Molecular Infection Biology

Gastrointestinal infections are counted among the most common types of infectious diseases worldwide. In particular in developing countries, diarrhoeal diseases are still a leading course of death. Indeveloped countries, diarrhoeal diseases are under better control, but they still represent a very common affliction, especially among children and the elderly. Among the most important bacterial pathogens of food-animal origin are Salmonella, Shiga toxin-producing Escherichia coli, and enteropathogenic Yersinia species. Their primary route of transmission from animals to humans is through contaminated food. Once inside our bodies, they trigger an impressive range of different intestinal disorders from diarrhoea to acute infections of the small and large intestines – at times with severe consequences! Our primary focus is on Yersinia. We study the ways in which these bacteria adhere to the intestinal epithelium, penetrate it, and ultimately spread within the host.


Selected Publications

Heine W, Beckstette M, Heroven AK, Thiemann S, Heise U, Nuss AM, Pisano F, Strowig T, Dersch P (2018) Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency, PLoS Pathogens, 14(2):e1006858, DOI: 10.1371/journal.ppat.1006858.

Nuss AM*, Beckstette M*, Pimenova M, Schmühl C, Opitz W, Pisano F, Heroven AK, Dersch P (2017). Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host-pathogen transcriptomes, Proc Natl Acad Sci U S A, 114(5):E791-E800.

Nuss AM*, Schuster F*, Roselius* L, Klein J, Bücker R, Herbst K, Heroven AK, Pisano F, Wittmann C, Münch R, Müller J, Jahn D, Dersch P (2016). A precise temperature-responsive bistable switch controlling Yersinia virulencePLoS Pathogens, 12(12):e1006091.

Wang H, Avican K, Fahlgren A, Erttmann SF, Nuss AM, Dersch P, Fällman M, Edgren T, Wolf-Watz H (2016). Increased plasmid copy number is essential for Yersinia T3SS function and virulenceScience 353, 492-495.

Righetti F, Nuss AM, Twittenhoff C, Beele S, Urban K, Will S, Bernhart SH, Stadler PF, Dersch P, Narberhaus F (2016). Temperature-responsive in vitro RNA structurome of Yersinia pseudotuberculosisProc Natl Acad Sci U S A, 113(26):7237-42.

Nuss AM, Heroven AK, Waldmann B, Reinkensmeier J, Jarek M, Beckstette M, Dersch P (2015). Transcriptomic profiling of Yersinia pseudotuberculosis reveals reprogramming of the Crp regulon by temperature and uncovers Crp as a master regulator of small RNAs, PLoS Genetics, 11(3):e1005087.


  • Authors: Heine W, Beckstette M, Heroven AK, Thiemann S, Heise U, Nuss AM, Pisano F, Strowig T, Dersch P ( Year: 2018). Title: Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency, Journal: PLoS Pathogens.14(2):e1006858, DOI: 10.1371/journal.ppat.1006858.
  • Authors: Kusmierek M, Dersch, P.; ( Year: 2017) Regulation of host-pathogen interactions via the post-transcriptional Csr/Rsm system. Journal: Curr.Opin.Microbiol. 41:58-67. DOI: 10.1016/j.mib.2017.11.022.
