Human-Microbe Systems Bioinformatics
The human body encompasses fewer human cells than microbes. They constantly interact with each other and the host and greatly affect an individual's health and well-being. In our group, we develop and apply state-of-the-art bioinformatics software to study the human-microbe systems and aim to discover natural products involved in communication between the two realms. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).
ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome. Nucleic Acids Research, 2024-01, DOI: 10.1093/nar/gkad1086
MolDiscovery: learning mass spectrometry fragmentation of small molecules. Nature Communications, 2021-12 | DOI: 10.1038/s41467-021-23986-0
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cell Systems, 2019-12-18 | DOI: 10.1016/j.cels.2019.09.004
Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra. Nature Microbiology, 2018-03-22 | DOI: 10.1038/s41564-017-0094-2
QUAST: Quality assessment tool for genome assemblies. Bioinformatics, 2013 | DOI: 10.1093/bioinformatics/btt086
A current overview of the team and further information about the research group can be found on the HIPS page.