Innate Immunity and Viral Evasion

If a virus attacks us, our immune system registers this attack and starts a whole chain of reactions. Messengers initiate the release of cellular proteins, through which our cells prevent the spread of viruses – known as antiviral factors. However, some viruses have developed very effective strategies against these antiviral factors, so that the self-protection mechanism of the cells is ultimately insufficient to defend against the infection. Wanted: new antiviral factors which can fight off even these viruses – of which HIV is one. 


Selected Publications

Geis FK, Galla M, Hoffmann D, Kuehle J, Zychlinski D, Maetzig T, Schott JW, Schwarzer A, Goffinet C, Goff SP, Schambach A (2017) Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology 14(1): 34.

Siddharta, A., Pfaender, S., Malassa, A., Doerrbecker, J., Anggakusuma, Engelmann, M., Nugraha, B., Steinmann, J., Todt, D., Vondran, F.W.R., Mateu-Gelabert, P., Goffinet, C., Steinmann, E., Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. Scientific Reports, in press

Xu, S, Ducroux, A, Ponnurangam, A, Franz, S, Vieyres, G, Müsken, M, Zillinger, T, Malassa, A, Ewald, E, Hornung, V, Barchet, W, Häussler, S, Pietschmann, T, Goffinet, C, cGAS-mediated innate immunity spreads intercellularly through HIV-1 Env-induced membrane fusion sites. Cell Host & Microbe 20(4):443-457 (2016)

Goffinet C, Cellular Antiviral Factors that Target Particle Infectivity of HIV-1. Curr HIV Res 14(3):211 (2016)

Kusuma A, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E, Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation. Hepatology 62(3):702-14 (2015)

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