  • Authors: Pezoldt,J.*; Pisano,F.*; Heine,W.; Pasztoi,M.; Rosenheinrich,M.; Nuss,A.M.; Pils,M.C.; Prinz,I.; Forster,R.; Hühn,J.*; Dersch,P.*; ( Year: 2017). Title: CCR7 deficiency modulates T cell response and increases susceptibility to Yersinia pseudotuberculosis infection. Journal: J Infect.Dis. DOI: 10.1093/infdis/jix037 PubMed
  • Authors: Dersch,P.; Laub,M.; ( Year: 2017). Title: Editorial overview: Cell regulation: New insights into the versatile regulatory processes governing bacterial life. Journal: Curr.Opin.Microbiol. Volume: 36: Cell Regulation: New insights into the versatile regulatory processes governing bacterial life,  S-Page: v- E-Page: viii DOI: 10.1016/j.mib.2017.07.002 HZI repository PubMed
  • Authors: Pezoldt,J.; Pisano,F.; Heine,W.; Pasztoi,M.; Rosenheinrich,M.; Nuss,A.M.; Pils,M.C.; Prinz,I.; Forster,R.; Hühn,J.; Dersch,P.; ( Year: 2017). Title: Impact of CCR7 on T-cell response and susceptibility to Yersinia pseudotuberculosis infection. Journal: The Journal of infectious diseases Volume: 216 Issue: 6,  S-Page: 752- E-Page: 760 DOI: 10.1093/infdis/jix037 PubMed
  • Authors: Nuss,A.M.; Heroven,A.K.; Dersch,P.; ( Year: 2017). Title: RNA regulators: formidable modulators of Yersinia virulence. Journal: Trends Microbiol. Volume: 25 Issue: 1,  S-Page: 19- E-Page: 34 DOI: 10.1016/j.tim.2016.08.006 PubMed
  • Authors: Dersch,P.; Khan,M.A.; Mühlen,S.; Görke,B.; ( Year: 2017). Title: Roles of regulatory RNAs for antibiotic resistance in bacteria and their potential value as novel drug targets. Journal: Front.Microbiol. Volume: 8 Issue: Article number 803 DOI: 10.3389/fmicb.2017.00803 HZI repository PubMed
  • Authors: Nuss,A.M.; Beckstette,M.; Pimenova,M.; Schmühl,C.; Opitz,W.; Pisano,F.; Heroven,A.K.; Dersch,P.; ( Year: 2017). Title: Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host-pathogen transcriptomes. Journal: Proc.Natl.Acad.Sci U.S A Volume: 114 Issue: 5,  S-Page: E791- E-Page: E800 DOI: 10.1073/pnas.1613405114 HZI repository PubMed
  • Authors: Pasztoi,M.; Bonifacius,A.; Pezoldt,J.; Kulkarni,D.; Niemz,J.; Yang,J.; Teich,R.; Hajek,J.; Pisano,F.; Rohde,M.; Dersch,P.; Hühn,J.; ( Year: 2017). Title: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Journal: Cell Mol.Life Sci. Volume: 74 Issue: 15,  S-Page: 2839- E-Page: 2850 DOI: 10.1007/s00018-017-2516-y HZI repository PubMed
  • Authors: Solbach,P.; Dersch,P.; Bachmann,O.; ( Year: 2017). Title:  Individualized treatment strategies for Clostridium difficile infections. Journal: Internist (Berl) DOI: 10.1007/s00108-017-0268-2 PubMed
  • Authors: Nuss,A.M.; Schuster,F.; Roselius,L.; Klein,J.; Bücker,R.; Herbst,K.; Heroven,A.K.; Pisano,F.; Wittmann,C.; Münch,R.; Müller,J.; Jahn,D.; Dersch,P.; ( Year: 2016). Title: A precise temperature-responsive bistable switch controlling Yersinia virulence. Journal: PLoS Pathogens Volume: 12 Issue: 12,  S-Page: art. no. e1006091 DOI: 10.1371/journal.ppat.1006091 HZI repository PubMed
  • Authors: Mühlen,S.; Dersch,P.; ( Year: 2016). Title: Anti-virulence strategies to target bacterial infections. Journal: Curr Top.Microbiol.Immunol. Volume: 398,  S-Page: 147- E-Page: 184 PubMed
