Structure and Function of Proteins

Structural biology is a powerful method to derive an understanding of the molecular basis of biological phenomena by visualizing the involved biomacromolecules at atomic resolution. The Department Structure and Function of Proteins uses protein crystallography to investigate proteins that play a role in infectious disease, e.g. by controlling the production of toxic molecules or by acting as toxins themselves. Our research in structural biology is complemented by biochemical and biophysical methods, and we employ all of these technologies to also aid drug discovery projects at the HZI. 


Publications of Dirk Heinz

  • Authors: Storbeck,S.; Saha,S.; Krausze,J.; Klink,B.U.; Heinz,Dirk W.*; Layer,G.; ( Year: 2011). Title: Crystal Structure of the Heme d1 Biosynthesis Enzyme NirE in Complex with Its Substrate Reveals New Insights into the Catalytic Mechanism of S-Adenosyl-L-methionine-dependent Uroporphyrinogen III Methyltransferases.Journal: Journal of Biological Chemistry Volume: 286 Issue: 30, S-Page: 26754- E-Page: 26767 DOI: 10.1074/jbc.M111.239855HZI repositoryPubMed
  • Authors: Wilke,S.; Gröbe,Lothar*; Maffenbeier,V.; Jäger,Volker*; Gossen,M.; Josewski,J.; Duda,A.; Polle,L.; Owens,R.J.; Wirth,Dagmar*; Heinz,Dirk* W.; van den,Heuvel Joop*; Büssow,Konrad*; ( Year: 2011). Title: Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.Journal: PLoS ONE Volume: 6 Issue: 12, S-Page: e27829 DOI: 10.1371/journal.pone.0027829HZI repositoryPubMed
  • Authors: de Groot,J.C.; Schluter,K.; Carius,Y.; Quedenau,C.; Vingadassalom,D.; Faix,J.; Weiss,S.M.; Reichelt,J.; Standfuss-Gabisch,C.; Lesser,C.F.; Leong,J.M.; Heinz,Dirk W.*; Büssow,Konrad*; Stradal,Theresia E.*; ( Year: 2011). Title: Structural Basis for Complex Formation between Human IRSp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. coli.Journal: Structure Volume: 19 Issue: 9, S-Page: 1294- E-Page: 1306 DOI: 10.1016/j.str.2011.06.015HZI repositoryPubMed
  • Authors: Quade,N.; Dieckmann,M.; Haffke,M.; Heroven,A.K.; Dersch,P.; Heinz,D.W.; ( Year: 2011). Title: Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.Journal: Acta Crystallographica Section D: Biological Crystallography Volume: 67 Issue: Pt 2, S-Page: 81- E-Page: 90 DOI: 10.1107/S0907444910049681HZI repositoryPubMed
  • Authors: Quade,N.; Huo,L.; Rachid,S.; Heinz,Dirk W.*; Müller,Rolf*; ( Year: 2011). Title: Unusual carbon fixation gives rise to diverse polyketide extender units.Journal: Nature Chemical Biology Volume: 8 Issue: 1, S-Page: 117- E-Page: 124 PubMed
  • Authors: Brocker,M.J.; Schomburg,S.; Heinz,Dirk W.*; Jahn,D.; Schubert,W.D.; Moser,J.; ( Year: 2010). Title: Crystal structure of the nitrogenase-like dark operative protochlorophyllide oxidoreductase catalytic complex (ChlN/ChlB)2.Journal: Journal of Biological Chemistry Volume: 285 Issue: 35, S-Page: 27336- E-Page: 27345 PubMed
  • Authors: Heinz,Dirk W.*; Betzel,C.; Wilmanns,M.; ( Year: 2010). Title: Highlight: of systems and structures.Journal: Biological Chemistry Volume: 391 Issue: 7, S-Page: 717- E-Page: 718 PubMed
  • Authors: Ferraris,D.M.; Gherardi,E.; Di,Y.; Heinz,Dirk W.*; Niemann,H; ( Year: 2010). Title: Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InIB.Journal: Journal of Molecular Biology Volume: 395 Issue: 3, S-Page: 522- E-Page: 532 DOI: 10.1016/j.jmb.2009.10.074HZI repositoryPubMed
