Chemical Biology

In their ongoing quest for new therapies against pathogens, scientists are focusing primarily on chemical and biological agents. Discovering new drugs based on such agents, characterising their functionality and optimising their properties are the three main goals of the Department of Chemical Biology (CBIO) at the HZI.

Leader

Selected Publications

Peukert, C.; Popat Gholap, S.; Green, O.; Pinkert, L.; Van den Heuvel, J.; Van Ham, M.; Shabat, D.; Broenstrup. M. (2022) Enzyme-activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial ESKAPE Pathogens. Angewandte Chemie International Edition. DOI: 10.1002/anie.202201423

Tegge,W.; Guerra,G.; Höltke,A.; Schiller,L.; Beutling,U.; Harmrolfs,K.; Gröbe,L.; Wullenkord,H.; Xu,C.; Weich,H.; Brönstrup,M. (2021) Selective bacterial targeting and infection-triggered release of antibiotic colistin conjugates.Angewandte Chemie International Edition. 60, 17989-17997. DOI: 10.1002/anie.202104921

Testolin, G., Cirnski, K., Rox, K., Prochnow, H., Fetz, V., Grandclaudon, C., Mollner, T., Baiyoumy, A., Ritter, A., Leitner, C., Krull, J., van den Heuvel, J., Vassort, A, Sordello, S., Hamed, M.M., Elgaher, W.A.M., Herrmann, J., Hartmann, R.W., Müller, R., and Brönstrup, M. (2020) Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy. Chemical Science, 11, 1316 – 1334. DOI: 10.1039/C9SC04769G

Prochnow,H.; Fetz,V.; Hotop,S.-K.; García-Rivera,M.A.; Heumann,A.; Brönstrup,M. (2019) Subcellular Quantification of Uptake in Gram-Negative Bacteria. Analytical Chemistry. 91 3, 1863-1872

Ferreira, K., Hu, H.Y., Fetz, V., Prochnow, H., Rais, B., Müller, P.P. & Brönstrup, M. (2017) Multivalent Siderophore-DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections. Angewandte Chemie International Edition, 56, 8272-8276.

