Chemical Biology

In their ongoing quest for new therapies against pathogens, scientists are focusing primarily on chemical and biological agents. These can function as antibiotics or stimulate the immune system. Discovering new drugs, characterising their functionality and optimising their properties are the three main goals of the department “Chemical Biology” at the HZI.  

Leader

Selected Publications

The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates. Philipp Klahn, Verena Fetz, Antje Ritter, Wera Collisi, Bettina Hinkelmann, Tatjana Arnold, Werner Tegge, Katharina Rox, Stephan Huttel, Kathrin I. Mohr, Joachim Wink, Marc Stadler, Josef Wissing, Lothar Jansch, Mark Broenstrup, Chemical Science (2019), in press. DOI: 10.1039/c8sc05542d

Subcellular Quantification of Uptake in Gram-Negative Bacteria. Prochnow, Hans; Fetz, Verena; Hotop, Sven-Kevin; Garcia-Rivera, Mariel A.; Heumann, Axel; Broenstrup, Mark. Analytical Chemistry (2019), 91(3), 1863-1872.

Hüttel, S., Testolin, G., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. & Müller, R. (2017) Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogens. Angewandte Chemie International Edition, 56, in press, DOI: 10.1002/anie.201705913.

Ferreira, K., Hu, H.Y., Fetz, V., Prochnow, H., Rais, B., Müller, P.P. & Brönstrup, M. (2017) Multivalent Siderophore-DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections. Angewandte Chemie International Edition, 56, 8272-8276.

Hoffmann, H., Kogler, H., Heyse, W., Matter, H., Caspers, M., Schummer, D., Klemke-Jahn, C., Bauer, A., Penarier, G., Debussche, L. & Brönstrup, M. (2015) Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties. Angewandte Chemie International Edition, 54, 10145-10148.