  • Authors: Layer,G.; Reichelt,J.; Jahn,D.; Heinz,Dirk W.*; ( Year: 2010). Title: Structure and function of enzymes in heme biosynthesis.Journal: Protein Science Volume: 19 Issue: 6, S-Page: 1137- E-Page: 1161 PubMed
  • Authors: Klink,B.U.; Barden,S.; Heidler,T.V.; Borchers,C.; Ladwein,M.; Stradal,T.B.; Rottner,K.; Heinz,D.W.; ( Year: 2010). Title: Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry.Journal: Journal of Biological Chemistry Volume: 285 Issue: 22, S-Page: 17197- E-Page: 17208 DOI: 10.1074/jbc.M110.107953HZI repositoryPubMed
  • Authors: Heinemann,I.U.; Schulz,C.; Schubert,W.D.; Heinz,Dirk W.*; Wang,Y.G.; Kobayashi,Y.; Awa,Y.; Wachi,M.; Jahn,D.; Jahn,M.; ( Year: 2010). Title: Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin.Journal: Antimicrobial Agents and Chemotherapy Volume: 54 Issue: 1, S-Page: 267- E-Page: 272 PubMed
  • Authors: Haffke,M.; Menzel,A.; Carius,Y.; Jahn,D.; Heinz,Dirk W.*; ( Year: 2010). Title: Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides.Journal: Acta Crystallographica Section D: Biological Crystallography Volume: 66 Issue: Pt 9, S-Page: 979- E-Page: 987 PubMed
  • Authors: Rand,K.; Noll,C.; Schiebel,H.M.; Kemken,D.; Dulcks,T.; Kalesse,Markus*; Heinz,Dirk W.*; Layer,G.; ( Year: 2010). Title: The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX.Journal: Biological Chemistry Volume: 391 Issue: 1, S-Page: 55- E-Page: 63 PubMed
  • Authors: Marin,M.; Heinz,Dirk W.*; Pieper,Dietmar H.*; Klink,B.U.; ( Year: 2009). Title: Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase.Journal: Journal of Biological Chemistry Volume: 284 Issue: 47, S-Page: 32709- E-Page: 32716 PubMed
  • Authors: Bublitz,M.; Nimtz,Manfred*; Polle,L.; Holland,C.; Heinz,Dirk W.*; Schubert,Wolf-Dieter*; ( Year: 2009). Title: Structural basis for autoinhibition and activation of Auto, a virulence-associated peptidglycan hydrolase of.Journal: Molecular Microbiology Volume: 71 Issue: 6, S-Page: 1509- E-Page: 1522
  • Authors: Wiesand,U.; Sorg,I.; Amstutz,M.; Wagner,S.; van den Heuvel,Joop*; Lührs,Thorsten*; Cornelis,G.R.; Heinz,Dirk W.*; ( Year: 2009). Title: Structure of the type III secretion recognition protein YscU from.Journal: Journal of Molecular Biology Volume: 385 Issue: 3, S-Page: 854- E-Page: 866 DOI: 10.1016/j.jmb.2008.10.034HZI repositoryPubMed
  • Authors: Brocker,M.J.; Virus,S.; Ganskow,S.; Heathcote,P.; Heinz,Dirk W.*; Schubert,W.D.; Jahn,D.; Moser,J.; ( Year: 2008). Title: ATP-driven reduction by dark-operative protochlorophyllide oxidoreductase from Chlorobium tepidum mechanistically resembles nitrogenase catalysis.Journal: Journal of Biological Chemistry Volume: 283 Issue: 16, S-Page: 10559- E-Page: 10567 PubMed
  • Authors: Buettner,C.R.; Sorg,I.; Cornelis,G.R.; Heinz,D.W.; Niemann,H.H.; ( Year: 2008). Title: Structure of the.Journal: Journal of Molecular Biology Volume: 375 Issue: 4, S-Page: 997- E-Page: 1012 DOI: 10.1016/j.jmb.2007.11.009HZI repositoryPubMed
  • Authors: Wendt,K.U.; Weiss,M.S.; Cramer,P.; Heinz,Dirk W.*; ( Year: 2008). Title: Structures and diseases.Journal: Nature Structural and Molecular Biology Volume: 15 Issue: 2, S-Page: 117- E-Page: 120 DOI: 10.1038/nsmb0208-117HZI repositoryPubMed