Publications

  • Authors: Berger,T.; Alenfelder,J.; Steinmüller,S.; Heimann,D.; Gohain,N.; Petras,D.; Wang,M.; Berger,R.; Kostenis,E.; Reher,R.; ( Year: 2024). Title: A MassQL-Integrated Molecular Networking Approach for the Discovery and Substructure Annotation of Bioactive Cyclic Peptides.Journal: Journal of Natural Products DOI: 10.1021/acs.jnatprod.3c00750PubMed
  • Authors: Rox,K.; Medina,E.; ( Year: 2024). Title: Aerosolized delivery of ESKAPE pathogens for murine pneumonia models.Journal: Scientific Reports Volume: 14 Issue: 1 DOI: 10.1038/s41598-024-52958-9HZI repositoryPubMed
  • Authors: Pfütze,S.; Charria-Giron,E.; Schulzke,E.; Toshe,R.; Khonsanit,A.; Franke,R.; Surup,F.; Brönstrup,M.; Stadler,M.; ( Year: 2024). Title: Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth.Journal: Angew.Chem.Int.Ed Engl. DOI: 10.1002/anie.202318505HZI repositoryPubMed
  • Authors: Sake,S.M.; Zhang,X.; Rajak,M.K.; Urbanek-Quaing,M.; Carpentier,A.; Gunesch,A.P.; Grethe,C.; Matthaei,A.; R++ckert,J.; Galloux,M.; Larcher,T.; Le Goffic,R.; Hontonnou,F.; Chatterjee,A.K.; Johnson,K.; Morwood,K.; Rox,K.; Elgaher,W.A.M.; Huang,J.; Wetzke,M.; Hansen,G.; Fischer,N.; El+®ou+½t,J.F.; Rameix-Welti,M.A.; Hirsch,A.K.H.; Herold,E.; Empting,M.; Lauber,C.; Schulz,T.F.; Krey,T.; Haid,S.; Pietschmann,T.; ( Year: 2024). Title: Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.Journal: Nature Communications Volume: 15 Issue: 1 DOI: 10.1038/s41467-024-45241-yHZI repositoryPubMed
  • Authors: Zuffa,S.; Schmid,R.; Bauermeister,A.; Gomes,P.; Caraballo-Rodriguez,A.M.; El Abiead,Y.; Aron,A.T.; Gentry,E.C.; Zemlin,J.; Meehan,M.J.; Avalon,N.E.; Cichewicz,R.H.; Buzun,E.; Terrazas,M.C.; Hsu,C.Y.; Oles,R.; Ayala,A.V.; Zhao,J.; Chu,H.; Kuijpers,M.C.M.; Jackrel,S.L.; Tugizimana,F.; Nephali,L.P.; Dubery,I.A.; Madala,N.E.; Moreira,E.A.; Costa-Lotufo,L.V.; Lopes,N.P.; Rezende-Teixeira,P.; Jimenez,P.C.; Rimal,B.; Patterson,A.D.; Traxler,M.F.; Pessotti,R.D.C.; Alvarado-Villalobos,D.; Tamayo-Castillo,G.; Chaverri,P.; Escudero-Leyva,E.; Quiros-Guerrero,L.M.; Bory,A.J.; Joubert,J.; Rutz,A.; Wolfender,J.L.; Allard,P.M.; Sichert,A.; Pontrelli,S.; Pullman,B.S.; Bandeira,N.; Gerwick,W.H.; Gindro,K.; Massana-Codina,J.; Wagner,B.C.; Forchhammer,K.; Petras,D.; Aiosa,N.; Garg,N.; Liebeke,M.; Bourceau,P.; Kang,K.B.; Gadhavi,H.; Carvalho,L.P.S.; Silva dos Santos,M.; Perez-Lorente,A.I.; Molina-Santiago,C.; Romero,D.; Franke,R.; Brönstrup,M.; Vera-Ponce de Leon,A.; Pope,P.B.; La Rosa,S.L.; La Barbera,G.; Roager,H.M.; Laursen,M.F.; Hammerle,F.; Siewert,B.; Peintner,U.; Licona-Cassani,C.; Rodriguez-Orduna,L.; Rampler,E.; Hildebrand,F.; Koellensperger,G.; Schoeny,H.; Hohenwallner,K.; Panzenboeck,L.; Gregor,R.; O'Neill,E.C.; Roxborough,E.T.; Odoi,J.; Bale,N.J.; Ding,S.; Sinninghe Damste,J.S.; Guan,X.L.; Cui,J.J.; Ju,K.S.; Silva,D.B.; Silva,F.M.R.; da Silva,G.F.; Koolen,H.H.F.; Grundmann,C.; Clement,J.A.; Mohimani,H.; Broders,K.; McPhail,K.L.; Ober-Singleton,S.E.; Rath,C.M.; McDonald,D.; Knight,R.; Wang,M.; Dorrestein,P.C.; ( Year: 2024). Title: microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data.Journal: Nature microbiology Volume: 9 Issue: 2 DOI: 10.1038/s41564-023-01575-9HZI repositoryPubMed
  • Authors: Rox,K.; Jansen,R.; Lukezic,T.; Greweling-Pils,M.; Herrmann,J.; Miethke,M.; Hüttel,S.; Hennessen,F.; Abou,Fayad A.; Holzhausen,C.; Lundberg,C.V.; Teague,J.; Sudarman,E.; Bülter,L.; Hesterkamp,T.; Stadler,M.; Brönstrup,M.; Müller,R.; ( Year: 2024). Title: Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models.Journal: Microbiol.Spectr. Volume: 12 Issue: 1 DOI: 10.1128/spectrum.01289-23HZI repositoryPubMed
  • Authors: Haid,S.; Matthaei,A.; Winkler,M.; Sake,S.M.; Gunesch,A.P.; Milke,V.; Köhler,N.M.; Rückert,J.; Vieyres,G.; Kühl,D.; Nguyen,T.-T.; Göhl,M.; Lasswitz,L.; Zapatero-Belinchon,F.J.; Brogden,G.; Gerold,G.; Wiegmann,B.; Bilitewski,U.; Brown,R.J.P.; Brönstrup,M.; Schulz,T.F.; Pietschmann,T.; ( Year: 2024). Title: Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.Journal: Antimicrobial Agents and Chemotherapy DOI: 10.1128/aac.01210-23HZI repositoryPubMed
  • Authors: Couturier,C.; Ronzon,Q.; Lattanzi,G.; Lingard,I.; Coyne,S.; Cazals,V.; Dubarry,N.; Yvon,S.; Leroi-Geissler,C.; Gracia,O.R.; Teague,J.; Sordello,S.; Corbett,D.; Bauch,C.; Monlong,C.; Payne,L.; Taillier,T.; Fuchs,H.; Broenstrup,M.; Harrison,P.H.; Moynie,L.; Lakshminarayanan,A.; Gianga,T.M.; Hussain,R.; Naismith,J.H.; Mourez,M.; Bacque,E.; Björkling,F.; Sabuco,J.F.; Franzyk,H.; ( Year: 2024). Title: Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs).Journal: European Journal of Medicinal Chemistry Volume: 265 DOI: 10.1016/j.ejmech.2023.116097PubMed
  • Authors: Mahdavi,S.M.; Bockfeld,D.; Büssing,R.; Karge,B.; Bannenberg,T.; Frank,R.; Brönstrup,M.; Ott,I.; Tamm,M.; ( Year: 2024). Title: Synthesis of N-heterocyclic carbene gold(i) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate.Journal: Dalton Transactions DOI: 10.1039/d3dt04135bHZI repositoryPubMed
  • Authors: Zapol'skii,V.A.; Kaul,S.; Karge,B.; Brönstrup,M.; Gjikaj,M.; Kaufmann,D.E.; ( Year: 2023). Title: A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities â .Journal: Molecules. Volume: 28 Issue: 6 DOI: 10.3390/molecules28062479HZI repositoryPubMed
  • Authors: Khalid,K.; Rox,K.; ( Year: 2023). Title: All Roads Lead to Rome: Enhancing the Probability of Target Attainment with Different Pharmacokinetic/Pharmacodynamic Modelling Approaches.Journal: Antibiotics.(Basel) Volume: 12 Issue: 4 DOI: 10.3390/antibiotics12040690HZI repositoryPubMed
  • Authors: Abouzeid,S.; Beutling,U.; Elekhnawy,E.; Selmar,D.; ( Year: 2023). Title: Antibacterial and Antibiofilm Effects of Allelopathic Compounds Identified in Medicago sativa L. Seedling Exudate against Escherichia coli.Journal: Molecules. Volume: 28 Issue: 6 DOI: 10.3390/molecules28062645HZI repositoryPubMed
  • Authors: Schneider,I.; Fetz,V.; Prochnow,H.P.; Brönstrup,M.; ( Year: 2023). Title: Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli.Journal: Isr.J.Chem. Volume: 63 Issue: 7-8 DOI: 10.1002/ijch.202300057HZI repositoryWEBURLS
  • Authors: Flury,P.; Breidenbach,J.; Krüger,N.; Voget,R.; Schäkel,L.; Si,Y.; Krasniqi,V.; Calistri,S.; Olfert,M.; Sylvester,K.; Rocha,C.; Ditzinger,R.; Rasch,A.; Pöhlmann,S.; Kronenberger,T.; Poso,A.; Rox,K.; Laufer,S.A.; Müller,C.E.; Gütschow,M.; Pillaiyar,T.; ( Year: 2023). Title: Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity.Journal: ACS Pharmacology and Translational Science DOI: 10.1021/acsptsci.3c00313WEBURLS
  • Authors: Allartz,P.; Hotop,S.K.; Muntau,B.; Schlaphof,A.; Thome-Bolduan,C.; Gabriel,M.; Petersen,N.; Lintzel,M.; Behrens,C.; Eggert,P.; Pörtner,K.; Steiner,J.; Brönstrup,M.; Tappe,D.; ( Year: 2023). Title: Detection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study.Journal: Infection DOI: 10.1007/s15010-023-02048-1HZI repositoryPubMed
  • Authors: Jian,L.; Zscherp,R.; Beutling,U.; Shen,X.; Xu,S.; Zhang,X.; Brönstrup,M.; Klahn,P.; Sun,Q.; ( Year: 2023). Title: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.Journal: J.Med.Chem. DOI: 10.1021/acs.jmedchem.3c00549PubMed
  • Authors: Simonis,A.; Kreer,C.; Albus,A.; Rox,K.; Yuan,B.; Holzmann,D.; Wilms,J.A.; Zuber,S.; Kottege,L.; Winter,S.; Meyer,M.; Schmitt,K.; Gruell,H.; Theobald,S.J.; Hellmann,A.M.; Meyer,C.; Ercanoglu,M.S.; Cramer,N.; Munder,A.; Hallek,M.; F+ñtkenheuer,G.; Koch,M.; Seifert,H.; Rietschel,E.; Marlovits,T.C.; van Koningsbruggen-Rietschel,S.; Klein,F.; Rybniker,J.; ( Year: 2023). Title: Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa.Journal: Cell Volume: 186 Issue: 23 DOI: 10.1016/j.cell.2023.10.002HZI repositoryPubMed
  • Authors: Wu,Y.; Zoller,B.G.E.; Kamal,M.A.M.; Hotop,S.K.; Lehr,C.M.; Brönstrup,M.; Dersch,P.; Empting,M.; ( Year: 2023). Title: Establishment of an In Bacterio assay for the Assessment of Carbon Storage Regulator A (CsrA) inhibitors.Journal: Chembiochem. DOI: 10.1002/cbic.202300369HZI repositoryPubMed
  • Authors: Schwitalla,J.W.; Le,N.T.H.; Um,S.; Schalk,F.; Brönstrup,M.; Baunach,M.; Beemelmanns,C.; ( Year: 2023). Title: Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A.Journal: RSC Adv. Volume: 13 Issue: 48 DOI: 10.1039/d3ra05931fHZI repositoryPubMed
  • Authors: Konstantinovic,J.; Kany,A.M.; Alhayek,A.; Abdelsamie,A.S.; Sikandar,A.; Voos,K.; Yao,Y.; Andreas,A.; Shafiei,R.; Loretz,B.; Schönauer,E.; Bals,R.; Brandstetter,H.; Hartmann,R.W.; Ducho,C.; Lehr,C.M.; Beisswenger,C.; Müller,R.; Rox,K.; Haupenthal,J.; Hirsch,A.K.; ( Year: 2023). Title: Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.Journal: ACS Cent.Sci. Volume: 9 Issue: 12 DOI: 10.1021/acscentsci.3c01102HZI repositoryPubMed
  • Authors: Charria-Giron,E.; Marin-Felix,Y.; Beutling,U.; Franke,R.; Brönstrup,M.; Vasco-Palacios,A.M.; Caicedo,N.H.; Surup,F.; ( Year: 2023). Title: Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes.Journal: Microbiol.Spectr. DOI: 10.1128/spectrum.02743-23HZI repositoryPubMed
  • Authors: Lai,Y.H.; Franke,R.; Pinkert,L.; Overwin,H.; Brönstrup,M.; ( Year: 2023). Title: Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli.Journal: ACS infectious diseases Volume: 9 Issue: 3 DOI: 10.1021/acsinfecdis.2c00567HZI repositoryPubMed
  • Authors: Cedeno-Sanchez,M.; Charria-Giron,E.; Lambert,C.; Luangsa-ard,J.J.; Decock,C.; Franke,R.; Brönstrup,M.; Stadler,M.; ( Year: 2023). Title: Segregation of the genus Parahypoxylon (Hypoxylaceae, Xylariales) from Hypoxylon by a polyphasic taxonomic approach.Journal: MycoKeys Volume: 95 DOI: 10.3897/MYCOKEYS.95.98125HZI repositoryWEBURLS
  • Authors: Peukert,C.; Vetter,A.C.; Fuchs,H.L.S.; Harmrolfs,K.; Karge,B.; Stadler,M.; Brönstrup,M.; ( Year: 2023). Title: Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli.Journal: Chemical Science Volume: 14 DOI: 10.1039/d2sc06850hHZI repositoryWEBURLS
  • Authors: Graspeuntner,S.; Koethke,K.; Scholz,C.; Semmler,L.; Lupatsii,M.; Kirchhoff,L.; Herrmann,J.; Rox,K.; Wittstein,K.; Käding,N.; Hanker,L.C.; Stadler,M.; Bönstrup,M.; Müller,R.; Shima,K.; Rupp,J.; ( Year: 2023). Title: Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment.Journal: Antibiotics.(Basel) Volume: 12 Issue: 5 DOI: 10.3390/antibiotics12050795HZI repositoryPubMed
  • Authors: Maingot,M.; Bourotte,M.; Vetter,A.C.; Schellhorn,B.; Antraygues,K.; Scherer,H.; Gitzinger,M.; Kemmer,C.; Dale,G.E.; Defert,O.; Lociuro,S.; Brönstrup,M.; Willand,N.; Trebosc,V.; ( Year: 2023). Title: Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii.Journal: European Journal of Medicinal Chemistry Volume: 252 DOI: 10.1016/j.ejmech.2023.115257PubMed
  • Authors: Peukert,C.; Rox,K.; Karge,B.; Hotop,S.K.; Brönstrup,M.; ( Year: 2023). Title: Synthesis and Characterization of DOTAM-Based Sideromycins for Bacterial Imaging and Antimicrobial Therapy.Journal: ACS infectious diseases Volume: 9 Issue: 2 DOI: 10.1021/acsinfecdis.2c00523HZI repositoryPubMed
  • Authors: Friederich,J.; Xu,C.; Raunft,P.; Fuchs,H.L.S.; Brönstrup,M.; ( Year: 2023). Title: Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin.Journal: Chemical Communications Volume: 59 Issue: 48 DOI: 10.1039/d3cc01334kPubMed
  • Authors: Eggert,A.; Schuppe,K.T.; Fuchs,H.L.S.; Brönstrup,M.; Kalesse,M.; ( Year: 2023). Title: Total Synthesis of Acanthodoral Using a Rearrangement Strategy.Journal: Organic Letters DOI: 10.1021/acs.orglett.3c03717HZI repositoryPubMed
  • Authors: Hamed,M.M.; Abdelsamie,A.S.; Rox,K.; Schütz,C.; Kany,A.M.; Röhrig,T.; Schmelz,S.; Blankenfeldt,W.; Arce-Rodriguez,A.; Borrero-de Acuna,J.M.; Jahn,D.; Rademacher,J.; Ringshausen,F.C.; Cramer,N.; Tümmler,B.; Hirsch,A.K.H.; Hartmann,R.W.; Empting,M.; ( Year: 2023). Title: Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.Journal: Advanced Science DOI: 10.1002/advs.202204443HZI repositoryPubMed
  • Authors: Fiorini,F.; Bajerski,F.; Jeske,O.; Lepleux,C.; Overmann,J.; Brönstrup,M.; ( Year: 2022). Title: A Metabolomics-Based Toolbox to Assess and Compare the Metabolic Potential of Unexplored, Difficult-to-Grow Bacteria.Journal: Mar Drugs Volume: 20 Issue: 11 DOI: 10.3390/md20110713HZI repositoryPubMed
  • Authors: Ahsendorf,H.P.; Diesterbeck,U.S.; Hotop,S.K.; Winkler,M.; Brönstrup,M.; Czerny,C.P.; ( Year: 2022). Title: Characterisation of an Anti-Vaccinia Virus F13 Single Chain Fragment Variable from a Human Anti-Vaccinia Virus-Specific Recombinant Immunoglobulin Library.Journal: Viruses Volume: 14 Issue: 2, S-Page: Article number 197 DOI: 10.3390/v14020197HZI repositoryPubMed
  • Authors: Brauer,M.; Hotop,S.K.; Wurster,M.; Herrmann,J.; Miethke,M.; Schlüter,R.; Dittmann,S.; Zühlke,D.; Brönstrup,M.; Lalk,M.; Müller,R.; Sievers,S.; Bernhardt,J.; Riedel,K.; ( Year: 2022). Title: Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress.Journal: mSphere DOI: 10.1128/msphere.00302-22HZI repositoryPubMed
  • Authors: Suerbaum,S.; Coombs,N.; Patel,L.; Pscheniza,D.; Rox,K.; Falk,C.; Gruber,A.D.; Kershaw,O.; Chhatwal,P.; Brönstrup,M.; Bilitewski,U.; Josenhans,C.; ( Year: 2022). Title: Correction for Suerbaum et al., "Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model".Journal: MBio. DOI: 10.1128/mbio.02301-22HZI repositoryPubMed
  • Authors: Cooper,M.S.; Zhang,L.; Ibrahim,M.; Zhang,K.; Sun,X.; Röske,J.; Göhl,M.; Brönstrup,M.; Cowell,J.K.; Sauerhering,L.; Becker,S.; Vangeel,L.; Jochmans,D.; Neyts,J.; Rox,K.; Marsh,G.P.; Maple,H.J.; Hilgenfeld,R.; ( Year: 2022). Title: Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease.Journal: J.Med.Chem. Volume: 65 Issue: 19 DOI: 10.1021/acs.jmedchem.2c01131HZI repositoryPubMed
