Biostatistics

High-Throughput-technologies generate large amounts of data. The drawback: these biological and medical data must be processed to results with statistical methods and models. Concepts from robust and computational statistics as well as visualisation techniques help to better understand, estimate and cope with the uncertainty and strong variation that are often inherent in biological and medical data.
The project group „Biostatistics“ is part of the research group „Cellular Proteome Research” which is led by Lothar Jänsch.

Leader

Publications

  • Authors: Sieg,A.L.; Martin Das,A.; Maria Muschol,N.; Köhn,A.; Lampe,C.; Kortum,X.; Mehmecke,S.; Blöß,S.; Lechner,W.; Klawonn,F.; Grigull,L.; ( Year: 2019). Title: Artificial intelligence for diagnostic support in selected rare lysosomal storage disorders: Results of a pilot study.Journal: Klin.Padiatr. Volume: 231 Issue: 2, S-Page: 60- E-Page: 66 DOI: 10.1055/a-0816-5681PubMed
  • Authors: Caputo,M.; Zoch-Lesniak,B.; Karch,A.; Vital,M.; Meyer,F.; Klawonn,F.; Baillot,A.; Pieper,D.H.; Mikolajczyk,R.T.; ( Year: 2019). Title: Bacterial community structure and effects of picornavirus infection on the anterior nares microbiome in early childhood.Journal: BMC.Microbiol. Volume: 19 Issue: 1, S-Page: 1 DOI: 10.1186/s12866-018-1372-8HZI repositoryPubMed
  • Authors: Grigull,L.; Mehmecke,S.; Rother,A.K.; Blöß,S.; Klemann,C.; Schumacher,U.; Mücke,U.; Kortum,X.; Lechner,W.; Klawonn,F.; ( Year: 2019). Title: Common pre-diagnostic features in individuals with different rare diseases represent a key for diagnostic support with computerized pattern recognition?.Journal: PLoS One. Volume: 14 Issue: 10, S-Page: e0222637 DOI: 10.1371/journal.pone.0222637HZI repositoryPubMed
  • Authors: Sieg,A.L.; Martin Das,A.; Maria,Muschol N.; Köhn,A.; Lampe,C.; Kortum,X.; Mehmecke,S.; Blöß,S.; Lechner,W.; Klawonn,F.; Grigull,L.; ( Year: 2019). Title: Künstliche Intelligenz zur diagnostischen Unterstützung ausgewählter seltener lysosomaler Speichererkrankungen: Ergebnisse einer Pilotstudie. [Artificial intelligence for diagnostic support in selected rare lysosomal storage disorders: Results of a pilot .Journal: Klin.Padiatr. Volume: 231 Issue: 2, S-Page: 60- E-Page: 66 DOI: 10.1055/a-0816-5681HZI repositoryPubMed
  • Authors: Döring,M.; Blees,H.; Koller,N.; Tischer-Zimmermann,S.; Müsken,M.; Henrich,F.; Becker,J.; Grabski,E.; Wang,J.; Janssen,H.; Zuschratter,W.; Neefjes,J.; Klawonn,F.; Eiz-Vesper,B.; Tampe,R.; Kalinke,U.; ( Year: 2019). Title: Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.Journal: Blood Adv. Volume: 3 Issue: 6, S-Page: 839- E-Page: 850 DOI: 10.1182/bloodadvances.2018027268HZI repositoryPubMed
  • Authors: Franke,R.; Hinkelmann,B.; Fetz,V.; Stradal,T.; Sasse,F.; Klawonn,F.; Brönstrup,M.; ( Year: 2019). Title: xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery.Journal: SLAS.Discov., S-Page: 2472555218819459 DOI: 10.1177/2472555218819459HZI repositoryPubMed
  • Authors: Ambrosch,A.; Wahrburg,K.; Klawonn,F.; ( Year: 2018). Title: Bacterial load and pathogenic species on healthcare personnel attire: implications of alcohol hand-rub use, profession, and time of duty.Journal: J Hosp Infect Volume: 101 Issue: 4, S-Page: 414- E-Page: 421 DOI: 10.1016/j.jhin.2018.10.017WEBURLS
  • Authors: Bernal,I.; Hofmann,J.D.; Bulitta,B.; Klawonn,F.; Michel,A.M.; Jahn,D.; Neumann-Schaal,M.; Bruder,D.; Jänsch,L.; ( Year: 2018). Title: Clostridioides difficile activates human mucosal-associated invariant t cells.Journal: Front.Microbiol. Volume: 9 Issue: OCT DOI: 10.3389/fmicb.2018.02532HZI repositoryPubMed
  • Authors: Croce,P.; Marsili,F.; Klawonn,F.; Formichi,P.; Landi,F.; ( Year: 2018). Title: Evaluation of statistical parameters of concrete strength from secondary experimental test data.Journal: Constr Build Mater Volume: 163, S-Page: 343- E-Page: 359 DOI: 10.1016/j.conbuildmat.2017.11.001WEBURLS
  • Authors: Klawonn,F.; ( Year: 2018). Title: Exploring time-resolved data for patterns and validating single clusters.Book Title: Frontiers in Computational Intelligence Publisher: Springer, S-Page: 61- E-Page: 71 DOI: 10.1007/978-3-319-67789-7_5PubMed