  • Authors: Niemann,H.H.; Petoukhov,M.V.; Hartlein,M.; Moulin,M.; Gherardi,E.; Timmins,P.; Heinz,D.W.; Svergun,D.I.; ( Year: 2008). Title: X-ray and neutron small-angle scattering analysis of the complex formed by the met receptor and the Listeria monocytogenes invasion protein InlB.Journal: Journal of Molecular Biology Volume: 377 Issue: 2, S-Page: 489- E-Page: 500 DOI: 10.1016/j.jmb.2008.01.027HZI repositoryPubMed
  • Authors: Hagelüken,G.; Wiehlmann,L.; Adams,T.M.; Kolmar,H.; Heinz,Dirk W.*; Tümmler,B.; Schubert,Wolf-Dieter*; ( Year: 2007). Title: Crystal structure of the electron transfer complex rubredoxin-rubredoxin reductase of.Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Volume: 104 Issue: 30, S-Page: 12276- E-Page: 12281 DOI: 10.1073/pnas.0702919104HZI repositoryPubMed
  • Authors: Wollert,T.; Pasche,Bastian*; Rochon,Maike*; Deppenmeier,S.; van den Heuvel,Joop*; Gruber,A.D.; Heinz,Dirk W.*; Lengeling,Andreas*; Schubert,Wolf-Dieter*; ( Year: 2007). Title: Extending the host range of.Journal: Cell Volume: 129 Issue: 5, S-Page: 891- E-Page: 902
  • Authors: Lüer,C.; Schauer,S.; Virus,S.; Schubert,Wolf-Dieter*; Heinz,Dirk W.*; Jahn,D.; Moser,J.; ( Year: 2007). Title: Glutamate recognition and hydride transfer by.Journal: FEBS Journal Volume: 274 Issue: 17, S-Page: 4609- E-Page: 4614 DOI: 10.1111/j.1742-4658.2007.05989.xHZI repositoryPubMed
  • Authors: Niemann,H.N.; Jäger,Volker*; Butler,P.J.G.; van den Heuvel,Joop*; Schmidt,S.; Ferraris,D.; Gherardi,E.; Heinz,Dirk W.*; ( Year: 2007). Title: Structure of the human receptor tyrosine kinase met in complex with the.Journal: Cell Volume: 130 Issue: 2, S-Page: 235- E-Page: 246 DOI: 10.1016/j.cell.2007.05.037HZI repositoryPubMed
  • Authors: Wollert,Thomas*; Heinz,Dirk W.*; Schubert,Wolf-Dieter*; ( Year: 2007). Title: Thermodynamically reengineering the listerial invasion complex InIA/E-Cadherin.Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Volume: 104 Issue: 35, S-Page: 13960- E-Page: 13965 DOI: 10.1073/pnas.0702199104HZI repositoryPubMed
  • Authors: Heinz,D.W.; Weiss,M.S.; Wendt,K.U.; ( Year: 2006). Title: Biomacromolecular interactions, assemblies and machines: A structural view.Journal: ChemBioChem Volume: 7 Issue: 203, S-Page: 208 DOI: 10.1002/cbic.200500459HZI repositoryPubMed
  • Authors: Schulze,J.O.; Masoumi,A.; Nickel,D.; Jahn,M.; Schubert,Wolf-Dieter*; Heinz,Dirk W.*; ( Year: 2006). Title: Crystal structure of a non-discriminating glutamyl-tRNA synthetase.Journal: Journal of Molecular Biology Volume: 361, S-Page: 888- E-Page: 897 DOI: 10.1016/j.jmb.2006.06.054HZI repositoryPubMed
  • Authors: Schulze,J.O.; Schubert,Wolf-Dieter*; Moser,J.; Jahn,D.; Heinz,Dirk W.*; ( Year: 2006). Title: Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis.Journal: Journal of Molecular Biology Volume: 358, S-Page: 1212- E-Page: 1220 DOI: 10.1016/j.jmb.2006.02.064HZI repositoryPubMed
  • Authors: Frese,S.; Schubert,Wolf-Dieter*; Findeis,A.C.; Marquardt,T.; Roske,Y.S.; Stradal,Theresia E.B.*; Heinz,Dirk W.*; ( Year: 2006). Title: Phosphotyrosine binding specificities of Nck1 and Nck2.Journal: Journal of Biological Chemistry Volume: 281, S-Page: 18236- E-Page: 18245
  • Authors: Frere,F.; Nentwich,M.; Gacond,S.; Heinz,Dirk W.*; Neier,R.; Frankenberg-Dinkel,N.; ( Year: 2006). Title: Probing the active site of.Journal: Biochemistry Volume: 45, S-Page: 8243- E-Page: 8253