  • Authors: Mala,P.; Siebs,E.; Meiers,J.; Rox,K.; Varrot,A.; Imberty,A.; Titz,A.; ( Year: 2022). Title: Discovery of N-ß-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB.Journal: J.Med.Chem. DOI: 10.1021/acs.jmedchem.2c01373HZI repositoryPubMed
  • Authors: Suo,H.; Hochnadel,I.; Petriv,N.; Franke,R.; Schmidt,J.; Limanska,N.; Tugai,A.; Jedicke,N.; Brönstrup,M.; Manns,M.P.; Yevsa,T.; ( Year: 2022). Title: Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro.Journal: Front Pharmacol. Volume: 13 DOI: 10.3389/fphar.2022.906468HZI repositoryPubMed
  • Authors: Peukert,C.; Popat Gholap,S.; Green,O.; Pinkert,L.; van den Heuvel,J.; Van Ham,M.; Shabat,D.; Brönstrup,M.; ( Year: 2022). Title: Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens.Journal: Angew.Chem.Int.Ed Engl., S-Page: e202201423 DOI: 10.1002/anie.202201423HZI repositoryPubMed
  • Authors: Göhl,M.; Zhang,L.; El Kilani,H.; Sun,X.; Zhang,K.; Brönstrup,M.; Hilgenfeld,R.; ( Year: 2022). Title: From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease.Journal: Molecules Volume: 27 Issue: 13 DOI: 10.3390/molecules27134292HZI repositoryPubMed
  • Authors: Suerbaum,S.; Coombs,N.; Patel,L.; Pscheniza,D.; Rox,K.; Falk,C.; Gruber,A.D.; Kershaw,O.; Chhatwal,P.; Brönstrup,M.; Bilitewski,U.; Josenhans,C.; ( Year: 2022). Title: Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model.Journal: MBio. Volume: 13 Issue: 2, S-Page: e0375521 DOI: 10.1128/mbio.03755-21HZI repositoryPubMed
  • Authors: Rox,K.; ( Year: 2022). Title: Influence of tramadol on bacterial burden in the standard neutropenic thigh infection model.Journal: Sci.Rep. Volume: 12 Issue: 1 DOI: 10.1038/s41598-022-24111-xHZI repositoryPubMed
  • Authors: Kruck,D.; Bode,H.; Krusche,J.; Beck,C.; Ohlsen,K.; Sander,J.; Römling,U.; Burrichter,A.; Varo,J.G.; Charoenpattarapreeda,J.; Brönstrup,M.; ( Year: 2022). Title: Journal Club : [u.a.] Gesteuerter Abbau von Proteinen in Bakterien durch BacPROTAC-Wirkstoffe [etc.].Journal: Biospektrum Volume: 28 Issue: 7 DOI: 10.1007/s12268-022-1853-zWEBURLS
  • Authors: Meiers,J.; Rox,K.; Titz,A.; ( Year: 2022). Title: Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release.Journal: J.Med.Chem. Volume: 65 Issue: 20 DOI: 10.1021/acs.jmedchem.2c01214HZI repositoryPubMed
  • Authors: Borgert,S.R.; Henke,S.; Witzgall,F.; Schmelz,S.; Zur Lage,S.; Hotop,S.K.; Stephen,S.; Lübken,D.; Krüger,J.; Gomez,N.O.; Van Ham,M.; Jänsch,L.; Kalesse,M.; Pich,A.; Brönstrup,M.; Häußler,S.; Blankenfeldt,W.; ( Year: 2022). Title: Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa.Journal: Nature Communications Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-35030-wHZI repositoryPubMed
  • Authors: Hassan,K.; Matio Kemkuignou,B.; Kirchenwitz,M.; Wittstein,K.; Rascher-Albaghdadi,M.; Chepkirui,C.; Matasyoh,J.C.; Decock,C.; Köster,R.W.; Stradal,T.E.B.; Stadler,M.; ( Year: 2022). Title: Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota.Journal: International Journal of Molecular Sciences Volume: 23 Issue: 21 DOI: 10.3390/ijms232113593HZI repositoryPubMed
  • Authors: Zahorska,E.; Rosato,F.; Stober,K.; Kuhaudomlarp,S.; Meiers,J.; Hauck,D.; Reith,D.; Gillon,E.; Rox,K.; Imberty,A.; Römer,W.; Titz,A.; ( Year: 2022). Title: Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors.Journal: Angew.Chem.Int.Ed Engl. DOI: 10.1002/anie.202215535HZI repositoryPubMed
  • Authors: Testolin,G.; Richter,J.; Ritter,A.; Prochnow,H.; Köhnke,J.; Brönstrup,M.; ( Year: 2022). Title: Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids.Journal: Chemistry - A European Journal DOI: 10.1002/chem.202201297HZI repositoryPubMed
  • Authors: Ballmann,R.; Hotop,S.K.; Bertoglio,F.; Steinke,S.; Heine,P.A.; Chaudhry,M.Z.; Jahn,D.; Pucker,B.; Baldanti,F.; Piralla,A.; Schubert,M.; Cícín-Saín,L.; Brönstrup,M.; Hust,M.; Dübel,S.; ( Year: 2022). Title: ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein.Journal: Viruses. Volume: 14 Issue: 6, S-Page: 1326 DOI: 10.3390/v14061326HZI repositoryPubMed
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  • Authors: Wäschke,N.; Hardge,K.; Hancock,C.; Hilker,M.; Obermaier,E.; Meiners,Torsten; ( Year: 2014). Title: Habitats as complex odour environments: how does plant diversity affect herbivore and parasitoid orientation?.Journal: PLoS ONE Volume: 9 Issue: 1, S-Page: e85152 PubMed
  • Authors: Sergeev,G.; Roy,S.; Jarek,M.; Zapolskii,V.; Kaufmann,D.E.; Nandy,R.K.; Tegge,W.; ( Year: 2014). Title: High-throughput screening and whole genome sequencing identifies an antimicrobially active inhibitor of Vibrio cholerae.Journal: BMC Microbiology Volume: 14 Issue: 1, S-Page: 49 DOI: 10.1186/1471-2180-14-49HZI repositoryPubMed
  • Authors: Rahioui,I.; Eyraud,V.; Karaki,L.; Sasse,Florenz; Carre-Pierrat,M.; Qin,A.; Zheng,M.H.; Toepfer,S.; Sivignon,C.; Royer,C.; Da,Silva P.; Gressent,F.; ( Year: 2014). Title: Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.Journal: Toxicon Volume: 89, S-Page: 67- E-Page: 76 PubMed
  • Authors: Bauer,A.; Brönstrup,M.; ( Year: 2014). Title: Industrial natural product chemistry for drug discovery and development.Journal: Nat.Prod.Rep. Volume: 31 Issue: 1, S-Page: 35- E-Page: 60 DOI: 10.1039/c3np70058eWEBURLS
  • Authors: Kopf,T.; Schaefer,H.L.; Troetzmueller,M.; Koefeler,H.; Brönstrup,Marc; Konovalova,T.; Schmitz,G.; ( Year: 2014). Title: Influence of fenofibrate treatment on triacylglycerides, diacylglycerides and fatty acids in fructose fed rats.Journal: PLoS ONE Volume: 9 Issue: 9, S-Page: e106849 DOI: 10.1371/journal.pone.0106849HZI repositoryPubMed
  • Authors: Harikrishna,K.; Mukkamala,R.; Hinkelmann,Bettina; Sasse,Florenz; Aidhen,I.S.; ( Year: 2014). Title: Iodine-promoted oxidative conversion of o-vinyl diaryl ketones into o-acetyl diaryl ketones, synthesis of 1-methyl-4-arylphthalazines as analogues of podophyllotoxin.Journal: European Journal of Organic Chemistry Volume: 2014 Issue: 5, S-Page: 1066- E-Page: 1075 WEBURLS
  • Authors: Hotop,S.K.; Abd El Wahed,A.; Beutling,U.; Jentsch,D.; Motzkus,D.; Frank,R.; Hunsmann,G.; Stahl-Hennig,C.; Fritz,H.J.; ( Year: 2014). Title: Multiple antibody targets on herpes B glycoproteins B and D identified by screening sera of infected rhesus macaques with peptide microarrays.Journal: PLoS ONE Volume: 9 Issue: 1, S-Page: e86857 DOI: 10.1371/journal.pone.0086857HZI repositoryPubMed
  • Authors: Fuchs,M.; Kämpfer,S.; Helmsing,S.; Spallek,R.; Oehlmann,W.; Prilop,W.; Frank,R.; Dübel,S.; Singh,M.; Hust,M.; ( Year: 2014). Title: Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B.Journal: BMC Biotechnol. Volume: 14 DOI: 10.1186/1472-6750-14-68HZI repositoryPubMed
  • Authors: Austel,N.; Björkman,C.; Hilker,M.; Meiners,Torsten; ( Year: 2014). Title: Phenotypic plasticity in host plant preference of the willow leaf beetle Phratora vulgatissima: The impact of experience made by adults.Journal: Agricultural and Forest Entomology Volume: 16 Issue: 4, S-Page: 417- E-Page: 425 DOI: 10.1111/afe.12071HZI repositoryPubMed
  • Authors: Harmrolfs,K.; Mancuso,L.; Drung,B.; Sasse,Florenz; Kirschning,A.; ( Year: 2014). Title: Preparation of new alkyne-modified ansamitocins by mutasynthesis.Journal: Beilstein Journal of Organic Chemistry Volume: 10, S-Page: 535- E-Page: 543 PubMed
  • Authors: Mancuso,L.; Knobloch,T.; Buchholz,J.; Hartwig,J.; Müller,L.; Seidel,K.; Collisi,W.; Sasse,F.; Kirschning,A.; ( Year: 2014). Title: Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach.Journal: Chemistry - A European Journal Volume: 20 Issue: 52, S-Page: 17541- E-Page: 17551
  • Authors: Jerz,G.; Elnakady,Yasser A.; Braun,A.; Jackel,K.; Sasse,Florenz; Al Ghamdi,A.A.; Omar,M.O.; Winterhalter,P.; ( Year: 2014). Title: Preparative mass-spectrometry profiling of bioactive metabolites in Saudi-Arabian propolis fractionated by high-speed countercurrent chromatography and off-line atmospheric pressure chemical ionization mass-spectrometry injection.Journal: Journal of Chromatography A Volume: 1347, S-Page: 17- E-Page: 29 DOI: 10.1016/j.chroma.2014.04.068PubMed
  • Authors: Lutz,V.; Mannchen,F.; Krebs,M.; Park,N.; Kruger,C.; Raja,A.; Sasse,Florenz; Baro,A.; Laschat,S.; ( Year: 2014). Title: SAR studies on hydropentalene derivatives-Important core units of biologically active tetramic acid macrolactams and ptychanolides.Journal: Bioorganic and Medicinal Chemistry Volume: 22 Issue: 13, S-Page: 3252- E-Page: 3261 DOI: 10.1016/j.bmc.2014.04.063HZI repositoryPubMed
  • Authors: Böchel,K.; Austel,N.; Mayer,M.; Gershenzon,J.; Fenning,T.M.; Meiners,Torsten; ( Year: 2014). Title: Smelling the tree and the forest: Elm background odours affect egg parasitoid orientation to herbivore induced terpenoids.Journal: BioControl Volume: 59 Issue: 1, S-Page: 29- E-Page: 43 WEBURLS
  • Authors: Shaaban,S.; Sasse,Florenz; Burkholz,T.; Jacob,C.; ( Year: 2014). Title: Sulfur, selenium and tellurium pseudopeptides: Synthesis and biological evaluation.Journal: Bioorganic and Medical Chemistry Volume: 22 Issue: 14, S-Page: 3610- E-Page: 3619 DOI: 10.1016/j.bmc.2014.05.019HZI repositoryPubMed
  • Authors: Hentschel,F.; Raimer,B.; Kelter,G.; Fiebig,H.-H.; Sasse,Florenz; Lindel,T.; ( Year: 2014). Title: Synthesis and cytotoxicity of a diazirine-based photopsammaplin.Journal: European Journal of Organic Chemistry Volume: 2014 Issue: 10, S-Page: 2120- E-Page: 2127
  • Authors: Müller,S.; Sasse,Florenz; Maier,M.E.; ( Year: 2014). Title: Synthesis of pladienolide b and its 7-epimer with insights into the role of the allylic acetate.Journal: European Journal of Organic Chemistry Volume: 2014 Issue: 5, S-Page: 1025- E-Page: 1036 WEBURLS
  • Authors: Fleta-Soriano,E.; Martinez,J.P.; Hinkelmann,B.; Gerth,K.; Washausen,P.; Diez,J.; Frank,R.; Sasse,F.; Meyerhans,A.; ( Year: 2014). Title: The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway.Journal: Microbial Cell Factories Volume: 13 Issue: 1 DOI: 10.1186/1475-2859-13-17HZI repositoryWEBURLS
  • Authors: Mancuso,L.; Jurjens,G.; Hermane,J.; Harmrolfs,Kirsten; Eichner,S.; Fohrer,J.; Collisi,Wera; Sasse,Florenz; Kirschning,A.; ( Year: 2013). Title: Bioreduction of Aryl Azides during Mutasynthesis of New Ansamitocins.Journal: Organic Letters Volume: 15 Issue: 17, S-Page: 4442- E-Page: 4445 PubMed
  • Authors: Adla,S.K.; Sasse,Florenz; Kelter,G.; Fiebig,H.H.; Lindel,T.; ( Year: 2013). Title: Doubly prenylated tryptamines: Cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A.Journal: Organic and Biomolecular Chemistry Volume: 11 Issue: 36, S-Page: 6119- E-Page: 6130 WEBURLS
  • Authors: Pohla,H.; Buchner,A.; Stadlbauer,B.; Frankenberger,B.; Stevanovic,S.; Walter,S.; Frank,R.; Schwachula,T.; Olek,S.; Kopp,J.; Willimsky,G.; Stief,C.G.; Hofstetter,A.; Pezzutto,A.; Blankenstein,T.; Oberneder,R.; Schendel,D.J.; ( Year: 2013). Title: High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination.Journal: Molecular Medicine Volume: 18, S-Page: 1499- E-Page: 1508 DOI: 10.2119/molmed.2012.00221HZI repositoryPubMed
  • Authors: Irschik,H.; Washausen,Peter; Sasse,Florenz; Fohrer,J.; Huch,V.; Müller,Rolf; Prusov,Evgeny V.; ( Year: 2013). Title: Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from myxobacteria.Journal: Angewandte Chemie International Edition Volume: 52 Issue: 20, S-Page: 5402- E-Page: 5405 PubMed
  • Authors: Altendorfer,M.; Raja,A.; Sasse,Florenz; Irschik,Herbert; Menche,D.; ( Year: 2013). Title: Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.Journal: Organic and Biomolecular Chemistry Volume: 11 Issue: 13, S-Page: 2116- E-Page: 2139 DOI: 10.1039/c2ob26906fHZI repositoryPubMed
  • Authors: Fulde,M.; Bernardo-Garcia,N.; Rohde,Manfred; Nachtigall,N.; Frank,Ronald; Preissner,K.T.; Klett,J.; Morreale,A.; Chhatwal,Gursharan S.; Hermoso,J.A.; Bergmann,S.; ( Year: 2013). Title: Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.Journal: Thrombosis and Haemostasis Volume: 111 Issue: 3, S-Page: 401- E-Page: 416 DOI: 10.1160/TH13-05-0421PubMed
  • Authors: Martinez,J.P.; Perez-Vilaro,G.; Muthukumar,Y.; Scheller,N.; Hirsch,Tatjana; Diestel,R.; Steinmetz,Heinrich; Jansen,Rolf; Frank,Ronald; Sasse,Florenz; Meyerhans,A.; Diez,J.; ( Year: 2013). Title: Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.Journal: RNA Biology Volume: 10 Issue: 11, S-Page: 1661- E-Page: 1669 Fulltext
  • Authors: Munzner,J.; Biersack,B.; Kaps,L.; Mahal,K.; Schobert,R.; Sasse,Florenz; ( Year: 2013). Title: Synergistic "gold effects" of anti-vascular 4,5-diarylimidazol-2-ylidene gold(I) carbene complexes.Journal: International Journal of Clinical Pharmacology and Therapeutics Volume: 51 Issue: 1, S-Page: 44- E-Page: 46 DOI: 10.5414/CPP51044PubMed
  • Authors: Kempf,K.; Raja,Aruna; Sasse,Florenz; Schobert,R.; ( Year: 2013). Title: Synthesis of penicillenol C1 and of a bis-azide analogue for photoaffinity labeling.Journal: Journal of Organic Chemistry Volume: 78 Issue: 6, S-Page: 2455- E-Page: 2461 WEBURLS
  • Authors: Ahmad,I.; Wigren,E.; Le,Guyon S.; Vekkeli,S.; Blanka,A.; El,Mouali Y.; Anwar,N.; Chuah,M.L.; Lünsdorf,H.; Frank,Ronald; Rhen,M.; Liang,Z.X.; Lindqvist,Y.; Romling,U.; ( Year: 2013). Title: The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in.Journal: Molecular Microbiology Volume: 90 Issue: 6, S-Page: 1216- E-Page: 1232 PubMed
