year: 2010). Title: Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.Journal: Journal of Experimental Medicine Volume: 207 Issue: 12, S-Page: 2561- E-Page: 2568 DOI: 10.1084/jem.20091154HZI repositoryPubMed
  • Authors: Humrich,J.Y.; Morbach,H.; Undeutsch,R.; Enghard,P.; Rosenberger,S.; Weigert,O.; Kloke,L.; Heimann,J.; Gaber,T.; Brandenburg,S.; Scheffold,A.; Hühn,Jochen*; Radbruch,A.; Burmester,G.R.; Riemekasten,G.; ( Year: 2010). Title: Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 Issue: 1, S-Page: 204- E-Page: 209 PubMed
  • Authors: Polansky,J.K.; Schreiber,L.; Thelemann,C.; Ludwig,L.; Kruger,M.; Baumgrass,R.; Cording,S.; Floess,S.; Hamann,A.; Hühn,Jochen*; ( Year: 2010). Title: Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.Journal: Journal of Molecular Medicine Volume: 88 Issue: 10, S-Page: 1029- E-Page: 1040 PubMed
  • Authors: Menning,A.; Loddenkemper,C.; Westendorf,A.M.; Szilagyi,B.; Buer,J.; Siewert,C.; Hamann,A.; Hühn,Jochen*; ( Year: 2010). Title: Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation.Journal: European Journal of Immunology Volume: 40 Issue: 9, S-Page: 2539- E-Page: 2548 PubMed
  • Authors: Klages,K.; Mayer,C.T.; Lahl,K.; Loddenkemper,C.; Teng,M.W.; Ngiow,S.F.; Smyth,M.J.; Hamann,A.; Hühn,Jochen*; Sparwasser,T.; ( Year: 2010). Title: Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.Journal: Cancer Research Volume: 70 Issue: 20, S-Page: 7788- E-Page: 7799 PubMed
  • Authors: Koenecke,C.; Czeloth,N.; Bubke,A.; Schmitz,S.; Kissenpfennig,A.; Malissen,B.; Hühn,Jochen*; Ganser,A.; Forster,R.; Prinz,I.; ( Year: 2009). Title: Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD.Journal: European Journal of Immunology Volume: 39 Issue: 11, S-Page: 3091- E-Page: 3096 PubMed
  • Authors: Hühn,Jochen*; Polansky,J.K.; Hamann,A.; ( Year: 2009). Title: Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?.Journal: Nature Reviews Immunology Volume: 9 Issue: 2, S-Page: 83- E-Page: 89 DOI: 10.1038/nri2474PubMed
  • Authors: Polansky,J.K.; Floess,S.; Freyer,J.; Hamann,A.; Hühn,J.; ( Year: 2009). Title: Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells.Book Title: The Epigenetics of Autoimmune Diseases Publisher: John Wiley and Sons, S-Page: 21- E-Page: 38 ISBN: 9780470758618 (ISBN)DOI: BookWEBURLS
  • Authors: Rausch,S.; Hühn,Jochen*; Loddenkemper,C.; Hepworth,M.R.; Klotz,C.; Sparwasser,T.; Hamann,A.; Lucius,R.; Hartmann,S.; ( Year: 2009). Title: Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells.Journal: Europen Journal of Immunology Volume: 39 Issue: 11, S-Page: 3066- E-Page: 3077 PubMed
  • Authors: Hoffmann,P.; Boeld,T.J.; Eder,R.; Hühn,Jochen*; Floess,S.; Wieczorek,G.; Olek,S.; Dietmaier,W.; Andreesen,R.; Edinger,M.; ( Year: 2009). Title: Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.Journal: European Journal of Immunology Volume: 39 Issue: 4, S-Page: 1088- E-Page: 1097 DOI: 10.1002/eji.200838904PubMed
  • Authors: Schaub,B.; Liu,J.; Hoppler,S.; Schleich,I.; Hühn,Jochen*; Olek,S.; Wieczorek,G.; Illi,S.; von,Mutius E.; ( Year: 2009). Title: Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells.Journal: Journal of Allergy and Clinical Immunology Volume: 123 Issue: 4, S-Page: 774- E-Page: 782 DOI: 10.1016/j.jaci.2009.01.056HZI repositoryPubMed
  • Authors: Lahl,K.; Mayer,C.T.; Bopp,T.; Hühn,Jochen*; Loddenkemper,C.; Eberl,G.; Wirnsberger,G.; Dornmair,K.; Geffers,Robert*; Schmitt,E.; Buer,J.; Sparwasser,T.; ( Year: 2009). Title: Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.Journal: Journal of Immunology Volume: 183 Issue: 9, S-Page: 5662- E-Page: 5672 PubMed
