Dynamics of Respiratory Infections
Several chronic inflammatory diseases of the lung have been recently associated with alterations in the composition of the airway microbiome. Moreover, the lung microbiota can be classified according to its predominance either of proinflammatory bacteria, such as strains from the genera Staphylococcus, Pseudomonas, and Haemophilus or of low-stimulatory bacteria from genera like Prevotella, Streptococcus, and Veillonella. Moreover, it is already known that the commensal lung microbiota can influence host immune system activation by producing numerous structural ligands and metabolites such as lipopolysaccharide, peptidoglycan, and secondary metabolites. However, the interaction between the lung microbiota and the airway epithelium, as well as their interactions with pulmonary pathogens, are not well understood.
A better understanding of the host-microbe interactions in the lung may help us to develop novel therapeutic strategies for a variety of respiratory infections.
Prof Dr med Hortense Slevogt has established herself as a distinguished researcher and physician in the fields of respiratory infections and immunology. Her academic journey began with a degree in medicine at Freie Universität Berlin, during which she developed a particular interest in infectious diseases and their impact on respiratory health. Driven by her passion for understanding the intricate workings of the human immune system, she pursued further specialization in Internal Medicine and Pulmonology, becoming a recognized expert in the field.
In 2009, Prof Slevogt's achievements were acknowledged through the completion of her habilitation in Internal Medicine at Charité - Universitätsmedizin Berlin. This significant milestone marked her expertise and profound understanding of the intricate nature of severe infections. A few years later, in 2011, Prof. Slevogt assumed the leadership of the Host Septomics Group at Universitätsklinikum Jena.
In 2022, she obtained the W3-Professorship at Medizinische Hochschule Hannover (MHH) and became the Head of the Research Group "Respiratory Infection Dynamics" (DINF) at the Helmholtz Centre for Infection Research (HZI) in Braunschweig. Her role entails spearheading translational projects that involve collaborations with esteemed academic and medical partners at the MHH. Through these endeavors, Dr Slevogt investigates host-pathogen interactomes and elucidates the mechanisms underlying immune responses and their control.
In parallel to her research pursuits, Dr Slevogt remains dedicated to clinical practice, ensuring that her findings directly benefit patients. She serves as the Senior Consultant in Clinical Infectiology at the Department of Respiratory Medicine and Infectious Diseases (MHH), contributing her expertise to the diagnosis and treatment of respiratory infections.