Cellular Proteome Research

Pathogenic bacteria and viruses utilize and manipulate cellular processes of our immune system. The identification of protein functions in the human immune system that decisively control the progression of infections constitutes the central aim of the research group Cellular Proteomics at the HZI.



Control of immunological synapse formation in regulatory T lymphocytes with focus on micro vesicle transport (Project B16, CRC854, with Prof. B. Schraven, Prof. A. Müller, Dr. S. Kliche, Dr. W. Zuschratter, University Magdeburg, Germany).

Characterization of human mucosal associated invariant T cells in Clostridium difficile infection (ABINEB & Land Niedersachsen, with Prof. D. Jahn, TU-BS, Prof. D. Bruder, University Magdeburg, Prof. A. Canbay, Klinikum Magdeburg).

Characterization of human NK immunity (iMED)

  • in HCV infection and therapy 
    (with Prof. H. Wedemeyer, University Essen; Prof. M. Cornberg, Hannover Medical School; Prof. H.G. Ljunggren, Prof. J. Sandberg, Karolinska, SE; Prof. E. Mace, Baylor College of Medicine, US)
  • in HIV infected patients 
    (with Prof. J. Sandberg, Karolinska, SE and Dr. M. Eller, MHRP, US).

Respirasome dynamics in activated T lymphocytes with focus on ROS-dependent mucosal immunity (PROCOMPAS DFG graduate school, with Prof. R. Mendel, Prof. K. Hiller, TU-BS)

"Drug-target identification and mode-of-action proteome studies in the framework of the Helmholtz Drug Research Initiative: DRUG RESEARCH"

Exosome characterizations along norovirus infections in the framework of the Big data consortium “Paving the Way towards Personalized Prevention and Care of Severe Norovirus Gastroenteritis: PRESENt“ (new)

Plasma proteomics and immune cell monitoring in the framework of the Big data consortium “Paving the way towards individualized vaccination: i.Vacc” (new)

Former Projects

De-ubiquitin protease mediated immune control in SIRS and Sepsis (iMED; with Prof. D. Schlüter, University Magdeburg and Dr. U. Lodes ICU Magdeburg).

EBV-specific alterations of the ubiquitin system in the process of B cell transformation (with Prof. H. Delecluse, DKFZ, Heidelberg).

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