Human-Microbe Systems Bioinformatics
The human body encompasses fewer human cells than microbes. They constantly interact with each other and the host and greatly affect an individual's health and well-being. In our group, we develop and apply state-of-the-art bioinformatics software to study the human-microbe systems and aim to discover natural products involved in communication between the two realms. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).
Leader
Selected Publications
MolDiscovery: learning mass spectrometry fragmentation of small molecules. Nature Communications, 2021-12 | DOI: 10.1038/s41467-021-23986-0
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. Nature Communications, 2021-12 | DOI: 10.1038/s41467-021-23502-4
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cell Systems, 2019-12-18 | DOI: 10.1016/j.cels.2019.09.004
Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra. Nature Microbiology, 2018-03-22 | DOI: 10.1038/s41564-017-0094-2
QUAST: Quality assessment tool for genome assemblies. Bioinformatics, 2013 | DOI: 10.1093/bioinformatics/btt086
Further Information
A current overview of the team and further information about the research group can be found on the HIPS page.