  • Authors: Zeitouni,N.E.; Dersch,P.; Naim,H.Y.; Von Köckritz-Blickwede,M.; ( Year: 2016). Title: Hypoxia decreases invasin-mediated Yersinia enterocolitica internalization into Caco-2 Cells. Journal: PLoS ONE Volume: 11 Issue: 1 DOI: 10.1371/journal.pone.0146103 HZI repository PubMed
  • Authors: Wang,H.; Avican,K.; Fahlgren,A.; Erttmann,S.F.; Nuss,A.M.; Dersch,P.; Fallman,M.; Edgren,T.; Wolf-Watz,H.; ( Year: 2016). Title: Increased plasmid copy number is essential for Yersinia T3SS function and virulence. Journal: Science Volume: 353,  S-Page: 492- E-Page: 495 PubMed
  • Authors: Menina,S.; Labouta,H.I.; Geyer,R.; Krause,T.; Gordon,S.; Dersch,P.; Lehr,C.M.; ( Year: 2016). Title: Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs. Journal: RSC Adv. Volume: 6 Issue: 47,  S-Page: 41622- E-Page: 41629 DOI: 10.1039/c6ra02988d WEBURLS
  • Authors: Heroven,A.K.; Dersch,P.; ( Year: 2016). Title: Metabolic adaptation of human pathogenic yersiniae. Book Title: & quot; Host - Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives & quot; Editors: G.Unden,E.Thines,and A.Schüffler; (Ed.). Publisher: Wiley-Blackwell,  S-Page: 3- E-Page: 18
  • Authors: Drechsler-Hake,D.; Alamir,H.; Gunter,M.; Wagner,S.; Schutz,M.; Bohn,E.; Schenke-Layland,K.; Pisano,F.; Dersch,P.; Autenrieth,I.B.; Autenrieth,S.E.; ( Year: 2016). Title: Mononuclear phagocytes contribute to intestinal invasion and dissemination of Yersiniaenterocolitica. Journal: Int.J Med.Microbiol. Volume: 306 Issue: 6,  S-Page: 357- E-Page: 366 PubMed
  • Authors: Heroven,A.K.; Nuss,A.M.; Dersch,P.; ( Year: 2016). Title: RNA-based mechanisms of virulence control in Enterobacteriaceae. Journal: RNA Biology,  S-Page: 1- E-Page: 17 DOI: 10.1080/15476286.2016.1201617 HZI repository PubMed
  • Authors: Righetti,F.; Nuss,A.M.; Twittenhoff,C.; Beele,S.; Urban,K.; Will,S.; Bernhart,S.H.; Stadler,P.F.; Dersch,P.; Narberhaus,F.; ( Year: 2016). Title: Temperature-responsive in vitro RNA structurome of Yersinia pseudotuberculosis. Journal: Proc.Natl.Acad.Sci U.S A DOI: 10.1073/pnas.1523004113 HZI repository PubMed
  • Authors: Avican,U.; Beckstette,M.; Heroven,A.K.; Lavander,M.; Dersch,P.; Forsberg,A.; ( Year: 2016). Title: Transcriptomic and phenotypic analysis reveals new functions for the Tat pathway in Yersinia pseudotuberculosis. Journal: J Bacteriol. Volume: 198,  S-Page: 2876- E-Page: 2886 DOI: 10.1128/JB.00352-16 HZI repository PubMed
  • Authors: Labouta,H.I.; Menina,S.; Kochut,A.; Gordon,S.; Geyer,R.; Dersch,P.; Lehr,C.M.; ( Year: 2015). Title: Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery. Journal: J Control Release Volume: 220,  S-Page: 414- E-Page: 424 DOI: 10.1016/j.jconrel.2015.10.052 HZI repository PubMed
  • Authors: Rosenheinrich,M.; Heine,W.; Schmuhl,C.M.; Pisano,F.; Dersch,P.; ( Year: 2015). Title: Natural killer cells mediate protection against Yersinia pseudotuberculosis in the mesenteric lymph nodes. Journal: PLoS ONE Volume: 10 Issue: 8,  S-Page: e0136290 DOI: 10.1371/journal.pone.0136290 HZI repository PubMed