  • Authors: Bietenbeck,A.; Geilenkeuser,W.J.; Klawonn,F.; Spannagl,M.; Nauck,M.; Petersmann,A.; Thaler,M.A.; Winter,C.; Luppa,P.B.; ( Year: 2018). Title: External quality assessment schemes for glucose measurements in Germany: Factors for successful participation, analytical performance and medical impact.Journal: Clin.Chem.Lab.Med. Volume: 56 Issue: 8, S-Page: 1238- E-Page: 1250 DOI: 10.1515/cclm-2017-1142FulltextPubMed
  • Authors: Kortum,X.; Grigull,L.; Muecke,U.; Lechner,W.; Klawonn,F.; ( Year: 2018). Title: Improving the Decision Support in Diagnostic Systems Using Classifier Probability Calibration.Book Title: Intelligent Data Engineering and Automated Learning - IDEAL 2018 : 19th International Conference, Madrid, Spain, November 21-23, 2018, Proceedings, Part I Editors: Yin,H.; Camacho,D.; Novais,P.; Tallon-Ballesteros,A.J.; (Ed.). Publisher: Springer, S-Page: 419- E-Page: 428 DOI: 10.1007/978-3-030-03493-1_44HZI repositoryWEBURLS
  • Authors: Hoffmann,G.; Klawonn,F.; ( Year: 2018). Title: Indirekte Überprüfung von Referenzintervallen - Leberwerte in neuem Licht.Journal: Trillium Diagnostik Volume: 2018 Issue: 2 DOI: -WEBURLS
  • Authors: Brennecke,A.-M.; Düber,S.; Roy,B.; Thomsen,I.; Garbe,A.I.; Klawonn,F.; Pabst,O.; Kretschmer,K.; Weiss,S.; ( Year: 2018). Title: Induced B Cell Development in Adult Mice.Journal: Front Immunol Volume: 9, S-Page: 2483 DOI: 10.3389/fimmu.2018.02483HZI repositoryPubMed
  • Authors: Hoffmann,G.; Klawonn,F.; Lichtinghagen,R.; Orth,M.; ( Year: 2018). Title: Letter to the editor by Winter et al.: Reply.Journal: J.Lab.Med. Volume: 42 Issue: 1-2, S-Page: 63- E-Page: 65 DOI: 10.1515/labmed-2018-0011HZI repositoryWEBURLS
  • Authors: Kuhn,M.; Sühs,K.W.; Akmatov,M.K.; Klawonn,F.; Wang,J.; Skripuletz,T.; Kaever,V.; Stangel,M.; Pessler,F.; ( Year: 2018). Title: Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.Journal: J.Neuroinflammation. Volume: 15 Issue: 1, S-Page: 20 WORKTYPEHZI repositoryPubMed
  • Authors: Voigt,J.; Malone,D.F.G.; Dias,J.; Leeansyah,E.; Björkstrom,N.K.; Ljunggren,H.G.; Gröbe,L.; Klawonn,F.; Heyner,M.; Sandberg,J.K.; Jänsch,L.; ( Year: 2018). Title: Proteome analysis of human CD56(neg) NK cells reveals a homogeneous phenotype surprisingly similar to CD56(dim) NK cells.Journal: European Journal of Immunology Volume: 48 Issue: 9, S-Page: 1456- E-Page: 1469 DOI: 10.1002/eji.201747450PubMed
  • Authors: Bulitta,B.; Zuschratter,W.; Bernal,I.; Bruder,D.; Klawonn,F.; von,Bergen M.; Garritsen,H.S.P.; Jänsch,L.; ( Year: 2018). Title: Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype.Journal: European Journal of Immunology Volume: 48 Issue: 8, S-Page: 1336- E-Page: 1349 DOI: 10.1002/eji.201747398PubMed
  • Authors: Ambrosch,A.; Klinger,A.; Luber,D.; Arp,C.; Lepiorz,M.; Schroll,S.; Klawonn,F.; ( Year: 2018). Title: [Clinical Characteristics and Course of Infections by Influenza A- and Respiratory Syncytial Virus (RSV) in Hospitalized Adults] Symptomatologie und klinischer Verlauf bei hospitalisierten Erwachsenen mit Virusinfektionen durch Influenza A und Respiratory.Journal: Dtsch.Med.Wochenschr. DOI: 10.1055/s-0044-102004PubMed
  • Authors: Hoffmann,G.; Klawonn,F.; Lichtinghagen,R.; Orth,M.; ( Year: 2018). Title: [The zlog-value as basis for the standardization of laboratory results] Der zlog-Wert als Basis für die Standardisierung von Laborwerten.Journal: LaboratoriumsMedizin Volume: 41 Issue: 1, S-Page: 23- E-Page: 32 DOI: 10.1515/labmed-2016-0087FulltextHZI repositoryPubMed
  • Authors: Hoffmann,G.; Klawonn,F.; ( Year: 2017). Title: Big Data in der Labormedizin: Von der Utopie zur Strategie.Journal: Trillum Diagnostik Volume: 14 Issue: 1, S-Page: 24- E-Page: 26 DOI: -PubMed
  • Authors: Lingel,H.; Wissing,J.; Arra,A.; Schanze,D.; Lienenklaus,S.; Klawonn,F.; Pierau,M.; Zenker,M.; Jänsch,L.; Brunner-Weinzierl,M.C.; ( Year: 2017). Title: CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.Journal: Cell Death.Differ. Volume: 24 Issue: 10, S-Page: 1739- E-Page: 1749 DOI: 10.1038/cdd.2017.102 HZI repository PubMed