  • Authors: Hagelüken,G.; Adams,T.M.; Wiehlmann,L.; Widow,Ute*; Kolmar,H.; Tümmler,B.; Heinz,Dirk W.*; Schubert,Wolf-Dieter*; ( Year: 2006). Title: The crystal structure of SdsA1, an alkylsulfatase from.Journal: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Volume: 103, S-Page: 7631- E-Page: 7636 DOI: 10.1073/pnas.0510501103HZI repositoryPubMed
  • Authors: Layer,G.; Pierik,A.J.; Trost,M.; Jänsch,Lothar*; Leech,H.K.; Warren,M.J.; Rigby,S.E.; Astner,I.; Grage,K.; Breckau,D.; Heinz,Dirk W.*; Jahn,D.; ( Year: 2006). Title: The substrate radical of.Journal: Journal of Biological Chemistry Volume: 281, S-Page: 15727- E-Page: 15734
  • Authors: Jahn,D.; Moser,J.; Schubert,Wolf-Dieter*; Heinz,Dirk W.*; ( Year: 2006). Title: Transfer RNA-dependent aminolevulinic acid formation: structure and function of glutamyl-tRNA synthase, reductase and glutamate-1-semialdehyde-2,1-aminomutase.Book Title: Chlorophylls and Bacteriochlorophylls: Biochemistry, Biophysics, Functions and Applications Editors: Grimm,B.; Porra,R.J.; Rudiger,W.; Scheer,H.; (Ed.). City: Dordrecht Publisher: Springer Verlag, S-Page: 159- E-Page: 171
  • Authors: Reichelt,J.; Dieterich,G.; Kvesic,M.; Schomburg,D.; Heinz,D.W.; ( Year: 2005). Title: BRAGI. Linking and visualization of database information in a 3D-viewer and modelling tool.Journal: Bioinformatics Volume: 21, S-Page: 1291- E-Page: 1293
  • Authors: Lüer,C.; Schauer,S.; Möbius,K.; Schulze,J.; Schubert,W.-D.; Heinz,D.W.; Jahn,D.; Moser,J.; ( Year: 2005). Title: Complex formation between Glutamyl-tRNA Reductase and Glutamate-1-semialdehyde-2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.Journal: Journal of Biological Chemistry Volume: 280, S-Page: 18568- E-Page: 18572
  • Authors: Buettner,C.; Cornelis,G.R.; Heinz,D.W.; Niemann,H.H.; ( Year: 2005). Title: Crystal structure of.Journal: Protein Science Volume: 14, S-Page: 1993- E-Page: 2002
  • Authors: Astner,I.; Schulze,J.O.; van den Heuvel,J.; Jahn,D.; Schubert,W.-D.; Heinz,D.W.; ( Year: 2005). Title: Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.Journal: Embo Journal Volume: 24, S-Page: 3166- E-Page: 3177 DOI: 10.1038/sj.emboj.7600792HZI repository
  • Authors: Heinz,D.W.; Schubert,W.-D.; Höfle,G.; ( Year: 2005). Title: Much anticipated - The bioactive conformation of epothilone and its binding to tubulin.Journal: Angewandte Chemie - International Edition Volume: 44, S-Page: 1298- E-Page: 1301
  • Authors: Heinz,D.W.; Schubert,W.-D.; ( Year: 2005). Title: Proteins in motion.Journal: Angewandte Chemie - International Edition Volume: 44, S-Page: 4428
  • Authors: Layer,G.; Kervio,E.; Morlock,G.; Heinz,D.W.; Jahn,D.; Retey,J.; Schubert,W.-D.; ( Year: 2005). Title: Structural and functional comparison of HemN to other radical SAM enzymes.Journal: Biological Chemistry Volume: 386, S-Page: 971- E-Page: 980
  • Authors: Eiting,M.; Hagelüken,G.; Schubert,W.-D.; Heinz,D.W.; ( Year: 2005). Title: The mutation G145S in PrfA, a key virulence regulator of.Journal: Molecular Microbiology Volume: 56 Issue: 2, S-Page: 433- E-Page: 446 DOI: 10.1111/j.1365-2958.2005.04561.xPubMed
  • Authors: Frere,F.; Reents,H.; Schubert,W.-D.; Heinz,D.W.; ( Year: 2005). Title: Tracking the evolution of porphobilinogen synthase metal dependence in vitro.Journal: Journal of Molecular Biology Volume: 345 Issue: 5, S-Page: 1059- E-Page: 1070