  • Authors: Wieczorek,G.; Asemissen,A.; Model,F.; Turbachova,I.; Floess,S.; Liebenberg,V.; Baron,U.; Stauch,D.; Kotsch,K.; Pratschke,J.; Hamann,A.; Loddenkemper,C.; Stein,H.; Volk,H.D.; Hoffmuller,U.; Grutzkau,A.; Mustea,A.; Hühn,Jochen*; Scheibenbogen,C.; Olek,S.; ( Year: 2009). Title: Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.Journal: Cancer Research Volume: 69 Issue: 2, S-Page: 599- E-Page: 608 PubMed
  • Authors: Loddenkemper,C.; Hoffmann,C.; Stanke,J.; Nagorsen,D.; Baron,U.; Olek,S.; Hühn,Jochen*; Ritz,J.P.; Stein,H.; Kaufmann,A.M.; Schneider,A.; Cichon,G.; ( Year: 2009). Title: Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer.Journal: Cancer Science Volume: 100 Issue: 6, S-Page: 1112- E-Page: 1117 DOI: 10.1111/j.1349-7006.2009.01153.xPubMed
  • Authors: Doebis,C.; Siegmund,K.; Loddenkemper,C.; Lowe,J.B.; Issekutz,A.C.; Hamann,A.; Hühn,Jochen*; Syrbe,U.; ( Year: 2008). Title: Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.Journal: American Journal of Pathology Volume: 173 Issue: 4, S-Page: 1067- E-Page: 1076 PubMed
  • Authors: Apostolou,I.; Verginis,P.; Kretschmer,K.; Polansky,J.; Hühn,Jochen*; von,Boehmer H.; ( Year: 2008). Title: Peripherally induced Treg: mode, stability, and role in specific tolerance.Journal: Journal of Clinical Immunology Volume: 28 Issue: 6, S-Page: 619- E-Page: 624 PubMed
  • Authors: Menning,A.; Hopken,U.E.; Siegmund,K.; Lipp,M.; Hamann,A.; Hühn,Jochen*; ( Year: 2007). Title: Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets.Journal: European Journal of Immunology Volume: 37 Issue: 6, S-Page: 1575- E-Page: 1583 PubMed
  • Authors: Baron,U.; Floess,S.; Wieczorek,G.; Baumann,K.; Grutzkau,A.; Dong,J.; Thiel,A.; Boeld,T.J.; Hoffmann,P.; Edinger,M.; Turbachova,I.; Hamann,A.; Olek,S.; Hühn,Jochen*; ( Year: 2007). Title: DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.Journal: European Journal of Immunology Volume: 37 Issue: 9, S-Page: 2378- E-Page: 2389 DOI: 10.3390/md8122976HZI repositoryPubMed
  • Authors: Marson,A.; Kretschmer,Karsten*; Frampton,G.M.; Jacobsen,E.S.; Polansky,J.K.; MacIsaac,K.D.; Levine,S.S.; Fraenkel,E.; von,Boehmer H.; Young,R.A.; ( Year: 2007). Title: Foxp3 occupancy and regulation of key target genes during T-cell stimulation.Journal: Nature Volume: 445 Issue: 7130, S-Page: 931- E-Page: 935 PubMed
  • Authors: Siewert,C.; Menning,A.; Dudda,J.; Siegmund,K.; Lauer,U.; Floess,S.; Campbell,D.J.; Hamann,A.; Hühn,Jochen*; ( Year: 2007). Title: Induction of organ-selective CD4+ regulatory T cell homing.Journal: European Journal of Immunology Volume: 37 Issue: 4, S-Page: 978- E-Page: 989 PubMed
  • Authors: Lahl,K.; Loddenkemper,C.; Drouin,C.; Freyer,J.; Arnason,J.; Eberl,G.; Hamann,A.; Wagner,H.; Hühn,Jochen*; Sparwasser,T.; ( Year: 2007). Title: Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.Journal: Journal of Experimental Medicine Volume: 204 Issue: 1, S-Page: 57- E-Page: 63 PubMed
  • Authors: Kroger,A.; Stirnweiss,A.; Pulverer,J.E.; Klages,K.; Grashoff,M.; Reimann,J.; Hauser,Hansjörg*; ( Year: 2007). Title: Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1.Journal: Cancer Research Volume: 67 Issue: 7, S-Page: 2972- E-Page: 2981 PubMed
  • Authors: Polansky,J.K.; Hühn,Jochen*; ( Year: 2007). Title: [To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells].Journal: Zeitschrift für Rheumatologie Volume: 66 Issue: 5, S-Page: 417- E-Page: 420 PubMed
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