  • Authors: Blöß,S.; Klemann,C.; Rother,A.K.; Mehmecke,S.; Schumacher,U.; Mücke,U.; Mücke,M.; Stieber,C.; Klawonn,F.; Kortum,X.; Lechner,W.; Grigull,L.; ( Year: 2017). Title: Diagnostic needs for rare diseases and shared prediagnostic phenomena: Results of a German-wide expert Delphi survey.Journal: PLoS ONE Volume: 12 Issue: 2, S-Page: e0172532 DOI: 10.1371/journal.pone.0172532HZI repositoryPubMed
  • Authors: Tschumitschew,K.; Klawonn,F.; ( Year: 2017). Title: Effects of drift and noise on the optimal sliding window size for data stream regression models.Journal: Commun Stat Theory Methods Volume: 46 Issue: 10, S-Page: 5109- E-Page: 5132 DOI: 10.1080/03610926.2015.1096388HZI repositoryWEBURLS
  • Authors: Bakuli,A.; Klawonn,F.; Karch,A.; Mikolajczyk,R.; ( Year: 2017). Title: Effects of pathogen dependency in a multi-pathogen infectious disease system including population level heterogeneity-a simulation study.Journal: Theor.Biol.Med.Model. Volume: 14 Issue: 1, S-Page: Article number 26 DOI: 10.1186/s12976-017-0072-7HZI repositoryWEBURLS
  • Authors: Mücke,U.; Klemann,C.; Baumann,U.; Meyer-Bahlburg,A.; Kortum,X.; Klawonn,F.; Lechner,W.M.; Grigull,L.; ( Year: 2017). Title: Patient's Experience in Pediatric Primary Immunodeficiency Disorders: Computerized Classification of Questionnaires.Journal: Front Immunol. Volume: 8 Issue: 5, S-Page: Article 384 DOI: 10.3389/fimmu.2017.00384HZI repositoryPubMed
  • Authors: Bietenbeck,A.; Thaler,M.A.; Luppa,P.B.; Klawonn,F.; ( Year: 2017). Title: Stronger Together: Aggregated Z-values of Traditional Quality Control Measurements and Patient Medians Improve Detection of Biases.Journal: Clin.Chem. Volume: 63 Issue: 8, S-Page: 1377- E-Page: 1387 DOI: 10.1373/clinchem.2016.269845PubMed
  • Authors: Van Ham,M.; Teich,R.; Philipsen,L.; Niemz,J.; Amsberg,N.; Wissing,J.; Nimtz,M.; Grobe,L.; Kliche,S.; Thiel,N.; Klawonn,F.; Hubo,M.; Jonuleit,H.; Reichardt,P.; Muller,A.J.; Hühn,J.; Jänsch,L.; ( Year: 2017). Title: TCR signalling network organization at the immunological synapses of murine regulatory T cells.Journal: European Journal of Immunology Volume: 47 Issue: 12, S-Page: 2043- E-Page: 2058 DOI: 10.1002/eji.201747041HZI repositoryPubMed
  • Authors: Abidi,N.; Franke,R.; Findeisen,P.; Klawonn,F.; ( Year: 2016). Title: Alignment of time-resolved data from high throughput experiments.Journal: J.Bioinformatics Comput.Biol. Volume: 14 Issue: 6, S-Page: 1650030 DOI: 10.1142/S021972001650030XPubMed
  • Authors: Nguyen,V.K.; Klawonn,F.; Mikolajczyk,R.; Hernandez-Vargas,E.A.; ( Year: 2016). Title: Analysis of practical identifiability of a viral infection model.Journal: PLoS ONE Volume: 11 Issue: 12, S-Page: e0167568 DOI: 10.1371/journal.pone.0167568HZI repositoryPubMed
  • Authors: Kortum,X.; Grigull,L.; Muecke,U.; Lechner,W.; Klawonn,F.; ( Year: 2016). Title: Diagnosis support for orphan diseases - a case study using a classifier fusion method.Book Title: Intelligent Data Engineering and Automated Learning - IDEAL 2016 Editors: Yin,H.; Gao,Y.; Li,B.; Zhang,D.; Yang,M.; Li,Y.; Klawonn,Frank; Tallón-Ballesteros,A.J.; (Ed.). City: Cham Publisher: Springer, S-Page: 379- E-Page: 385 ISBN: 978-3-319-46256-1 (ISBN)DOI: 10.1007/978-3-319-46257-8_41PubMed
  • Authors: Grigull,L.; Lechner,W.; Petri,S.; Kollewe,K.; Dengler,R.; Mehmecke,S.; Schumacher,U.; Lucke,T.; Schneider-Gold,C.; Kohler,C.; Guttsches,A.K.; Kortum,X.; Klawonn,F.; ( Year: 2016). Title: Diagnostic support for selected neuromuscular diseases using answer-pattern recognition and data mining techniques: a proof of concept multicenter prospective trial.Journal: BMC Med.Inform.Decis.Mak. Volume: 16 Issue: 1, S-Page: 31 DOI: 10.1186/s12911-016-0268-5HZI repositoryPubMed
  • Authors: Klawonn,F.; ( Year: 2016). Title: Exploring Data Sets for Clusters and Validating Single Clusters.Journal: Procedia Computer Science Volume: 96, S-Page: 1381- E-Page: 1390 DOI: 10.1016/j.procs.2016.08.183WEBURLS
  • Authors: Klawonn,F.; Wang,J.; Koch,I.; Eberhard,J.; Omar,M.; ( Year: 2016). Title: HAUCA curves for the evaluation of biomarker pilot studies with small sample sizes and large numbers of features.Journal: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics Volume: 9897, S-Page: 356- E-Page: 367 DOI: 10.1007/978-3-319-46349-0_31WEBURLS