  • Authors: Niemann,H.; Schubert,W.-D.; Heinz,D.; ( Year: 2004). Title: Adhesins and invasions of pathogenic bacteria: a structural view.Journal: Microbes and Infection Volume: 6, S-Page: 101- E-Page: 112
  • Authors: Freiberg,A.; Machner,M-P.; Pfeil,W.; Schubert,W.-D.; Heinz,D.W.; Seckler,R.; ( Year: 2004). Title: Folding and stability of the leucine-rich repeat domain of internalin B from Listeria monocytogenes.Journal: Journal of Molecular Biology Volume: 337 Issue: 2, S-Page: 453- E-Page: 461
  • Authors: Dieterich,G.; Kvesic,M.; Schomburg,D.; Heinz,D.W.; Reichelt,J.; ( Year: 2004). Title: Integrating public databases into an existing protein visualization and modeling program BRAGI.Journal: Lecture Notes in Informatics Volume: P-53, S-Page: 149- E-Page: 156
  • Authors: Ehinger,S.; Schubert,W.-D.; Bergmann,S.; Hammerschmidt,S.; Heinz,D.W.; ( Year: 2004). Title: Plasmin(ogen)-binding alpha-Enolase from.Journal: Journal of Molecular Biology Volume: 343, S-Page: 997- E-Page: 1005
  • Authors: Layer,G.; Heinz,D.W.; Jahn,D.; Schubert,W.-D.; ( Year: 2004). Title: Structure and function of radical SAM enzymes.Journal: Current Opinion in Chemical Biology Volume: 8, S-Page: 468- E-Page: 476
  • Authors: Machner,M.P.; Frese,S.; Schubert,W.-D.; Orian-Rousseau,V.; Gherardi,E.; Wehland,J.; Niemann,H.H.; Heinz,D.W.; ( Year: 2003). Title: Aromatic amino acids at the surface of In1B are essential for host cell invasion by Lysteria monocytogenes.Journal: Molecular Microbiology Volume: 48, S-Page: 1525- E-Page: 1536
  • Authors: Schubert,W.-D.; Heinz,D.W.; ( Year: 2003). Title: Details der Wechselwirkung zwischen Bakterium und Mensch.Journal: Laborwelt Issue: 1, S-Page: 16
  • Authors: Heesemann,J.; Heinz,D.W.; Rüssmann,H.; Wehland,J.; Goebel,W.; Kuhn,M.; ( Year: 2003). Title: Lektionen aus der Bakterienwelt: Ausnutzung von Wirtszellprozessen durch pathogene Mikroben.Journal: Biospektrum Volume: 9, S-Page: 486- E-Page: 489
  • Authors: Schubert,W.-D.; Heinz,D.W.; ( Year: 2003). Title: Structural aspects of adhesion and invasion of host cells by the human pathogen Listeria monocytogenes.Journal: ChemBioChem Volume: 4, S-Page: 1285- E-Page: 1291
  • Authors: van den Heuvel,J.; Heinz,D.W.; ( Year: 2002). Title: "Plug and Play"-expression systems for high-quality production of recombinant proteins for structural analysis.Journal: Gene Function & Disease Volume: 3 Issue: 1/2, S-Page: 33- E-Page: 38
  • Authors: Schauer,S.; Chaturvedi,S.; Randau,L.; Moser,J.; Kitabatake,M.; Lorenz,S.; Verkamp,E.; Schubert,W.-D.; Nakayashiki,T.; Murai,M.; Wall,K.; Thomann,U.; Heinz,D.W.; Inokuchi,H.; Söll,D.; Jahn,D.; ( Year: 2002). Title: Escherichia coli glutamyl-tRNA reductase: trapping the thioester intermediate..Journal: Journal of Biological Chemistry Volume: 247 Issue: 50, S-Page: 48656- E-Page: 48663
  • Authors: Heinz,D.W.; ( Year: 2002). Title: Modellsystem für Infektionen - Pathogene Bakterien auf ihrem unheilvollen Weg verfolgt.Journal: Jahreshefte der Helmholtz-Gesellschaft, S-Page: 10- E-Page: 11
  • Authors: Schubert,W.D.; Moser,J.; Schauer,S.; Heinz,D.W.; Jahn,D.; ( Year: 2002). Title: Structure and function of glutamyl-tRNA reductases, the first enzyme of tetrapyrrole biosynthesis in plants and prokaryotes.Journal: Photosynthesis Research Volume: 74, S-Page: 205- E-Page: 215