  • Authors: Muthukumar,Y.; Roy,M.; Raja,A.; Taylor,R.E.; Sasse,Florenz; ( Year: 2013). Title: The marine polyketide myriaporone 3/4 stalls translation by targeting the elongation phase.Journal: ChemBioChem Volume: 14 Issue: 2, S-Page: 260- E-Page: 264 DOI: 10.1002/cbic.201200522PubMed
  • Authors: Frei,R.; Staedler,D.; Raja,A.; Franke,R.; Sasse,Florenz; Gerber-Lemaire,S.; Waser,J.; ( Year: 2013). Title: Total synthesis and biological evaluation of jerantinine e.Journal: Angewandte Chemie International Edition Volume: 52 Issue: 50, S-Page: 13373- E-Page: 13376 PubMed
  • Authors: Plaza,A.; Garcia,R.; Bifulco,G.; Martinez,J.P.; Huttel,S.; Sasse,Florenz; Meyerhans,A.; Stadler,Marc; Müller,Rolf; ( Year: 2012). Title: Aetheramides A and B, Potent HIV-Inhibitory Depsipeptides from a Myxobacterium of the New Genus "Aetherobacter".Journal: Organic Letters Volume: 14 Issue: 11, S-Page: 2854- E-Page: 2857 PubMed
  • Authors: Diaz,N.; Zhu,M.; Ehrlich,G.; Eggert,U.; Muthukumar,Y.; Sasse,Florenz; Kalesse,Markus; ( Year: 2012). Title: An improved route to (+)-tedanolide and analysis of its subtle effects controlling conformation and biological behaviour.Journal: Chemistry Volume: 18 Issue: 16, S-Page: 4946- E-Page: 4952 PubMed
  • Authors: Dalby,A.R.; Emam,I.; Franke,R.; ( Year: 2012). Title: Analysis of gene expression data from non-small cell lung carcinoma cell lines reveals distinct sub-classes from those identified at the phenotype level.Journal: PLoS ONE Volume: 7 Issue: 11, S-Page: e50253 DOI: 10.1371/journal.pone.0050253HZI repositoryPubMed
  • Authors: Eichner,S.; Eichner,T.; Floss,H.G.; Fohrer,J.; Hofer,E.; Sasse,Florenz; Zeilinger,C.; Kirschning,A.; ( Year: 2012). Title: Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.Journal: Journal of the American Chemical Society Volume: 134 Issue: 3, S-Page: 1673- E-Page: 1679 PubMed
  • Authors: Standfuss-Gabisch,C.; Al-Halbouni,D.; Hofer,B.; ( Year: 2012). Title: Characterization of biphenyl dioxygenase sequences and activities encoded by the metagenomes of highly polychlorobiphenyl-contaminated soils.Journal: Applied and Environmental Microbiology Volume: 78 Issue: 8, S-Page: 2706- E-Page: 2715 DOI: 10.1128/AEM.07381-11HZI repositoryPubMed
  • Authors: Taft,F.; Harmrolfs,K.; Nickeleit,I.; Heutling,A.; Kiene,M.; Malek,N.; Sasse,Florenz; Kirschning,A.; ( Year: 2012). Title: Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.Journal: Chemistry Volume: 18 Issue: 3, S-Page: 880- E-Page: 886 PubMed
  • Authors: Schneider,T.; Muthukumar,Y.; Hinkelmann,B.; Franke,R.; Döring,M.; Jacob,C.; Sasse,Florenz; ( Year: 2012). Title: Deciphering intracellular targets of organochalcogen based redox catalysts.Journal: MedChemComm Volume: 3 Issue: 7, S-Page: 784- E-Page: 787
  • Authors: Hentschel,F.; Sasse,Florenz; Lindel,T.; ( Year: 2012). Title: Fluorescent analogs of the marine natural product psammaplin A: synthesis and biological activity.Journal: Organic and Biomolecular Chemistry Volume: 10 Issue: 35, S-Page: 7120- E-Page: 7133 PubMed
  • Authors: Hofle,G.; Gerth,Klaus; Reichenbach,H.; Kunze,B.; Sasse,Florenz; Forche,E.; Prusov,E.V.; ( Year: 2012). Title: Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex i inhibitor.Journal: Chemistry Volume: 18 Issue: 36, S-Page: 11362- E-Page: 11370 PubMed
  • Authors: Diez,J.; Martinez,J.P.; Mestres,J.; Sasse,Florenz; Frank,Ronald; Meyerhans,A.; ( Year: 2012). Title: Myxobacteria: Natural pharmaceutical factories.Journal: Microbial Cell Factories Volume: 11, S-Page: 52 DOI: 10.1186/1475-2859-11-52HZI repositoryPubMed
  • Authors: Shaaban,S.; Diestel,R.; Hinkelmann,B.; Muthukumar,Y.; Verma,R.P.; Sasse,Florenz; Jacob,C.; ( Year: 2012). Title: Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents.Journal: European Journal of Medicinal Chemistry Volume: 58, S-Page: 192- E-Page: 205 HZI repositoryPubMed
  • Authors: Diaz,N.; Naini,A.; Muthukumar,Y.; Sasse,Florenz; Kalesse,Markus; ( Year: 2012). Title: Synthesis of simplified tedanolide analogues-connecting tedanolide to myriaporone and gephyronic Acid.Journal: ChemMedChem Volume: 7 Issue: 5, S-Page: 771- E-Page: 775 PubMed
  • Authors: Eichner,S.; Knobloch,T.; Floss,H.G.; Fohrer,J.; Harmrolfs,K.; Hermane,J.; Schulz,A.; Sasse,Florenz; Spiteller,P.; Taft,F.; Kirschning,A.; ( Year: 2012). Title: The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.Journal: Angewandte Chemie International Edition Volume: 51 Issue: 3, S-Page: 752- E-Page: 757 PubMed
  • Authors: Reboll,M.R.; Ritter,B.; Sasse,Florenz; Niggemann,Jutta; Frank,Ronald; Nourbakhsh,M.; ( Year: 2012). Title: The myxobacterial compounds spirangien a and spirangien m522 are potent inhibitors of IL-8 expression.Journal: ChemBioChem Volume: 13 Issue: 3, S-Page: 409- E-Page: 415 PubMed
  • Authors: Ushakov,D.B.; Raja,A.; Franke,R.; Sasse,Florenz; Maier,M.E.; ( Year: 2012). Title: Total synthesis of (+/-)moluccanic acid methyl ester.Journal: Synlett Volume: 23 Issue: 9, S-Page: 1358- E-Page: 1360
  • Authors: Knobloch,T.; Dräger,G.; Collisi,W.; Sasse,Florenz; Kirschning,A.; ( Year: 2012). Title: Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.Journal: Beilstein Journal of Organic Chemistry Volume: 8, S-Page: 861- E-Page: 869 DOI: 10.3762/bjoc.8.96HZI repositoryPubMed
  • Authors: Montaner,A.D.; Denichilo,A.; Rodriguez,J.M.; Flo,J.; Lopez,R.A.; Pontoriero,A.; Savy,V.; Baumeister,E.; Frank,Ronald*; Zorzopulos,J.; Elias,F.; ( Year: 2011). Title: Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire.Journal: Nucleic Acid Therapeutics Volume: 21 Issue: 4, S-Page: 265- E-Page: 274 PubMed
  • Authors: Elsebai,M.F.; Kehraus,S.; Lindequist,U.; Sasse,Florenz*; Shaaban,S.; Gutschow,M.; Josten,M.; Sahl,H.G.; Konig,G.M.; ( Year: 2011). Title: Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale.Journal: Organic and Biomolecular Chemistry Volume: 9 Issue: 3, S-Page: 802- E-Page: 808 PubMed
  • Authors: Horstmann,N.; Essig,S.; Bockelmann,S.; Wieczorek,H.; Huss,M.; Sasse,Florenz; Menche,D.; ( Year: 2011). Title: Archazolid A-15-O-beta-d-glucopyranoside and iso-Archazolid B: Potent V-ATPase Inhibitory Polyketides from the Myxobacteria Cystobacter violaceus and Archangium gephyra.Journal: Journal of Natural Products Volume: 74 Issue: 5, S-Page: 1100- E-Page: 1105 DOI: 10.1021/np200036vHZI repositoryPubMed
  • Authors: Grelle,G.; Otto,A.; Lorenz,M.; Frank,Ronald F.*; Wanker,E.E.; Bieschke,J.; ( Year: 2011). Title: Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-beta and alpha-Synuclein Fibrils.Journal: Biochemistry Volume: 50 Issue: 49, S-Page: 10624- E-Page: 10636 PubMed
  • Authors: Effenberger-Neidnicht,K.; Breyer,S.; Mahal,K.; Diestel,R.; Sasse,Florenz*; Schobert,R.; ( Year: 2011). Title: Cellular localisation of antitumoral 6-alkyl thymoquinones revealed by an alkyne-azide click reaction and the streptavidin-biotin system.Journal: ChemBioChem Volume: 12 Issue: 8, S-Page: 1237- E-Page: 1241 DOI: 10.1002/cbic.201000762HZI repositoryPubMed
  • Authors: Biersack,B.; Muthukumar,Y.; Schobert,R.; Sasse,Florenz*; ( Year: 2011). Title: Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles.Journal: Bioorganic and Medicinal Chemistry Letters Volume: 21 Issue: 21, S-Page: 6270- E-Page: 6273 DOI: 10.1016/j.bmcl.2011.09.005HZI repositoryPubMed
  • Authors: Ritter,B.; Kilian,P.; Reboll,M.R.; Resch,K.; Distefano,J.K.; Frank,Ronald*; Beil,W.; Nourbakhsh,M.; ( Year: 2011). Title: Differential Effects of Multiplicity of Infection on Helicobacter pylori-Induced Signaling Pathways and Interleukin-8 Gene Transcription.Journal: Journal of Clinical Immunology Volume: 31 Issue: 1, S-Page: 60- E-Page: 68 PubMed
  • Authors: Nicolas,L.; Anderl,T.; Sasse,Florenz*; Steinmetz,H.; Jansen,Rolf*; Hofle,G.; Laschat,S.; Taylor,R.E.; ( Year: 2011). Title: Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid.Journal: Angewandte Chemie International Edition Volume: 50 Issue: 4, S-Page: 938- E-Page: 941 PubMed
  • Authors: Anderl,T.; Nicolas,L.; Munkemer,J.; Baro,A.; Sasse,Florenz*; Steinmetz,H.; Jansen,Rolf*; Hofle,G.; Taylor,R.E.; Laschat,S.; ( Year: 2011). Title: Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid.Journal: Angewandte Chemie International Edition Volume: 50 Issue: 4, S-Page: 942- E-Page: 945 PubMed
  • Authors: Gentzsch,J.; Hinkelmann,B.; Kaderali,L.; Irschik,Herbert*; Jansen,Rolf*; Sasse,Florenz*; Frank,Ronald*; Pietschmann,Thomas*; ( Year: 2011). Title: Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity.Journal: Antiviral Research Volume: 89 Issue: 2, S-Page: 136- E-Page: 148 PubMed
  • Authors: Schneider,J.; Fricke,C.; Overwin,H.; Hofer,B.; ( Year: 2011). Title: High level expression of a recombinant amylosucrase gene and selected properties of the enzyme.Journal: Applied Microbiology and Biotechnology Volume: 89 Issue: 6, S-Page: 1821- E-Page: 1829 DOI: 10.1007/s00253-010-3000-xHZI repositoryPubMed
  • Authors: Elsebai,M.F.; Natesan,L.; Kehraus,S.; Mohamed,I.E.; Schnakenburg,G.; Sasse,Florenz*; Shaaban,S.; Gutschow,M.; Konig,G.M.; ( Year: 2011). Title: HLE-Inhibitory Alkaloids with a Polyketide Skeleton from the Marine-Derived Fungus Coniothyrium cereale.Journal: Journal of Natural Products Volume: 74 Issue: 10, S-Page: 2282- E-Page: 2285 PubMed
  • Authors: Wunderlich,K.; Juozapaitis,M.; Ranadheera,C.; Kessler,U.; Martin,A.; Eisel,J.; Beutling,U.; Frank,Ronald; Schwemmle,M.; ( Year: 2011). Title: Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase.Journal: Antimicrobial Agents and Chemotherapy Volume: 55 Issue: 2, S-Page: 696- E-Page: 702 DOI: 10.1128/AAC.01419-10FulltextPubMed
  • Authors: Knappe,T.A.; Manzenrieder,F.; Mas-Moruno,C.; Linne,U.; Sasse,Florenz*; Kessler,H.; Xie,X.; Marahiel,M.A.; ( Year: 2011). Title: Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.Journal: Angewandte Chemie International Edition Volume: 50 Issue: 37, S-Page: 8714- E-Page: 8717 PubMed
  • Authors: Meyer,T.; Stratmann-Selke,J.; Meens,J.; Schirrmann,T.; Gerlach,G.F.; Frank,Ronald*; Dubel,S.; Strutzberg-Minder,K.; Hust,M.; ( Year: 2011). Title: Isolation of scFv fragments specific to OmpD of Salmonella Typhimurium.Journal: Veterinary Microbiology Volume: 147 Issue: 1-2, S-Page: 162- E-Page: 169 PubMed
  • Authors: Omnus,D.J.; Mehrtens,S.; Ritter,B.; Resch,K.; Yamada,M.; Frank,Ronald*; Nourbakhsh,M.; Reboll,M.R.; ( Year: 2011). Title: JKTBP1 Is Involved in Stabilization and IRES-Dependent Translation of NRF mRNAs by Binding to 5' and 3' Untranslated Regions.Journal: Journal of Molecular Biology Volume: 407 Issue: 4, S-Page: 492- E-Page: 504 DOI: 10.1016/j.jmb.2011.01.050HZI repositoryPubMed
  • Authors: Reboll,M.R.; Schweda,A.T.; Bartels,M.; Franke,R.; Frank,Ronald*; Nourbakhsh,M.; ( Year: 2011). Title: Mapping of NRF binding motifs of NF-kappaB p65 subunit.Journal: Journal of Biochemistry Volume: 150 Issue: 5, S-Page: 553- E-Page: 562 DOI: 10.1093/jb/mvr099HZI repositoryPubMed
  • Authors: Kraemer,S.; Lue,H.; Zernecke,A.; Kapurniotu,A.; Andreetto,E.; Frank,Ronald*; Lennartz,B.; Weber,C.; Bernhagen,J.; ( Year: 2011). Title: MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism.Journal: FASEB journal Volume: 25 Issue: 3, S-Page: 894- E-Page: 906 PubMed
  • Authors: Effenberger-Neidnicht,K.; Breyer,S.; Mahal,K.; Sasse,Florenz*; Schobert,R.; ( Year: 2011). Title: Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.Journal: Cancer Chemotherapy and Pharmacology Volume: 69 Issue: 1, S-Page: 85- E-Page: 90 DOI: 10.1007/s00280-011-1675-zHZI repositoryPubMed
  • Authors: Knobloch,T.; Harmrolfs,K.; Taft,F.; Thomaszewski,B.; Sasse,Florian*; Kirschning,A.; ( Year: 2011). Title: Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-oriented Approach to Exploit Biosynthetic Flexibility.Journal: ChemBioChem Volume: 13 Issue: 4, S-Page: 540- E-Page: 547 DOI: 10.1002/cbic.201000608HZI repositoryPubMed
  • Authors: Bremer,C.M.; Sominskaya,I.; Skrastina,D.; Pumpens,P.; Wahed,A.A.; Beutling,U.; Frank,Ronald*; Fritz,H.J.; Hunsmann,G.; Gerlich,W.H.; Glebe,D.; ( Year: 2011). Title: N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus.Journal: Journal of Hepatology Volume: 11 Issue: 1, S-Page: 29- E-Page: 37 PubMed
  • Authors: Buntru,A.; Kopp,K.; Voges,M.; Frank,Ronald*; Bachmann,V.; Hauck,C.R.; ( Year: 2011). Title: Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis.Journal: Journal of Biological Chemistry Volume: 286 Issue: 11, S-Page: 9555- E-Page: 9566 DOI: 10.1074/jbc.M110.216085HZI repositoryPubMed
  • Authors: Capell,A.; Liebscher,S.; Fellerer,K.; Brouwers,N.; Willem,M.; Lammich,S.; Gijselinck,I.; Bittner,T.; Carlson,A.M.; Sasse,Florenz*; Kunze,B*.; Steinmetz,H*.; Jansen,Rolf*; Dormann,D.; Sleegers,K.; Cruts,M.; Herms,J.; Van,Broeckhoven C.; Haass,C.; ( Year: 2011). Title: Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.Journal: Journal of Neuroscience Volume: 31 Issue: 5, S-Page: 1885- E-Page: 1894 PubMed
  • Authors: Bieschke,J.; Herbst,M.; Wiglenda,T.; Friedrich,R.P.; Boeddrich,A.; Schiele,F.; Kleckers,D.; Lopez Del Amo,J.M.; Gruning,B.A.; Wang,Q.; Schmidt,M.R.; Lurz,R.; Anwyl,R.; Schnoegl,S.; Fandrich,M.; Frank,Ronald F.*; Reif,B.; Gunther,S.; Walsh,D.M.; Wanker,E.E.; ( Year: 2011). Title: Small-molecule conversion of toxic oligomers to nontoxic beta-sheet-rich amyloid fibrils.Journal: Nature Chemical Biology Volume: 8 Issue: 1, S-Page: 93- E-Page: 101 PubMed