  • Authors: Thumfart,J.O.; Abidi,N.; Mindt,S.; Costina,V.; Hofheinz,R.; Klawonn,F.; Neumaier,M.; Findeisen,P.; ( Year: 2016). Title: LC/MS based monitoring of endogenous decay markers for quality assessment of serum specimens.Journal: J Proteomics Bioinform Volume: 8 Issue: 5, S-Page: 091- E-Page: 097 DOI: 10.4172/jpb.1000356HZI repositoryPubMed
  • Authors: Kummer,A.; Nishanth,G.; Koschel,J.; Klawonn,F.; Schluter,D.; Jänsch,L.; ( Year: 2016). Title: Listeriosis down-regulates hepatic cytochrome P450 enzymes in sub-lethal murine infection.Journal: Proteomics Clin.Appl. Volume: 10 Issue: 9-10, S-Page: 1025- E-Page: 1035 DOI: 10.1002/prca.201600030PubMed
  • Authors: Seeger,B.; Klawonn,F.; Nguema,Bekale B.; Steinberg,P.; ( Year: 2016). Title: Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor alpha and beta.Journal: PLoS ONE Volume: 11 Issue: 1, S-Page: e0147490 DOI: 10.1371/journal.pone.0147490HZI repositoryPubMed
  • Authors: Khaledi,A.; Schniederjans,M.; Pohl,S.; Rainer,R.; Bodenhofer,U.; Xia,B.; Klawonn,F.; Bruchmann,S.; Preusse,M.; Eckweiler,D.; Dötsch,A.; Häußler,S.; ( Year: 2016). Title: Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa.Journal: Antimicrobial Agents Chemother. Volume: 60 Issue: 8, S-Page: 4722- E-Page: 4733 DOI: 10.1128/AAC.00075-16PubMed
  • Authors: Omar,M.; Klawonn,F.; Brand,S.; Stiesch,M.; Krettek,C.; Eberhard,J.; ( Year: 2016). Title: Transcriptome-Wide High-Density Microarray Analysis Reveals Differential Gene Transcription in Periprosthetic Tissue From Hips With Chronic Periprosthetic Joint Infection vs Aseptic Loosening.Journal: J Arthroplasty Volume: 32, S-Page: 234- E-Page: 240 DOI: 10.1016/j.arth.2016.06.036PubMed
  • Authors: Pfaender,S.; Walter,S.; Todt,D.; Behrendt,P.; Doerrbecker,J.; Woelk,B.; Engelmann,M.; Gravemann,U.; Seltsam,A.; Steinmann,J.; Burbelo,P.D.; Klawonn,F.; Feige,K.; Pietschmann,T.; Cavalleri,J.M.; Steinmann,E.; ( Year: 2015). Title: Assessment of cross-species transmission of hepatitis C-related non-primate hepacivirus in a population of humans at high risk of exposure.Journal: J Gen.Virol. Volume: 96 Issue: 9, S-Page: 2636- E-Page: 2642 DOI: 10.1099/vir.0.000208HZI repositoryPubMed
  • Authors: Rother,A.K.; Schwerk,N.; Brinkmann,F.; Klawonn,F.; Lechner,W.; Grigull,L.; ( Year: 2015). Title: Diagnostic Support for Selected Paediatric Pulmonary Diseases Using Answer-Pattern Recognition in Questionnaires Based on Combined Data Mining Applications-A Monocentric Observational Pilot Study.Journal: PLoS ONE Volume: 10 Issue: 8, S-Page: e0135180 DOI: 10.1371/journal.pone.0135180HZI repositoryPubMed
  • Authors: Klawonn,F.; Kruse,R.; Winkler,R.; ( Year: 2015). Title: Fuzzy clustering: More than just fuzzification.Journal: Fuzzy Sets Syst Volume: 281, S-Page: 272- E-Page: 279 DOI: 10.1016/j.fss.2015.06.024HZI repositoryPubMed
  • Authors: Preusse,M.; Schughart,K.; Wilk,E.; Klawonn,F.; Pessler,F.; ( Year: 2015). Title: Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains Infectious Diseases.Journal: BMC Res.Notes Volume: 8 Issue: 1, S-Page: Article number 225 DOI: 10.1186/s13104-015-1195-8HZI repositoryPubMed
  • Authors: Szafranski,S.P.; Wos-Oxley,M.L.; Vilchez-Vargas,R.; Jauregui,R.; Plumeier,I.; Klawonn,F.; Tomasch,J.; Meisinger,C.; Kühnisch,J.; Sztajer,H.; Pieper,D.H.; Wagner-Döbler,I.; ( Year: 2015). Title: High-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis.Journal: Appl.Environ.Microbiol. Volume: 81 Issue: 3, S-Page: 1047- E-Page: 1058 DOI: 10.1128/AEM.03534-14HZI repositoryPubMed
  • Authors: König,J.; Grigull,L.; Fritsch,H.-W.; Klawonn,F.; ( Year: 2015). Title: IT-Unterstützung zur Diagnosefindung seltener Erkrankungen - Umfassende Datenanalyse bei komplexen Fällen.Journal: Der Klinikarzt Volume: 44, S-Page: 16- E-Page: 21
  • Authors: J. König, L. Grigull, H.-W. Fritsch, F. Klawonn; ( Year: 2015). Title: IT-Unterstützung zur Diagnosefindung seltener Erkrankungen - Umfassende Datenanalyse bei komplexen Fällen.Journal: Der Klinikarzt Issue: 44, S-Page: 16- E-Page: 21
  • Authors: Wirsing,L.; Klawonn,F.; Sassen,W.A.; Lünsdorf,H.; Probst,C.; Hust,M.; Mendel,R.R.; Kruse,T.; Jänsch,L.; ( Year: 2015). Title: Linear Discriminant Analysis Identifies Mitochondrially Localized Proteins in Neurospora crassa.Journal: J Proteome.Res Volume: 14 Issue: 9, S-Page: 3900- E-Page: 3911 PubMed
