Microbial Drugs

The majority of the medically important antibiotic drugs (including e.g., penicillins, cephalosporins, erythromycin, vancomycin, and daptomycin) are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches based on synthetic chemistry, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.

Leader

Team

Dr Frank Surup

Scientist

Portrait of Frank Surup, Scientist

+49 531 6181-4256

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Curriculum Vitae

PROFESSIONAL APPOINTMENTS:

07/2010-present   
Research associate at the research groups of Prof. Müller & Stadler Helmholtz Centre for Infection Research, Braunschweig, Germany

03/2008-03/2010   
Research associate at the research group of Prof. Clardy Harvard Medical School, Boston, USA

08/2007-01/2008   
Research associate at the research group of Prof. Grond/Zeeck Georg-August Universität, Göttingen, Germany


EDUCATION:

2004-2007
Graduate student (Dr. rer. nat.) at the University of Göttingen, Chair of Organic and Biomolecular Chemistry

7/2007   
Rigorosum

5/2007   
Dissertation “Metagenom-Technologie zur Wirkstoffsuche sowie Untersuchungen der Iromycine aus Streptomyces sp.“, Advisor: Prof. Dr. Axel Zeeck / Dr. Stephanie Grond

1999-2004   
Studies in chemistry at the University of Göttingen

01/2004   
Diplom in Organic Chemistry “Biosynthesestudien zu den Iromycinen mit Streptomyces sp. Dra17 “ Advisor: Prof. Dr. Axel Zeeck / Dr. Stephanie Grond

10/2001   
Vordiplom in Chemistry    
    
1998-1999
Military service in German army

06/1998       
Abitur


RESEARCH INTERESTS: Isolation, structure elucidation and derivatisation of natural products

Mycology

Natural Product Chemistry

Fermentation

Microbial Strain Collection

Guests and former members

MWIS


Dr. Kevin Becker

Dr. Smitha Bhuyan

Dr. Lilibeth Chaverra-Munoz

Dr. Clara Chepkirui

Dr. Boontiya-Blye Chuankind

Burkhard Ebert

Dr. Güner Ekiz

Sandra Halecker

Dr. Khadija Hassan                                

Dr. Stephan Hüttel

Dr. Lili Jia         

Christel Kakoschke                                                                  

Sae Kanaki

Heba Khayata

Dr. Abolfal Narmani Kordlar

Dr. Wilawan Kuephadungphan

Dr. Eric Kuhnert

Dr. Allan Patrick Macabeo

Dr. Ausana Mapook

Dana Nedder                                   

Dr. Sarah Raouia Noumeur

Dr. Pathompong Paomephan

M.Sc. Chitwadee Phithakrotchanakoon

Dr. Chayanard Phukhamsakda

Kunthida Gift Phutthacharoen

Dr. Gian Primahana

Dr. Monique Rascher

Dr. Christian Richter

Dr. Zeljka Rupcic

Dr. Lulu Shao

Dr. Enge Sudarman

Dr. Rémy Bertrand Teponno

Dr. Benjarong Thongbai (Zine)

Jörg Wieschhaus

Dr. Kathrin Wittstein

Nadine Wurzler

Dr. Adela Cmokova

 

MISG

PD Dr. Joachim Wink

Dr. Shadi Khodamoradi

Dr. Senlie Octaviana

Dr. Nasim Safaei

Kerstin Schober

Romy Vogel

Story: New drugs from fungi

Excursion to ECOPARK in the vicinity of Yaoundé

HZI researchers traveled to Yaoundé, Cameroon, for a workshop on the collection, culture and identification of fungal strains. A new research hub will strengthen natural product research in fungi in the country. [read more]

Bachelor & Master
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Video

  • How do researchers at the HZI and HIPS develop antibiotic candidates from natural products?

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