Drug Design and Optimization

• Dr Martin Empting

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News

• 2023-11-16

  Pharmaceutical research knocking on wood

  

  The basis for the developed strategy to produce new active ingredients is the compound lignin. Lignin is a biopolymer found in plants and is responsible for their lignification and stability. Chemically, lignin is made up of a large number of various aromatic compounds that are linked together. If lignin is broken down into its individual building blocks, these can then be used to…

• 2023-10-30

  Pathoblockers to the rescue

  

  Your work describes a new treatment option against Pseudomonas aeruginosa. Why is this bacterium so dangerous and why is there a need for new treatment concepts? J. Haupenthal: "This pathogen plays an a major role in infections of the lungs, wounds and eyes and is mainly transmitted in hospitals. During infection, the bacterium produces a whole range of toxins, some with…

• 2023-01-24

  ERC Proof of Concept Grant for Anna Hirsch

  

  The COVID-19 pandemic has highlighted the importance of effective drugs to combat infectious diseases and has led to numerous innovations and developments in antiviral agents. At the same time, however, it may also have provided a significant boost to the spread of antibiotic resistance. This is because many of the patients infected with SARS-CoV-2 were treated with antibiotics as a…

Video

• HIPS Infofilm (English)

  Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

• How do researchers at the HZI and HIPS develop a new antibiotic?

Audio Podcast

• Kündigung für Biofilm-WGs – Pharmazeuten des HIPS stören BakteriengemeinschaftenBakterien haben einen ausgeprägten Gemeinschaftssinn und verschanzen sich gerne in schleimigen Biofilmen. Etwa 60 Prozent aller bakteriellen Infektionen lösen inzwischen Biofilme aus. Ein besonders geselliger Keim ist Pseudomonas aeruginosa. Er ist besonders für Mukoviszidose-Patienten gefährlich. Wissenschaftler am Helmholtz-Institut für Pharmazeutische Forschung Saarland suchen nach Wegen, seine Biofilme aufzulösen – damit Medikamente wirken können. Begleiten Sie Anke Steinbach in Ihre Labore...