  • Authors: Moser,J.; Schubert,W.-D.; Heinz,D.W.; Jahn,D.; ( Year: 2002). Title: Structure and function of glutamyl-tRNA-reductase involved in 5-aminolevulinic acid formation.Journal: Biochemical Society Transactions Volume: 30, S-Page: 579- E-Page: 584
  • Authors: Frere,F.; Schubert,W.-D.; Neier,R.; Jahn,D.Heinz D.W.; ( Year: 2002). Title: Structure of porphobilinogen synthase from.Journal: Journal of Molecular Biology Volume: 320, S-Page: 237- E-Page: 247
  • Authors: Schubert,W.-D.; Urbanke,C.; Ziehm,T.; Beier,V.; Machner,M.P.; Domann,E.; Wehland,J.; Chakraborty,T.; Heinz,D.W.; ( Year: 2002). Title: Structure of the complex of internalin, a major invasion protein of Listeria monocytogenes with its human receptor, E-cadherin..Journal: Cell Volume: 111, S-Page: 825- E-Page: 836
  • Authors: Heinz,D.W.; Jahn,D.; ( Year: 2002). Title: Strukturbiologie zur gerichteten Wirkstoffentwicklung.Journal: CHEManager Volume: 11, S-Page: 14
  • Authors: Schubert,W.D.; Göbel,G.; Diepholz,M.; Darji,A.; Kloer,D.; Hain,T.; Chakraborty,T.; Wehland,J.; Domann,E.; Heinz,D.W.; ( Year: 2001). Title: Internalins from the human pathogen Listeria monocytogenes combine three distinct folds into a contiguous internalin domain.Journal: Journal of Molecular Biology Volume: 312 Issue: 4, S-Page: 783- E-Page: 794 PubMed
  • Authors: Barzik,M.; Carl,U.D.; Schubert,W.D.; Frank,R.; Wehland,J.; Heinz,D.W.; ( Year: 2001). Title: The N-terminal domain of Homer/Vesl is a new class II EVH1 domain.Journal: Journal of Molecular Biology Volume: 309 Issue: 1, S-Page: 155- E-Page: 169 PubMed
  • Authors: Moser,J.; Schubert,W.D.; Beier,V.; Bringemeier,I.; Jahn,D.; Heinz,D.W.; ( Year: 2001). Title: V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA- dependent tetrapyrrole biosynthesis.Journal: Embo Journal Volume: 20 Issue: 23, S-Page: 6583- E-Page: 6590 PubMed
  • Authors: Barzik,M.; Schubert,W.D.; Carl,U.; Wehland,J.; Heinz,D.W.; ( Year: 2000). Title: Crystallization and preliminary X-ray analysis of the EVH1 domain of Vesl-2b.Journal: Acta crystallographica.Section D: Biological crystallography. Volume: 56 Issue: 7, S-Page: 930- E-Page: 932 DOI: 10.1107/S0907444900005758FulltextHZI repositoryPubMed

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!


  • Doppelt aktiviert besser

    Bakterien ist jedes Mittel recht, um einen Organismus zu infizieren. Sie dringen in Zellen ein, wandern durch den Körper, täuschen das Immunsystem oder missbrauchen Abläufe der Wirtszelle für ihre Zwecke. Jedes Bakterium hat dabei seine eigene Methode. Welche Mechanismen Listeria-Bakterien nutzen, haben jetzt Strukturbiologen des Helmholtz-Zentrums für Infektionsforschung (HZI) in Braunschweig herausgefunden. Der Trick der Erreger: Sie binden mit zwei Invasionsproteinen an einen Rezeptor auf menschlichen Zellen und lassen sich in die Zelle einschleusen. Diese Eintrittskarte ist eigentlich für Faktoren reserviert, die das Zellwachstum und die Wundheilung steuern. Sehen Sie, wie Professor Dirk Heinz und seine Arbeitsgruppe den Bakterien auf die Spur gekommen sind…
    Länge 06:15

  • Video showing the mobility of PqsBC

    PqsBC exists in different conformational states. Computer simulations can be used to derive a dynamic mechanism from these states, in which PqsBC can bind to the fatty acid chain by closing the molecule.

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