Computational Biology for Individualised Medicine
Infections are among the biggest threats to health and the most significant causes of death worldwide. Our aim is to reveal the host genetic risk factors and their downstream molecular pathways, which are crucial to make progress in understanding and treating infectious diseases in an individualised manner as well as to improve the identification of patients at risk. The department is part of the developing CiiM and currently housed at the TWINCORE in Hannover.
Leader
Selected Publications
Zhang, B., Zhang, Z., Koeken, V.A.C.M., Kumar, S., Aillaud, M., Tsay, H.-C., Liu, Z., Kraft, A.R.M., Soon, C.F., Odak, I., Bošnjak, B., Vlot, A., Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz, M.A., Ohler, U., Geffers, R., Illig, T., Huehn, J., Saliba, A.E., Sander, L.E., Förster, R., Xu, C.-J., Cornberg, M., Schulte, L.N., Li, Y.* Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. Cell Genomics, December 2, 2022. https://doi.org/10.1016/j.xgen.2022.100232
Zhang, B., Roesner, L.M., Traidl, S., Koeken, V.A.C.M., Xu, C.-J., Werfel, T., Li, Y. Single-cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis. Allergy, 00: 1- 15 (2022). https://doi: 10.1111/all.15486
Zhang, B., Moorlag, S., Domínguez-Andrés, J., Bulut, Ö., Kilic, G., Liu, Z., van Crevel, R., Xu,C.-J., Joosten, L.A.B., Netea, M.G.#, Li, Y.# Single-cell RNA sequencing reveals induction of distinct trained immunity programs in human monocytes. J Clin Invest, 132(7), e147719 (2022) https://doi:10.1172/JCI147719
Chu X., Jaeger M., Beumer J., Bakker O. B., Aguirre-Gamboa R., Oosting M., Smeekens S. P., Moorlag S., Mourits V. P., Koeken V. ACM, de Bree C., Jansen T., Mathews T., Dao K., Najhawan M., Watrous J. D., Joosten .I, Sharma S., Koenen H., Withoff S., Jonkers I. H., Netea-Maier R. T., Xavier R., Franke L., Xu C-J., Joosten L., Sanna S., Jain M., Kumar V., Clevers H., Wijmenga C., Netea M. G., Li Y. Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. Genome Biology 22/198, (2021). https://doi.org/10.1186/s13059-021-02413-z
Schulte-Schrepping J.*, Reusch N.*, Paclik D.*, Baßle, K*., Schlickeiser S.*, Zhang B.*, Kräme B.*, Krammer T.*, Brumhard S.*, Bonaguro L.*, De Domenico E.*, Wendisch D.*, Grasshof, M., Kapellos T. S., Beckstette M., Pecht T., Saglam A., Dietrich O., Me, H. E., Schul, A. R., Conrad C., Kunkel D., Vafadarnejad E., Xu C.-J., Horne A., Herbert M., Drews A., Thibeault C., Pfeiffer M., Hippenstiel S., Hocke A., Müller-Redetzky H., Heim, K.-M., Machleidt F., Uhrig A., Bosquillon de Jarcy L., Jürgens L., Stegemann M., Glösenkamp C. R., Volk H.-D., Goffinet C., Landthaler M., Wyler Georg P., Schneider M., Dang-Heine C., Neuwinger N., Kappert K., Taubert R., Corman V., Raabe J., Kaiser K. M., Vinh M. T., Riek, G., Meisel C., Ulas, T., Becker M., Geffers R., Witzenrath M., Drosten C., Suttor, N., von Kalle C., Kurth F., Händler K., Schultze J. L.#, Aschenbrenner A. C.#, Li Y.#, Nattermann J.#, Sawitzki B.#, Saliba A.-E.#, Sander L. E.#, Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell 182 (6), 1419-1440.e23 (2020). doi.org/10.1016/j.cell.2020.08.001
For all publications by Yang Li see Google Scholar.
Further Information
A current overview of the team and further information about the research group can be found on the TWINCORE page.
