Human-Microbe Systems Bioinformatics

The human body encompasses fewer human cells than microbes. They constantly interact with each other and the host and greatly affect an individual's health and well-being. In our group, we develop and apply state-of-the-art bioinformatics software to study the human-microbe systems and aim to discover natural products involved in communication between the two realms. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).

Leader

Selected Publications

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome. Nucleic Acids Research, 2024-01, DOI: 10.1093/nar/gkad1086

MolDiscovery: learning mass spectrometry fragmentation of small molecules. Nature Communications, 2021-12 | DOI: 10.1038/s41467-021-23986-0

MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cell Systems, 2019-12-18 | DOI: 10.1016/j.cels.2019.09.004

Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra. Nature Microbiology, 2018-03-22 | DOI: 10.1038/s41564-017-0094-2

QUAST: Quality assessment tool for genome assemblies. Bioinformatics, 2013 | DOI: 10.1093/bioinformatics/btt086

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