  • Authors: Worthmann,H.; Tryc,A.B.; Dirks,M.; Schuppner,R.; Brand,K.; Klawonn,F.; Lichtinghagen,R.; Weissenborn,K.; ( Year: 2015). Title: Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection.Journal: J.Neuroinflamm. Volume: 12 Issue: 1 DOI: 10.1186/s12974-014-0231-2HZI repositoryPubMed
  • Authors: Novoselova,N.; Wang,J.; Klawonn,F.; ( Year: 2015). Title: Optimized leaf ordering with class labels for hierarchical clustering.Journal: J.Bioinformatics Comput.Biol. Volume: 13 Issue: 4, S-Page: Article number 1550012 WEBURLS
  • Authors: Winkler,R.; Klawonn,F.; Kruse,R.; ( Year: 2015). Title: Prototype based fuzzy clustering algorithms in high-dimendional features spaces.Journal: Studies in Fuzzines and Soft Computing Volume: 322, S-Page: 233- E-Page: 243
  • Authors: Rand,U.; Riedel,J.; Hillebrand,U.; Shin,D.; Willenberg,S.; Behme,S.; Klawonn,F.; Köster,M.; Hauser,H.; Wirth,D.; ( Year: 2015). Title: Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters.Journal: Biotechnol.J. Volume: 10 Issue: 2, S-Page: 323- E-Page: 331 WEBURLS
  • Authors: Seeger,B.; Klawonn,F.; Bekale,B.N.; Steinberg,P.; ( Year: 2015). Title: The ability of the YAS and AR CALUX assays to detect the additive effects of anti-androgenic fungicide mixtures.Journal: Toxicol.Lett. Volume: 241, S-Page: 193- E-Page: 199 PubMed
  • Authors: Wu,Ching-Fang; Andzinski,Lisa; Kasnitz,Nadine; Kröger,Andrea; Klawonn,Frank; Lienenklaus,Stefan; Weiss,Siegfried; Jablonska,Jadwiga; ( Year: 2015). Title: The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung.Journal: International Journal of Cancer Volume: 137, S-Page: 837- E-Page: 847 PubMed
  • Authors: Casilag,F.; Lorenz,A.; Kruger,J.; Klawonn,F.; Weiss,S.; Häußler,S.; ( Year: 2015). Title: The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition.Journal: Infection and Immunity Volume: 84, S-Page: 162- E-Page: 171 PubMed
  • Authors: Zhang,X.; Klawonn,F.; Grigull,L.; Lechner,W.; ( Year: 2015). Title: VoQs: A web application for visualization of questionnaire surveys.Journal: Lecture Notes in Computer Science Volume: 9385, S-Page: 334- E-Page: 343
  • Authors: Klawonn,F.; Höppner,F.; Jayaram,B.; ( Year: 2015). Title: What are clusters in high dimensions and are they difficult to find?.Journal: Lecture Notes in Computer Science Volume: 7627, S-Page: 14- E-Page: 33
  • Authors: Ince,K.; Klawonn,Frank; ( Year: 2014). Title: Decision and regression trees in the context of attributes with different granularity levels.Journal: Studies in Fuzziness and Soft Computing Volume: 285, S-Page: 331- E-Page: 342
  • Authors: Milanez-Almeida,P.; Klawonn,F.; Meyer-Hermann,M.; Hühn,J.; ( Year: 2014). Title: Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 4 Issue: 3, S-Page: 147- E-Page: 155 PubMed
  • Authors: Ince,K.; Klawonn,Frank; ( Year: 2014). Title: Handling different levels of granularity within naive Bayes classifiers.Journal: Lecture Notes in Computer Science Volume: 8206 LNCS, S-Page: 521- E-Page: 528
  • Authors: Tschumitschew,K.; Klawonn,Frank; ( Year: 2014). Title: High against low quantile comparison for biomarker and classifier evalution.Journal: Lecture Notes in Computer Science Volume: 8206 LNCS, S-Page: 561- E-Page: 568
  • Authors: Shevchuk,Olga; Abidi,Nada; Klawonn,Frank; Wissing,Josef; Nimtz,Manfred; Kugler,C.; Steinert,M.; Goldmann,T.; Jänsch,Lothar; ( Year: 2014). Title: HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies.Journal: Journal of Proteome Research Volume: 13 Issue: 11, S-Page: 5230- E-Page: 5239 WEBURLS
  • Authors: Novoselova,N.; Della,Beffa Cristina; Wang,Junxi; Li,J.; Pessler,Frank; Klawonn,Frank; ( Year: 2014). Title: HUM calculator and HUM package for R: easy-to-use software tools for multicategory receiver operating characteristic analysis.Journal: Bioinformatics Volume: 30 Issue: 11, S-Page: 1635- E-Page: 1636 PubMed
  • Authors: Montvida,O.; Klawonn,Frank; ( Year: 2014). Title: Relative cost curves: An alternative to AUC and an extension to 3-class problems.Journal: Kybernetika Volume: 50 Issue: 5, S-Page: 647- E-Page: 660 WEBURLS