  • Authors: Erhardt,M.; Dersch,P.; ( Year: 2015). Title: Regulatory principles governing Salmonella and Yersinia virulence. Journal: Front Microbiol. Volume: 6,  S-Page: 949 PubMed
  • Authors: Avican,K.; Fahlgren,A.; Huss,M.; Heroven,AK.; Beckstette,M.; Dersch,P.; Fällman,M.; ( Year: 2015). Title: Reprogramming of Yersinia from virulent to persistent mode revealed by complex in vivo RNA-seq Analysis. Journal: PLoS Pathogens Volume: 11 Issue: 1,  S-Page: e1004600 DOI: 10.1371/journal.ppat.1004600 HZI repository PubMed
  • Authors: Nuss,A.M.; Heroven,A.K.; Waldmann,B.; Reinkensmeier,J.; Jarek,M.; Beckstette,M.; Dersch,P.; ( Year: 2015). Title: Transcriptomic profiling of Yersinia pseudotuberculosis reveals reprogramming of the Crp regulon by temperature and uncovers Crp as a master regulator of small RNAs. Journal: PLoS Genet. Volume: 11 Issue: 3 DOI: 10.1371/journal.pgen.1005087 HZI repository PubMed
  • Authors: Mollerherm,H.; Neumann,A.; Schilcher,K.; Blodkamp,S.; Zeitouni,N.E.; Dersch,P.; Luthje,P.; Naim,H.Y.; Zinkernagel,A.S.; von Kockritz-Blickwede,M.; ( Year: 2015). Title: Yersiniaenterocolitica-mediated degradation of neutrophil extracellular traps (NETs). Journal: FEMS Microbiol.Lett. Volume: 362 Issue: 23,  S-Page: fnv192 PubMed
  • Authors: Nuss,A.M.; Schuster,F.; Heroven,A.K.; Heine,W.; Pisano,F.; Dersch,P.; ( Year: 2014). Title: A direct link between the global regulator PhoP and the Csr regulon in Yersinia pseudotuberculosis through the small regulatory RNA CsrC. Journal: RNA Biology Volume: 11 Issue: 5 PubMed
  • Authors: Heroven,AK.; Dersch,P.; ( Year: 2014). Title: Bacterial protein and RNA thermometers: Molecular thermometers for the control of the virulence ofYersinia. Journal: Biospektrum Volume: 20 Issue: 4,  S-Page: 376- E-Page: 379 WEBURLS
  • Authors: Heroven,A.K.; Dersch,P.; ( Year: 2014). Title: Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae. Journal: Front.Cell.Infect.Microbiol. Volume: 4 Issue: OCT,  S-Page: 146 DOI: Review WEBURLS
  • Authors: Schaake,Julia; Drees,A.; Grüning,P.; Uliczka,F.; Pisano,F.; Thiermann,T.; von Altrock,A.; Seehusen,F.; Valentin-Weigand,P.; Dersch,P.; ( Year: 2014). Title: Essential role of invasin for colonization and persistence of Yersinia enterocolitica in its natural reservoir host, the pig. Journal: Infection and Immunity Volume: 82 Issue: 3,  S-Page: 960- E-Page: 969 WEBURLS
  • Authors: Pisano,F.; Heine,W.; Rosenheinrich,M.; Schweer,J.; Nuss,A. M.; Dersch,P.; ( Year: 2014). Title: Influence of PhoP and intra-species variations on virulence of Yersiniapseudotuberculosis during the natural oral infection route. Journal: PLoS ONE Volume: 9 Issue: 7,  S-Page: e103541 DOI: 10.1371/journal.pone.0103541 HZI repository PubMed
  • Authors: Bücker,R.; Heroven,AK.; Becker,J.; Dersch,P.; Wittmann,C.; ( Year: 2014). Title: The pyruvate - tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis. Journal: Journal of Biological Chemistry Volume: 289,  S-Page: 30114- E-Page: 30132 DOI: 10.1074/jbc.M114.581348 HZI repository PubMed
  • Authors: Valentin-Weigand,P.; Heesemann,J.; Dersch,P.; ( Year: 2014). Title: Unique virulence properties of Yersinia enterocolitica O:3 - An emerging zoonotic pathogen using pigs as preferred reservoir host. Journal: International Journal of Medical Microbiology Volume: 304,  S-Page: 824- E-Page: 834 PubMed