Publications

  • Authors: Fu,C.; Xie,F.; Hoffmann,J.; Wang,Q.; Bauer,A.; Brönstrup,M.; Mahmud,T.; Müller,R.; ( Year: 2019). Title: Armeniaspirol antibiotic biosynthesis: Chlorination and oxidative dechlorination steps affording spiro[4.4]non-8-ene formation.Journal: Chembiochem. Volume: 20 Issue: 6, S-Page: 764- E-Page: 769 DOI: 10.1002/cbic.201800791PubMed
  • Authors: Depke,T.; Franke,R.; Brönstrup,M.; ( Year: 2019). Title: CluMSID: an R package for similarity-based clustering of tandem mass spectra to aid feature annotation in metabolomics.Journal: Bioinformatics. DOI: 10.1093/bioinformatics/btz005PubMed
  • Authors: Hansen,S.; Hotop,S.K.; Faye,O.; Ndiaye,O.; Böhlken-Fascher,S.; Pessoa,R.; Hufert,F.; Stahl-Hennig,C.; Frank,R.; Czerny,C.P.; Schmidt-Chanasit,J.; Sanabani,S.S.; Sall,A.A.; Niedrig,M.; Brönstrup,M.; Fritz,H.J.; Abd El Wahed,A.; ( Year: 2019). Title: Diagnosing Zika virus infection against a background of other flaviviruses: Studies in high resolution serological analysis.Journal: Sci.Rep. Volume: 9 Issue: 1, S-Page: Article number 3648 DOI: 10.1038/s41598-019-40224-2HZI repositoryPubMed
  • Authors: Smith,D.; Buddie,A.G.; Goss,R.J.M.; Overmann,J.; Lepleux,C.; Brönstrup,M.; Kloareg,B.; Meiners,T.; Brennecke,P.; Ianora,A.; Bouget,F.Y.; Gribbon,P.; Pina,M.; ( Year: 2019). Title: Discovery pipelines for marine resources: an ocean of opportunity for biotechnology?.Journal: World Journal of Microbiology and Biotechnology Volume: 35 Issue: 7, S-Page: 107 DOI: 10.1007/s11274-019-2685-yHZI repositoryPubMed
  • Authors: Brennecke,P.; Rasina,D.; Aubi,O.; Herzog,K.; Landskron,J.; Cautain,B.; Vicente,F.; Quintana,J.; Mestres,J.; Stechmann,B.; Ellinger,B.; Brea,J.; Kolanowski,J.L.; Pilarski,R.; Orzaez,M.; Pineda-Lucena,A.; Laraia,L.; Nami,F.; Zielenkiewicz,P.; Paruch,K.; Hansen,E.; von Kries,J.P.; Neuenschwander,M.; Specker,E.; Bartunek,P.; Simova,S.; Lesnikowski,Z.; Krauss,S.; Lehtio,L.; Bilitewski,U.; Brönstrup,M.; Tasken,K.; Jirgensons,A.; Lickert,H.; Clausen,M.H.; Andersen,J.H.; Vicent,M.J.; Genilloud,O.; Martinez,A.; Nazare,M.; Fecke,W.; Gribbon,P.; ( Year: 2019). Title: EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.Journal: SLAS.Discov. Volume: 24 Issue: 3, S-Page: 398- E-Page: 413 DOI: 10.1177/2472555218816276PubMed
  • Authors: Jarrad,A.M.; ( Year: 2019). Title: Firefly Bioluminescence-Based Detection of ATP.Journal: Aust.J.Chem. Volume: 2019 DOI: 10.1071/CH19127HZI repositoryWEBURLS
  • Authors: Chen,L.; Keller,L.J.; Cordasco,E.; Bogyo,M.; Lentz,C.S.; ( Year: 2019). Title: Fluorescent Triazole Urea Activity-Based Probes for the Single-Cell Phenotypic Characterization of Staphylococcus aureus.Journal: Angewandte Chemie - International Edition Volume: 58 Issue: 17, S-Page: 5643- E-Page: 5647 DOI: 10.1002/anie.201900511HZI repositoryPubMed
  • Authors: Grobe,S.; Doberenz,S.; Ferreira,K.; Krueger,J.; Brönstrup,M.; Kaever,V.; Häußler,S.; ( Year: 2019). Title: Identification and quantification of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry.Journal: Chembiochem. DOI: 10.1002/cbic.201800741HZI repositoryPubMed
  • Authors: Koch,S.; Damas,M.; Freise,A.; Hage,E.; Dhingra,A.; Ruckert,J.; Gallo,A.; Kremmer,E.; Tegge,W.; Brönstrup,M.; Brune,W.; Schulz,T.F.; ( Year: 2019). Title: Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression.Journal: PLoS.Pathog. Volume: 15 Issue: 5, S-Page: e1007743 DOI: 10.1371/journal.ppat.1007743HZI repositoryPubMed
  • Authors: Berndt,V.; Beckstette,M.; Volk,M.; Dersch,P.; Brönstrup,M.; ( Year: 2019). Title: Metabolome and transcriptome-wide effects of the carbon storage regulator A in enteropathogenic Escherichia coli.Journal: Sci.Rep. Volume: 9 Issue: 1, S-Page: Article number 138 DOI: 10.1038/s41598-018-36932-wHZI repositoryPubMed
  • Authors: Hermane,J.; Eichner,S.; Mancuso,L.; Schröder,B.; Sasse,F.; Zeilinger,C.; Kirschning,A.; ( Year: 2019). Title: New geldanamycin derivatives with anti Hsp properties by mutasynthesis.Journal: Organic and Biomolecular Chemistry Volume: 17 Issue: 21, S-Page: 5269- E-Page: 5278 DOI: 10.1039/c9ob00892fHZI repositoryPubMed
  • Authors: Chen,L.; Keller,L.J.; Cordasco,E.A.; Bogyo,M.; Lentz,C.S.; ( Year: 2019). Title: Single-cell phenotypic characterization of Staphylococcus aureus with fluorescent triazole urea activity-based probes.Journal: Angew.Chem.Int.Ed Engl. Volume: 58 Issue: 17, S-Page: 5643- E-Page: 5647 DOI: 10.1002/anie.201900511HZI repositoryPubMed
  • Authors: Ahsendorf,H.P.; Gan,L.L.; Eltom,K.H.; Abd El,Wahed A.; Hotop,S.K.; Roper,R.L.; Beutling,U.; Brönstrup,M.; Stahl-Hennig,C.; Hoelzle,L.E.; Czerny,C.P.; ( Year: 2019). Title: Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses.Journal: Viruses. Volume: 11 Issue: 6, S-Page: E493 DOI: 10.3390/v11060493HZI repositoryPubMed
  • Authors: Abouzeid,S.; Beutling,U.; Selmar,D.; ( Year: 2019). Title: Stress-induced modification of indole alkaloids : Phytomodificines as a new category of specialized metabolites.Journal: Phytochemistry Volume: 159 Issue: March, S-Page: 102- E-Page: 107 DOI: 10.1016/j.phytochem.2018.12.015PubMed
  • Authors: Prochnow,H.; Fetz,V.; Hotop,S.-K.; García-Rivera,M.A.; Heumann,A.; Brönstrup,M; ( Year: 2019). Title: Subcellular Quantification of Uptake in Gram-Negative Bacteria.Journal: Anal.Chem. Volume: 91 Issue: 3, S-Page: 1863- E-Page: 1872 DOI: 10.1021/acs.analchem.8b03586HZI repositoryPubMed
  • Authors: Naini,A.; Sasse,F.; Brönstrup,M.; ( Year: 2019). Title: The intriguing chemistry and biology of soraphens.Journal: Nat.Prod.Rep. DOI: 10.1039/c9np00008aHZI repositoryPubMed
  • Authors: Klahn,P.; Fetz,V.; Ritter,A.; Collisi,W.; Hinkelmann,B.; Arnold,T.; Tegge,W.; Rox,K.; Hüttel,S.; Mohr,K.I.; Wink,J.; Stadler,M.; Wissing,J.; Jänsch,L.; Brönstrup,M.; ( Year: 2019). Title: The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates.Journal: Chemical Science Volume: 10 Issue: 20, S-Page: 5197- E-Page: 5210 DOI: 10.1039/c8sc05542dHZI repositoryPubMed
  • Authors: Franke,R.; Hinkelmann,B.; Fetz,V.; Stradal,T.; Sasse,F.; Klawonn,F.; Brönstrup,M.; ( Year: 2019). Title: xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery.Journal: SLAS.Discov., S-Page: 2472555218819459 DOI: 10.1177/2472555218819459HZI repositoryPubMed
  • Authors: Schmidt,C.; Albrecht,L.; Balasupramaniam,S.; Misgeld,R.; Karge,B.; Brönstrup,M.; Prokop,A.; Baumann,K.; Reichl,S.; Ott,I.; ( Year: 2018). Title: A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs.Journal: Metallomics. Volume: 11 Issue: 3, S-Page: 533- E-Page: 545 DOI: 10.1039/c8mt00306hPubMed
  • Authors: Jönsson,T.J.; Schäfer,H.L.; Herling,A.W.; Brönstrup,M.; ( Year: 2018). Title: A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone.Journal: PLoS ONE Volume: 13 Issue: 11, S-Page: e0207210 DOI: 10.1371/journal.pone.0207210HZI repositoryPubMed
  • Authors: Sikandar,A.; Cirnski,K.; Testolin,G.; Volz,C.; Brönstrup,M.; Kalinina,O.V.; Müller,R.; Koehnke,J.; ( Year: 2018). Title: Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA.Journal: Journal of the American Chemical Society Volume: 140 Issue: 48, S-Page: 16641- E-Page: 16649 DOI: 10.1021/jacs.8b08895PubMed
  • Authors: Jarrad,A.M.; Blaskovich,M.A.T.; Prasetyoputri,A.; Karoli,T.; Hansford,K.A.; Cooper,M.A.; ( Year: 2018). Title: Detection and investigation of eagle effect resistance to vancomycin in Clostridium difficile With an ATP-bioluminescence assay.Journal: Front.Microbiol. Volume: 9 Issue: JUL, S-Page: Article no. 1420 DOI: 10.3389/fmicb.2018.01420HZI repositoryPubMed
  • Authors: Raud,B.; Roy,D.G.; Divakaruni,A.S.; Tarasenko,T.N.; Franke,R.; Ma,E.H.; Samborska,B.; Hsieh,W.Y.; Wong,A.H.; Stüve,P.; rnold-Schrauf,C.; Guderian,M.; Lochner,M.; Rampertaap,S.; Romito,K.; Monsale,J.; Brönstrup,M.; Bensinger,S.J.; Murphy,A.N.; McGuire,P.J.; Jones,R.G.; Sparwasser,T.; Berod,L.; ( Year: 2018). Title: Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.Journal: Cell Metab. Volume: 28 Issue: 3, S-Page: 504- E-Page: 515 DOI: 10.1016/j.cmet.2018.06.002PubMed
  • Authors: Sommer,R.; Wagner,S.; Rox,K.; Varrot,A.; Hauck,D.; Wamhoff,E.C.; Schreiber,J.; Ryckmans,T.; Brunner,T.; Rademacher,C.; Hartmann,R.W.; Brönstrup,M.; Imberty,A.; Titz,A.; ( Year: 2018). Title: Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.Journal: Journal of the American Chemical Society Volume: 140 Issue: 7, S-Page: 2537- E-Page: 2545 DOI: 10.1021/jacs.7b11133PubMed
  • Authors: Mohammadi-Ostad-Kalayeh,S.; Stahl,F.; Scheper,T.; Kock,K.; Herrmann,C.; Heleno Batista,F.A.; Borges,J.C.; Sasse,F.; Eichner,S.; Ongouta,J.; Zeilinger,C.; Kirschning,A.; ( Year: 2018). Title: Heat Shock Proteins Revisited: Using a Mutasynthetically Generated Reblastatin Library to Compare the Inhibition of Human and Leishmania Hsp90s.Journal: ChemBioChem Volume: 19 Issue: 6, S-Page: 562- E-Page: 574 DOI: 10.1002/cbic.201700616PubMed
  • Authors: Graef,F.; Richter,R.; Fetz,V.; Murgia,X.; De Rossi,C.; Schneider-Daum,N.; Allegretta,G.; Elgaher,W.; Haupenthal,J.; Empting,M.; Beckmann,F.; Brönstrup,M.; Hartmann,R.; Gordon,S.; Lehr,C.M.; ( Year: 2018). Title: In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics.Journal: ACS Infect.Dis. Volume: 4 Issue: 8, S-Page: 1188- E-Page: 1196 DOI: 10.1021/acsinfecdis.7b00165PubMed
  • Authors: Kumar,M.; Tegge,W.; Wangoo,N.; Jain,R.; Sharma,R.K.; ( Year: 2018). Title: Insights into cell penetrating peptide conjugated gold nanoparticles for internalization into bacterial cells.Journal: Biophys.Chem. Volume: 237 Issue: June, S-Page: 38- E-Page: 46 DOI: 10.1016/j.bpc.2018.03.005PubMed
  • Authors: Muthukumar,Y.; Münkemer,J.; Mathieu,D.; Richter,C.; Schwalbe,H.; Steinmetz,H.; Kessler,W.; Reichelt,J.; Beutling,U.; Frank,R.; Bussow,K.; van den,Heuvel J.; Brönstrup,M.; Taylor,R.E.; Laschat,S.; Sasse,F.; ( Year: 2018). Title: Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria.Journal: PLoS One. Volume: 13 Issue: 7, S-Page: e0201605 DOI: 10.1371/journal.pone.0201605HZI repositoryPubMed
  • Authors: Tappe,D.; Schlottau,K.; Cadar,D.; Hoffmann,B.; Balke,L.; Bewig,B.; Hoffmann,D.; Eisermann,P.; Fickenscher,H.; Krumbholz,A.; Laufs,H.; Huhndorf,M.; Rosenthal,M.; Schulz-Schaeffer,W.; Ismer,G.; Hotop,S.K.; Brönstrup,M.; Ott,A.; Schmidt-Chanasit,J.; Beer,M.; ( Year: 2018). Title: Occupation-associated fatal limbic encephalitis caused by variegated squirrel bornavirus 1, Germany, 2013.Journal: Emerg.Infect.Dis. Volume: 24 Issue: 6, S-Page: 978- E-Page: 987 DOI: 10.3201/eid2406.172027FulltextPubMed
  • Authors: Witzgall,F.; Depke,T.; Hoffmann,M.; Empting,M.; Brönstrup,M.; Müller,R.; Blankenfeldt,W.; ( Year: 2018). Title: The Alkylquinolone Repertoire of Pseudomonas aeruginosa is linked to Structural Flexibility of the FabH-like PQS Biosynthesis Enzyme PqsBC.Journal: Chembiochem. DOI: 10.1002/cbic.201800153PubMed
  • Authors: Prasetyoputri,A.; Jarrad,A.M.; Cooper,M.A.; Blaskovich,M.A.T.; ( Year: 2018). Title: The Eagle Effect and Antibiotic-Induced Persistence: Two Sides of the Same Coin?.Journal: Trends in Microbiology Volume: 27 Issue: 4, S-Page: 339- E-Page: 354 DOI: 10.1016/j.tim.2018.10.007PubMed
  • Authors: Wildermuth,R.; Speck,K.; Haut,F.L.; Mayer,P.; Karge,B.; Brönstrup,M.; Magauer,T.; ( Year: 2017). Title: A modular synthesis of tetracyclic meroterpenoid antibiotics.Journal: Nature Communications Volume: 8 Issue: 1, S-Page: Article number 2083 DOI: 10.1038/s41467-017-02061-7FulltextPubMed
  • Authors: Klahn,P.; Brönstrup,M.; ( Year: 2017). Title: Bifunctional antimicrobial conjugates and hybrid antimicrobials.Journal: Nat.Prod.Rep. Volume: 34 Issue: 7, S-Page: 832- E-Page: 885 DOI: 10.1039/c7np00006ePubMed
  • Authors: Gilardi,A.; Bhamidimarri,S.P.; Brönstrup,M.; Bilitewski,U.; Marreddy,R.K.R.; Pos,K.M.; Benier,L.; Gribbon,P.; Winterhalter,M.; Windshugel,B.; ( Year: 2017). Title: Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt.Journal: Biochim.Biophys.Acta DOI: 10.1016/j.bbagen.2017.07.014PubMed
  • Authors: Lukat,P.; Katsuyama,Y.; Wenzel,S.; Binz,T.; Konig,C.; Blankenfeldt,W.; Brönstrup,M.; Müller,R.; ( Year: 2017). Title: Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.Journal: Chemical Science Volume: 8 Issue: 11, S-Page: 7521- E-Page: 7527 DOI: 10.1039/c7sc02622fHZI repositoryPubMed
  • Authors: Schmidt,C.; Karge,B.; Misgeld,R.; Prokop,A.; Brönstrup,M.; Ott,I.; ( Year: 2017). Title: Biscarbene gold(i) complexes: Structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability.Journal: MedChemComm Volume: 8 Issue: 8, S-Page: 1681- E-Page: 1689 DOI: 10.1039/c7md00269fWEBURLS
  • Authors: Elnakady,Y.A.; Rushdi,A.I.; Franke,R.; Abutaha,N.; Ebaid,H.; Baabbad,M.; Omar,M.O.; Al Ghamdi,A.A.; ( Year: 2017). Title: Characteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi Arabia.Journal: Sci Rep. Volume: 7, S-Page: 41453 DOI: 10.1038/srep41453HZI repositoryPubMed
  • Authors: Depke,T.; Franke,R.; Brönstrup,M.; ( Year: 2017). Title: Clustering of MS2 spectra using unsupervised methods to aid the identification of secondary metabolites from Pseudomonas aeruginosa.Journal: J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. Volume: 7071, S-Page: 19- E-Page: 28 DOI: 10.1016/j.jchromb.2017.06.002PubMed
  • Authors: Rahim,M.I.; Weizbauer,A.; Evertz,F.; Hoffmann,A.; Rohde,M.; Glasmacher,B.; Windhagen,H.; Gross,G.; Seitz,J.M.; Müller,P.P.; ( Year: 2017). Title: Differential magnesium implant corrosion coat formation and contribution to bone bonding.Journal: J.Biomed.Mater.Res.A Volume: 105 Issue: 3, S-Page: 697- E-Page: 709 DOI: 10.1002/jbm.a.35943HZI repositoryPubMed
  • Authors: Hüttel,S.; Testolin,G.; Herrmann,J.; Planke,T.; Gille,F.; Moreno,M.; Stadler,M.; Brönstrup,M.; Kirschning,A.; Müller,R.; ( Year: 2017). Title: Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens.Journal: Angewandte Chemie - International Edition Volume: 56 Issue: 41, S-Page: 12760- E-Page: 12764 DOI: 10.1002/anie.201705913PubMed
  • Authors: Miller,A.K.; Brönstrup,M.; ( Year: 2017). Title: Drug Innovation in Academia: A Helmholtz Drug Research Initiative Conference.Journal: ChemMedChem. Volume: 12 Issue: 19, S-Page: 1652- E-Page: 1654 DOI: 10.1002/cmdc.201700469PubMed
  • Authors: Moore,B.S.; Carter,G.T.; Brönstrup,M.; ( Year: 2017). Title: Editorial: Are natural products the solution to antimicrobial resistance?.Journal: Nat.Prod.Rep. Volume: 34 Issue: 7, S-Page: 685- E-Page: 686 DOI: 10.1039/c7np90026kPubMed
  • Authors: Rohne,P.; Wolf,S.; Dorr,C.; Ringen,J.; Holtz,A.; Gollan,R.; Renner,B.; Prochnow,H.; Baiersdorfer,M.; Koch-Brandt,C.; ( Year: 2017). Title: Erratum to: exposure of vital cells to necrotic cell lysates induce the IRE1alpha branch of the unfolded protein response and cell proliferation.Journal: Cell Stress.Chaperones. Volume: 23 Issue: 1, S-Page: 89 DOI: 10.1007/s12192-017-0831-8Fulltext HZI repository PubMed
  • Authors: Rohne,P.; Wolf,S.; Dörr,C.; Ringen,J.; Holtz,A.; Gollan,R.; Renner,B.; Prochnow,H.; Baierdörfer,M.; Brandt,C.-K.; ( Year: 2017). Title: Exposure of vital cells to necrotic cell lysates induce the IREaalpha branch of the unfolded protein response and cell proliferation.Journal: Cell Stress and Chaperones Volume: 23 Issue: 1, S-Page: 77- E-Page: 88 DOI: 10.1007/s12192-017-0825-6Fulltext HZI repository PubMed
  • Authors: Schmidt,C.; Karge,B.; Misgeld,R.; Prokop,A.; Franke,R.; Brönstrup,M.; Ott,I.; ( Year: 2017). Title: Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.Journal: Chemistry - A European Journal Volume: 23 Issue: 8, S-Page: 1869- E-Page: 1880 DOI: 10.1002/chem.201604512 HZI repository PubMed
  • Authors: Kanwal,S.; Jensch,I.; Palm,G.J.; Brönstrup,M.; Rohde,M.; Kohler,T.P.; Somplatzki,D.; Tegge,W.; Jenkinson,H.F.; Hammerschmidt,S.; ( Year: 2017). Title: Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.Journal: Molecular Microbiology DOI: 10.1111/mmi.13740PubMed
  • Authors: Ferreira,K.; Hu,H.Y.; Fetz,V.; Prochnow,H.; Rais,B.; Muller,P.P.; Brönstrup,M.; ( Year: 2017). Title: Multivalent Siderophore-DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections.Journal: Angew.Chem.Int.Ed Engl. Volume: 56 Issue: 28, S-Page: 8272- E-Page: 8276 DOI: 10.1002/anie.201701358HZI repositoryPubMed
  • Authors: Krasavin,M.; Parchinsky,V.; Kantin,G.; Manicheva,O.; Dogonadze,M.; Vinogradova,T.; Karge,B.; Brönstrup,M.; ( Year: 2017). Title: New nitrofurans amenable by isocyanide multicomponent chemistry are active against multidrug-resistant and poly-resistant Mycobacterium tuberculosis.Journal: Bioorg.Med.Chem. Volume: 25 Issue: 6, S-Page: 1867- E-Page: 1874 DOI: 10.1016/j.bmc.2017.02.003PubMed
  • Authors: Magdy,W.; Abdel-Motaal,F.F.; El-Zayat,S.A.; El-Sayed,M.A.; Helaly,S.E.; ( Year: 2017). Title: Nigragillin, nigerazine B and five naphtho-?-pyrones from Aspergillus japonicus isolated from hot desert soil.Journal: Nat.Prod.J. Volume: 7 Issue: 3, S-Page: 216- E-Page: 223 DOI: 10.2174/2210315507666170306165326WEBURLS
