Genome Mining for Secondary Metabolites
The misuse of antibiotics on a global scale has led to an ever-growing antibiotic resistance crisis. Novel antimicrobial compounds are urgently needed. Microorganisms are considered to be one of the most prolific sources for natural product drugs including antibiotics. Developing novel genome mining approaches to harness the potential of the underexplored biosynthetic gene pathways and discover novel microbial natural products, is a potential antibiotic resistance crisis mitigation path. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
„Nature has great possibilities to produce novel small-molecular drugs. Developing new genome-mining approaches will help us to harness the potential of cryptic bacterial biosynthetic gene pathways for secondary metabolites.”
Dr Chengzhang Fu
Chengzhang Fu studied biotechnology from 2002 to 2006 at Zhejiang University, China. He received his PhD degree in biochemistry and molecular biology at Institute of Microbiology, Chinese Academy of Sciences in 2011. In 2012, he became Alexander von Humboldt fellow in the group of Professor Rolf Müller at Saarland University, Germany. He continued to work with Professor Müller as a postdoc scientist at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS). In 2019, he joined the “Helmholtz International Labs” programme at HIPS as a junior group leader. His group works on exploring and engineering biosynthetic gene pathways from bacteria and environmental DNA.