  • Authors: Kochut,A.; Dersch,P.; ( Year: 2013). Title: Bacterial invasion factors: Tools for crossing biological barriers and drug delivery?. Journal: European Journal of Pharmaceutics and Biopharmaceutics Volume: 84 Issue: 2,  S-Page: 242- E-Page: 250 DOI: 10.1016/j.ejpb.2012.11.013 HZI repository PubMed
  • Authors: Schaake,J.; Kronshage,M.; Uliczka,F.; Rohde,M.; Knuuti,T.; Strauch,E.; Fruth,A.; Wos-Oxley,M.; Dersch,P.; ( Year: 2013). Title: Human and animal isolates of Yersiniaenterocolitica show significant serotype-specific colonization and host-specific immune defense properties. Journal: Infection and Immunity Volume: 81 Issue: 11,  S-Page: 4013- E-Page: 4025 DOI: 10.1128/IAI.00572-13 HZI repository PubMed
  • Authors: Schweer,J.; Kulkarni,D.; Kochut,A.; Pezoldt,J.; Pisano,F.; Pils,M.C.; Genth,H.; Hühn,J.; Dersch,P.; ( Year: 2013). Title: The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases. Journal: PLoS Pathogens Volume: 9 Issue: 11,  S-Page: e1003746 DOI: 10.1371/journal.ppat.1003746 HZI repository PubMed
  • Authors: Steinmann,R.; Dersch,P.; ( Year: 2013). Title: Thermosensing to adjust bacterial virulence in a fluctuating environment. Journal: Future Microbiology Volume: 8 Issue: 1,  S-Page: 85- E-Page: 105 DOI: 10.2217/fmb.12.129 HZI repository PubMed
  • Authors: Böhme,K*; Steinmann,R.*; Kortmann,J.; Seekircher,S.; Heroven,A.K.; Berger,E.; Pisano,F.; Thiermann,T.; Wolf-Watz,H.; Narberhaus,F.; Dersch,P.; ( Year: 2012). Title: Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence. Journal: PLoS Pathogens Volume: 8 Issue: 2,  S-Page: e1002518 DOI: 10.1371/journal.ppat.1002518 HZI repository PubMed
  • Authors: Heroven,A.K.; Sest,M.; Pisano,F.; Scheb-Wetzel,M.; Steinmann,R.; Bohme,K.; Klein,J.; Munch,R.; Schomburg,D.; Dersch,P.; ( Year: 2012). Title: Crp induces switching of the CsrB and CsrC RNAs in Yersinia pseudotuberculosis and links nutritional status to virulence. Journal: Frontiers in Cellular and Infection Microbiology Volume: 2,  S-Page: 158 DOI: 10.3389/fcimb.2012.00158 HZI repository PubMed
  • Authors: Pisano,F.; Kochut,A.; Uliczka,F.; Geyer,R.; Stolz,T.; Thiermann,T.; Rohde,M.; Dersch,P.; ( Year: 2012). Title: In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence. Journal: Infection and Immunity Volume: 80 Issue: 3,  S-Page: 1050- E-Page: 1064 PubMed
  • Authors: Dersch,P.; ( Year: 2012). Title: Protein folding, transport and degradation. Book Title: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology Editors: Schomburg,D.; (Ed.). Publisher: John Wiley & Sons,  S-Page: 244- E-Page: 258
  • Authors: Heroven,A.K.; Böhme,K.; Dersch,P.; ( Year: 2012). Title: Regulation of virulence gene expression by regulatory RNA elements in Yersinia pseudotuberculosis. Journal: Advances in Experimental Medicine and Biology Volume: 954,  S-Page: 315- E-Page: 323 PubMed
  • Authors: Quade,N.; Mendonca,C.; Herbst,K.; Heroven,A.K.; Ritter,C.; Heinz,D.W.; Dersch,P.; ( Year: 2012). Title: Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia. Journal: Journal of Biological Chemistry Volume: 287 Issue: 43,  S-Page: 35796- E-Page: 35803 DOI: 10.1074/jbc.M112.379156 HZI repository PubMed