  • Authors: Appendino,G.; Brönstrup,M.; Kubanek,J.M.; ( Year: 2017). Title: Olfaction, taste and chemoreception: Scientific evidence replaces "Essays in biopoetry".Journal: Nat.Prod.Rep. Volume: 34 Issue: 5, S-Page: 469- E-Page: 471 DOI: 10.1039/c7np90016cHZI repositoryPubMed
  • Authors: Frichert,A.; Jones,P.G.; Brönstrup,M.; Lindel,T.; ( Year: 2017). Title: Oxidation of the Meroterpenoid (-)-Terreumol C from the Mushroom Tricholoma terreum: Discovery of Cytotoxic Analogues.Journal: Journal of Natural Products Volume: 80 Issue: 10, S-Page: 2652- E-Page: 2658 DOI: 10.1021/acs.jnatprod.7b00236PubMed
  • Authors: Zhang,Q.; Wang,Q.; Sun,Y.; Zuo,L.; Fetz,V.; Hu,H.Y.; ( Year: 2017). Title: Superior Fluorogen-Activating Protein Probes Based on 3-Indole-Malachite Green.Journal: Organic Letters Volume: 19 Issue: 7, S-Page: 4496- E-Page: 4499 DOI: 10.1021/acs.orglett.7b02055PubMed
  • Authors: Abere,B.; Mamo,T.M.; Hartmann,S.; Samarina,N.; Hage,E.; Ruckert,J.; Hotop,S.K.; Busche,G.; Schulz,T.F.; ( Year: 2017). Title: The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target.Journal: PLoS Pathogens Volume: 13 Issue: 9, S-Page: e1006639 DOI: 10.1371/journal.ppat.1006639HZI repositoryPubMed
  • Authors: Fleta-Soriano,E.; Smutna,K.; Martinez,J.P.; Lorca,Oro C.; Sadiq,S.K.; Mirambeau,G.; Lopez-Iglesias,C.; Bosch,M.; Pol,A.; Brönstrup,M.; Diez,J.; Meyerhans,A.; ( Year: 2017). Title: The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.Journal: Antimicrobial Agents and Chemotherapy Volume: 81 Issue: 8, S-Page: art.no. e00739 DOI: 10.1128/AAC.00739-17HZI repositoryPubMed
  • Authors: Abouzeid,S.; Beutling,U.; Surup,F.; Abdel Bar,F.M.; Amer,M.M.; Badria,F.A.; Yahyazadeh,M.; Brönstrup,M.; Selmar,D.; ( Year: 2017). Title: Treatment of Vinca minor Leaves with Methyl Jasmonate Extensively Alters the Pattern and Composition of Indole Alkaloids.Journal: Journal of Natural Products Volume: 80 Issue: 11, S-Page: 2905- E-Page: 2909 DOI: 10.1021/acs.jnatprod.7b00424PubMed
  • Authors: van Duuren,J.B.J.H.; Müsken,M.; Karge,B.; Tomasch,J.; Wittmann,C.; Häußler,S.; Brönstrup,M.; ( Year: 2017). Title: Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa.Journal: Sci.Rep. Volume: 7 Issue: 1, S-Page: 5223 DOI: 10.1038/s41598-017-05273-5HZI repositoryPubMed
  • Authors: Andritschke,D.; Dilling,S.; Emmenlauer,M.; Welz,T.; Schmich,F.; Misselwitz,B.; Ramo,P.; Rottner,K.; Kerkhoff,E.; Wada,T.; Penninger,J.M.; Beerenwinkel,N.; Horvath,P.; Dehio,C.; Hardt,W.D.; ( Year: 2016). Title: A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.Journal: PLoS ONE Volume: 11 Issue: 9, S-Page: e0161965 DOI: 10.1159/000450705HZI repositoryPubMed
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  • Authors: Hotop,S.K.; Abd El Wahed,A.; Beutling,U.; Jentsch,D.; Motzkus,D.; Frank,R.; Hunsmann,G.; Stahl-Hennig,C.; Fritz,H.J.; ( Year: 2014). Title: Multiple antibody targets on herpes B glycoproteins B and D identified by screening sera of infected rhesus macaques with peptide microarrays.Journal: PLoS ONE Volume: 9 Issue: 1, S-Page: e86857 DOI: 10.1371/journal.pone.0086857HZI repositoryPubMed
  • Authors: Fuchs,M.; Kämpfer,S.; Helmsing,S.; Spallek,R.; Oehlmann,W.; Prilop,W.; Frank,R.; Dübel,S.; Singh,M.; Hust,M.; ( Year: 2014). Title: Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B.Journal: BMC Biotechnol. Volume: 14 DOI: 10.1186/1472-6750-14-68HZI repositoryPubMed
  • Authors: Austel,N.; Björkman,C.; Hilker,M.; Meiners,Torsten; ( Year: 2014). Title: Phenotypic plasticity in host plant preference of the willow leaf beetle Phratora vulgatissima: The impact of experience made by adults.Journal: Agricultural and Forest Entomology Volume: 16 Issue: 4, S-Page: 417- E-Page: 425 DOI: 10.1111/afe.12071HZI repositoryPubMed
  • Authors: Harmrolfs,K.; Mancuso,L.; Drung,B.; Sasse,Florenz; Kirschning,A.; ( Year: 2014). Title: Preparation of new alkyne-modified ansamitocins by mutasynthesis.Journal: Beilstein Journal of Organic Chemistry Volume: 10, S-Page: 535- E-Page: 543 PubMed
  • Authors: Mancuso,L.; Knobloch,T.; Buchholz,J.; Hartwig,J.; Müller,L.; Seidel,K.; Collisi,W.; Sasse,F.; Kirschning,A.; ( Year: 2014). Title: Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach.Journal: Chemistry - A European Journal Volume: 20 Issue: 52, S-Page: 17541- E-Page: 17551
  • Authors: Jerz,G.; Elnakady,Yasser A.; Braun,A.; Jackel,K.; Sasse,Florenz; Al Ghamdi,A.A.; Omar,M.O.; Winterhalter,P.; ( Year: 2014). Title: Preparative mass-spectrometry profiling of bioactive metabolites in Saudi-Arabian propolis fractionated by high-speed countercurrent chromatography and off-line atmospheric pressure chemical ionization mass-spectrometry injection.Journal: Journal of Chromatography A Volume: 1347, S-Page: 17- E-Page: 29 DOI: 10.1016/j.chroma.2014.04.068PubMed
  • Authors: Lutz,V.; Mannchen,F.; Krebs,M.; Park,N.; Kruger,C.; Raja,A.; Sasse,Florenz; Baro,A.; Laschat,S.; ( Year: 2014). Title: SAR studies on hydropentalene derivatives-Important core units of biologically active tetramic acid macrolactams and ptychanolides.Journal: Bioorganic and Medicinal Chemistry Volume: 22 Issue: 13, S-Page: 3252- E-Page: 3261 DOI: 10.1016/j.bmc.2014.04.063HZI repositoryPubMed
  • Authors: Böchel,K.; Austel,N.; Mayer,M.; Gershenzon,J.; Fenning,T.M.; Meiners,Torsten; ( Year: 2014). Title: Smelling the tree and the forest: Elm background odours affect egg parasitoid orientation to herbivore induced terpenoids.Journal: BioControl Volume: 59 Issue: 1, S-Page: 29- E-Page: 43 WEBURLS
  • Authors: Shaaban,S.; Sasse,Florenz; Burkholz,T.; Jacob,C.; ( Year: 2014). Title: Sulfur, selenium and tellurium pseudopeptides: Synthesis and biological evaluation.Journal: Bioorganic and Medical Chemistry Volume: 22 Issue: 14, S-Page: 3610- E-Page: 3619 DOI: 10.1016/j.bmc.2014.05.019HZI repositoryPubMed
  • Authors: Hentschel,F.; Raimer,B.; Kelter,G.; Fiebig,H.-H.; Sasse,Florenz; Lindel,T.; ( Year: 2014). Title: Synthesis and cytotoxicity of a diazirine-based photopsammaplin.Journal: European Journal of Organic Chemistry Volume: 2014 Issue: 10, S-Page: 2120- E-Page: 2127
  • Authors: Müller,S.; Sasse,Florenz; Maier,M.E.; ( Year: 2014). Title: Synthesis of pladienolide b and its 7-epimer with insights into the role of the allylic acetate.Journal: European Journal of Organic Chemistry Volume: 2014 Issue: 5, S-Page: 1025- E-Page: 1036 WEBURLS
  • Authors: Fleta-Soriano,E.; Martinez,J.P.; Hinkelmann,B.; Gerth,K.; Washausen,P.; Diez,J.; Frank,R.; Sasse,F.; Meyerhans,A.; ( Year: 2014). Title: The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway.Journal: Microbial Cell Factories Volume: 13 Issue: 1 DOI: 10.1186/1475-2859-13-17HZI repositoryWEBURLS
  • Authors: Mancuso,L.; Jurjens,G.; Hermane,J.; Harmrolfs,Kirsten; Eichner,S.; Fohrer,J.; Collisi,Wera; Sasse,Florenz; Kirschning,A.; ( Year: 2013). Title: Bioreduction of Aryl Azides during Mutasynthesis of New Ansamitocins.Journal: Organic Letters Volume: 15 Issue: 17, S-Page: 4442- E-Page: 4445 PubMed
  • Authors: Adla,S.K.; Sasse,Florenz; Kelter,G.; Fiebig,H.H.; Lindel,T.; ( Year: 2013). Title: Doubly prenylated tryptamines: Cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A.Journal: Organic and Biomolecular Chemistry Volume: 11 Issue: 36, S-Page: 6119- E-Page: 6130 WEBURLS
  • Authors: Pohla,H.; Buchner,A.; Stadlbauer,B.; Frankenberger,B.; Stevanovic,S.; Walter,S.; Frank,R.; Schwachula,T.; Olek,S.; Kopp,J.; Willimsky,G.; Stief,C.G.; Hofstetter,A.; Pezzutto,A.; Blankenstein,T.; Oberneder,R.; Schendel,D.J.; ( Year: 2013). Title: High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination.Journal: Molecular Medicine Volume: 18, S-Page: 1499- E-Page: 1508 DOI: 10.2119/molmed.2012.00221HZI repositoryPubMed
  • Authors: Irschik,H.; Washausen,Peter; Sasse,Florenz; Fohrer,J.; Huch,V.; Müller,Rolf; Prusov,Evgeny V.; ( Year: 2013). Title: Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from myxobacteria.Journal: Angewandte Chemie International Edition Volume: 52 Issue: 20, S-Page: 5402- E-Page: 5405 WEBURLS
  • Authors: Altendorfer,M.; Raja,A.; Sasse,Florenz; Irschik,Herbert; Menche,D.; ( Year: 2013). Title: Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.Journal: Organic and Biomolecular Chemistry Volume: 11 Issue: 13, S-Page: 2116- E-Page: 2139 DOI: 10.1039/c2ob26906fHZI repositoryPubMed
  • Authors: Fulde,M.; Bernardo-Garcia,N.; Rohde,Manfred; Nachtigall,N.; Frank,Ronald; Preissner,K.T.; Klett,J.; Morreale,A.; Chhatwal,Gursharan S.; Hermoso,J.A.; Bergmann,S.; ( Year: 2013). Title: Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.Journal: Thrombosis and Haemostasis Volume: 111 Issue: 3, S-Page: 401- E-Page: 416 DOI: 10.1160/TH13-05-0421PubMed
  • Authors: Martinez,J.P.; Perez-Vilaro,G.; Muthukumar,Y.; Scheller,N.; Hirsch,Tatjana; Diestel,R.; Steinmetz,Heinrich; Jansen,Rolf; Frank,Ronald; Sasse,Florenz; Meyerhans,A.; Diez,J.; ( Year: 2013). Title: Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.Journal: RNA Biology Volume: 10 Issue: 11, S-Page: 1661- E-Page: 1669 Fulltext
  • Authors: Munzner,J.; Biersack,B.; Kaps,L.; Mahal,K.; Schobert,R.; Sasse,Florenz; ( Year: 2013). Title: Synergistic "gold effects" of anti-vascular 4,5-diarylimidazol-2-ylidene gold(I) carbene complexes.Journal: International Journal of Clinical Pharmacology and Therapeutics Volume: 51 Issue: 1, S-Page: 44- E-Page: 46 DOI: 10.5414/CPP51044PubMed
  • Authors: Kempf,K.; Raja,Aruna; Sasse,Florenz; Schobert,R.; ( Year: 2013). Title: Synthesis of penicillenol C1 and of a bis-azide analogue for photoaffinity labeling.Journal: Journal of Organic Chemistry Volume: 78 Issue: 6, S-Page: 2455- E-Page: 2461 WEBURLS
  • Authors: Ahmad,I.; Wigren,E.; Le,Guyon S.; Vekkeli,S.; Blanka,A.; El,Mouali Y.; Anwar,N.; Chuah,M.L.; Lünsdorf,H.; Frank,Ronald; Rhen,M.; Liang,Z.X.; Lindqvist,Y.; Romling,U.; ( Year: 2013). Title: The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium.Journal: Molecular Microbiology Volume: 90 Issue: 6, S-Page: 1216- E-Page: 1232 PubMed
  • Authors: Muthukumar,Y.; Roy,M.; Raja,A.; Taylor,R.E.; Sasse,Florenz; ( Year: 2013). Title: The marine polyketide myriaporone 3/4 stalls translation by targeting the elongation phase.Journal: ChemBioChem Volume: 14 Issue: 2, S-Page: 260- E-Page: 264 DOI: 10.1002/cbic.201200522PubMed
  • Authors: Frei,R.; Staedler,D.; Raja,A.; Franke,R.; Sasse,Florenz; Gerber-Lemaire,S.; Waser,J.; ( Year: 2013). Title: Total synthesis and biological evaluation of jerantinine e.Journal: Angewandte Chemie International Edition Volume: 52 Issue: 50, S-Page: 13373- E-Page: 13376 PubMed
  • Authors: Plaza,A.; Garcia,R.; Bifulco,G.; Martinez,J.P.; Huttel,S.; Sasse,Florenz; Meyerhans,A.; Stadler,Marc; Müller,Rolf; ( Year: 2012). Title: Aetheramides A and B, Potent HIV-Inhibitory Depsipeptides from a Myxobacterium of the New Genus "Aetherobacter".Journal: Organic Letters Volume: 14 Issue: 11, S-Page: 2854- E-Page: 2857 PubMed
  • Authors: Diaz,N.; Zhu,M.; Ehrlich,G.; Eggert,U.; Muthukumar,Y.; Sasse,Florenz; Kalesse,Markus; ( Year: 2012). Title: An improved route to (+)-tedanolide and analysis of its subtle effects controlling conformation and biological behaviour.Journal: Chemistry Volume: 18 Issue: 16, S-Page: 4946- E-Page: 4952 PubMed
  • Authors: Dalby,A.R.; Emam,I.; Franke,R.; ( Year: 2012). Title: Analysis of gene expression data from non-small cell lung carcinoma cell lines reveals distinct sub-classes from those identified at the phenotype level.Journal: PLoS ONE Volume: 7 Issue: 11, S-Page: e50253 DOI: 10.1371/journal.pone.0050253HZI repositoryPubMed
  • Authors: Eichner,S.; Eichner,T.; Floss,H.G.; Fohrer,J.; Hofer,E.; Sasse,Florenz; Zeilinger,C.; Kirschning,A.; ( Year: 2012). Title: Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.Journal: Journal of the American Chemical Society Volume: 134 Issue: 3, S-Page: 1673- E-Page: 1679 PubMed
  • Authors: Standfuss-Gabisch,C.; Al-Halbouni,D.; Hofer,B.; ( Year: 2012). Title: Characterization of biphenyl dioxygenase sequences and activities encoded by the metagenomes of highly polychlorobiphenyl-contaminated soils.Journal: Applied and Environmental Microbiology Volume: 78 Issue: 8, S-Page: 2706- E-Page: 2715 DOI: 10.1128/AEM.07381-11HZI repositoryPubMed
  • Authors: Taft,F.; Harmrolfs,K.; Nickeleit,I.; Heutling,A.; Kiene,M.; Malek,N.; Sasse,Florenz; Kirschning,A.; ( Year: 2012). Title: Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.Journal: Chemistry Volume: 18 Issue: 3, S-Page: 880- E-Page: 886 PubMed
  • Authors: Schneider,T.; Muthukumar,Y.; Hinkelmann,B.; Franke,R.; Döring,M.; Jacob,C.; Sasse,Florenz; ( Year: 2012). Title: Deciphering intracellular targets of organochalcogen based redox catalysts.Journal: MedChemComm Volume: 3 Issue: 7, S-Page: 784- E-Page: 787
  • Authors: Hentschel,F.; Sasse,Florenz; Lindel,T.; ( Year: 2012). Title: Fluorescent analogs of the marine natural product psammaplin A: synthesis and biological activity.Journal: Organic and Biomolecular Chemistry Volume: 10 Issue: 35, S-Page: 7120- E-Page: 7133 PubMed
  • Authors: Hofle,G.; Gerth,Klaus; Reichenbach,H.; Kunze,B.; Sasse,Florenz; Forche,E.; Prusov,E.V.; ( Year: 2012). Title: Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex i inhibitor.Journal: Chemistry Volume: 18 Issue: 36, S-Page: 11362- E-Page: 11370 PubMed
  • Authors: Diez,J.; Martinez,J.P.; Mestres,J.; Sasse,Florenz; Frank,Ronald; Meyerhans,A.; ( Year: 2012). Title: Myxobacteria: Natural pharmaceutical factories.Journal: Microbial Cell Factories Volume: 11, S-Page: 52 DOI: 10.1186/1475-2859-11-52HZI repositoryPubMed
  • Authors: Shaaban,S.; Diestel,R.; Hinkelmann,B.; Muthukumar,Y.; Verma,R.P.; Sasse,Florenz; Jacob,C.; ( Year: 2012). Title: Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents.Journal: European Journal of Medicinal Chemistry Volume: 58, S-Page: 192- E-Page: 205 HZI repositoryPubMed
  • Authors: Diaz,N.; Naini,A.; Muthukumar,Y.; Sasse,Florenz; Kalesse,Markus; ( Year: 2012). Title: Synthesis of simplified tedanolide analogues-connecting tedanolide to myriaporone and gephyronic Acid.Journal: ChemMedChem Volume: 7 Issue: 5, S-Page: 771- E-Page: 775 PubMed
  • Authors: Eichner,S.; Knobloch,T.; Floss,H.G.; Fohrer,J.; Harmrolfs,K.; Hermane,J.; Schulz,A.; Sasse,Florenz; Spiteller,P.; Taft,F.; Kirschning,A.; ( Year: 2012). Title: The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.Journal: Angewandte Chemie International Edition Volume: 51 Issue: 3, S-Page: 752- E-Page: 757 PubMed
  • Authors: Reboll,M.R.; Ritter,B.; Sasse,Florenz; Niggemann,Jutta; Frank,Ronald; Nourbakhsh,M.; ( Year: 2012). Title: The myxobacterial compounds spirangien a and spirangien m522 are potent inhibitors of IL-8 expression.Journal: ChemBioChem Volume: 13 Issue: 3, S-Page: 409- E-Page: 415 PubMed
  • Authors: Ushakov,D.B.; Raja,A.; Franke,R.; Sasse,Florenz; Maier,M.E.; ( Year: 2012). Title: Total synthesis of (+/-)moluccanic acid methyl ester.Journal: Synlett Volume: 23 Issue: 9, S-Page: 1358- E-Page: 1360
  • Authors: Knobloch,T.; Dräger,G.; Collisi,W.; Sasse,Florenz; Kirschning,A.; ( Year: 2012). Title: Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.Journal: Beilstein Journal of Organic Chemistry Volume: 8, S-Page: 861- E-Page: 869 DOI: 10.3762/bjoc.8.96HZI repositoryPubMed
  • Authors: Montaner,A.D.; Denichilo,A.; Rodriguez,J.M.; Flo,J.; Lopez,R.A.; Pontoriero,A.; Savy,V.; Baumeister,E.; Frank,Ronald*; Zorzopulos,J.; Elias,F.; ( Year: 2011). Title: Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire.Journal: Nucleic Acid Therapeutics Volume: 21 Issue: 4, S-Page: 265- E-Page: 274 PubMed
  • Authors: Elsebai,M.F.; Kehraus,S.; Lindequist,U.; Sasse,Florenz*; Shaaban,S.; Gutschow,M.; Josten,M.; Sahl,H.G.; Konig,G.M.; ( Year: 2011). Title: Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale.Journal: Organic and Biomolecular Chemistry Volume: 9 Issue: 3, S-Page: 802- E-Page: 808 PubMed
  • Authors: Horstmann,N.; Essig,S.; Bockelmann,S.; Wieczorek,H.; Huss,M.; Sasse,Florenz; Menche,D.; ( Year: 2011). Title: Archazolid A-15-O-beta-d-glucopyranoside and iso-Archazolid B: Potent V-ATPase Inhibitory Polyketides from the Myxobacteria Cystobacter violaceus and Archangium gephyra.Journal: Journal of Natural Products Volume: 74 Issue: 5, S-Page: 1100- E-Page: 1105 DOI: 10.1021/np200036vHZI repositoryPubMed
  • Authors: Grelle,G.; Otto,A.; Lorenz,M.; Frank,Ronald F.*; Wanker,E.E.; Bieschke,J.; ( Year: 2011). Title: Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-beta and alpha-Synuclein Fibrils.Journal: Biochemistry Volume: 50 Issue: 49, S-Page: 10624- E-Page: 10636 PubMed