  • Authors: Anderl,T.; Nicolas,L.; Münkemer,J.; Muthukumar,Y.; Baro,A.; Frey,W.; Sasse,Florenz*; Taylor,R.E.; Laschat,S.; ( Year: 2011). Title: Synthesis and biological evaluation of gephyronic acid derivatives: Initial steps towards the identification of the biological target of polyketide inhibitors of eukaryotic protein synthesis.Journal: European Journal of Organic Chemistry Volume: 36, S-Page: 7294- E-Page: 7307
  • Authors: Müller,S.; Mayer,T.; Sasse,Florenz*; Maier,M.E.; ( Year: 2011). Title: Synthesis of a Pladienolide B Analogue with the Fully Functionalized Core Structure.Journal: Organic Letters Volume: 13 Issue: 15, S-Page: 3940- E-Page: 3943 PubMed
  • Authors: Zhdanko,A.; Schmauder,A.; Ma,C.I.; Sibley,L.D.; Sept,D.; Sasse,Florenz*; Maier,M.E.; ( Year: 2011). Title: Synthesis of Chondramide A Analogues with Modified beta-Tyrosine and Their Biological Evaluation.Journal: Chemistry Volume: 17 Issue: 47, S-Page: 13349- E-Page: 13357 PubMed
  • Authors: Garcia,J.; Barluenga,S.; Gorska,K.; Sasse,Florenz*; Winssinger,N.; ( Year: 2011). Title: Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.Journal: Bioorganic and Medicinal Chemistry Volume: 20 Issue: 2, S-Page: 672- E-Page: 680 PubMed
  • Authors: Fries,T.; Frank,Ronald*; Bailer,S.M.; ( Year: 2011). Title: The.Journal: Biochemical and Biophysical Research Communications Volume: 411 Issue: 1, S-Page: 197- E-Page: 201 PubMed
  • Authors: Ushakov,D.B.; Navickas,V.; Strobele,M.; Maichle-Mossmer,C.; Sasse,Florenz*; Maier,M.E.; ( Year: 2011). Title: Total synthesis and biological evaluation of (-)-9-deoxy-englerin A.Journal: Organic Letters Volume: 13 Issue: 8, S-Page: 2090- E-Page: 2093 PubMed
  • Authors: Nickl,C.K.; Raidas,S.K.; Zhao,H.; Sausbier,M.; Ruth,P.; Tegge,Werner*; Brayden,J.E.; Dostmann,W.R.; ( Year: 2010). Title: (d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha.Journal: Biochimica et biophysica acta Volume: 1804 Issue: 3, S-Page: 524- E-Page: 532 PubMed
  • Authors: Gloriam,D.E.; Orchard,S.; Bertinetti,D.; Bjorling,E.; Bongcam-Rudloff,E.; Borrebaeck,C.A.; Bourbeillon,J.; Bradbury,A.R.; de,Daruvar A.; Dubel,S.; Frank,Roland*; Gibson,T.J.; Gold,L.; Haslam,N.; Herberg,F.W.; Hiltke,T.; Hoheisel,J.D.; Kerrien,S.; Koegl,M.; Konthur,Z.; Korn,B.; Landegren,U.; Montecchi-Palazzi,L.; Palcy,S.; Rodriguez,H.; Schweinsberg,S.; Sievert,V.; Stoevesandt,O.; Taussig,M.J.; Ueffing,M.; Uhlen,M.; van der,Maarel S.; Wingren,C.; Woollard,P.; Sherman,D.J.; Hermjakob,H.; ( Year: 2010). Title: A community standard format for the representation of protein affinity reagents.Journal: Molecular and Cellular Proteomics Volume: 9 Issue: 1, S-Page: 1- E-Page: 10 PubMed
  • Authors: Schlenk,A.; Diestel,R.; Sasse,Florenz*; Schobert,R.; ( Year: 2010). Title: A selective 3-acylation of tetramic acids and the first synthesis of ravenic acid.Journal: Chemistry Volume: 16 Issue: 8, S-Page: 2599- E-Page: 2604 DOI: 10.1002/chem.200902544HZI repositoryPubMed
  • Authors: Westermann,J.; Florcken,A.; Willimsky,G.; van,Lessen A.; Kopp,J.; Takvorian,A.; Johrens,K.; Lukowsky,A.; Schonemann,C.; Sawitzki,B.; Pohla,H.; Frank,R.; Dorken,B.; Schendel,D.J.; Blankenstein,T.; Pezzutto,A.; ( Year: 2010). Title: Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study.Journal: Gene Therapy Volume: 18 Issue: 4, S-Page: 354- E-Page: 363 DOI: 10.1038/gt.2010.143HZI repositoryPubMed
  • Authors: Micklinghoff,J.C.; Schmidt,M.; Geffers,Robert*; Tegge,Werner*; Bange,F.C.; ( Year: 2010). Title: Analysis of expression and regulatory functions of the ribosome-binding protein TypA in Mycobacterium tuberculosis under stress conditions.Journal: Archives of Microbiology Volume: 192 Issue: 6, S-Page: 499- E-Page: 504 PubMed
  • Authors: Schulz,S.; Dickschat,J.S.; Kunze,B.; Wagner-Döbler,Irene*; Diestel,R.; Sasse,Florenz*; ( Year: 2010). Title: Biological activity of volatiles from marine and terrestrial bacteria.Journal: Marine Drugs Volume: 8, S-Page: 2976- E-Page: 2987
  • Authors: Harmrolfs,K.; Brunjes,M.; Drager,G.; Floss,H.G.; Sasse,Florenz*; Taft,F.; Kirschning,A.; ( Year: 2010). Title: Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.Journal: ChemBioChem Volume: 11 Issue: 18, S-Page: 2517- E-Page: 2520 PubMed
  • Authors: Lisurek,M.; Rupp,B.; Wichard,J.; Neuenschwander,M.; von Kries,J.P.; Frank,Ronald*; Rademann,J.; Kuhne,R.; ( Year: 2010). Title: Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.Journal: Molecular Diversity Volume: 14 Issue: 2, S-Page: 401- E-Page: 408 DOI: 10.1007/s11030-009-9187-z.PubMed
  • Authors: Maenz,B.; Goetz,V.; Wunderlich,K.; Eisel,J.; Kirchmair,J.; Stech,J.; Stech,O.; Chase,G.; Frank,Ronald*; Schwemmle,M.; ( Year: 2010). Title: Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza a virus.Journal: Journal of Biological Chemistry Volume: 286 Issue: 10, S-Page: 8414- E-Page: 8424 PubMed
  • Authors: Beutling,U.; Frank,Ronald*; ( Year: 2010). Title: Epitope analysis using synthetic peptide repertoires prepared by SPOT synthesis technology.Book Title: Antibody Engineering Editors: Kontermann,R.; Dübel,S.; (Ed.). City: Berlin, Heidelberg Publisher: Springer-Verlag
  • Authors: Franke,R.; Theis,F.J.; Klamt,S.; ( Year: 2010). Title: From binary to multivalued to continuous models: the lac operon as a case study.Journal: Journal of Integrative Bioinformatics Volume: 7 Issue: 1, S-Page: 151- E-Page: 169 DOI: 10.2390/biecoll-jib-2010-151HZI repositoryPubMed
  • Authors: Voigt,J.; Kiess,M.; Getzlaff,R.; Wostemeyer,J.; Frank,Ronald*; ( Year: 2010). Title: Generation of the heterodimeric precursor GP3 of the Chlamydomonas cell wall.Journal: Molecular Microbiology Volume: 77 Issue: 6, S-Page: 1512- E-Page: 1526 PubMed
  • Authors: Andreetto,E.; Yan,L.M.; Tatarek-Nossol,M.; Velkova,A.; Frank,Ronald*; Kapurniotu,A.; ( Year: 2010). Title: Identification of Hot Regions of the Abeta-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association.Journal: Angewandte Chemie - International Edition Volume: 49 Issue: 17, S-Page: 3081- E-Page: 3085 PubMed
  • Authors: Brodmann,T.; Janssen,D.; Sasse,Florenz*; Irschik,Herbert*; Jansen,Rolf*; Müller,Rolf*; Kalesse,Markus*; ( Year: 2010). Title: Isolation and synthesis of chivotriene, a chivosazole shunt product from.Journal: European Journal of Organic Chemistry Volume: 27, S-Page: 5155- E-Page: 5159 DOI: 10.1002/ejoc.201000781
  • Authors: Heinzelmann,K.; Scholz,B.A.; Nowak,A.; Fossum,E.; Kremmer,E.; Haas,J.; Frank,R.; Kempkes,B.; ( Year: 2010). Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.Journal: Journal of Virology Volume: 84 Issue: 23, S-Page: 12255- E-Page: 12264 DOI: 10.1128/JVI.01484-10HZI repositoryPubMed
  • Authors: Bourbeillon,J.; Orchard,S.; Benhar,I.; Borrebaeck,C.; de,Daruvar A.; Dubel,S.; Frank,Ronald*; Gibson,F.; Gloriam,D.; Haslam,N.; Hiltker,T.; Humphrey-Smith,I.; Hust,M.; Juncker,D.; Koegl,M.; Konthur,Z.; Korn,B.; Krobitsch,S.; Muyldermans,S.; Nygren,P.A.; Palcy,S.; Polic,B.; Rodriguez,H.; Sawyer,A.; Schlapshy,M.; Snyder,M.; Stoevesandt,O.; Taussig,M.J.; Templin,M.; Uhlen,M.; van der,Maarel S.; Wingren,C.; Hermjakob,H.; Sherman,D.; ( Year: 2010). Title: Minimum information about a protein affinity reagent (MIAPAR).Journal: Nature Biotechnology Volume: 28 Issue: 7, S-Page: 650- E-Page: 653 DOI: 10.1038/nbt0710-650HZI repositoryPubMed
  • Authors: Sharma,R.K.; Sundriyal,S.; Wangoo,N.; Tegge,Werner*; Jain,R.; ( Year: 2010). Title: New antimicrobial hexapeptides: synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies.Journal: ChemMedChem Volume: 5 Issue: 1, S-Page: 86- E-Page: 95 PubMed
  • Authors: Buchner,A.; Pohla,H.; Willimsky,G.; Frankenberger,B.; Frank,Ronald*; Baur-Melnyk,A.; Siebels,M.; Stief,C.G.; Hofstetter,A.; Kopp,J.; Pezzutto,A.; Blankenstein,T.; Oberneder,R.; Schendel,D.J.; ( Year: 2010). Title: Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinoma.Journal: Human gene therapy Volume: 21 Issue: 3, S-Page: 285- E-Page: 297 PubMed
  • Authors: Rink,C.; Sasse,Florenz*; Zubriene,A.; Matulis,D.; Maier,M.E.; ( Year: 2010). Title: Probing the influence of an allylic methyl group in zearalenone analogues on binding to Hsp90.Journal: Chemistry Volume: 16 Issue: 48, S-Page: 14469- E-Page: 14478 PubMed
  • Authors: Barnickel,B.; Bayliffe,F.; Diestel,R.; Kempf,K.; Laschat,S.; Pachali,S.; Sasse,Florenz*; Schlenk,A.; Schobert,R.; ( Year: 2010). Title: Structure-activity relationships of precursors and analogs of natural 3-enoyl-tetramic acids.Journal: Chemistry & Biodiversity Volume: 7 Issue: 12, S-Page: 2830- E-Page: 2845 DOI: 10.1002/cbdv.201000179HZI repositoryPubMed
  • Authors: Bulow,L.; Nickeleit,I.; Girbig,A.K.; Brodmann,T.; Rentsch,A.; Eggert,U.; Sasse,Florenz*; Steinmetz,Heinrich*; Frank,Ronald*; Carlomagno,T.; Malek,N.P.; Kalesse,Markus*; ( Year: 2010). Title: Synthesis and biological characterization of argyrin F.Journal: ChemMedChem Volume: 5 Issue: 6, S-Page: 832- E-Page: 836 PubMed
  • Authors: Tegge,W.; Bonafe,C.F.S.; Teichmann,A.; Erck,C.; ( Year: 2010). Title: Synthesis of peptides from alpha- And beta-tubulin containing glutamic acid side-chain linked oligo-glu with defined length.Journal: International Journal of Peptides Volume: 2010 DOI: 10.1155/2010/189396WEBURLS
  • Authors: Schackel,R.; Hinkelmann,B.; Sasse,Florenz*; Kalesse,Markus*; ( Year: 2010). Title: The synthesis of novel disorazoles.Journal: Angewandte Chemie International Edition Volume: 49 Issue: 9, S-Page: 1619- E-Page: 1622 PubMed
  • Authors: Kubicek,K.; Grimm,S.K.; Orts,J.; Sasse,Florenz*; Carlomagno,T.; ( Year: 2010). Title: The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin.Journal: Angewandte Chemie International Edition Volume: 49 Issue: 28, S-Page: 4809- E-Page: 4812 PubMed
  • Authors: Schobert,R.; Sasse,Florenz*; Biersack,B.; Effenberger,K.; Breyer,S.; Diestel,R.; ( Year: 2010). Title: Tumor-selective amphiphilic para-quinones and tetramic acids.Journal: International Journal of Clinicl Pharmacology and Therapeutics Volume: 48 Issue: 7, S-Page: 459- E-Page: 461 HZI repositoryPubMed
  • Authors: Meens,J.; Bolotin,V.; Frank,Ronald*; Bohmer,J.; Gerlach,G.F.; ( Year: 2009). Title: Characterization of a highly immunogenic Mycoplasma hyopneumoniae lipoprotein Mhp366 identified by peptide-spot array.Journal: Veterinary Microbiology Volume: 142 Issue: 3-4, S-Page: 293- E-Page: 302 PubMed
  • Authors: Diestel,R.; Irschik,Herbert*; Jansen,Rolf*; Khalil,M.W.; Reichenbach,H.; Sasse,Florian*; ( Year: 2009). Title: Chivosazoles A and F, cytostatic macrolides from myxobacteria, interfere with actin.Journal: ChemBioChem Volume: 10 Issue: 18, S-Page: 2900- E-Page: 2903 DOI: 10.1002/cbic.200900562HZI repositoryPubMed
  • Authors: Sharma,R.K.; Reddy,R.P.; Tegge,Werner*; Jain,R.; ( Year: 2009). Title: Discovery of Trp-His and His-Arg analogues as new structural classes of short antimicrobial peptides.Journal: Journal of Medicinal Chemistry Volume: 52 Issue: 23, S-Page: 7421- E-Page: 7431 PubMed
  • Authors: Lottersberger,J.; Guerrero,S.A.; Tonarelli,G.G.; Frank,Ronald*; Tarabla,H.; Vanasco,N.B.; ( Year: 2009). Title: Epitope mapping of pathogenic Leptospira LipL32.Journal: Letters in Applied Microbiology Volume: 49 Issue: 5, S-Page: 641- E-Page: 645 DOI: 10.1111/j.1472-765X.2009.02723.xHZI repositoryPubMed
  • Authors: Galeyeva,Y.; Morr,M.; Sasse,Florian*; Diestel,R.; Laschat,S.; Baro,A.; Frey,W.; ( Year: 2009). Title: Ex chiral pool synthesis from a highly methyl-branched wax ester and biological properties of (+)-capensifuranone.Journal: Zeitschrift für Naturforschung B - A Journal of Chemical Sciences Volume: 64 Issue: 6, S-Page: 639- E-Page: 645
  • Authors: Mecklenburg,S.; Shaaban,S.; Ba,L.A.; Burkholz,T.; Schneider,T.; Diesel,B.; Kiemer,A.K.; Roseler,A.; Becker,K.; Reichrath,J.; Stark,A.; Tilgen,W.; Abbas,M.; Wessjohann,L.A.; Sasse,Florenz*; Jacob,C.; ( Year: 2009). Title: Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents.Journal: Organic and Biomolecular Chemistry Volume: 7 Issue: 22, S-Page: 4753- E-Page: 4762 PubMed
  • Authors: Suryanarayanan,T.S.; Thirunavukkarasu,N.; Gowindarajulu,M.B.; Sasse,Florian*; Jansen,Rolf*; Murali,T.S.; ( Year: 2009). Title: Fungal endophytes and bioprospecting.Journal: Fungal Biology Reviews Volume: 23 Issue: 1-2, S-Page: 9- E-Page: 19 DOI: 10.1016/j.fbr.2009.07.001HZI repository
  • Authors: Schneider,J.; Fricke,C.; Overwin,H.; Hofmann,B.; Hofer,B.; ( Year: 2009). Title: Generation of amylosucrase variants that terminate catalysis of acceptor elongation at the di- or trisaccharide stage.Journal: Applied and Environmental Microbiology Volume: 75 Issue: 23, S-Page: 7453- E-Page: 7460 PubMed
  • Authors: Turner,J.G.; Marchion,D.C.; Dawson,J.L.; Emmons,M.F.; Hazlehurst,L.A.; Washausen,Peter*; Sullivan,D.M.; ( Year: 2009). Title: Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition.Journal: Cancer Research Volume: 69 Issue: 17, S-Page: 6899- E-Page: 6905 PubMed
  • Authors: Wunderlich,K.; Mayer,D.; Ranadheera,C.; Holler,A.S.; Manz,B.; Martin,A.; Chase,G.; Tegge,Werner*; Frank,Ronald*; Kessler,U.; Schwemmle,M.; ( Year: 2009). Title: Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication.Journal: PLoS ONE Volume: 4 Issue: 10, S-Page: e7517 DOI: 10.1371/journal.pone.0007517HZI repositoryPubMed
  • Authors: Schutte,M.; Thullier,P.; Pelat,T.; Wezler,X.; Rosenstock,P.; Hinz,D.; Kirsch,M.I.; Hasenberg,M.; Frank,Ronald*; Schirrmann,T.; Gunzer,M.; Hust,M.; Dubel,S.; ( Year: 2009). Title: Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus.Journal: PLoS ONE Volume: 4 Issue: 8, S-Page: e6625 PubMed