  • Authors: Wuestefeld,T.; Pesic,M.; Rudalska,R.; Dauch,D.; Longerich,T.; Kang,T.W.; Yevsa,T.; Heinzmann,F.; Hoenicke,L.; Hohmeyer,A.; Potapova,A.; Rittelmeier,I.; Jarek,Michael; Geffers,Robert; Scharfe,Maren; Klawonn,Frank; Schirmacher,P.; Malek,N.P.; Ott,M.; Nordheim,A.; Vogel,A.; Manns,M.P.; Zender,L.; ( Year: 2013). Title: A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.Journal: Cell Volume: 153 Issue: 2, S-Page: 389- E-Page: 401 WEBURLS
  • Authors: Klawonn,Frank; Jayaram,B.; Crull,Katja; Kukita,A.; Pessler,Frank; ( Year: 2013). Title: Analysis of contingency tables based on generalized median polish with power transformations and non-additive models.Journal: Health Information Science & Systems Volume: 1, S-Page: 11
  • Authors: Jayaram,B.; Klawonn,Frank; ( Year: 2013). Title: Can fuzzy clustering avoid local minima and undesired partitions?.Journal: Studies in Computational Intelligence Volume: 445, S-Page: 31- E-Page: 44
  • Authors: Klawonn,Frank; ( Year: 2013). Title: Case-centred multidimensional scaling for classification visualisation in medical diagnosis.Journal: LNCS Volume: 7798, S-Page: 137- E-Page: 148 DOI: 10.1007/978-3-642-37899-7_12HZI repository
  • Authors: Tschumitschew,K.; Klawonn,Frank; ( Year: 2013). Title: Change Detection Based on the Distribution of p-Values.Book Title: Towards Advanced Data Analysis by Combining Soft Computing and Statistics Editors: Borgelt,C.; Gil,M.A.; Sousa,J.M.C.; Verleysen,M.; (Ed.). City: Berlin Publisher: Springer, S-Page: 191- E-Page: 203 ISBN: 978-3-642-30277-0 (ISBN)DOI: 10.1007/978-3-642-30278-7_16
  • Authors: Jayaram,B.; Klawonn,Frank; ( Year: 2013). Title: Generalised median Polish based on additive generators.Journal: Advances in Intelligent Systems and Computing Volume: 190 AISC, S-Page: 439- E-Page: 448
  • Authors: Preusse,M.; Tantawy,M.A.; Klawonn,F.; Schughart,K.; Pessler,F.; ( Year: 2013). Title: Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice.Journal: BMC Microbiology Volume: 13 Issue: 1, S-Page: art.no. 293 WEBURLS
  • Authors: Scheiter,Maxi; Bulitta,Björn; van,Ham Marco; Klawonn,Frank; Konig,S.; Jänsch,Lothar; ( Year: 2013). Title: Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions.Journal: Frontiers in Immunology Volume: 4, S-Page: 66 DOI: 10.3389/fimmu.2013.00066HZI repositoryPubMed
  • Authors: Scheiter,Maxi; Lau,Ulrike; van,Ham Marco; Bulitta,Björn; Gröbe,Lothar; Garritsen,H.; Klawonn,Frank; Konig,S.; Jänsch,Lothar; ( Year: 2013). Title: Proteome analysis of distinct developmental stages of human natural killer (NK) cells.Journal: Molecular and Cellular Proteomics Volume: 12 Issue: 5, S-Page: 1099- E-Page: 1114 DOI: 10.1074/mcp.M112.024596HZI repositoryPubMed
  • Authors: Bodenhofer,U.; Krone,M.; Klawonn,Frank; ( Year: 2013). Title: Testing noisy numerical data for monotonic association.Journal: Information Sciences Volume: 245, S-Page: 21- E-Page: 37 DOI: 10.1016/j.ins.2012.11.026HZI repositoryPubMed
  • Authors: Della Beffa,Cristina; Slansky,E.; Pommerenke,C.; Klawonn,Frank; Li,J.; Dai,L.; Schumacher,H.R.,Jr.; Pessler,Frank; ( Year: 2013). Title: The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification.Journal: PLoS ONE Volume: 8 Issue: 8, S-Page: e72494 DOI: 10.1371/journal.pone.0072494HZI repositoryPubMed
  • Authors: Abidi,N.; Klawonn,Frank; Thumfart,J.O.; ( Year: 2013). Title: Time point estimation of a single sample from high throughput experiments based on time-resolved data and robust correlation measures.Journal: LNCS (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)) Volume: 8207, S-Page: 32- E-Page: 43
  • Authors: Klawonn,F.; ( Year: 2013). Title: What can fuzzy cluster analysis contribute to clustering of high-dimensional data?.Journal: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) Volume: 8256 LNAI, S-Page: 1- E-Page: 14
  • Authors: Pommerenke,C.; Friedrich,B.; Johl,T.; Jänsch,Lothar; Häußler,Susanne; Klawonn,F.; ( Year: 2012). Title: A modified apriori algorithm for analysing high-dimensional gene data.Journal: LNCS Volume: 6936, S-Page: 236- E-Page: 243
  • Authors: Winkler,R.; Kruse,R.; Klawonn,Frank; ( Year: 2012). Title: A New Distance Function for Fuzzy c-Means Clustering in High-Dimensional Spaces with Applications in S.O.D.A..Book Title: Data Analysis Methods and its Applications Editors: Pociecha,J.; Decker,R.; (Ed.). City: Warszawa Publisher: Wydawnictwo C.H. Beck ISBN: 978-83-7252-578-9 (ISBN)