  • Authors: Effenberger-Neidnicht,K.; Breyer,S.; Mahal,K.; Diestel,R.; Sasse,Florenz*; Schobert,R.; ( Year: 2011). Title: Cellular localisation of antitumoral 6-alkyl thymoquinones revealed by an alkyne-azide click reaction and the streptavidin-biotin system.Journal: ChemBioChem Volume: 12 Issue: 8, S-Page: 1237- E-Page: 1241 DOI: 10.1002/cbic.201000762HZI repositoryPubMed
  • Authors: Biersack,B.; Muthukumar,Y.; Schobert,R.; Sasse,Florenz*; ( Year: 2011). Title: Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles.Journal: Bioorganic and Medicinal Chemistry Letters Volume: 21 Issue: 21, S-Page: 6270- E-Page: 6273 DOI: 10.1016/j.bmcl.2011.09.005HZI repositoryPubMed
  • Authors: Ritter,B.; Kilian,P.; Reboll,M.R.; Resch,K.; Distefano,J.K.; Frank,Ronald*; Beil,W.; Nourbakhsh,M.; ( Year: 2011). Title: Differential Effects of Multiplicity of Infection on Helicobacter pylori-Induced Signaling Pathways and Interleukin-8 Gene Transcription.Journal: Journal of Clinical Immunology Volume: 31 Issue: 1, S-Page: 60- E-Page: 68 PubMed
  • Authors: Nicolas,L.; Anderl,T.; Sasse,Florenz*; Steinmetz,H.; Jansen,Rolf*; Hofle,G.; Laschat,S.; Taylor,R.E.; ( Year: 2011). Title: Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid.Journal: Angewandte Chemie International Edition Volume: 50 Issue: 4, S-Page: 938- E-Page: 941 PubMed
  • Authors: Anderl,T.; Nicolas,L.; Munkemer,J.; Baro,A.; Sasse,Florenz*; Steinmetz,H.; Jansen,Rolf*; Hofle,G.; Taylor,R.E.; Laschat,S.; ( Year: 2011). Title: Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid.Journal: Angewandte Chemie International Edition Volume: 50 Issue: 4, S-Page: 942- E-Page: 945 PubMed
  • Authors: Gentzsch,J.; Hinkelmann,B.; Kaderali,L.; Irschik,Herbert*; Jansen,Rolf*; Sasse,Florenz*; Frank,Ronald*; Pietschmann,Thomas*; ( Year: 2011). Title: Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity.Journal: Antiviral Research Volume: 89 Issue: 2, S-Page: 136- E-Page: 148 PubMed
  • Authors: Elsebai,M.F.; Natesan,L.; Kehraus,S.; Mohamed,I.E.; Schnakenburg,G.; Sasse,Florenz*; Shaaban,S.; Gutschow,M.; Konig,G.M.; ( Year: 2011). Title: HLE-Inhibitory Alkaloids with a Polyketide Skeleton from the Marine-Derived Fungus Coniothyrium cereale.Journal: Journal of Natural Products Volume: 74 Issue: 10, S-Page: 2282- E-Page: 2285 PubMed
  • Authors: Wunderlich,K.; Juozapaitis,M.; Ranadheera,C.; Kessler,U.; Martin,A.; Eisel,J.; Beutling,U.; Frank,Ronald; Schwemmle,M.; ( Year: 2011). Title: Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase.Journal: Antimicrobial Agents and Chemotherapy Volume: 55 Issue: 2, S-Page: 696- E-Page: 702 DOI: 10.1128/AAC.01419-10FulltextPubMed
  • Authors: Knappe,T.A.; Manzenrieder,F.; Mas-Moruno,C.; Linne,U.; Sasse,Florenz*; Kessler,H.; Xie,X.; Marahiel,M.A.; ( Year: 2011). Title: Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.Journal: Angewandte Chemie International Edition Volume: 50 Issue: 37, S-Page: 8714- E-Page: 8717 PubMed
  • Authors: Meyer,T.; Stratmann-Selke,J.; Meens,J.; Schirrmann,T.; Gerlach,G.F.; Frank,Ronald*; Dubel,S.; Strutzberg-Minder,K.; Hust,M.; ( Year: 2011). Title: Isolation of scFv fragments specific to OmpD of Salmonella Typhimurium.Journal: Veterinary Microbiology Volume: 147 Issue: 1-2, S-Page: 162- E-Page: 169 PubMed
  • Authors: Omnus,D.J.; Mehrtens,S.; Ritter,B.; Resch,K.; Yamada,M.; Frank,Ronald*; Nourbakhsh,M.; Reboll,M.R.; ( Year: 2011). Title: JKTBP1 Is Involved in Stabilization and IRES-Dependent Translation of NRF mRNAs by Binding to 5' and 3' Untranslated Regions.Journal: Journal of Molecular Biology Volume: 407 Issue: 4, S-Page: 492- E-Page: 504 DOI: 10.1016/j.jmb.2011.01.050HZI repositoryPubMed
  • Authors: Reboll,M.R.; Schweda,A.T.; Bartels,M.; Franke,R.; Frank,Ronald*; Nourbakhsh,M.; ( Year: 2011). Title: Mapping of NRF binding motifs of NF-kappaB p65 subunit.Journal: Journal of Biochemistry Volume: 150 Issue: 5, S-Page: 553- E-Page: 562 DOI: 10.1093/jb/mvr099HZI repositoryPubMed
  • Authors: Kraemer,S.; Lue,H.; Zernecke,A.; Kapurniotu,A.; Andreetto,E.; Frank,Ronald*; Lennartz,B.; Weber,C.; Bernhagen,J.; ( Year: 2011). Title: MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism.Journal: FASEB journal Volume: 25 Issue: 3, S-Page: 894- E-Page: 906 PubMed
  • Authors: Effenberger-Neidnicht,K.; Breyer,S.; Mahal,K.; Sasse,Florenz*; Schobert,R.; ( Year: 2011). Title: Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.Journal: Cancer Chemotherapy and Pharmacology Volume: 69 Issue: 1, S-Page: 85- E-Page: 90 DOI: 10.1007/s00280-011-1675-zHZI repositoryPubMed
  • Authors: Knobloch,T.; Harmrolfs,K.; Taft,F.; Thomaszewski,B.; Sasse,Florian*; Kirschning,A.; ( Year: 2011). Title: Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-oriented Approach to Exploit Biosynthetic Flexibility.Journal: ChemBioChem Volume: 13 Issue: 4, S-Page: 540- E-Page: 547 DOI: 10.1002/cbic.201000608HZI repositoryPubMed
  • Authors: Bremer,C.M.; Sominskaya,I.; Skrastina,D.; Pumpens,P.; Wahed,A.A.; Beutling,U.; Frank,Ronald*; Fritz,H.J.; Hunsmann,G.; Gerlich,W.H.; Glebe,D.; ( Year: 2011). Title: N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus.Journal: Journal of Hepatology Volume: 11 Issue: 1, S-Page: 29- E-Page: 37 PubMed
  • Authors: Buntru,A.; Kopp,K.; Voges,M.; Frank,Ronald*; Bachmann,V.; Hauck,C.R.; ( Year: 2011). Title: Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis.Journal: Journal of Biological Chemistry Volume: 286 Issue: 11, S-Page: 9555- E-Page: 9566 DOI: 10.1074/jbc.M110.216085HZI repositoryPubMed
  • Authors: Capell,A.; Liebscher,S.; Fellerer,K.; Brouwers,N.; Willem,M.; Lammich,S.; Gijselinck,I.; Bittner,T.; Carlson,A.M.; Sasse,Florenz*; Kunze,B*.; Steinmetz,H*.; Jansen,Rolf*; Dormann,D.; Sleegers,K.; Cruts,M.; Herms,J.; Van,Broeckhoven C.; Haass,C.; ( Year: 2011). Title: Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.Journal: Journal of Neuroscience Volume: 31 Issue: 5, S-Page: 1885- E-Page: 1894 PubMed
  • Authors: Bieschke,J.; Herbst,M.; Wiglenda,T.; Friedrich,R.P.; Boeddrich,A.; Schiele,F.; Kleckers,D.; Lopez Del Amo,J.M.; Gruning,B.A.; Wang,Q.; Schmidt,M.R.; Lurz,R.; Anwyl,R.; Schnoegl,S.; Fandrich,M.; Frank,Ronald F.*; Reif,B.; Gunther,S.; Walsh,D.M.; Wanker,E.E.; ( Year: 2011). Title: Small-molecule conversion of toxic oligomers to nontoxic beta-sheet-rich amyloid fibrils.Journal: Nature Chemical Biology Volume: 8 Issue: 1, S-Page: 93- E-Page: 101 PubMed
  • Authors: Anderl,T.; Nicolas,L.; Münkemer,J.; Muthukumar,Y.; Baro,A.; Frey,W.; Sasse,Florenz*; Taylor,R.E.; Laschat,S.; ( Year: 2011). Title: Synthesis and biological evaluation of gephyronic acid derivatives: Initial steps towards the identification of the biological target of polyketide inhibitors of eukaryotic protein synthesis.Journal: European Journal of Organic Chemistry Volume: 36, S-Page: 7294- E-Page: 7307
  • Authors: Müller,S.; Mayer,T.; Sasse,Florenz*; Maier,M.E.; ( Year: 2011). Title: Synthesis of a Pladienolide B Analogue with the Fully Functionalized Core Structure.Journal: Organic Letters Volume: 13 Issue: 15, S-Page: 3940- E-Page: 3943 PubMed
  • Authors: Zhdanko,A.; Schmauder,A.; Ma,C.I.; Sibley,L.D.; Sept,D.; Sasse,Florenz*; Maier,M.E.; ( Year: 2011). Title: Synthesis of Chondramide A Analogues with Modified beta-Tyrosine and Their Biological Evaluation.Journal: Chemistry Volume: 17 Issue: 47, S-Page: 13349- E-Page: 13357 PubMed
  • Authors: Garcia,J.; Barluenga,S.; Gorska,K.; Sasse,Florenz*; Winssinger,N.; ( Year: 2011). Title: Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.Journal: Bioorganic and Medicinal Chemistry Volume: 20 Issue: 2, S-Page: 672- E-Page: 680 PubMed
  • Authors: Fries,T.; Frank,Ronald*; Bailer,S.M.; ( Year: 2011). Title: The Saccharomyces cerevisiae ubiquitin E3 ligase Asr1p targets calmodulin for ubiquitylation.Journal: Biochemical and Biophysical Research Communications Volume: 411 Issue: 1, S-Page: 197- E-Page: 201 PubMed
  • Authors: Ushakov,D.B.; Navickas,V.; Strobele,M.; Maichle-Mossmer,C.; Sasse,Florenz*; Maier,M.E.; ( Year: 2011). Title: Total synthesis and biological evaluation of (-)-9-deoxy-englerin A.Journal: Organic Letters Volume: 13 Issue: 8, S-Page: 2090- E-Page: 2093 PubMed
  • Authors: Nickl,C.K.; Raidas,S.K.; Zhao,H.; Sausbier,M.; Ruth,P.; Tegge,Werner*; Brayden,J.E.; Dostmann,W.R.; ( Year: 2010). Title: (d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha.Journal: Biochimica et biophysica acta Volume: 1804 Issue: 3, S-Page: 524- E-Page: 532 PubMed
  • Authors: Gloriam,D.E.; Orchard,S.; Bertinetti,D.; Bjorling,E.; Bongcam-Rudloff,E.; Borrebaeck,C.A.; Bourbeillon,J.; Bradbury,A.R.; de,Daruvar A.; Dubel,S.; Frank,Roland*; Gibson,T.J.; Gold,L.; Haslam,N.; Herberg,F.W.; Hiltke,T.; Hoheisel,J.D.; Kerrien,S.; Koegl,M.; Konthur,Z.; Korn,B.; Landegren,U.; Montecchi-Palazzi,L.; Palcy,S.; Rodriguez,H.; Schweinsberg,S.; Sievert,V.; Stoevesandt,O.; Taussig,M.J.; Ueffing,M.; Uhlen,M.; van der,Maarel S.; Wingren,C.; Woollard,P.; Sherman,D.J.; Hermjakob,H.; ( Year: 2010). Title: A community standard format for the representation of protein affinity reagents.Journal: Molecular and Cellular Proteomics Volume: 9 Issue: 1, S-Page: 1- E-Page: 10 PubMed
  • Authors: Schlenk,A.; Diestel,R.; Sasse,Florenz*; Schobert,R.; ( Year: 2010). Title: A selective 3-acylation of tetramic acids and the first synthesis of ravenic acid.Journal: Chemistry Volume: 16 Issue: 8, S-Page: 2599- E-Page: 2604 DOI: 10.1002/chem.200902544HZI repositoryPubMed
  • Authors: Westermann,J.; Florcken,A.; Willimsky,G.; van,Lessen A.; Kopp,J.; Takvorian,A.; Johrens,K.; Lukowsky,A.; Schonemann,C.; Sawitzki,B.; Pohla,H.; Frank,R.; Dorken,B.; Schendel,D.J.; Blankenstein,T.; Pezzutto,A.; ( Year: 2010). Title: Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study.Journal: Gene Therapy Volume: 18 Issue: 4, S-Page: 354- E-Page: 363 DOI: 10.1038/gt.2010.143HZI repositoryPubMed
  • Authors: Micklinghoff,J.C.; Schmidt,M.; Geffers,Robert*; Tegge,Werner*; Bange,F.C.; ( Year: 2010). Title: Analysis of expression and regulatory functions of the ribosome-binding protein TypA in Mycobacterium tuberculosis under stress conditions.Journal: Archives of Microbiology Volume: 192 Issue: 6, S-Page: 499- E-Page: 504 PubMed
  • Authors: Schulz,S.; Dickschat,J.S.; Kunze,B.; Wagner-Döbler,Irene*; Diestel,R.; Sasse,Florenz*; ( Year: 2010). Title: Biological activity of volatiles from marine and terrestrial bacteria.Journal: Marine Drugs Volume: 8, S-Page: 2976- E-Page: 2987
  • Authors: Harmrolfs,K.; Brunjes,M.; Drager,G.; Floss,H.G.; Sasse,Florenz*; Taft,F.; Kirschning,A.; ( Year: 2010). Title: Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.Journal: ChemBioChem Volume: 11 Issue: 18, S-Page: 2517- E-Page: 2520 PubMed
  • Authors: Lisurek,M.; Rupp,B.; Wichard,J.; Neuenschwander,M.; von Kries,J.P.; Frank,Ronald*; Rademann,J.; Kuhne,R.; ( Year: 2010). Title: Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.Journal: Molecular Diversity Volume: 14 Issue: 2, S-Page: 401- E-Page: 408 DOI: 10.1007/s11030-009-9187-z.PubMed
  • Authors: Maenz,B.; Goetz,V.; Wunderlich,K.; Eisel,J.; Kirchmair,J.; Stech,J.; Stech,O.; Chase,G.; Frank,Ronald*; Schwemmle,M.; ( Year: 2010). Title: Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza a virus.Journal: Journal of Biological Chemistry Volume: 286 Issue: 10, S-Page: 8414- E-Page: 8424 PubMed
  • Authors: Beutling,U.; Frank,Ronald*; ( Year: 2010). Title: Epitope analysis using synthetic peptide repertoires prepared by SPOT synthesis technology.Book Title: Antibody Engineering Editors: Kontermann,R.; Dübel,S.; (Ed.). City: Berlin, Heidelberg Publisher: Springer-Verlag
  • Authors: Franke,R.; Theis,F.J.; Klamt,S.; ( Year: 2010). Title: From binary to multivalued to continuous models: the lac operon as a case study.Journal: Journal of Integrative Bioinformatics Volume: 7 Issue: 1, S-Page: 151- E-Page: 169 DOI: 10.2390/biecoll-jib-2010-151HZI repositoryPubMed
  • Authors: Voigt,J.; Kiess,M.; Getzlaff,R.; Wostemeyer,J.; Frank,Ronald*; ( Year: 2010). Title: Generation of the heterodimeric precursor GP3 of the Chlamydomonas cell wall.Journal: Molecular Microbiology Volume: 77 Issue: 6, S-Page: 1512- E-Page: 1526 PubMed
  • Authors: Andreetto,E.; Yan,L.M.; Tatarek-Nossol,M.; Velkova,A.; Frank,Ronald*; Kapurniotu,A.; ( Year: 2010). Title: Identification of Hot Regions of the Abeta-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association.Journal: Angewandte Chemie - International Edition Volume: 49 Issue: 17, S-Page: 3081- E-Page: 3085 PubMed
  • Authors: Brodmann,T.; Janssen,D.; Sasse,Florenz*; Irschik,Herbert*; Jansen,Rolf*; Müller,Rolf*; Kalesse,Markus*; ( Year: 2010). Title: Isolation and synthesis of chivotriene, a chivosazole shunt product from Sorangium cellulosum.Journal: European Journal of Organic Chemistry Volume: 27, S-Page: 5155- E-Page: 5159 DOI: 10.1002/ejoc.201000781
  • Authors: Heinzelmann,K.; Scholz,B.A.; Nowak,A.; Fossum,E.; Kremmer,E.; Haas,J.; Frank,R.; Kempkes,B.; ( Year: 2010). Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.Journal: Journal of Virology Volume: 84 Issue: 23, S-Page: 12255- E-Page: 12264 DOI: 10.1128/JVI.01484-10HZI repositoryPubMed
  • Authors: Bourbeillon,J.; Orchard,S.; Benhar,I.; Borrebaeck,C.; de,Daruvar A.; Dubel,S.; Frank,Ronald*; Gibson,F.; Gloriam,D.; Haslam,N.; Hiltker,T.; Humphrey-Smith,I.; Hust,M.; Juncker,D.; Koegl,M.; Konthur,Z.; Korn,B.; Krobitsch,S.; Muyldermans,S.; Nygren,P.A.; Palcy,S.; Polic,B.; Rodriguez,H.; Sawyer,A.; Schlapshy,M.; Snyder,M.; Stoevesandt,O.; Taussig,M.J.; Templin,M.; Uhlen,M.; van der,Maarel S.; Wingren,C.; Hermjakob,H.; Sherman,D.; ( Year: 2010). Title: Minimum information about a protein affinity reagent (MIAPAR).Journal: Nature Biotechnology Volume: 28 Issue: 7, S-Page: 650- E-Page: 653 DOI: 10.1038/nbt0710-650HZI repositoryPubMed
  • Authors: Sharma,R.K.; Sundriyal,S.; Wangoo,N.; Tegge,Werner*; Jain,R.; ( Year: 2010). Title: New antimicrobial hexapeptides: synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies.Journal: ChemMedChem Volume: 5 Issue: 1, S-Page: 86- E-Page: 95 PubMed
  • Authors: Buchner,A.; Pohla,H.; Willimsky,G.; Frankenberger,B.; Frank,Ronald*; Baur-Melnyk,A.; Siebels,M.; Stief,C.G.; Hofstetter,A.; Kopp,J.; Pezzutto,A.; Blankenstein,T.; Oberneder,R.; Schendel,D.J.; ( Year: 2010). Title: Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinoma.Journal: Human gene therapy Volume: 21 Issue: 3, S-Page: 285- E-Page: 297 PubMed
  • Authors: Rink,C.; Sasse,Florenz*; Zubriene,A.; Matulis,D.; Maier,M.E.; ( Year: 2010). Title: Probing the influence of an allylic methyl group in zearalenone analogues on binding to Hsp90.Journal: Chemistry Volume: 16 Issue: 48, S-Page: 14469- E-Page: 14478 PubMed
  • Authors: Barnickel,B.; Bayliffe,F.; Diestel,R.; Kempf,K.; Laschat,S.; Pachali,S.; Sasse,Florenz*; Schlenk,A.; Schobert,R.; ( Year: 2010). Title: Structure-activity relationships of precursors and analogs of natural 3-enoyl-tetramic acids.Journal: Chemistry & Biodiversity Volume: 7 Issue: 12, S-Page: 2830- E-Page: 2845 DOI: 10.1002/cbdv.201000179HZI repositoryPubMed
  • Authors: Bulow,L.; Nickeleit,I.; Girbig,A.K.; Brodmann,T.; Rentsch,A.; Eggert,U.; Sasse,Florenz*; Steinmetz,Heinrich*; Frank,Ronald*; Carlomagno,T.; Malek,N.P.; Kalesse,Markus*; ( Year: 2010). Title: Synthesis and biological characterization of argyrin F.Journal: ChemMedChem Volume: 5 Issue: 6, S-Page: 832- E-Page: 836 PubMed
  • Authors: Tegge,W.; Bonafe,C.F.S.; Teichmann,A.; Erck,C.; ( Year: 2010). Title: Synthesis of peptides from alpha- And beta-tubulin containing glutamic acid side-chain linked oligo-glu with defined length.Journal: International Journal of Peptides Volume: 2010 DOI: ArticleWEBURLS
  • Authors: Schackel,R.; Hinkelmann,B.; Sasse,Florenz*; Kalesse,Markus*; ( Year: 2010). Title: The synthesis of novel disorazoles.Journal: Angewandte Chemie International Edition Volume: 49 Issue: 9, S-Page: 1619- E-Page: 1622 PubMed
  • Authors: Kubicek,K.; Grimm,S.K.; Orts,J.; Sasse,Florenz*; Carlomagno,T.; ( Year: 2010). Title: The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin.Journal: Angewandte Chemie International Edition Volume: 49 Issue: 28, S-Page: 4809- E-Page: 4812 PubMed
  • Authors: Schobert,R.; Sasse,Florenz*; Biersack,B.; Effenberger,K.; Breyer,S.; Diestel,R.; ( Year: 2010). Title: Tumor-selective amphiphilic para-quinones and tetramic acids.Journal: International Journal of Clinicl Pharmacology and Therapeutics Volume: 48 Issue: 7, S-Page: 459- E-Page: 461 HZI repositoryPubMed
  • Authors: Meens,J.; Bolotin,V.; Frank,Ronald*; Bohmer,J.; Gerlach,G.F.; ( Year: 2009). Title: Characterization of a highly immunogenic Mycoplasma hyopneumoniae lipoprotein Mhp366 identified by peptide-spot array.Journal: Veterinary Microbiology Volume: 142 Issue: 3-4, S-Page: 293- E-Page: 302 PubMed