  • Authors: Heroven,A.K.; Böhme,K.; Dersch,P.; ( Year: 2012). Title: The Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence. Journal: RNA Biology Volume: 9 Issue: 4,  S-Page: 379- E-Page: 391 HZI repository PubMed
  • Authors: Uliczka,F.; Dersch,P.; ( Year: 2012). Title: Unique virulence properties of Yersiniaenterocolitica O:3. Journal: Advances in Experimental Medicine and Biology Volume: 954,  S-Page: 281- E-Page: 287 DOI: 10.1007/978-1-4614-3561-7_35 HZI repository PubMed
  • Authors: Uliczka,F.; Pisano,F.; Kochut,A.; Opitz,W.; Herbst,K.; Stolz,T.; Dersch,P.( Year: 2011). Title: Monitoring of gene expression in bacteria during infections using an adaptable set of bioluminescent, fluorescent and colorigenic fusion vectors. Journal: PLoS ONE Volume: 6 Issue: 6,  S-Page: e20425 DOI: 10.1371/journal.pone.0020425 HZI repository PubMed
  • Authors: Quade,N.; Dieckmann,M.; Haffke,M.; Heroven,A.K.; Dersch,P.; Heinz,D.W.; ( Year: 2011). Title: Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis. Journal: Acta Crystallographica Section D: Biological Crystallography Volume: 67 Issue: Pt 2,  S-Page: 81- E-Page: 90 DOI: 10.1107/S0907444910049681 HZI repository PubMed
  • Authors: Uliczka,F.; Pisano,F.; Schaake,J.; Stolz,T.; Rohde,M.; Fruth,A.; Strauch,E.; Skurnik,M.; Batzilla,J.; Rakin,A.; Heesemann,J.; Dersch,P.; ( Year: 2011). Title: Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis. Journal: PLoS Pathogens Volume: 7 Issue: 7,  S-Page: e1002117 DOI: 10.1371/journal.ppat.1002117 HZI repository PubMed
  • Authors: Homann,A.; Qamar,R.-U.; Serim,S.; Dersch,Petra*; Seibel,J.; ( Year: 2010). Title: Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. Journal: Beilstein Journal of Organic Chemistry Volume: 6 Issue: art. no. 24 DOI: 10.3762/bjoc.6.24 HZI repository PubMed
  • Authors: Göpel,Y.; Lüttmann,D.; Heroven,A.K.; Reichenbach,B.; Dersch,P.; Görke,B.; ( Year: 2010). Title: Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae. Journal: Nucleic Acids Research Volume: 39 Issue: 4,  S-Page: 1294-1309 DOI: 10.1093/nar/gkq986 PubMed
  • Authors: Fleissner,A.; Dersch,P.; ( Year: 2010). Title: Expression and export: recombinant protein production systems for Aspergillus. Journal: Applied Microbiology and Biotechnology Volume: 87 Issue: 4,  S-Page: 1255- E-Page: 1270 PubMed
  • Authors: Driouch,H.; Roth,A.; Dersch,P.; Wittmann,C.; ( Year: 2010). Title: Filamentous fungi in good shape: Microparticles for tailor-made fungal morphology and enhanced enzyme production. Journal: Bioengineered Bugs Volume: 2 Issue: 2 DOI: 10.4161/bbug.2.2.13757 HZI repository PubMed
  • Authors: Heroven,A.K.; Dersch,P.; ( Year: 2010). Title: Global virulence gene regulation networks in enteropathogenic Yersiniae. Book Title: Research Advances in Molecular Microbiology Editors: Mohan,R.M.; (Ed.). City: Kerala, Indien Publisher: Global Research Network,  S-Page: 1- E-Page: 17