  • Authors: Jayaram,B.; Klawonn,Frank; ( Year: 2012). Title: Can unbounded distance measures mitigate the curse of dimensionality?.Journal: International Journal of Data Mining, Modelling and Management Volume: 4 Issue: 4, S-Page: 361- E-Page: 383 DOI: 10.1504/IJDMMM.2012.049883
  • Authors: Klawonn,F.; Abidi,N.; Berger,E.; Jänsch,Lothar*; ( Year: 2012). Title: Curve fitting for short time series data from high throughput experiments with correction for biological variation.Journal: Lecture Notes in Computer Science Volume: LNCS 7619, S-Page: 150- E-Page: 160
  • Authors: Johl,T.; Nimtz,Manfred; Jänsch,Lothar; Klawonn,Frank; ( Year: 2012). Title: Detecting glycosylations in complex samples.Journal: IFIP Advances in Information and Communication Technology Volume: 381 AICT (Part 1) Issue: 234, S-Page: 243
  • Authors: Nedelko,T.; Kollmus,H.; Klawonn,F.; Spijker,S.; Lu,L.; Hessman,M.; Alberts,R.; Williams,R.W.; Schughart,K.; ( Year: 2012). Title: Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.Journal: BMC GENOMICS Volume: 13, S-Page: 411 DOI: 10.1186/1471-2164-13-411HZI repositoryPubMed
  • Authors: Tschumitschew,K.; Klawonn,F.; ( Year: 2012). Title: Incremental statistical measures.Book Title: Learning in Non-Stationary Environments: Methods and Applications Publisher: Springer New York, S-Page: 21- E-Page: 55 ISBN: 9781441980205 (ISBN)1441980199 (ISBN)9781441980199 (ISBN)WEBURLS
  • Authors: Klawonn,Frank; Crull,Katja; Kukita,A.; Pessler,Frank; ( Year: 2012). Title: Median polish with power transformations as an alternative for the analysis of contingency tables with patient data.Journal: LNCS (Lecture Notes in Computer Sience (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)) Volume: 7231, S-Page: 25- E-Page: 35
  • Authors: Grigull,L.; Betzel,C.; Schumacher,U.; Rother,A.-K.; Mücke,U.; Klawonn,F.; Lechner,W.M.; ( Year: 2012). Title: Should paediatricians use a computer to receive diagnostic support? [Sollten Kinderärzte zur Unterstützung bei der Diagnostik einen Computer nutzen?].Journal: Pediatrische Praxis Volume: 79 Issue: 4, S-Page: 545- E-Page: 555
  • Authors: Gernert,C.; Klawonn,Frank; Jänsch,Lothar; ( Year: 2012). Title: SignalNet: Visualization of signal network responses by quantitative proteome data.Journal: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics Volume: 6936 LNCS, S-Page: 361- E-Page: 368
  • Authors: Klawonn,Frank; ( Year: 2012). Title: Significance tests to identify regulated proteins based on a large number of small samples.Journal: Kybernetika Volume: 48 Issue: 3, S-Page: 478- E-Page: 493
  • Authors: Gernert,C.; Berger,E.; Klawonn,F.; Jänsch,Lothar; ( Year: 2012). Title: Tackling misleading peptide regulation fold changes in quantitative proteomics.Journal: Advances in Intelligent and Soft Computing Volume: 154, S-Page: 269- E-Page: 276
  • Authors: Klawonn,Frank*; Höppner,F.; May,S.; ( Year: 2011). Title: An alternative to ROC and AUC analysis of classifiers.Journal: LNCS (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)) Volume: 7014, S-Page: 210- E-Page: 221
  • Authors: Georgieva,O.; Tschumitschew,K.; Klawonn,Frank*; ( Year: 2011). Title: Cluster validity measures based on the minimum description length principle.Journal: Lecture Notes in Computer Science Volume: 6881 LNAI (part 1), S-Page: 82- E-Page: 89
  • Authors: Della Beffa,Cristina*; Klawonn,Frank*; Menetski,J.P.; Schumacher,H.R.; Pessler,Frank*; ( Year: 2011). Title: Evaluation of glyceraldehyde-3-phosphate, prolylpeptidyl isomerase A, and a set of stably expressed genes as reference mRNAs in urate crystal inflammation.Journal: BMC Research Notes Volume: 4, S-Page: 443 DOI: 10.1186/1756-0500-4-443HZI repository
  • Authors: Winkler,R.; Klawonn,Frank*; Kruse,R.; ( Year: 2011). Title: Fuzzy clustering with polynomial fuzzifier function in connection with m-estimators.Journal: Applied and Computational Mathematics Volume: 10 Issue: 1, S-Page: 146- E-Page: 163