  • Authors: Diestel,R.; Irschik,Herbert*; Jansen,Rolf*; Khalil,M.W.; Reichenbach,H.; Sasse,Florian*; ( Year: 2009). Title: Chivosazoles A and F, cytostatic macrolides from myxobacteria, interfere with actin.Journal: ChemBioChem Volume: 10 Issue: 18, S-Page: 2900- E-Page: 2903 DOI: 10.1002/cbic.200900562HZI repositoryPubMed
  • Authors: Sharma,R.K.; Reddy,R.P.; Tegge,Werner*; Jain,R.; ( Year: 2009). Title: Discovery of Trp-His and His-Arg analogues as new structural classes of short antimicrobial peptides.Journal: Journal of Medicinal Chemistry Volume: 52 Issue: 23, S-Page: 7421- E-Page: 7431 PubMed
  • Authors: Lottersberger,J.; Guerrero,S.A.; Tonarelli,G.G.; Frank,Ronald*; Tarabla,H.; Vanasco,N.B.; ( Year: 2009). Title: Epitope mapping of pathogenic Leptospira LipL32.Journal: Letters in Applied Microbiology Volume: 49 Issue: 5, S-Page: 641- E-Page: 645 DOI: 10.1111/j.1472-765X.2009.02723.xHZI repositoryPubMed
  • Authors: Galeyeva,Y.; Morr,M.; Sasse,Florian*; Diestel,R.; Laschat,S.; Baro,A.; Frey,W.; ( Year: 2009). Title: Ex chiral pool synthesis from a highly methyl-branched wax ester and biological properties of (+)-capensifuranone.Journal: Zeitschrift für Naturforschung B - A Journal of Chemical Sciences Volume: 64 Issue: 6, S-Page: 639- E-Page: 645
  • Authors: Mecklenburg,S.; Shaaban,S.; Ba,L.A.; Burkholz,T.; Schneider,T.; Diesel,B.; Kiemer,A.K.; Roseler,A.; Becker,K.; Reichrath,J.; Stark,A.; Tilgen,W.; Abbas,M.; Wessjohann,L.A.; Sasse,Florenz*; Jacob,C.; ( Year: 2009). Title: Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents.Journal: Organic and Biomolecular Chemistry Volume: 7 Issue: 22, S-Page: 4753- E-Page: 4762 PubMed
  • Authors: Suryanarayanan,T.S.; Thirunavukkarasu,N.; Gowindarajulu,M.B.; Sasse,Florian*; Jansen,Rolf*; Murali,T.S.; ( Year: 2009). Title: Fungal endophytes and bioprospecting.Journal: Fungal Biology Reviews Volume: 23 Issue: 1-2, S-Page: 9- E-Page: 19 DOI: 10.1016/j.fbr.2009.07.001HZI repository
  • Authors: Schneider,J.; Fricke,C.; Overwin,H.; Hofmann,B.; Hofer,B.; ( Year: 2009). Title: Generation of amylosucrase variants that terminate catalysis of acceptor elongation at the di- or trisaccharide stage.Journal: Applied and Environmental Microbiology Volume: 75 Issue: 23, S-Page: 7453- E-Page: 7460 PubMed
  • Authors: Turner,J.G.; Marchion,D.C.; Dawson,J.L.; Emmons,M.F.; Hazlehurst,L.A.; Washausen,Peter*; Sullivan,D.M.; ( Year: 2009). Title: Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition.Journal: Cancer Research Volume: 69 Issue: 17, S-Page: 6899- E-Page: 6905 PubMed
  • Authors: Wunderlich,K.; Mayer,D.; Ranadheera,C.; Holler,A.S.; Manz,B.; Martin,A.; Chase,G.; Tegge,Werner*; Frank,Ronald*; Kessler,U.; Schwemmle,M.; ( Year: 2009). Title: Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication.Journal: PLoS ONE Volume: 4 Issue: 10, S-Page: e7517 DOI: 10.1371/journal.pone.0007517HZI repositoryPubMed
  • Authors: Schutte,M.; Thullier,P.; Pelat,T.; Wezler,X.; Rosenstock,P.; Hinz,D.; Kirsch,M.I.; Hasenberg,M.; Frank,Ronald*; Schirrmann,T.; Gunzer,M.; Hust,M.; Dubel,S.; ( Year: 2009). Title: Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus.Journal: PLoS ONE Volume: 4 Issue: 8, S-Page: e6625 PubMed
  • Authors: Weiss,S.M.; Ladwein,M.; Schmidt,D.; Ehinger,J.; Lommel,S.; Städing,K.; Beutling,U.; Disanza,A.; Frank,R.; Jänsch,L.; Scita,G.; Gunzer,F.; Rottner,K.; Stradal,T.E.; ( Year: 2009). Title: IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.Journal: Cell Host and Microbe Volume: 5 Issue: 3, S-Page: 244- E-Page: 258 PubMed
  • Authors: Poltz,R.; Franke,R.; Schweitzer,K.; Klamt,S.; Gilles,E.-D.; Naumann,M.; G; ( Year: 2009). Title: Logical network of genotoxic stress-induced NF-kappaB signal transduction predicts putative target structures for therapeutic intervention strategies.Journal: Advances and Applications in Bioinformatics and Chemistry Volume: 2009 Issue: 2, S-Page: 125- E-Page: 138
  • Authors: Biersack,B.; Diestel,R.; Jagusch,C.; Sasse,Florenz*; Schobert,R.; ( Year: 2009). Title: Metal complexes of natural melophlins and their cytotoxic and antibiotic activities.Journal: Journal of Inorganic Biochemistry Volume: 103 Issue: 1, S-Page: 72- E-Page: 76 DOI: 10.1016/j.jinorgbio.2008.09.005HZI repositoryPubMed
  • Authors: Lucas,N.; Franke,R.; Hinze,A.; Klages,C.-P.; Frank,Ronald*; Büttgenbach,S.; ( Year: 2009). Title: Microplasma stamps for area-selective modification of polymer surfaces.Journal: Plasma Processes and Polymers Volume: 6, S-Page: 5370- E-Page: 5374 DOI: 10.1002/ppap.200930912HZI repository
  • Authors: Shaaban,S.; Ba,L.A.; Abbas,M.; Burkholz,T.; Denkert,A.; Gohr,A.; Wessjohann,L.A.; Sasse,Florenz; Weber,W.; Jacob,C.; ( Year: 2009). Title: Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells.Journal: Chemical Communications (Camb.) Issue: 31, S-Page: 4702- E-Page: 4704 PubMed
  • Authors: Bocquet,A.; Berges,R.; Frank,Ronald*; Robert,P.; Peterson,A.C.; Eyer,J.; ( Year: 2009). Title: Neurofilaments bind tubulin and modulate its polymerization.Journal: Journal of Neuroscience Volume: 29 Issue: 35, S-Page: 11043- E-Page: 11054 PubMed
  • Authors: Eichner,S.; Floss,H.G.; Sasse,Florenz*; Kirschning,A.; ( Year: 2009). Title: New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis.Journal: ChemBioChem Volume: 10 Issue: 11, S-Page: 1801- E-Page: 1805 PubMed
  • Authors: Ugele,M.; Sasse,Florian*; Knapp,S.; Fedorov,O.; Zubriene,A.; Matulis,D.; Maier,M.E.; ( Year: 2009). Title: Propionate analogues of zearalenone bind to Hsp90.Journal: ChemBioChem Volume: 10 Issue: 13, S-Page: 2203- E-Page: 2212 PubMed
  • Authors: Kratzer,U.; Frank,Ronald*; Kalbacher,H.; Biehl,B.; Wostemeyer,J.; Voigt,J.; ( Year: 2009). Title: Subunit structure of the vicilin-like globular storage protein of cocoa seeds and the origin of cocoa- and chocolate-specific aroma precursors.Journal: Food Chemistry Volume: 113 Issue: 4, S-Page: 903- E-Page: 913
  • Authors: Voigt,J.; Frank,Ronald*; Wostemeyer,J.; ( Year: 2009). Title: The chaotrope-soluble glycoprotein GP1 is a constituent of the insoluble glycoprotein framework of the Chlamydomonas cell wall.Journal: Fems Microbiology Letters Volume: 291 Issue: 2, S-Page: 209- E-Page: 215 PubMed
  • Authors: Ottinger,M.; Pliquet,D.; Christalla,T.; Frank,Ronald*; Stewart,J.P.; Schulz,T.F.; ( Year: 2009). Title: The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters.Journal: Journal of Virology Volume: 83 Issue: 9, S-Page: 4423- E-Page: 4434 DOI: 10.1128/JVI.02274-08HZI repositoryPubMed
  • Authors: Nickeleit,I.; Zender,S.; Sasse,Florenz*; Geffers,Robert*; Brandes,G.; Sorensen,I.; Steinmetz,Heinrich*; Kubicka,S.; Carlomagno,T.; Menche,D.; Gutgemann,I.; Buer,J.; Gossler,A.; Manns,M.P.; Kalesse,Markus*; Frank,Ronald*; Malek,N.P.; ( Year: 2008). Title: Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.Journal: Cancer Cell Volume: 14 Issue: 1, S-Page: 23- E-Page: 35 PubMed
  • Authors: Eggert,U.; Diestel,R.; Sasse,Florenz*; Jansen,Rolf*; Kunze,Brigitte*; Kalesse,Markus*; ( Year: 2008). Title: Chondramide C: Synthesis, configurational assignment, and structure-activity relationship studies.Journal: Angewandte Chemie - International Edition Volume: 47 Issue: 43, S-Page: 6478- E-Page: 6482
  • Authors: Hellmuth,H.; Wittrock,S.; Kralj,S.; Dijkhuizen,L.; Hofer,B.; Seibel,J.; ( Year: 2008). Title: Engineering the Glucansucrase GTFR Enzyme Reaction and Glycosidic Bond Specificity: Toward Tailor-Made Polymer and Oligosaccharide Products.Journal: Biochemistry Volume: 47 Issue: 25, S-Page: 6678- E-Page: 6684 PubMed
  • Authors: Biersack,B.; Diestel,R.; Jagusch,C.; Rapp,G.; Sasse,Florian; Schobert,R.; ( Year: 2008). Title: First syntheses of melophlins P, Q, and R, and effects of melophlins on the growth of microorganisms and tumor cells.Journal: Chemistry & Biodiversity Volume: 5 Issue: 11, S-Page: 2423- E-Page: 2430 DOI: 10.1002/cbdv.200890207HZI repositoryPubMed
  • Authors: Swistowska,A.M.; Wittrock,S.; Collisi,W.; Hofer,B.; ( Year: 2008). Title: Heterologous hyper-expression of a glucansucrase-type glycosyltransferase gene.Journal: Applied Microbiology and Biotechnology Volume: 79 Issue: 2, S-Page: 255- E-Page: 261 PubMed
  • Authors: Taft,F.; Brunjes,M.; Floss,H.G.; Czempinski,N.; Grond,S.; Sasse,Florian*; Kirschning,A.; ( Year: 2008). Title: Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.Journal: ChemBioChem Volume: 9 Issue: 7, S-Page: 1057- E-Page: 1060 PubMed
  • Authors: Jansen,R.; Steinmetz,H.; Sasse,F.; Schubert,W.-D.; Hagelüken,G.; Albrecht,S.C.; Müller,R.; ( Year: 2008). Title: Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria).Journal: Tetrahedron Letters Volume: 49, S-Page: 5796- E-Page: 5799 DOI: 10.1016/j.tetlet.2008.07.132PubMed
  • Authors: Beutling,U.; Stading,K.; Stradal,Theresia E.B.*; Frank,Ronald*; ( Year: 2008). Title: Large-scale analysis of protein-protein interactions using cellulose-bound peptide arrays.Journal: Advances in Biochemical Engineering/Biotechnology Volume: 110, S-Page: 115- E-Page: 152 DOI: 10.1007/10_2008_096HZI repositoryPubMed
  • Authors: Wittrock,S.; Swistowska,A.M.; Collisi,W.; Hofmann,B.; Hecht,H.-J.; Hofer,B.; ( Year: 2008). Title: Re- or displacement of invariant residues in the C-terminal half of the catalytic domain strongly affects catalysis by glucosyltransferase R.Journal: Febs Letters Volume: 582 Issue: 4, S-Page: 491- E-Page: 496 PubMed
  • Authors: Höfle,Gerhard*; Bohlendorf,B.; Fecker,T.; Sasse,Florian*; Kunze,Brigitte*; ( Year: 2008). Title: Semisynthesis and Antiplasmodial Activity of the Quinoline Alkaloid Aurachin E.Journal: Journal of Natural Products Volume: 71 Issue: 11, S-Page: 1967- E-Page: 1969 PubMed
  • Authors: Vintonyak,V.V.; Cala,M.; Lay,F.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; ( Year: 2008). Title: Synthesis and biological evaluation of cruentaren A analogues.Journal: Chemistry - A European Journal Volume: 14 Issue: 12, S-Page: 3709- E-Page: 3720 PubMed
  • Authors: Cramer,N.; Helbig,S.; Baro,A.; Laschat,S.; Diestel,R.; Sasse,Florenz*; Mathieu,D.; Richter,C.; Kummerlowe,G.; Luy,B.; Schwalbe,H.; ( Year: 2008). Title: Synthesis and biological properties of cylindramide derivatives: evidence for calcium-dependent cytotoxicity of tetramic acid lactams.Journal: ChemBioChem Volume: 9 Issue: 15, S-Page: 2474- E-Page: 2486 DOI: 10.1002/cbic.200800284FulltextHZI repositoryPubMed
  • Authors: Timm,C.; Volk,C.; Sasse,Florian*; Kock,M.; ( Year: 2008). Title: The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity.Journal: Organic & Biomolecular Chemistry Volume: 6 Issue: 21, S-Page: 4036- E-Page: 4040 PubMed
  • Authors: Kolberg,J.; Hammerschmidt,S.; Frank,Ronald*; Jonak,J.; Sanderova,H.; Aase,A.; ( Year: 2008). Title: The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci.Journal: Fems Immunology and Medical Microbiology Volume: 53 Issue: 2, S-Page: 222- E-Page: 230 DOI: 10.1111/j.1574-695X.2008.00419.xHZI repositoryPubMed
  • Authors: Vintonyak,V.V.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; ( Year: 2008). Title: Total synthesis and biological activity of neopeltolide and analogues.Journal: Chemistry Volume: 14 Issue: 35, S-Page: 11132- E-Page: 11140 PubMed
  • Authors: Ebensen,T.; Link,C.; Riese,P.; Schulze,K.; Morr,M.; Guzmán,Carlos A.*; ( Year: 2007). Title: A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties.Journal: Journal of Immunology (Baltimore, Md.: 1950) Volume: 179 Issue: 4, S-Page: 2065- E-Page: 2073
  • Authors: Menche,Dirk*; Hassfeld,J.; Steinmetz,Heinrich*; Huss,M.; Wieczorek,H.; Sasse,Florian*; ( Year: 2007). Title: Archazolid-7-O//b//-d-glucopyranosid: Isolation, structural elucidation and solution conformation of a novel V-ATPase inhibitor from the Myxobacterium / Cystobacter violaceus.Journal: European Journal of Organic Chemistry Volume: 2007, S-Page: 1196- E-Page: 1202 DOI: 10.1002/ejoc.200600912HZI repository
  • Authors: Chase,G.; Mayer,D.; Hildebrand,A.; Frank,Ronald*; Hayashi,Y.; Tomonaga,K.; Schwemmle,M.; ( Year: 2007). Title: Borna disease virus matrix protein is an integral component of the viral rionucleoprotein complex that does not interfere with polymerase activity.Journal: Journal of Virology Volume: 81 Issue: 2, S-Page: 743- E-Page: 749 DOI: 10.1128/JVI.01351-06.FulltextHZI repository
  • Authors: Meyer,A.; Brünjes,M.; Taft,F.; Frenzel,T.; Sasse,Florian*; Kirschning,A.; ( Year: 2007). Title: Chemoenzymatic approaches toward dechloroansamitocin P-3.Journal: Organic Letters Volume: 9 Issue: 8, S-Page: 1489- E-Page: 1492
  • Authors: Frank,R.; Hoffmann,S.; Kieß,M.; Lahmann,H.; Tegge,W.; Behn,C.; Gausepohl,H.; ( Year: 2007). Title: Combinatorial synthesis on membrane supports by the SPOT technique: Imaging peptide sequence and shape space.Book Title: Combinatorial Peptide and Nonpeptide Libraries: A Handbook Editors: Jung,G.; (Ed.). Publisher: wiley, S-Page: 363- E-Page: 386 ISBN: 9783527614912 (ISBN)9783527293803 (ISBN)DOI: 10.1002/9783527614912.ch13WEBURLS
  • Authors: Kunze,Brigitte*; Sasse,Florian*; Wieczorek,H.; Huss,M.; ( Year: 2007). Title: Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases.Journal: Febs Letters Volume: 581 Issue: 18, S-Page: 3523- E-Page: 3527 DOI: 10.1016/j.febslet.2007.06.069
  • Authors: Menche,Dirk*; Hassfeld,J.; Sasse,Florian*; Huss,M.; Wieczorek,H.; ( Year: 2007). Title: Design, synthesis and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor.Journal: Bioorganic & Medicinal Chemistry Letters Volume: 17 Issue: 6, S-Page: 1732- E-Page: 1735
  • Authors: Patterson,A.W.; Peltier,H.M.; Sasse,Florian*; Ellman,J.A.; ( Year: 2007). Title: Design, synthesis, and biological properties of highly potent tubulysin D analogues.Journal: Chemisty - A European Journal Volume: 13, S-Page: 9534- E-Page: 9541
  • Authors: Schirrmann,T.; Hust,M.; Konthur,Z.; Frank,Ronald*; Toleikis,L.; Dübel,S.; ( Year: 2007). Title: Die Antibody Factory - Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz.Journal: Laborwelt Volume: 8 Issue: 2, S-Page: 16- E-Page: 20
  • Authors: Menche,Dirk*; Arikan,F.; Li,J.; Rudolph,S.; Sasse,Florian*; ( Year: 2007). Title: Efficient one-pot synthesis of biologically active polysubstituted aromatic amines.Journal: Bioorganic & Medicinal Chemistry Volume: 15 Issue: 23, S-Page: 7311- E-Page: 7317
  • Authors: Elnakady,Y.A.; Rohde,Manfred*; Sasse,Florian*; Backes,C.; Keller,A.; Lenhof,H.-P.; Weissman,K.J.; Müller,Rolf*; ( Year: 2007). Title: Evidence for the mode of the highly cytotoxic Streptomyces polyketide Kendomycin.Journal: ChemBioChem Volume: 8 Issue: 11, S-Page: 1261- E-Page: 1272 DOI: 10.1002/cbic.200700050HZI repositoryPubMed
  • Authors: Camara,B.; Seeger,M.; Gonzalez,M.; Standfuß-Gabisch,C.; Kahl,S.; Hofer,B.; ( Year: 2007). Title: Generation by a widely applicable approach of a hybrid dioxygenase showing improved oxidation of polychlorobiphenyls.Journal: Applied and Environmental Microbiology Volume: 73 Issue: 8, S-Page: 2682- E-Page: 2689 DOI: 10.1128/AEM.02523-06HZI repositoryPubMed
  • Authors: Selke,M.; Meens,J.; Springer,S.; Frank,Ronald*; Gerlach,G.-F.; ( Year: 2007). Title: Immunization of pigs to prevent disease in humans: Construction and protective efficacy of a Salmonella enterica serovar typhimurium live negative-marker vaccine.Journal: Infection and Immunity Volume: 75 Issue: 5, S-Page: 2476- E-Page: 2483 DOI: 10.1128/IAI.01908-06HZI repositoryPubMed
  • Authors: Grube,A.; Assmann,M.; Lichte,E.; Sasse,Florian*; Pawlik,J.R.; Köck,A.; ( Year: 2007). Title: New bioactive metabolites from the Caribbean sponge Aka coralliphagum.Journal: Journal of Natural Products Volume: 70 Issue: 4, S-Page: 504- E-Page: 509
  • Authors: Bartels,M.; Schweda,A.T.; Dreikhausen,U.; Frank,Ronald*; Resch,K.; Beil,W.; Nourbakhsh,M.; ( Year: 2007). Title: Peptide mediated disruption of NF-kappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori.Journal: Journal of Immunology Volume: 179 Issue: 11, S-Page: 7605- E-Page: 7613 FulltextHZI repository
  • Authors: Ghanem,A.; Mayer,D.; Chase,G.; Tegge,W.; Frank,R.; Kochs,G.; Garcia-Sastre,A.; Schwemmle,M.; ( Year: 2007). Title: Peptide-mediated interference with the influenza A virus polymerase.Journal: Journal of Virology Volume: 81 Issue: 14, S-Page: 7801- E-Page: 7804 DOI: 10.1128/JVI.00724-07HZI repositoryPubMed
  • Authors: Krohn,K.; Gehle,D.; Dey,S.K.; Nahar,N.; Mosihuzzaman,M.; Sultana,N.; Sohroab,M.H.; Stephens,P.J.; Pan,J.-J.; Sasse,Florian*; ( Year: 2007). Title: Prismatomerin, a new irioid from Prismatomeris tetrandra . Structure elucidation, determination of absolute configuration, and cytotoxicity.Journal: Journal of Natural Products Volume: 70 Issue: 8, S-Page: 1339- E-Page: 1343 DOI: 10.1021/np070202+HZI repositoryPubMed