  • Authors: Weiss,S.M.; Ladwein,M.; Schmidt,D.; Ehinger,J.; Lommel,S.; Städing,K.; Beutling,U.; Disanza,A.; Frank,R.; Jänsch,L.; Scita,G.; Gunzer,F.; Rottner,K.; Stradal,T.E.; ( Year: 2009). Title: IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.Journal: Cell Host and Microbe Volume: 5 Issue: 3, S-Page: 244- E-Page: 258 PubMed
  • Authors: Poltz,R.; Franke,R.; Schweitzer,K.; Klamt,S.; Gilles,E.-D.; Naumann,M.; ( Year: 2009). Title: Logical network of genotoxic stress-induced NF-kappaB signal transduction predicts putative target structures for therapeutic intervention strategies.Journal: Advances and Applications in Bioinformatics and Chemistry Volume: 2009 Issue: 2, S-Page: 125- E-Page: 138 WEBURLS
  • Authors: Biersack,B.; Diestel,R.; Jagusch,C.; Sasse,Florenz*; Schobert,R.; ( Year: 2009). Title: Metal complexes of natural melophlins and their cytotoxic and antibiotic activities.Journal: Journal of Inorganic Biochemistry Volume: 103 Issue: 1, S-Page: 72- E-Page: 76 DOI: 10.1016/j.jinorgbio.2008.09.005HZI repositoryPubMed
  • Authors: Lucas,N.; Franke,R.; Hinze,A.; Klages,C.-P.; Frank,Ronald*; Büttgenbach,S.; ( Year: 2009). Title: Microplasma stamps for area-selective modification of polymer surfaces.Journal: Plasma Processes and Polymers Volume: 6, S-Page: 5370- E-Page: 5374 DOI: 10.1002/ppap.200930912HZI repository
  • Authors: Shaaban,S.; Ba,L.A.; Abbas,M.; Burkholz,T.; Denkert,A.; Gohr,A.; Wessjohann,L.A.; Sasse,Florenz; Weber,W.; Jacob,C.; ( Year: 2009). Title: Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells.Journal: Chemical Communications (Camb.) Issue: 31, S-Page: 4702- E-Page: 4704 PubMed
  • Authors: Bocquet,A.; Berges,R.; Frank,Ronald*; Robert,P.; Peterson,A.C.; Eyer,J.; ( Year: 2009). Title: Neurofilaments bind tubulin and modulate its polymerization.Journal: Journal of Neuroscience Volume: 29 Issue: 35, S-Page: 11043- E-Page: 11054 PubMed
  • Authors: Eichner,S.; Floss,H.G.; Sasse,Florenz*; Kirschning,A.; ( Year: 2009). Title: New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis.Journal: ChemBioChem Volume: 10 Issue: 11, S-Page: 1801- E-Page: 1805 PubMed
  • Authors: Ugele,M.; Sasse,Florian*; Knapp,S.; Fedorov,O.; Zubriene,A.; Matulis,D.; Maier,M.E.; ( Year: 2009). Title: Propionate analogues of zearalenone bind to Hsp90.Journal: ChemBioChem Volume: 10 Issue: 13, S-Page: 2203- E-Page: 2212 PubMed
  • Authors: Kratzer,U.; Frank,Ronald*; Kalbacher,H.; Biehl,B.; Wostemeyer,J.; Voigt,J.; ( Year: 2009). Title: Subunit structure of the vicilin-like globular storage protein of cocoa seeds and the origin of cocoa- and chocolate-specific aroma precursors.Journal: Food Chemistry Volume: 113 Issue: 4, S-Page: 903- E-Page: 913
  • Authors: Voigt,J.; Frank,Ronald*; Wostemeyer,J.; ( Year: 2009). Title: The chaotrope-soluble glycoprotein GP1 is a constituent of the insoluble glycoprotein framework of the Chlamydomonas cell wall.Journal: Fems Microbiology Letters Volume: 291 Issue: 2, S-Page: 209- E-Page: 215 PubMed
  • Authors: Ottinger,M.; Pliquet,D.; Christalla,T.; Frank,Ronald*; Stewart,J.P.; Schulz,T.F.; ( Year: 2009). Title: The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters.Journal: Journal of Virology Volume: 83 Issue: 9, S-Page: 4423- E-Page: 4434 DOI: 10.1128/JVI.02274-08HZI repositoryPubMed
  • Authors: Nickeleit,I.; Zender,S.; Sasse,Florenz*; Geffers,Robert*; Brandes,G.; Sorensen,I.; Steinmetz,Heinrich*; Kubicka,S.; Carlomagno,T.; Menche,D.; Gutgemann,I.; Buer,J.; Gossler,A.; Manns,M.P.; Kalesse,Markus*; Frank,Ronald*; Malek,N.P.; ( Year: 2008). Title: Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.Journal: Cancer Cell Volume: 14 Issue: 1, S-Page: 23- E-Page: 35 PubMed
  • Authors: Eggert,U.; Diestel,R.; Sasse,Florenz*; Jansen,Rolf*; Kunze,Brigitte*; Kalesse,Markus*; ( Year: 2008). Title: Chondramide C: Synthesis, configurational assignment, and structure-activity relationship studies.Journal: Angewandte Chemie - International Edition Volume: 47 Issue: 43, S-Page: 6478- E-Page: 6482
  • Authors: Hellmuth,H.; Wittrock,S.; Kralj,S.; Dijkhuizen,L.; Hofer,B.; Seibel,J.; ( Year: 2008). Title: Engineering the Glucansucrase GTFR Enzyme Reaction and Glycosidic Bond Specificity: Toward Tailor-Made Polymer and Oligosaccharide Products.Journal: Biochemistry Volume: 47 Issue: 25, S-Page: 6678- E-Page: 6684 PubMed
  • Authors: Biersack,B.; Diestel,R.; Jagusch,C.; Rapp,G.; Sasse,Florian; Schobert,R.; ( Year: 2008). Title: First syntheses of melophlins P, Q, and R, and effects of melophlins on the growth of microorganisms and tumor cells.Journal: Chemistry & Biodiversity Volume: 5 Issue: 11, S-Page: 2423- E-Page: 2430 DOI: 10.1002/cbdv.200890207HZI repositoryPubMed
  • Authors: Swistowska,A.M.; Wittrock,S.; Collisi,W.; Hofer,B.; ( Year: 2008). Title: Heterologous hyper-expression of a glucansucrase-type glycosyltransferase gene.Journal: Applied Microbiology and Biotechnology Volume: 79 Issue: 2, S-Page: 255- E-Page: 261 PubMed
  • Authors: Taft,F.; Brunjes,M.; Floss,H.G.; Czempinski,N.; Grond,S.; Sasse,Florian*; Kirschning,A.; ( Year: 2008). Title: Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.Journal: ChemBioChem Volume: 9 Issue: 7, S-Page: 1057- E-Page: 1060 PubMed
  • Authors: Jansen,R.; Steinmetz,H.; Sasse,F.; Schubert,W.-D.; Hagelüken,G.; Albrecht,S.C.; Müller,R.; ( Year: 2008). Title: Isolation and structure revision of the actin-binding macrolide rhizopodin from.Journal: Tetrahedron Letters Volume: 49, S-Page: 5796- E-Page: 5799 DOI: 10.1016/j.tetlet.2008.07.132PubMed
  • Authors: Beutling,U.; Stading,K.; Stradal,Theresia E.B.*; Frank,Ronald*; ( Year: 2008). Title: Large-scale analysis of protein-protein interactions using cellulose-bound peptide arrays.Journal: Advances in Biochemical Engineering/Biotechnology Volume: 110, S-Page: 115- E-Page: 152 DOI: 10.1007/10_2008_096HZI repositoryPubMed
  • Authors: Wittrock,S.; Swistowska,A.M.; Collisi,W.; Hofmann,B.; Hecht,H.-J.; Hofer,B.; ( Year: 2008). Title: Re- or displacement of invariant residues in the C-terminal half of the catalytic domain strongly affects catalysis by glucosyltransferase R.Journal: Febs Letters Volume: 582 Issue: 4, S-Page: 491- E-Page: 496 PubMed
  • Authors: Höfle,Gerhard*; Bohlendorf,B.; Fecker,T.; Sasse,Florian*; Kunze,Brigitte*; ( Year: 2008). Title: Semisynthesis and Antiplasmodial Activity of the Quinoline Alkaloid Aurachin E.Journal: Journal of Natural Products Volume: 71 Issue: 11, S-Page: 1967- E-Page: 1969 PubMed
  • Authors: Vintonyak,V.V.; Cala,M.; Lay,F.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; ( Year: 2008). Title: Synthesis and biological evaluation of cruentaren A analogues.Journal: Chemistry - A European Journal Volume: 14 Issue: 12, S-Page: 3709- E-Page: 3720 PubMed
  • Authors: Cramer,N.; Helbig,S.; Baro,A.; Laschat,S.; Diestel,R.; Sasse,Florenz*; Mathieu,D.; Richter,C.; Kummerlowe,G.; Luy,B.; Schwalbe,H.; ( Year: 2008). Title: Synthesis and biological properties of cylindramide derivatives: evidence for calcium-dependent cytotoxicity of tetramic acid lactams.Journal: ChemBioChem Volume: 9 Issue: 15, S-Page: 2474- E-Page: 2486 DOI: 10.1002/cbic.200800284FulltextHZI repositoryPubMed
  • Authors: Timm,C.; Volk,C.; Sasse,Florian*; Kock,M.; ( Year: 2008). Title: The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity.Journal: Organic & Biomolecular Chemistry Volume: 6 Issue: 21, S-Page: 4036- E-Page: 4040 PubMed
  • Authors: Kolberg,J.; Hammerschmidt,S.; Frank,Ronald*; Jonak,J.; Sanderova,H.; Aase,A.; ( Year: 2008). Title: The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci.Journal: Fems Immunology and Medical Microbiology Volume: 53 Issue: 2, S-Page: 222- E-Page: 230 DOI: 10.1111/j.1574-695X.2008.00419.xHZI repositoryPubMed
  • Authors: Vintonyak,V.V.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; ( Year: 2008). Title: Total synthesis and biological activity of neopeltolide and analogues.Journal: Chemistry Volume: 14 Issue: 35, S-Page: 11132- E-Page: 11140 PubMed
  • Authors: Ebensen,T.; Link,C.; Riese,P.; Schulze,K.; Morr,M.; Guzmán,C.A.; ( Year: 2007). Title: A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties.Journal: Journal of Immunology (Baltimore, Md.: 1950) Volume: 179 Issue: 4, S-Page: 2065- E-Page: 2073 DOI: 10.4049/jimmunol.179.4.2065HZI repositoryPubMed
  • Authors: Menche,Dirk*; Hassfeld,J.; Steinmetz,Heinrich*; Huss,M.; Wieczorek,H.; Sasse,Florian*; ( Year: 2007). Title: Archazolid-7-O//b//-d-glucopyranosid: Isolation, structural elucidation and solution conformation of a novel V-ATPase inhibitor from the Myxobacterium /.Journal: European Journal of Organic Chemistry Volume: 2007, S-Page: 1196- E-Page: 1202 DOI: 10.1002/ejoc.200600912HZI repository
  • Authors: Chase,G.; Mayer,D.; Hildebrand,A.; Frank,Ronald*; Hayashi,Y.; Tomonaga,K.; Schwemmle,M.; ( Year: 2007). Title: Borna disease virus matrix protein is an integral component of the viral rionucleoprotein complex that does not interfere with polymerase activity.Journal: Journal of Virology Volume: 81 Issue: 2, S-Page: 743- E-Page: 749 DOI: 10.1128/JVI.01351-06.FulltextHZI repository
  • Authors: Meyer,A.; Brünjes,M.; Taft,F.; Frenzel,T.; Sasse,Florian*; Kirschning,A.; ( Year: 2007). Title: Chemoenzymatic approaches toward dechloroansamitocin P-3.Journal: Organic Letters Volume: 9 Issue: 8, S-Page: 1489- E-Page: 1492
  • Authors: Frank,R.; Hoffmann,S.; Kieß,M.; Lahmann,H.; Tegge,W.; Behn,C.; Gausepohl,H.; ( Year: 2007). Title: Combinatorial synthesis on membrane supports by the SPOT technique: Imaging peptide sequence and shape space.Book Title: Combinatorial Peptide and Nonpeptide Libraries: A Handbook Editors: Jung,G.; (Ed.). Publisher: wiley, S-Page: 363- E-Page: 386 ISBN: 9783527614912 (ISBN)9783527293803 (ISBN)DOI: 10.1002/9783527614912.ch13WEBURLS
  • Authors: Kunze,B.; Sasse,F.; Wieczorek,H.; Huss,M.; ( Year: 2007). Title: Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases.Journal: Febs Letters Volume: 581 Issue: 18, S-Page: 3523- E-Page: 3527 DOI: 10.1016/j.febslet.2007.06.069HZI repositoryPubMed
  • Authors: Menche,Dirk*; Hassfeld,J.; Sasse,Florian*; Huss,M.; Wieczorek,H.; ( Year: 2007). Title: Design, synthesis and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor.Journal: Bioorganic & Medicinal Chemistry Letters Volume: 17 Issue: 6, S-Page: 1732- E-Page: 1735
  • Authors: Patterson,A.W.; Peltier,H.M.; Sasse,Florian*; Ellman,J.A.; ( Year: 2007). Title: Design, synthesis, and biological properties of highly potent tubulysin D analogues.Journal: Chemisty - A European Journal Volume: 13, S-Page: 9534- E-Page: 9541
  • Authors: Schirrmann,T.; Hust,M.; Konthur,Z.; Frank,Ronald*; Toleikis,L.; Dübel,S.; ( Year: 2007). Title: Die Antibody Factory - Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz.Journal: Laborwelt Volume: 8 Issue: 2, S-Page: 16- E-Page: 20
  • Authors: Menche,Dirk*; Arikan,F.; Li,J.; Rudolph,S.; Sasse,Florian*; ( Year: 2007). Title: Efficient one-pot synthesis of biologically active polysubstituted aromatic amines.Journal: Bioorganic & Medicinal Chemistry Volume: 15 Issue: 23, S-Page: 7311- E-Page: 7317
  • Authors: Elnakady,Y.A.; Rohde,Manfred*; Sasse,Florian*; Backes,C.; Keller,A.; Lenhof,H.-P.; Weissman,K.J.; Müller,Rolf*; ( Year: 2007). Title: Evidence for the mode of the highly cytotoxic.Journal: ChemBioChem Volume: 8 Issue: 11, S-Page: 1261- E-Page: 1272 DOI: 10.1002/cbic.200700050HZI repositoryPubMed
  • Authors: Selke,M.; Meens,J.; Springer,S.; Frank,Ronald*; Gerlach,G.-F.; ( Year: 2007). Title: Immunization of pigs to prevent disease in humans: Construction and protective efficacy of a Salmonella enterica serovar typhimurium live negative-marker vaccine.Journal: Infection and Immunity Volume: 75 Issue: 5, S-Page: 2476- E-Page: 2483 DOI: 10.1128/IAI.01908-06HZI repositoryPubMed
  • Authors: Grube,A.; Assmann,M.; Lichte,E.; Sasse,Florian*; Pawlik,J.R.; Köck,A.; ( Year: 2007). Title: New bioactive metabolites from the Caribbean sponge.Journal: Journal of Natural Products Volume: 70 Issue: 4, S-Page: 504- E-Page: 509
  • Authors: Bartels,M.; Schweda,A.T.; Dreikhausen,U.; Frank,Ronald*; Resch,K.; Beil,W.; Nourbakhsh,M.; ( Year: 2007). Title: Peptide mediated disruption of NF-kappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or.Journal: Journal of Immunology Volume: 179 Issue: 11, S-Page: 7605- E-Page: 7613 FulltextHZI repository
  • Authors: Ghanem,A.; Mayer,D.; Chase,G.; Tegge,W.; Frank,R.; Kochs,G.; Garcia-Sastre,A.; Schwemmle,M.; ( Year: 2007). Title: Peptide-mediated interference with the influenza A virus polymerase.Journal: Journal of Virology Volume: 81 Issue: 14, S-Page: 7801- E-Page: 7804 DOI: 10.1128/JVI.00724-07HZI repositoryPubMed
  • Authors: Krohn,K.; Gehle,D.; Dey,S.K.; Nahar,N.; Mosihuzzaman,M.; Sultana,N.; Sohroab,M.H.; Stephens,P.J.; Pan,J.-J.; Sasse,Florian*; ( Year: 2007). Title: Prismatomerin, a new irioid from.Journal: Journal of Natural Products Volume: 70 Issue: 8, S-Page: 1339- E-Page: 1343 DOI: 10.1021/np070202+HZI repositoryPubMed
  • Authors: Umbach,P.; Lange,U.; Frank,Ronald*; Schnögl,S.; Wanker,E.; ( Year: 2007). Title: Proteinnetzwerke als Grundlage für neue Therapieansätze.Journal: GenomXPress (Sonderausgabe) Volume: 2/07, S-Page: 45- E-Page: 47