  • Authors: Krone,M.; Klawonn,Frank*; Lührs,Thorsten*; ( Year: 2011). Title: Identification of nuclear magnetic resonance signals via Gaussian mixture decomposition.Journal: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) Volume: 7014 LNCS, S-Page: 234- E-Page: 245
  • Authors: Novoselova,N.; Klawonn,Frank*; Johl,T.; Reinl,T.; Jänsch,Lothar*; ( Year: 2011). Title: Identification of peptides with deviating regulation factors using a robust clustering scheme.Journal: Advances in Intelligent and Soft Computing Volume: 93, S-Page: 263- E-Page: 270
  • Authors: Krone,M.; Klawonn,Frank*; ( Year: 2011). Title: Rank correlation coefficient correction by removing worst cases.Book Title: Information Processing and Management of Uncertainty in Knowledge-Based Systems: Theory and Methods Editors: Hüllermeier,E.; Kruse,R.; Hoffmann,F.; (Ed.). City: Berlin Publisher: Springer, S-Page: 356- E-Page: 364 ISBN: 978-364214054-9 (ISBN)DOI: 10.1007/978-3-642-14055-6_37PubMed
  • Authors: Dötsch,A.; Klawonn,F.; Jarek,M.; Scharfe,M.; Blöcker,Helmut*; Häußler,Susanne*; ( Year: 2010). Title: Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa.Journal: BMC GENOMICS Volume: 11, S-Page: 234 DOI: 10.1186/1471-2164-11-234HZI repositoryPubMed
  • Authors: Alberts,R.; Srivastava,B.; Wu,H.; Viegas,N.; Geffers,Robert*; Klawonn,F.; Novoselova,N.; Zaverucha,do,V; Panthier,J.J.; Schughart,Klaus*; ( Year: 2010). Title: Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection.Journal: Microbes and Infection Volume: 12 Issue: 4, S-Page: 309- E-Page: 318 DOI: 10.1016/j.micinf.2010.01.008HZI repositoryPubMed
  • Authors: Pommerenke,C.; Musken,M.; Becker,T.; Dotsch,A.; Klawonn,Frank*; Häußler,Susanne*; ( Year: 2010). Title: Global genotype-phenotype correlations in Pseudomonas aeruginosa.Journal: PLoS Pathogens Volume: 6 Issue: 8, S-Page: 89- E-Page: 90 DOI: 10.1371/journal.ppat.1001074HZI repositoryPubMed
  • Authors: Tschumitschew,K.; Klawonn,Frank*; ( Year: 2010). Title: Incremental quantile estimation.Journal: Evolving Systems Volume: 1 Issue: 4, S-Page: 253- E-Page: 264
  • Authors: Klawonn,F.; Wüstefeld,T.; Zender,Lars*; ( Year: 2010). Title: Statistical modelling for data from experiments with short haripin RNAs.Journal: LNCS (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)) Volume: 6065, S-Page: 79- E-Page: 90 HZI repositoryPubMed
  • Authors: Tschumitschew,K.; Klawonn,Frank*; ( Year: 2010). Title: The need for benchmarks with data from stochastic processes and meta-models in evolving systems.Book Title: Proceedings of the International Symposium on Evolving Intelligent Systems Editors: Angelov,P.; Filev,D.; Kasabov,N.; (Ed.). City: Leicester Publisher: SSAISB, S-Page: 30- E-Page: 33
  • Authors: Tschumitschew,K.; Klawonn,Frank*; ( Year: 2009). Title: AVEDA: Statistical tests for finding interesting visulatisations.Journal: 5711 LNAI (Part 1) Volume: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, S-Page: 235- E-Page: 242
  • Authors: Höppner,F.; Klawonn,Frank*; ( Year: 2009). Title: Compensation of translational displacement in time series clustering using cross correlation.Journal: Lecture Notes in Computer Science Volume: (57772 LCNS), S-Page: 71- E-Page: 82
  • Authors: Hundertmark,C.; Fischer,R.; Reinl,T.; May,S.; Klawonn,F.; Jänsch,Lothar*; ( Year: 2009). Title: MS-specific noise model reveals the potential of iTRAQ in quantitative proteomics.Journal: Bioinformatics Volume: 25 Issue: 8, S-Page: 1004- E-Page: 1011 DOI: 10.1093/bioinformatics/btn551HZI repositoryPubMed
  • Authors: Hundertmark,Claudia*; Klawonn,Frank*; ( Year: 2008). Title: Clustering likelihood curves: Finding deviations from single clusters.Book Title: Hybrid Artificial Intelligence Systems Editors: Carchado,E.; Abraham,A.; Pedrycz,W.; (Ed.). City: Berlin Heidelberg Publisher: Springer Verlag, S-Page: 385- E-Page: 391 ISBN: 978-3-540-97655-7 (ISBN)DOI: 10.1007/978-3-540-87656-4
  • Authors: Reinl,Tobias*; Wissing,Josef*; Fischer,R.; Hundertmark,C.; Klawonn,F.; Daub,H.; Wehland,Jürgen*; Jänsch,Lothar*; ( Year: 2006). Title: Quantitative analysis of receptor tyrosine kinase signaling exploited by Listeria monocytogenes.Journal: Molecular & Cellular Proteomics Volume: 5 Issue: 10, S-Page: S168- E-Page: S168 654 Suppl.
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