  • Authors: Umbach,P.; Lange,U.; Frank,Ronald*; Schnögl,S.; Wanker,E.; ( Year: 2007). Title: Proteinnetzwerke als Grundlage für neue Therapieansätze.Journal: GenomXPress (Sonderausgabe) Volume: 2/07, S-Page: 45- E-Page: 47
  • Authors: Taussig,M.J.; Stoevesandt,O.; Borrebaeck,C.A.K.; Bradbury,A.R.; Cahill,D.; Cambillau,C.; De Daruvar,A.; Dübel,S.; Eichler,Jutta*; Frank,Ronald*; Gibson,T.J.; Gloriam,D.; Gold,T.; Herberg,F.W.; Hermjakob,H.; Hoheisel,J.D.; Joos,T.O.; Kallioniemi,O.; Koegll,M.; Konthur,Z.; Korn,B.; Kremmer,E.; Krobitsch,S.; Landegren,U.; van der Maarel,S.; McCafferty,J.; Muyldermans,S.; Nygren,P.A.; Palcy,S.; Plückthun,A.; Polic,B.; Przybylski,M.; Saviranta,P.; Sawyer,A.; Sherman,D.J.; Skerra,A.; Templin,M.; Ueffing,M.; Uhlén,M.; ( Year: 2007). Title: ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.Journal: Nature Methods Volume: 4, S-Page: 13- E-Page: 17
  • Authors: Frank,Ronald*; ( Year: 2007). Title: Segmented solid supports: My personal addiction to Merrifield's solid phase synthesis.Journal: International Journal of Peptide Research and Therapeutics Volume: 13 Issue: 1-2, S-Page: 45- E-Page: 52 DOI: 10.1007/s10989-006-9067-7HZI repository
  • Authors: Sasse,Florian*; Menche,Dirk*; ( Year: 2007). Title: Success in tubulysin D synthesis.Journal: Nature Chemical Biology Volume: 3 Issue: 2, S-Page: 87- E-Page: 89
  • Authors: Ritschel,J.; Sasse,Florian*; Maier,M.E.; ( Year: 2007). Title: Synthesis of a benzolactone collection using click chemistry.Journal: European Journal of Organic Chemistry Volume: 2007, S-Page: 78- E-Page: 87 DOI: 10.1002/ejoc.200600681HZI repository
  • Authors: Tegge,Werner*; Bautsch,W.; Frank,Ronald*; ( Year: 2007). Title: Synthesis of cyclic peptides and peptide libraries on a new disulfide linker.Journal: Journal of Peptide Science Volume: 13 Issue: 10, S-Page: 693- E-Page: 699
  • Authors: Soutullo,A.; Santi,M.N.; Perin,J.C.; Beltramini,L.M.; Borel,I.M.; Frank,Ronald*; Tonarelli,G.G.; ( Year: 2007). Title: Systematic epitope analysis of the p26 EIAV vore protein.Journal: Journal of Molecular Recognition Volume: 20 Issue: 4, S-Page: 227- E-Page: 237
  • Authors: Ebensen,Thomas*; Schulze,Kai*; Riese,Peggy*; Morr,Michael*; Guzmán,Carlos A.*; ( Year: 2007). Title: The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant.Journal: Clinical and Vaccine Immunology Volume: 14 Issue: 8, S-Page: 952- E-Page: 958 DOI: 10.1128/CVI.00119-07HZI repositoryPubMed
  • Authors: Ebensen,T.; Schulze,K.; Riese,P.; Link,C.; Morr,M.; Guzmán,C.A.; ( Year: 2007). Title: The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties.Journal: Vaccine Volume: 25 Issue: 8, S-Page: 1464- E-Page: 1469 DOI: 10.1128/CVI.00119-07
  • Authors: Voigt,J.; Woestemeyer,J.; Frank,Ronald*; ( Year: 2007). Title: The chaotrope-soluble glycoprotein GP2 is a precursor of the insoluble glycoprotein framework of the Chlamydomonas cell wall.Journal: Journal of Biological Chemistry Volume: 282 Issue: 42, S-Page: 30381- E-Page: 30392 DOI: 10.1074/jbc.M701673200HZI repositoryPubMed
  • Authors: Frank,Ronald*; Gerth,Klaus*; Kalesse,Markus*; Menche,Dirk*; Bilitewski,Ursula*; ( Year: 2007). Title: The chemical pipeline - a research program and infrastructure for the discovery and evaluation of new anti-infectives.Book Title: HZI Research Report 2006/2007 Editors: Jonas,Rainer; Schlender,Hannes; Braun,Manfred; (Ed.). City: Braunschweig Publisher: Helmholtz Centre for Infection Research GmbH (HZI), S-Page: 32- E-Page: 43
  • Authors: Menche,Dirk*; Hassfeld,J.; Steinmetz,Heinrich*; Huss,M.; Wieczorek,H.; Sasse,Florian*; ( Year: 2007). Title: The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus : Isolation, structural elucidation and V-ATPase inhibition.Journal: The Journal of Antibiotics Volume: 60 Issue: 5, S-Page: 328- E-Page: 331
  • Authors: Schmitter,T.; Pils,S.; Sakk,V.; Frank,Ronald*; Fischer,K.-D.; Hauck,C.R.; ( Year: 2007). Title: The granulocyte receptor CEACAM3 directly associates with Vav to promote phagocytosis of human pathogens.Journal: Journal of Immunology Volume: 178 Issue: 6, S-Page: 3797- E-Page: 3805
  • Authors: Boeddrich,A.; Gaumer,S.; Haacke,A.; Tzvetkov,N.; Albrecht,M.; Evert,B.O.; Müller,E.C.; Lurz,R.; Breuer,P.; Schugardt,N.; Plaßmann,S.; Xu,K.; Warrick,J.M.; Suopanki,J.; Wüllner,U.; Frank,Ronald*; Hartl,F.; Bonini,N.M.; Wanker,E.E.; ( Year: 2006). Title: An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.Journal: Embo Journal Volume: 25 Issue: 7, S-Page: 1547- E-Page: 1558
  • Authors: Spadaccini,R.; Reidt,U.; Dybkov,O.; Will,C.; Frank,Ronald*; Stier,G.; Corsini,L.; Wahl,M.C.; Lührmann,R.; Sattler,M.; ( Year: 2006). Title: Biochemical and NMR analysis of a SF3b155-p14-U2AFRNA interaction network involved in branch point definition during pre-mRNA splicing.Journal: RNA Volume: 12, S-Page: 410- E-Page: 425 DOI: 10.1261/rna.2271406HZI repositoryPubMed
  • Authors: Berg,T.; Mayer,T.U.; Frank,Ronald*; ( Year: 2006). Title: Biochemistry and molecular biology 2005.Journal: Nachrichten aus der Chemie Volume: 54 Issue: 3, S-Page: 265- E-Page: 270 ISI
  • Authors: Zhou,J.; Köhl,R.; Herr,B.; Frank,Ronald*; Brüne,B.; ( Year: 2006). Title: Calpain Mediates a von Hippel-Lindau Protein - independent Destruction of Hypoxia-inducible Factor-1alpha.Journal: Molecular Biology of the Cell Volume: 17, S-Page: 1549- E-Page: 1558
  • Authors: Montaner,A.D.; de Nichilo,A.; Elias,F.; Rogriguez,J.M.; Fló,J.M.; Lopez,R.A.; Zorzopulos,J.; Frank,Ronald*; ( Year: 2006). Title: Ganglioside GM1-binding peptides as adjuvants of antigens inocculated by the intranasal route.Journal: Vaccine Volume: 24, S-Page: 1889- E-Page: 1896 DOI: 10.1016/j.vaccine.2005.10.037
  • Authors: Zielinski,M.; Kahl,Silke*; Standfuss-Gabisch,C.; Camara,B.; Seeger,M.; Hofer,B.; ( Year: 2006). Title: Generation of novel-substrate-accepting biphenyl dioxygenases through segmental random mutagenesis and identification of residues involved in enzyme specificity.Journal: Applied and Environmental Microbiology Volume: 72 Issue: 3, S-Page: 2191- E-Page: 2199 DOI: 10.1128/AEM.72.3.2191-2199.2006HZI repositoryPubMed
  • Authors: Kader,A.; Simm,R.; Gerstel,U.; Morr,Michael*; Römling,U.; ( Year: 2006). Title: Hierachical involvement of various GGDEF domain proteins in rdar mophotype development of Salmonella enterica serovar Typhimurium.Journal: Molecular Microbiology Volume: 60, S-Page: 602- E-Page: 616 DOI: 10.1111/j.1365-2958.2006.05123.xHZI repositoryPubMed
  • Authors: Seibel,J.; Hellmuth,H.; Hofer,B.; Kicinska,A.M.; Schmalbruch,B.; ( Year: 2006). Title: Identification of new acceptor specificities of glycosyltransferase R with the aid of substrate microarrays.Journal: ChemBioChem Volume: 7, S-Page: 310- E-Page: 320 DOI: 10.1002/cbic.200500350HZI repositoryPubMed
  • Authors: Rachid,S.; Sasse,Florian*; Beyer,S.; Müller,R.; ( Year: 2006). Title: Identification of StiR, the first regulator of secondary metabolite formation in the mycobacterium Cystobacter fuscus Cb f17.1.Journal: Journal of Biotechnology Volume: 121 Issue: 4, S-Page: 429- E-Page: 441
  • Authors: Khalil,M.W.; Sasse,Florian; Lünsdorf,H.; Elnakady,Y.A.; Reichenbach,H.; ( Year: 2006). Title: Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.Journal: ChemBioChem Volume: 7, S-Page: 678- E-Page: 683 DOI: 10.1002/cbic.200500421PubMed
  • Authors: Dikmans,A.; Beutling,U.; Schmeisser,E.; Thiele,S.; Frank,Ronald*; ( Year: 2006). Title: SC2: A novel process for manufacturing multipurpose high-density chemical microarrays.Journal: QSAR and Combinatorial Science Volume: 25 Issue: 11, S-Page: 1069- E-Page: 1080 DOI: 10.1002/qsar.200640130HZI repository
  • Authors: Budde,M.; Morr,Michael*; Schmid,R.D.; Urlacher,V.B.; ( Year: 2006). Title: Selective hydroxylation of highly branched fatty acids and their derivatives by CYP102A1 from Bacillus megaterium.Journal: ChemBioChem Volume: 7, S-Page: 789- E-Page: 794
  • Authors: Gory-Fauré,S.; Windscheid,V.; Bosc,C.; Peris,L.; Proietto,D.; Frank,Ronald*; Denarrier,E.; Job,D.; Andrieux,A.; ( Year: 2006). Title: STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.Journal: Journal of Biological Chemistry Volume: 281 Issue: 38, S-Page: 28387- E-Page: 28396
  • Authors: Kolberg,J.; Aase,A.; Bergmann,S.; Herstad,T.K.; Rodal,G.; Frank,Ronald*; Rohde,Manfred*; Hammerschmidt,S.; ( Year: 2006). Title: Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface.Journal: Microbiology Volume: 152, S-Page: 1307- E-Page: 1317
  • Authors: Galeyeva,Y.; Helbig,S.; Morr,Michael*; Sasse,Florian*; Nimtz,Manfred*; Laschat,S.; Baro,A.; ( Year: 2006). Title: Total synthesis and biological evaluation of (-)-pectinatone employing a methyl branched wax ester as key building block.Journal: Chemistry and Biodiversity Volume: 3, S-Page: 935- E-Page: 941 DOI: 10.1002/cbdv.200690096HZI repositoryPubMed
  • Authors: Berg,T.; Frank,Ronald*; Mayer,T.; ( Year: 2006). Title: Trendbericht Chemische Biologie im Bericht Biochemie und Molekularbiologie 2005.Journal: Nachrichten aus der Chemie Volume: 54, S-Page: 265- E-Page: 270
  • Authors: Beutling,U.; Dikmans,A.; Thiele,S.; Frank,Ronald*; ( Year: 2005). Title: A novel process for manufacturing high density multipurpose chemical micro-arrays.Book Title: Peptides 2004; Proc. 28 Europ. Peptide Editors: Flegel; Fridkin; Gilon; Slaninova; (Ed.). City: Geneva Publisher: Kenes International, S-Page: 152- E-Page: 153
  • Authors: Zander,N.; Beutling,U.; Dikmans,A.; Thiele,S.; Frank,Ronald*; ( Year: 2005). Title: A special cellulose membrane support for the combinatorial and parallel synthesis of peptide libraries suitable for the SC 2 -type manufacturing of high density multi-purpose chemical microarrays.Book Title: Peptides 2004; Proc. 28 Europ. Peptide Editors: Flegel; Fridkin; Gilon; Slaninova; (Ed.). City: Geneva Publisher: Kenes International, S-Page: 405- E-Page: 406
  • Authors: Gail,R.; Frank,R.; Wittinghofer,A.; ( Year: 2005). Title: A systematic peptide-array based delineation of differential beta-Catenin interaction with Tcf4, E-Cadherin and APC.Journal: Journal of Biological Chemistry Volume: 280, S-Page: 7107- E-Page: 7117
  • Authors: Frank,R.; Dübel,S.; ( Year: 2005). Title: Analysis of protein interactions with immobilized peptide arrays synthesized on membrane supports.Book Title: Protein-Protein Interactions, A Molecular Cloning Manual Editors: Golemis,E.; Adams,P.; (Ed.). City: Cold Spring Harbor, NY Publisher: Cold Spring Harbor Laboratory Press ISBN: 0-87969-723-7 (ISBN)
  • Authors: Huss,M.; Sasse,F.; Kunze,B.; Jansen,R.; Steinmetz,H.; Ingenhorst,G.; Zeeck,A.; Wieczorek,H.; ( Year: 2005). Title: Archazolid and apicularen: Novel specific V-ATPase inhibitors.Journal: BMC Biochemistry Volume: 6, S-Page: 13 DOI: 10.1186/1471-2091-6-13HZI repositoryPubMed
  • Authors: Bredenbruch,F.; Nimtz,M.; Wray,V.; Morr,M.; Müller,R.; Häußler,S.; ( Year: 2005). Title: Biosynthetic pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinofines.Journal: Journal of Bacteriology Volume: 187, S-Page: 3630- E-Page: 3635
  • Authors: Foley,K.F.; De Frutos,S.; Laskovski,K.; Tegge,W.; Dostmann,W.R.; ( Year: 2005). Title: Culture conditions influence uptake and intracellular localization of the membrane permeable GMP-dependent protein kinase inhibitor DT-3.Journal: Frontiers in Bioscience Volume: 10, S-Page: 1302- E-Page: 1312
  • Authors: Rübenhagen,R.; Frank,R.; ( Year: 2005). Title: Ein neuer Weg zu Antikörper-Mikroarrays mit höherer Spezifität und Selektivität.Journal: Biospektrum - Sonderausgabe Volume: 11, S-Page: 506- E-Page: 507
  • Authors: Galeyeva,Y.; Morr,M.; Laschat,S.; Baro,A.; Nimtz,M.; Sasse,F.; ( Year: 2005). Title: Ex chiral pool synthesis of (-)-siphonarienone from a methyl-branched wax ester.Journal: Synthesis Volume: 17, S-Page: 2875- E-Page: 2880
  • Authors: Deswal,R.; Singh,R.; Lynn,A.M.; Frank,R.; ( Year: 2005). Title: Identification of immunodominant regions of Brassica juncea glyoxalase I as potential antitumor immunomodulation targets.Journal: peptides Volume: 26, S-Page: 395- E-Page: 404
  • Authors: Gingras,A.R.; Ziegler,W.H.; Frank,R.; Barsukov,I.L.; Roberts,G.C.K.; Critchley,D.R.; Emsley,J.; ( Year: 2005). Title: Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.Journal: Journal of Biological Chemistry Volume: 280 Issue: 44, S-Page: 37217- E-Page: 37224
  • Authors: Bialek,K.; Swistowski,A.; Frank,R.; ( Year: 2005). Title: Peptide and protein repertoires for global analysis of modules.Book Title: Modular Protein Domains Editors: Cesareni,G.; Gimona,M.; Sudal,M.; Yaffe,M.eds.; (Ed.). City: Weinheim Publisher: Wiley-VCH, S-Page: 409- E-Page: 438
  • Authors: Rampon,C.; Prandini,M.-H.; Bouillot,S.; Pointu,H.; Tillet,E.; Frank,R.; Vernet,M.; Huber,P.; ( Year: 2005). Title: Protocadherin 12 (VE-cadherin) is expressed in endothelial trophoblast and mesangial cells and is dispensable for normal mouse development.Journal: Experimental Cell Research Volume: 302, S-Page: 48- E-Page: 60
  • Authors: Taylor,M.S.; Brayden,J.E.; Laskovski,K.E.; Nickl,C.K.; Tegge,Werner*; Frank,Ronald*; ( Year: 2005). Title: Specific and membrane permeable inhibitors of cGMP-dependent protein kinase.Book Title: Peptides 2004; Proc. 28 Europ. Peptide Editors: Flegel; Fridkin; Gilon; Slaninova; (Ed.). City: Geneva Publisher: Kenes International, S-Page: 684- E-Page: 685
  • Authors: Petri,A.F.; Sasse,F.; Maier,M.E.; ( Year: 2005). Title: Synthesis and biological evaluation of apicularen A analogues.Journal: European Journal of Organic Chemistry Issue: 9, S-Page: 1865- E-Page: 1875
  • Authors: Schwardt,M.; Mayer,D.; Frank,R.; Schneider,U.; Planz,O.; Wolff,T.; Schwemmle,M.; ( Year: 2005). Title: The negative regulator of Borna Disease Virus polymerase is a non-structural protein.Journal: Journal of General Virology Volume: 86, S-Page: 3163- E-Page: 3169
  • Authors: Zander,N.; Frank,R.; ( Year: 2005). Title: The use of polystyrylsulfonyl chloride resin as a solid supported condensation reagent for the formation of esters: Synthesis of N--(9-fluorenylmethoxy)carbonyl)-L-aspartic acid; "-tert-butyl ester, ß-(2-ethyl[(1E)-4-nitrophenyl)azo]phenyl]amino]ethy.Book Title: Organic Syntheses City: Chichester Publisher: Wiley, S-Page: 235- E-Page: 243 ISBN: 0-471-68257-8 (ISBN)
  • Authors: Dikmans,A.J.; Morr,M.; Zander,N.; Adler,F.; Türk,G.; Frank,R.; ( Year: 2004). Title: A new compact disc format of high density array synthesis applied to peptide nucleic acids and in situ MALDI analysis.Journal: Molecular Diversity Volume: 8, S-Page: 197- E-Page: 207
  • Authors: Papagrigoriou,E.; Gringas,A.R.; Barsukov,I.L.; Bate,N.; Fillingham,I.J.; Patel,B.; Frank,R.; Ziegler,W.H.; Roberts,G.C.K.; Critchley,D.R.; Emsley,J.; ( Year: 2004). Title: Activation of a vinculin binding site in the talin rod involves re-arrangement of a five helix bundle.Journal: Embo Journal Volume: 23, S-Page: 2942- E-Page: 2951
  • Authors: Godehardt,A.; Hammerschmidt,S.; Frank,R.; Chhatwal,G.S.; ( Year: 2004). Title: Binding of alpha 2-macroglobulin to GRAB, an important virulence factor of group A streptococci, is mediated via two charged motifs in the Delta A region.Journal: Biochemical Journal Volume: 381, S-Page: 877- E-Page: 885
  • Authors: Leibold,T.; Sasse,F.; Reichenbach,H.; Höfle,G.; ( Year: 2004). Title: Cyrmenins, novel antifungal peptides containing a nitrogen-linked ß-methoxy-acrylate pharmacophore: Isolation and structure elucidation.Journal: European Journal of Organic Chemistry Issue: 2, S-Page: 431- E-Page: 435
  • Authors: Oggero,M.; Frank,R.; Etcheverrigaray,M.; Kratje,R.; ( Year: 2004). Title: Defining the antigenic structure of human GM-CSF and its implication to receptor interaction and therapeutic treatments.Journal: Molecular Diversity Volume: 8 Issue: 3, S-Page: 257- E-Page: 269
  • Authors: Bialek,K.; Swistowski,A.; Beutling,U.; Mühle,L.; Frank,R.; ( Year: 2004). Title: Development of a new biochip platform technology for the automated recognition and validation of peptide-protein-interactions.Book Title: Solid Phase Synthesis and Combinatorial Libraries Editors: Epton,R.; (Ed.). City: Kingswinford, UK Publisher: Mayflower Worldwide Ltd., S-Page: 35- E-Page: 38
  • Authors: Elnakady,Y.A.; Sasse,F.; Lünsdorf,H.; Reichenbach,H.; ( Year: 2004). Title: Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells.Journal: Biochemical Pharmacology Volume: 67, S-Page: 927- E-Page: 935
  • Authors: Elm,C.; Braathen,R.; Bergmann,S.; Frank,R.; Vaerman,J.-P.; Kaetzel,C.S.; Chhatwal,G.S.; Johansen,F.-E.; Hammerschmidt,S.; ( Year: 2004). Title: Ectodomains 3 and 4 of human polymeric immunoglobulin receptor (hplgR) mediate invasion of Streptococcus pneumoniae into the epithelium.Journal: Journal of Biological Chemistry Volume: 279 Issue: 8, S-Page: 6296- E-Page: 6304