  • Authors: Taussig,M.J.; Stoevesandt,O.; Borrebaeck,C.A.K.; Bradbury,A.R.; Cahill,D.; Cambillau,C.; De Daruvar,A.; Dübel,S.; Eichler,Jutta*; Frank,Ronald*; Gibson,T.J.; Gloriam,D.; Gold,T.; Herberg,F.W.; Hermjakob,H.; Hoheisel,J.D.; Joos,T.O.; Kallioniemi,O.; Koegll,M.; Konthur,Z.; Korn,B.; Kremmer,E.; Krobitsch,S.; Landegren,U.; van der Maarel,S.; McCafferty,J.; Muyldermans,S.; Nygren,P.A.; Palcy,S.; Plückthun,A.; Polic,B.; Przybylski,M.; Saviranta,P.; Sawyer,A.; Sherman,D.J.; Skerra,A.; Templin,M.; Ueffing,M.; Uhlén,M.; ( Year: 2007). Title: ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.Journal: Nature Methods Volume: 4, S-Page: 13- E-Page: 17
  • Authors: Frank,R.; ( Year: 2007). Title: Segmented solid supports: My personal addiction to Merrifield's solid phase synthesis.Journal: International Journal of Peptide Research and Therapeutics Volume: 13 Issue: 1-2, S-Page: 45- E-Page: 52 DOI: 10.1007/s10989-006-9067-7HZI repositoryWEBURLS
  • Authors: Sasse,Florian*; Menche,Dirk*; ( Year: 2007). Title: Success in tubulysin D synthesis.Journal: Nature Chemical Biology Volume: 3 Issue: 2, S-Page: 87- E-Page: 89
  • Authors: Ritschel,J.; Sasse,Florian*; Maier,M.E.; ( Year: 2007). Title: Synthesis of a benzolactone collection using click chemistry.Journal: European Journal of Organic Chemistry Volume: 2007, S-Page: 78- E-Page: 87 DOI: 10.1002/ejoc.200600681HZI repository
  • Authors: Tegge,Werner*; Bautsch,W.; Frank,Ronald*; ( Year: 2007). Title: Synthesis of cyclic peptides and peptide libraries on a new disulfide linker.Journal: Journal of Peptide Science Volume: 13 Issue: 10, S-Page: 693- E-Page: 699
  • Authors: Soutullo,A.; Santi,M.N.; Perin,J.C.; Beltramini,L.M.; Borel,I.M.; Frank,Ronald*; Tonarelli,G.G.; ( Year: 2007). Title: Systematic epitope analysis of the p26 EIAV vore protein.Journal: Journal of Molecular Recognition Volume: 20 Issue: 4, S-Page: 227- E-Page: 237
  • Authors: Ebensen,T.; Schulze,K.; Riese,P.; Morr,M.; Guzmán,C.A.; ( Year: 2007). Title: The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant.Journal: Clinical and Vaccine Immunology Volume: 14 Issue: 8, S-Page: 952- E-Page: 958 DOI: 10.1128/CVI.00119-07HZI repositoryPubMed
  • Authors: Ebensen,T.; Schulze,K.; Riese,P.; Link,C.; Morr,M.; Guzmán,C.A.; ( Year: 2007). Title: The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties.Journal: Vaccine Volume: 25 Issue: 8, S-Page: 1464- E-Page: 1469 DOI: 10.1128/CVI.00119-07
  • Authors: Voigt,J.; Woestemeyer,J.; Frank,Ronald*; ( Year: 2007). Title: The chaotrope-soluble glycoprotein GP2 is a precursor of the insoluble glycoprotein framework of the Chlamydomonas cell wall.Journal: Journal of Biological Chemistry Volume: 282 Issue: 42, S-Page: 30381- E-Page: 30392 DOI: 10.1074/jbc.M701673200HZI repositoryPubMed
  • Authors: Frank,Ronald*; Gerth,Klaus*; Kalesse,Markus*; Menche,Dirk*; Bilitewski,Ursula*; ( Year: 2007). Title: The chemical pipeline - a research program and infrastructure for the discovery and evaluation of new anti-infectives.Book Title: HZI Research Report 2006/2007 Editors: Jonas,Rainer; Schlender,Hannes; Braun,Manfred; (Ed.). City: Braunschweig Publisher: Helmholtz Centre for Infection Research GmbH (HZI), S-Page: 32- E-Page: 43
  • Authors: Schmitter,T.; Pils,S.; Sakk,V.; Frank,Ronald*; Fischer,K.-D.; Hauck,C.R.; ( Year: 2007). Title: The granulocyte receptor CEACAM3 directly associates with Vav to promote phagocytosis of human pathogens.Journal: Journal of Immunology Volume: 178 Issue: 6, S-Page: 3797- E-Page: 3805
  • Authors: Boeddrich,A.; Gaumer,S.; Haacke,A.; Tzvetkov,N.; Albrecht,M.; Evert,B.O.; Müller,E.C.; Lurz,R.; Breuer,P.; Schugardt,N.; Plaßmann,S.; Xu,K.; Warrick,J.M.; Suopanki,J.; Wüllner,U.; Frank,Ronald*; Hartl,F.; Bonini,N.M.; Wanker,E.E.; ( Year: 2006). Title: An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.Journal: Embo Journal Volume: 25 Issue: 7, S-Page: 1547- E-Page: 1558
  • Authors: Spadaccini,R.; Reidt,U.; Dybkov,O.; Will,C.; Frank,Ronald*; Stier,G.; Corsini,L.; Wahl,M.C.; Lührmann,R.; Sattler,M.; ( Year: 2006). Title: Biochemical and NMR analysis of a SF3b155-p14-U2AFRNA interaction network involved in branch point definition during pre-mRNA splicing.Journal: RNA Volume: 12, S-Page: 410- E-Page: 425 DOI: 10.1261/rna.2271406HZI repositoryPubMed
  • Authors: Berg,T.; Mayer,T.U.; Frank,Ronald*; ( Year: 2006). Title: Biochemistry and molecular biology 2005.Journal: Nachrichten aus der Chemie Volume: 54 Issue: 3, S-Page: 265- E-Page: 270 ISI
  • Authors: Zhou,J.; Köhl,R.; Herr,B.; Frank,Ronald*; Brüne,B.; ( Year: 2006). Title: Calpain Mediates a von Hippel-Lindau Protein - independent Destruction of Hypoxia-inducible Factor-1alpha.Journal: Molecular Biology of the Cell Volume: 17, S-Page: 1549- E-Page: 1558
  • Authors: Montaner,A.D.; de Nichilo,A.; Elias,F.; Rogriguez,J.M.; Fló,J.M.; Lopez,R.A.; Zorzopulos,J.; Frank,R.; ( Year: 2006). Title: Ganglioside GM1-binding peptides as adjuvants of antigens inocculated by the intranasal route.Journal: Vaccine Volume: 24, S-Page: 1889- E-Page: 1896 DOI: 10.1016/j.vaccine.2005.10.037HZI repositoryPubMed
  • Authors: Kader,A.; Simm,R.; Gerstel,U.; Morr,Michael*; Römling,U.; ( Year: 2006). Title: Hierachical involvement of various GGDEF domain proteins in rdar mophotype development of.Journal: Molecular Microbiology Volume: 60, S-Page: 602- E-Page: 616 DOI: 10.1111/j.1365-2958.2006.05123.xHZI repositoryPubMed
  • Authors: Rachid,S.; Sasse,Florian*; Beyer,S.; Müller,R.; ( Year: 2006). Title: Identification of StiR, the first regulator of secondary metabolite formation in the mycobacterium.Journal: Journal of Biotechnology Volume: 121 Issue: 4, S-Page: 429- E-Page: 441
  • Authors: Khalil,M.W.; Sasse,Florian; Lünsdorf,H.; Elnakady,Y.A.; Reichenbach,H.; ( Year: 2006). Title: Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.Journal: ChemBioChem Volume: 7, S-Page: 678- E-Page: 683 DOI: 10.1002/cbic.200500421PubMed
  • Authors: Dikmans,A.; Beutling,U.; Schmeisser,E.; Thiele,S.; Frank,Ronald*; ( Year: 2006). Title: SC2: A novel process for manufacturing multipurpose high-density chemical microarrays.Journal: QSAR and Combinatorial Science Volume: 25 Issue: 11, S-Page: 1069- E-Page: 1080 DOI: 10.1002/qsar.200640130HZI repository
  • Authors: Budde,M.; Morr,Michael*; Schmid,R.D.; Urlacher,V.B.; ( Year: 2006). Title: Selective hydroxylation of highly branched fatty acids and their derivatives by CYP102A1 from.Journal: ChemBioChem Volume: 7, S-Page: 789- E-Page: 794
  • Authors: Gory-Fauré,S.; Windscheid,V.; Bosc,C.; Peris,L.; Proietto,D.; Frank,Ronald*; Denarrier,E.; Job,D.; Andrieux,A.; ( Year: 2006). Title: STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.Journal: Journal of Biological Chemistry Volume: 281 Issue: 38, S-Page: 28387- E-Page: 28396
  • Authors: Kolberg,J.; Aase,A.; Bergmann,S.; Herstad,T.K.; Rodal,G.; Frank,Ronald*; Rohde,Manfred*; Hammerschmidt,S.; ( Year: 2006). Title: Streptococcus pneumoniae.Journal: Microbiology Volume: 152, S-Page: 1307- E-Page: 1317
  • Authors: Galeyeva,Y.; Helbig,S.; Morr,Michael*; Sasse,Florian*; Nimtz,Manfred*; Laschat,S.; Baro,A.; ( Year: 2006). Title: Total synthesis and biological evaluation of (-)-pectinatone employing a methyl branched wax ester as key building block.Journal: Chemistry and Biodiversity Volume: 3, S-Page: 935- E-Page: 941 DOI: 10.1002/cbdv.200690096HZI repositoryPubMed
  • Authors: Berg,T.; Frank,Ronald*; Mayer,T.; ( Year: 2006). Title: Trendbericht Chemische Biologie im Bericht Biochemie und Molekularbiologie 2005.Journal: Nachrichten aus der Chemie Volume: 54, S-Page: 265- E-Page: 270
  • Authors: Beutling,U.; Dikmans,A.; Thiele,S.; Frank,Ronald*; ( Year: 2005). Title: A novel process for manufacturing high density multipurpose chemical micro-arrays.Book Title: Peptides 2004; Proc. 28 Europ. Peptide Editors: Flegel; Fridkin; Gilon; Slaninova; (Ed.). City: Geneva Publisher: Kenes International, S-Page: 152- E-Page: 153
  • Authors: Zander,N.; Beutling,U.; Dikmans,A.; Thiele,S.; Frank,Ronald*; ( Year: 2005). Title: A special cellulose membrane support for the combinatorial and parallel synthesis of peptide libraries suitable for the SC.Book Title: Peptides 2004; Proc. 28 Europ. Peptide Editors: Flegel; Fridkin; Gilon; Slaninova; (Ed.). City: Geneva Publisher: Kenes International, S-Page: 405- E-Page: 406
  • Authors: Gail,R.; Frank,R.; Wittinghofer,A.; ( Year: 2005). Title: A systematic peptide-array based delineation of differential beta-Catenin interaction with Tcf4, E-Cadherin and APC.Journal: Journal of Biological Chemistry Volume: 280, S-Page: 7107- E-Page: 7117
  • Authors: Frank,R.; Dübel,S.; ( Year: 2005). Title: Analysis of protein interactions with immobilized peptide arrays synthesized on membrane supports.Book Title: Protein-Protein Interactions, A Molecular Cloning Manual Editors: Golemis,E.; Adams,P.; (Ed.). City: Cold Spring Harbor, NY Publisher: Cold Spring Harbor Laboratory Press ISBN: 0-87969-723-7 (ISBN)
  • Authors: Huss,M.; Sasse,F.; Kunze,B.; Jansen,R.; Steinmetz,H.; Ingenhorst,G.; Zeeck,A.; Wieczorek,H.; ( Year: 2005). Title: Archazolid and apicularen: Novel specific V-ATPase inhibitors.Journal: BMC Biochemistry Volume: 6, S-Page: 13 DOI: 10.1186/1471-2091-6-13HZI repositoryPubMed
  • Authors: Bredenbruch,F.; Nimtz,M.; Wray,V.; Morr,M.; Müller,R.; Häußler,S.; ( Year: 2005). Title: Biosynthetic pathway of.Journal: Journal of Bacteriology Volume: 187, S-Page: 3630- E-Page: 3635
  • Authors: Foley,K.F.; De Frutos,S.; Laskovski,K.; Tegge,W.; Dostmann,W.R.; ( Year: 2005). Title: Culture conditions influence uptake and intracellular localization of the membrane permeable GMP-dependent protein kinase inhibitor DT-3.Journal: Frontiers in Bioscience Volume: 10, S-Page: 1302- E-Page: 1312
  • Authors: Rübenhagen,R.; Frank,R.; ( Year: 2005). Title: Ein neuer Weg zu Antikörper-Mikroarrays mit höherer Spezifität und Selektivität.Journal: Biospektrum - Sonderausgabe Volume: 11, S-Page: 506- E-Page: 507
  • Authors: Galeyeva,Y.; Morr,M.; Laschat,S.; Baro,A.; Nimtz,M.; Sasse,F.; ( Year: 2005). Title: Ex chiral pool synthesis of (-)-siphonarienone from a methyl-branched wax ester.Journal: Synthesis Volume: 17, S-Page: 2875- E-Page: 2880
  • Authors: Deswal,R.; Singh,R.; Lynn,A.M.; Frank,R.; ( Year: 2005). Title: Identification of immunodominant regions of Brassica juncea glyoxalase I as potential antitumor immunomodulation targets.Journal: peptides Volume: 26, S-Page: 395- E-Page: 404
  • Authors: Gingras,A.R.; Ziegler,W.H.; Frank,R.; Barsukov,I.L.; Roberts,G.C.K.; Critchley,D.R.; Emsley,J.; ( Year: 2005). Title: Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.Journal: Journal of Biological Chemistry Volume: 280 Issue: 44, S-Page: 37217- E-Page: 37224
  • Authors: Bialek,K.; Swistowski,A.; Frank,R.; ( Year: 2005). Title: Peptide and protein repertoires for global analysis of modules.Book Title: Modular Protein Domains Editors: Cesareni,G.; Gimona,M.; Sudal,M.; Yaffe,M.eds.; (Ed.). City: Weinheim Publisher: Wiley-VCH, S-Page: 409- E-Page: 438
  • Authors: Rampon,C.; Prandini,M.-H.; Bouillot,S.; Pointu,H.; Tillet,E.; Frank,R.; Vernet,M.; Huber,P.; ( Year: 2005). Title: Protocadherin 12 (VE-cadherin) is expressed in endothelial trophoblast and mesangial cells and is dispensable for normal mouse development.Journal: Experimental Cell Research Volume: 302, S-Page: 48- E-Page: 60
  • Authors: Taylor,M.S.; Brayden,J.E.; Laskovski,K.E.; Nickl,C.K.; Tegge,Werner*; Frank,Ronald*; ( Year: 2005). Title: Specific and membrane permeable inhibitors of cGMP-dependent protein kinase.Book Title: Peptides 2004; Proc. 28 Europ. Peptide Editors: Flegel; Fridkin; Gilon; Slaninova; (Ed.). City: Geneva Publisher: Kenes International, S-Page: 684- E-Page: 685
  • Authors: Petri,A.F.; Sasse,F.; Maier,M.E.; ( Year: 2005). Title: Synthesis and biological evaluation of apicularen A analogues.Journal: European Journal of Organic Chemistry Issue: 9, S-Page: 1865- E-Page: 1875
  • Authors: Schwardt,M.; Mayer,D.; Frank,R.; Schneider,U.; Planz,O.; Wolff,T.; Schwemmle,M.; ( Year: 2005). Title: The negative regulator of Borna Disease Virus polymerase is a non-structural protein.Journal: Journal of General Virology Volume: 86, S-Page: 3163- E-Page: 3169
  • Authors: Zander,N.; Frank,R.; ( Year: 2005). Title: The use of polystyrylsulfonyl chloride resin as a solid supported condensation reagent for the formation of esters: Synthesis of N--(9-fluorenylmethoxy)carbonyl)-L-aspartic acid; "-tert-butyl ester, ß-(2-ethyl[(1E)-4-nitrophenyl)azo]phenyl]amino]ethyl es.Book Title: Organic Syntheses City: Chichester Publisher: Wiley, S-Page: 235- E-Page: 243 ISBN: 0-471-68257-8 (ISBN)
  • Authors: Buss,H.; Dörrie,A.; Schmitz,L.M.; Frank,R.; Livingstone,M.; Resch,K.; Kracht,M.; ( Year: 2004). Title: Phosphorylation of serine 468 by GSK-3ß negatively regulates basal p65 NF-KB activity.Journal: Journal of Biological Chemistry Volume: 279, S-Page: 49571- E-Page: 49574
  • Authors: Bayle,J.; Letard,S.; Frank,R.; Dubreuil,P.; De Sepulveda,P.; ( Year: 2004). Title: Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.Journal: Journal of Biological Chemistry Volume: 279, S-Page: 12249- E-Page: 12259 DOI: 10.1074/jbc.M313381200FulltextHZI repositoryPubMed
  • Authors: Adler,F.; Turk,G.Frank R.; Zander,N.; Wu,W.; Volkmer-Engert,R.; Schneider-Mergener,J.; Gausepohl,H.; ( Year: 2001). Title: A new array format for the automated parallel combinatorial synthesis by the SPOT-technique.Book Title: Solid Phase Synthesis & Combinatorial Libraries Editors: Epton,R.; (Ed.). City: Birmingham Publisher: Mayflower Worldwide Ltd., S-Page: 221- E-Page: 222

