Pathogenic bacteria can reside in a mammalian host for a life-long period and chronic carriers form a reservoir leading to recurrent infections. Despite the importance of chronic infections for public health, how a subset of pathogens escape the host’s immune surveillance and how the host contains the spread of bacteria are still poorly understood. Scientists within the Single-Cell Analysis group develop and use single-cell transcriptomics and computational approaches to decipher the microenvironments of individual pathogens and ultimately their functional consequences on infection outcome. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
“Single-cell sequencing is a terrific scientific revolution equivalent to genome sequencing. In ten years from now, all biology including infection biology will turn to be quantitative, predictive and mostly based on single-cell.”
Antoine-Emmanuel Saliba performed his undergraduate studies in biochemical engineering at the INSA Toulouse (France) and performed his PhD work under the supervision of Jean-Louis Viovy at the Institut Curie (Paris, France). During this time he pioneered the development of microfluidics-based integrated systems to sort and analyse rare cancer cell subpopulations. As postdoctoral EIPOD-fellow within the European Molecular Biology Laboratory (EMBL, Heidelberg, Germany), he developed one of the first systems-biology approaches to track protein-lipid interactions on the genome-scale. After this period, he joined the Vogel lab in Würzburg as senior postdoc where he introduced the use of single-cell RNA-seq to track the fate of individual infected cells with Salmonella enterica. Since 2017, he leads the Single-cell Analysis group within HIRI.