  • Authors: Frank,R.; ( Year: 2004). Title: Funktionelle und chemische Genomik: Kleine Moleküle kommen ganz groß raus.Journal: GenomXPress Volume: 2, S-Page: 14- E-Page: 15
  • Authors: Simm,R.; Morr,M.; Kader,A.; Nimtz,M.; Römling,U.; ( Year: 2004). Title: GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility.Journal: Molecular Microbiology Volume: 53, S-Page: 1123- E-Page: 1134
  • Authors: Eberhardt,M.O.; Frank,R.; Kratje,R.; Etcheverrigaray,M.; ( Year: 2004). Title: GM-CSF epitope analysis using a panel of monoclonal antibodies.Book Title: Biotechnological Advances and Applications in Bioconversion of Renewable Raw Materials Editors: Jonas,R.Pandey A.Tharun G.; (Ed.). City: Braunschweig, Germany Publisher: Döring Druck, S-Page: 250- E-Page: 254
  • Authors: Frank,R.; ( Year: 2004). Title: High-density synthetic peptide arrays.Journal: Molecular Diversity Volume: 8, S-Page: 175- E-Page: 176
  • Authors: Beutling,U.; Tegge,W.; Zander,N.; Frank,R.; ( Year: 2004). Title: High-throughout synthesis and screening without wells and walls.Book Title: Solid Phase Synthesis and Combinatorial Libraries Editors: Epton,R.; (Ed.). City: Kingswinford, UK Publisher: Mayflower Worldwide Ltd., S-Page: 191- E-Page: 194
  • Authors: Sandmann,A.; Sasse,F.; Müller,R.; ( Year: 2004). Title: Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.Journal: Chemistry and Biology Volume: 11 Issue: 8, S-Page: 1071- E-Page: 1079
  • Authors: Steinmetz,H.; Glaser,N.; Herdtweck,E.; Sasse,F.; Reichenbach,H.; Höfle,G.; ( Year: 2004). Title: Isolation, crystal and solution structure determination, and biosynthesis of tubulysins - powerful inhibitors of tubulin polymerization from myxobacteria.Journal: Angewandte Chemie - International Edition Volume: 43, S-Page: 4888- E-Page: 4892
  • Authors: Buss,H.; Dörrie,A.; Schmitz,L.M.; Frank,R.; Livingstone,M.; Resch,K.; Kracht,M.; ( Year: 2004). Title: Phosphorylation of serine 468 by GSK-3ß negatively regulates basal p65 NF-KB activity.Journal: Journal of Biological Chemistry Volume: 279, S-Page: 49571- E-Page: 49574
  • Authors: Zhou,J.; Schmid,T.; Frank,R.; Brüne,B.; ( Year: 2004). Title: PI3K/Akt is required for heat shock proteins to protect hypoxiainducible factor 1alpha from pVHL-independent degradation.Journal: Journal of Biological Chemistry Volume: 279 Issue: 14, S-Page: 13506- E-Page: 13513
  • Authors: Zander,N.; Frank,R.; ( Year: 2004). Title: Polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin: a new reagent for the anchoring of Fmoc-amino acids to membrane supports as esters by the SPOT Technique.Book Title: Solid Phase Synthesis and Combinatorial Libraries Editors: Epton,R.; (Ed.). City: Kingswinford, UK Publisher: Mayflower Worldwide, S-Page: 323- E-Page: 324
  • Authors: Bayle,J.; Letard,S.; Frank,R.; Dubreuil,P.; De Sepulveda,P.; ( Year: 2004). Title: Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.Journal: Journal of Biological Chemistry Volume: 279, S-Page: 12249- E-Page: 12259 DOI: 10.1074/jbc.M313381200FulltextHZI repository
  • Authors: Hultschig,C.; Hecht,H.-J.; Frank,R.; ( Year: 2004). Title: Systematic delineation of a calmodulin peptide interaction.Journal: Journal of Molecular Biology Volume: 343, S-Page: 559- E-Page: 568
  • Authors: Schiller,D.; Rübenhagen,R.; Krämer,R.; Morbach,S.; ( Year: 2004). Title: The C-terminal domain of the betaine carrier BetP of Corynebacterium glutamicum is directly involved in sensing K+ as an osmotic stimulus.Journal: Biochemistry Volume: 43 Issue: 15, S-Page: 5583- E-Page: 5591
  • Authors: Milkereit,G.; Morr,M.; Thiem,J.; Vill,V.; ( Year: 2004). Title: Thermotropic and lyotropic properties of long chain alkyl glycopyranosides.Journal: Chemistry and Physics of Lipids Volume: 127, S-Page: 47- E-Page: 63
  • Authors: Voigt,J.; Frank,R.; ( Year: 2003). Title: 14-3-3 proteins are constituents of the insoluble glycoprotein framework of the clamydomonas cell wall..Journal: Plant Cell Volume: 15 Issue: 6, S-Page: 1399- E-Page: 1413 DOI: 10.1105/tpc.010611HZI repositoryPubMed
  • Authors: Sasse,F.; Steinmetz,H.; Höfle,G.; Reichenbach,H.; ( Year: 2003). Title: Archazolid A, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria).Journal: Journal of Antibiotics Volume: 56 Issue: 6, S-Page: 520- E-Page: 525
  • Authors: Sasse,F.; Leibold,T.; Kunze,B.; Höfle,G.; Reichenbach,H.; ( Year: 2003). Title: Cyrmenins, new ß-methoxyacrylate of the respiratory chain isolated from Myxobacteria.Journal: Journal of Antibiotics Volume: 56, S-Page: 827- E-Page: 831
  • Authors: Borsutzky,S.; Fiorelli,V.; Ebensen,T.; Tripiciano,A.; Rharbaoui,F.; Scoglio,A.; Link,C.; Nappi,F.; Morr,M.; Buttó,S.; Cafaro,A.; Mühlradt,P.F.; Ensoli,B.; Guzmán,C.A.; ( Year: 2003). Title: Efficient mucosal delivery of the HIV-1 Tat protein using the synthetic lipopeptide MALP-2 as adjuvant..Journal: European Journal of Immunology Volume: 33, S-Page: 1548- E-Page: 1556
  • Authors: Bialek,K.; Swistowski,A.; Frank,R.; ( Year: 2003). Title: Epitope-targeted proteome analysis: Towards a large-scale automated protein-protein-interaction mapping utilizing synthetic peptide arrays.Journal: Analytical and Bioanalytical Chemistry Volume: 376 Issue: 7, S-Page: 1006- E-Page: 1013 DOI: 10.1007/s00216-003-1876-3FulltextHZI repository
  • Authors: Mataraza,J.M.; Briggs,M.W.; Li,Z.; Frank,R.; Sacks,D.B.; ( Year: 2003). Title: Identification and characterization of the Cdc42-binding site of IQGAP1.Journal: Biochemical and Biophysical Research Communications Volume: 305, S-Page: 315- E-Page: 321
  • Authors: Eberhardt,M.O.; Frank,R.; Kratje,R.; Etcheverrigaray,M.; ( Year: 2003). Title: Identification of two potential receptor-binding sites for hGM-CSF.Journal: Brazilian Journal of Chemical Engineering Volume: 20, S-Page: 15- E-Page: 20
  • Authors: Marcus,K.; Hultschig,C.; Frank,R.; Herberg,F.W.; Schuchhardt,J.; Seitz,H.; ( Year: 2003). Title: Innovative Forschungsansätze im NGFN Verbund "The Human Brain Proteome Projekct HBPP".Journal: GenomXPress Volume: 4, S-Page: 5- E-Page: 8
  • Authors: Scheele,U.; Alves,J.; Frank,R.; Duwel,M.; Kalthoff,C.; Ungewickell,E.J.; ( Year: 2003). Title: Molecular and functional characterization of clathrin and AP-2 binding determinants within a disordered domain of auxilin.Journal: Journal of Biological Chemistry Volume: 278 Issue: 28, S-Page: 25357- E-Page: 25368
  • Authors: Zander,N.; Gerhardt,J.; Frank,R.; ( Year: 2003). Title: Polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin: a new solid-supported reagent for the esterification of amino acids.Journal: Tetrahedron Letters Volume: 44 Issue: 35, S-Page: 6557- E-Page: 6560
  • Authors: Köster,M.; Lykke-Andersen,S.; Elnakady,Y.A.; Gerth,K.; Washausen,P.; Höfle,G.; Sasse,F.; Kjems,J.; Hauser,H.; ( Year: 2003). Title: Ratjadones inhibit nuclear export by blocking DRM1/exportin 1.Journal: Experimental Cell Research Volume: 286, S-Page: 321- E-Page: 331
  • Authors: Höfle,G.; Glaser,N.; Karama,U.; Leibold,T.; Sasse,F.; Steinmetz,H.; ( Year: 2003). Title: Semisynthesis and degradation of the tubulin inhibitors epothilone and tubulysin.Journal: Pure and applied chemistry Volume: 75, S-Page: 167- E-Page: 178
  • Authors: Schubert,A.; Zakikhany,K.; Schreiner,M.; Frank,R.; Spellerberg,B.; Eikmanns,B.J.; Renscheid,D.J.; ( Year: 2002). Title: A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand-binding sites.Journal: Molecular Microbiology Volume: 2, S-Page: 557- E-Page: 569
  • Authors: Zander,N.; Dittrich,F.; Michaelis,K.; Tegge,W.; Frank,R.; ( Year: 2002). Title: A new high-performance polypropylene-based membrane support for the parallel synthesis of peptides and small organic compounds.Book Title: Peptides 2002, Proceedings 27. European Peptide Symposium Editors: Benedetti,Ettore; Pedone,Carlo; (Ed.). City: Napoli Publisher: Edizioni Ziino, S-Page: 340- E-Page: 341 ISBN: 88-900948-1-8 (ISBN)
  • Authors: Sasse,F.; Steinmetz,H.; Schupp,T.; Petersen,F.; Memmert,K.; Hofmann,H.; Heusser,C.; Brinkmann,V.; Von Matt,P.; HofleG.; Reichenbach,H.; ( Year: 2002). Title: Argyrins, immunosuppressive cyclic peptides from Myxobacteria - I. Production, isolation, physico-chemical and biological properties.Journal: Journal of Antibiotics Volume: 55 Issue: 6, S-Page: 543- E-Page: 551 ISI
  • Authors: Frank,R.; ( Year: 2002). Title: Chemische Genomik: funktionelle Genomanalyse mit synthetischen Verbindungen..Journal: BioSpektrum, Sonderausgabe "Proteomics & Drug Development", S-Page: 474- E-Page: 477
  • Authors: Zander,Norbert; Gausepohl,Heinrich; ( Year: 2002). Title: Chemistry of Fmoc peptide synthesis on membranes.Book Title: Peptide arrays on membrane supports - synthesis and applications: Editors: Koch,Joachim; Mahler,Michael; (Ed.). City: Berlin Publisher: Springer-Verlag, S-Page: 23- E-Page: 40 ISBN: 3-540-42532-2 (ISBN)
  • Authors: Morr,M.; Takeuchi,O.; Akira,S.; Simon,M.; Mühlradt,P.F.; ( Year: 2002). Title: Differential recognition of structural details of bacterial lipopeptides by toll-like receptors.Journal: European Journal of Immunology Volume: 32, S-Page: 3337- E-Page: 3347
  • Authors: Dostmann,W.R.G.; Tegge,W.; Frank,R.; Nickl,C.K.; Taylor,M.S.; Brayden,J.E.; ( Year: 2002). Title: Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent protein kinase Ialpha.Journal: Pharmacology & Therapeutics Volume: 93 Issue: 2-3, S-Page: 203- E-Page: 215 ISI
  • Authors: Frank,R.; Balling,R.; ( Year: 2002). Title: Funktionelle Genomanalyse mit synthetischen Verbindungen: das NGFN unterstützt Initiative zur Chemischen Genomik.Journal: GenomXPress Volume: 02 Issue: 3, S-Page: 20- E-Page: 21
  • Authors: Billich,C.; Sauder,C.; Frank,R.; Herzog,S.; Bechter,K.; Takahashi,K.; Peters,H.; Staeheli,P.; Schwemmle,M.; ( Year: 2002). Title: High-avidity human serum antibodies recognizing linear epitopes of borna disease virus proteins.Journal: Biological Psychiatry Volume: 51 Issue: 12, S-Page: 979- E-Page: 987 DOI: 10.1016/S0006-322301387-2FulltextHZI repositoryPubMed
  • Authors: Frank,R.; ( Year: 2002). Title: High-density synthetic peptide microarrays: emerging tools for fuctional genomics and proteomics.Journal: Combinatorial Chemistry & High Throughput Screening Volume: 5, S-Page: 327- E-Page: 335
  • Authors: Schultz,A.; Laschat S.; Morr,M.; Diele,S.; Dreyer,M.; Bringmann,G.; ( Year: 2002). Title: Highly branched alkanoic acids from the preen-gland wax of the domestic goose as building blocks for chiral triphenylenes.Journal: Helvetica Chimica Acta Volume: 85, S-Page: 3909- E-Page: 3018
  • Authors: Frank,R.; Bialek,K.; Swistowski,A.; ( Year: 2002). Title: Large-scale protein-interaction mapping with synthetic peptide arrays: epitope-targeted proteome analysis.Book Title: Peptides 2002, Proceedings of the 27. European Peptide Symposium Editors: Benedetti,Ettore; Pedone,Carlo; (Ed.). City: Napoli Publisher: Edizioni Ziino, S-Page: 102- E-Page: 103 ISBN: 88-900948-1-8 (ISBN)
  • Authors: Niggemann,Jutta*; Michaelis,K.; Frank,Ronald*; Zander,N.; Höfle,Gerhard*; ( Year: 2002). Title: Natural product-derived building blocks for combinatorial synthesis. Part 1. Fragmentation of natural products from myxobacteria.Journal: Journal of The Chemical Society, Perkin Transactions I Volume: 1, S-Page: 2490- E-Page: 2503
  • Authors: Frank,Ronald; Schneider-Mergener,Jens; ( Year: 2002). Title: SPOT-Synthesis - Scope of applications.Book Title: Peptide Arrays on Membrane Supports - Synthesis and Application Editors: Koch,Joachim; Mahler,Michael; (Ed.). City: Berlin Publisher: Springer Verlag, S-Page: 1- E-Page: 24 ISBN: 3-540-42532-2 (ISBN)
  • Authors: Von Minden,H.M.; Morr,M.; Milkereit,G.; Heinz,E.; Vill,V.; ( Year: 2002). Title: Synthesis and mesogenic properties of glycosyl diacilglycerols.Journal: Chemistry and Physics of Lipids Volume: 114, S-Page: 55- E-Page: 80
  • Authors: Rharbaoui,F.; Drabner,B.; Borsutzky,S.; Winckler,U.; Morr,M.; Ensoli,B.; Mühlradt,P.F.; Guzmán,C.A.; ( Year: 2002). Title: The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant..Journal: European Journal of Immunology Volume: 32, S-Page: 2857- E-Page: 2865
  • Authors: Chevrier,V.; Piel; Collomb,N.; Saoudi,Y.; Frank,R.; Paintrand,M.; Narumiya,S.; Bornens,M.; Job,D.; ( Year: 2002). Title: The Rho-associated protein kinase p160ROCK is required for centrosome positioning..Journal: Journal of Cellular Biology Volume: 157 Issue: 5, S-Page: 807- E-Page: 817
  • Authors: Frank,R.; ( Year: 2002). Title: The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports-principles and applications.Journal: Journal of Immunological Methods Volume: 267 Issue: 1, S-Page: 13- E-Page: 26 PubMed
  • Authors: Adler,F.; Turk,G.Frank R.; Zander,N.; Wu,W.; Volkmer-Engert,R.; Schneider-Mergener,J.; Gausepohl,H.; ( Year: 2001). Title: A new array format for the automated parallel combinatorial synthesis by the SPOT-technique.Book Title: Solid Phase Synthesis & Combinatorial Libraries Editors: Epton,R.; (Ed.). City: Birmingham Publisher: Mayflower Worldwide Ltd., S-Page: 221- E-Page: 222
  • Authors: Cervoni L.; Lascu I.; Xu Y.; Gonin P.; Morr M.; Merouani M.; Janin J.; Giartosio A; ( Year: 2001). Title: Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.Journal: Biochemistry Volume: 40, S-Page: 4583- E-Page: 4589 DOI: 10.1021/bi002432sFulltextHZI repository
  • Authors: Takeuchi,O.; Kawai,T.; Mühlradt,P.F.; Morr,M.; Radolf,J.D.; Zychlinsky,A.; Takeda,K.; Akira,S.; ( Year: 2001). Title: Discrimination of bacterial lipoproteins by Toll-like receptor 6.Journal: International immunology Volume: 13 Issue: 7, S-Page: 933- E-Page: 940 PubMed
  • Authors: Morr,M.; Kakoschke,C.; Ernst,L.; ( Year: 2001). Title: Formation of phostonic acids during reduction of azidonucleosidephosphonic acids..Journal: Tetrahedron Letters Volume: 42, S-Page: 8841- E-Page: 8843
  • Authors: Bosc,C.; Frank,R.; Schweitzer,A.; Denarier,E.; Ronjat,M.; Wehland,J.; Job,D.; ( Year: 2001). Title: Identification of novel bifunctional calmodulin-binding and microtubule-stabilizing motifs in stop proteins.Journal: Journal of Biological Chemistry Volume: 276 Issue: 33, S-Page: 30904- E-Page: 30913 ISI
  • Authors: Corada,M.; Liao,F.; Lindgren,M.; Lampugnani,M.G.; Breviario,F.; Frank,R.; Müller,W.A.; Hicklin,D.J.; Bohlen,P.; Dejana,E.; ( Year: 2001). Title: Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability.Journal: Blood Volume: 97 Issue: 6, S-Page: 1679- E-Page: 1684 FulltextHZI repositoryPubMed
  • Authors: Hultschig,C.; Baensch,M.; Kohl,J.; Frank,R.; ( Year: 2001). Title: Multiplexed affinity sorting and analysis of libraries on libraries: Applications to protein design and proteome research.Book Title: Solid Phase Synthesis & Combinatorial Libraries Editors: Epton,R.; (Ed.). City: Birmingham Publisher: Mayflower Worldwide Ltd., S-Page: 7- E-Page: 10
  • Authors: Hardt,I.H.; Steinmetz,H.; Gerth,K.; Sasse,F.; Reichenbach,H.; Höfle,G.; ( Year: 2001). Title: New natural epothilones from Sorangium cellulosum , strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.Journal: Journal of Natural Products Volume: 64 Issue: 7, S-Page: 847- E-Page: 856 PubMed
  • Authors: Pilawa,S.; Zander,N.; Frank,R.; ( Year: 2001). Title: Optimized reaction conditions for the direct esterification of protected amino acids to cellulose membrane supports by the SPOT-technique.Book Title: Solid Phase Synthesis & Combinatorial Libraries 2000 Editors: Epton,R.; (Ed.). City: Birmingham Publisher: Mayflower Worldwide, S-Page: 337- E-Page: 338
  • Authors: Hawlisch,H.; Müller,M.; Frank,R.; Bautsch,W.; Klos,A.; Kohl,J.; ( Year: 2001). Title: Site-specific anti-C3a receptor single-chain antibodies selected by differential panning on cellulose sheets.Journal: Analytical biochemistry Volume: 293 Issue: 1, S-Page: 142- E-Page: 145 PubMed
  • Authors: Voigt,J.; Liebich,I.; Kiess,M.; Frank,R.; ( Year: 2001). Title: Subcellular distribution of 14-3-3 proteins in the unicellular green alga Chlamydomonas reinhardtii.Journal: European Journal of Biochemistry Volume: 268 Issue: 24, S-Page: 6449- E-Page: 6457 HZI repositoryPubMed
  • Authors: Barzik,M.; Carl,U.D.; Schubert,W.D.; Frank,R.; Wehland,J.; Heinz,D.W.; ( Year: 2001). Title: The N-terminal domain of Homer/Vesl is a new class II EVH1 domain.Journal: Journal of Molecular Biology Volume: 309 Issue: 1, S-Page: 155- E-Page: 169 PubMed
  • Authors: Rübenhagen,R.; Morbach,S.; Krämer,R.; ( Year: 2001). Title: The osmoreactive betaine carrier BetP from Corynebacterium glutamicum is a sensor for cytoplasmic K+.Journal: Embo Journal Volume: 20, S-Page: 5412- E-Page: 5420