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Video

  • Epothilon: Ein HZI-Molekül wird zum Krebsmedikament

    Wissenschaftler an der ehemaligen Gesellschaft für Biotechnologische Forschung (GBF), dem heutigen HZI, haben in den 1980er Jahren Epothilon B entdeckt. Dieser Naturstoff stört die Teilung von Krebszellen: Tumore werden durch ihn im Wachstum gebremst, schrumpfen und verschwinden. Das Pharmaunternehmen Bristol-Myers Squibb (BMS) hat jetzt auf der Basis von Epothilon B ein Krebsmedikament auf den US-amerikanischen Markt gebracht. Seine Entwicklung ist so spannend wie ein Krimi...
    Länge: 11:34

  • Molecular Trojan Horses Visualize Infections

    Researchers from the Helmholtz Centre for Infection Research (HZI) and the German Center for Infection Research (DZIF) recently developed molecular probes that utilise the iron transport system of bacteria to transport antibacterial agents into the bacterial cell. These "molecular Trojan horses" can also carry fluorescence markers and thus make infections in smaller animals visible and amenable to treatment. Kevin Ferreira explains here the new developed method in a minute.

  • 1 cure for ALL viruses? 6 new research teams in the challenge by the Federal Agency for Disruptive Innovations [Video in German]

    Six research teams have entered the second phase of the SPRIND Challenge "A Quantum Leap for New Antiviral Agents" with their approach to developing new antiviral agents. Scientists from the Helmholtz Centre for Infection Research are involved in three of the funded projects. YouTuber Jacob Beautemps introduces the teams.

  • How do researchers at the HZI and HIPS develop a new antibiotic?

Audio Podcast

  • Kleine Moleküle ganz groß – Mit Naturstoffen gegen Hepatitis CMit weltweit 130 Millionen Infizierten ist Hepatitis C eine der häufigsten Infektionskrankheiten. Die Therapien, die es derzeit gibt, sind langwierig, haben starke Nebenwirkungen und helfen nicht jedem Patienten. Florenz Sasse vom Braunschweiger Helmholtz-Zentrum für Infektionsforschung und Thomas Pietschmann vom TWINCORE in Hannover suchen gemeinsam nach neuen Wirkstoffen gegen das Hepatitis C-Virus. Hören Sie hier von ihren ersten Treffern und folgen Sie Florenz Sasse zu einer Bibliothek der anderen Art…
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