  • Authors: Driouch,H.; Roth,A.; Dersch,P.; Wittmann,C.; ( Year: 2010). Title: Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger. Journal: Applied Microbiology and Biotechnology Volume: 87 Issue: 6,  S-Page: 2011- E-Page: 2024 PubMed
  • Authors: Roth,A.H.; Dersch,P.; ( Year: 2009). Title: A novel expression system for intracellular production and purification of recombinant affinity-tagged proteins in Aspergillus niger. Journal: Applied Microbiology and Biotechnology Volume: 86 Issue: 2,  S-Page: 659- E-Page: 670 DOI: 10.1007/s00253-009-2252-9 HZI repository PubMed
  • Authors: Uliczka,F.; Kornprobst,T.; Eitel,J.; Schneider,D.; Dersch,P.; ( Year: 2009). Title: Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase. Journal: Cellular Microbiology Volume: 11 Issue: 12,  S-Page: 1782- E-Page: 1801 DOI: 10.1111/j.1462-5822.2009.01371.x HZI repository PubMed
  • Authors: Herbst,K.; Bujara,M.; Heroven,A.K.; Opitz,W.; Weichert,M.; Zimmermann,A.; Dersch,P.; ( Year: 2009). Title: Intrinsic thermal sensing controls proteolysis of Yersiniavirulence regulator RovA. Journal: PLoS Pathogens Volume: 5 Issue: 5,  S-Page: e1000435 DOI: 10.1371/journal.ppat.1000435 HZI repository PubMed
  • Authors: Vlahou,G.; Schmidt,O.; Wagner,B.; Uenlue,H.; Dersch,P.; Rivero,F.; Weissenmayer,B.A.; ( Year: 2009). Title: Yersinia outer protein YopE affects the actincytoskeleton in Dictyostelium discoideum through targeting of multiple Rho family GTPases. Journal: BMC Microbiology Volume: 9, art. no. 138
  • Authors: Heroven,A.K.; Bohme,K.; Rohde,M.; Dersch,P.; ( Year: 2008). Title: A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM. Journal: Molecular Microbiology Volume: 68 Issue: 5,  S-Page: 1179- E-Page: 1195 DOI: 10.1111/j.1365-2958.2008.06218.x HZI repository PubMed
  • Authors: Zuccaro,A.; Götze,S.; Kneip,S.; Dersch,P.; Seibel,J.; ( Year: 2008). Title: Tailor-made fructooligosaccharides by a combination of substrate and genetic engineering. Journal: ChemBioChem Volume: 9 Issue: 1,  S-Page: 143- E-Page: 149 PubMed
  • Authors: Melzer,G.; Dalpiaz,A.; Grote,A.; Kucklick,M.; Gocke,Y.; Jonas,R.; Dersch,P.; Franco-Lara,E.; Nörtemann,B.; Hempel,D.C.; ( Year: 2007). Title: Metabolic flux analysis using stoichiometric models for Aspergillus niger: comparison under glucoamylase-producing and non-producing conditions. Journal: Journal of Biotechnology Volume: 132 Issue: 4,  S-Page: 405- E-Page: 417 PubMed
  • Authors: Heroven,A.K.; Böhme,K.; Tran-Winkler,H.; Dersch,P.; ( Year: 2007). Title: Regulatory elements implicated in the environmental control of invasin expression in enteropathogenic Yersinia. Journal: Advances in Experimental Medicine and Biology Volume: 603,  S-Page: 156- E-Page: 166 PubMed


Audio Podcast

  • Bakterien mit Thermometer - Vom Kühlschrank in den KörperYersinien machen uns Bauchschmerzen. Wenn wir die Bakterien mit verseuchtem Fleisch zu uns nehmen, infizieren sie unsere Darmzellen und vermehren sich. Aber wie wissen die Yersinien, dass sie nicht mehr in der vergammelten Wurst sind sondern in unserem Körper? Die Antwort ist simpel: Die Bakterien haben ein Thermometer. Hören Sie zu, wie das funktioniert...
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