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  • Epothilon: Ein HZI-Molekül wird zum Krebsmedikament

    Wissenschaftler an der ehemaligen Gesellschaft für Biotechnologische Forschung (GBF), dem heutigen HZI, haben in den 1980er Jahren Epothilon B entdeckt. Dieser Naturstoff stört die Teilung von Krebszellen: Tumore werden durch ihn im Wachstum gebremst, schrumpfen und verschwinden. Das Pharmaunternehmen Bristol-Myers Squibb (BMS) hat jetzt auf der Basis von Epothilon B ein Krebsmedikament auf den US-amerikanischen Markt gebracht. Seine Entwicklung ist so spannend wie ein Krimi...
    Länge: 11:34

  • Molecular Trojan Horses Visualize Infections

    Researchers from the Helmholtz Centre for Infection Research (HZI) and the German Center for Infection Research (DZIF) recently developed molecular probes that utilise the iron transport system of bacteria to transport antibacterial agents into the bacterial cell. These "molecular Trojan horses" can also carry fluorescence markers and thus make infections in smaller animals visible and amenable to treatment. Kevin Ferreira explains here the new developed method in a minute.

Audio Podcast

  • Kleine Moleküle ganz groß – Mit Naturstoffen gegen Hepatitis CMit weltweit 130 Millionen Infizierten ist Hepatitis C eine der häufigsten Infektionskrankheiten. Die Therapien, die es derzeit gibt, sind langwierig, haben starke Nebenwirkungen und helfen nicht jedem Patienten. Florenz Sasse vom Braunschweiger Helmholtz-Zentrum für Infektionsforschung und Thomas Pietschmann vom TWINCORE in Hannover suchen gemeinsam nach neuen Wirkstoffen gegen das Hepatitis C-Virus. Hören Sie hier von ihren ersten Treffern und folgen Sie Florenz Sasse zu einer Bibliothek der anderen Art…
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