Chemical Biology of Carbohydrates

Carbohydrates and glycoconjugates belong to the three major classes of biopolymers. Complex carbohydrates play important roles in biological recognition processes that are represented by the presence of dense glycoconjugate layers on cells known as the glycocalyx. Despite their importance, the study of carbohydrates suffers from limited methods for their synthesis and analysis contrary to nucleic acids or proteins.
This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Leader

Selected Publications

Zahorska, E.; Rosato, F.; Stober, K.; Kuhaudomlarp, S.; Meiers, J.; Hauck, D.; Reith, D.; Gillon, E.; Rox, K.; Imberty, A.; Römer, W.*, Titz, A.* Neutralizing the impact of the virulence factor LecA from Pseudomonas aeruginosa on human cells with new glycomimetic inhibitors, Angew. Chem. Int. Ed. Engl. 2023, 62(7), e202215535, DOI: 10.1002/anie.202215535

Leusmann, S.; Menova, P.; Shanin, E.; Titz, A.*, Rademacher, C.* Glycomimetics for the inhibition and modulation of lectins, Chem. Soc. Rev. 2023, 52, 3663-3740, DOI: 110.1039/D2CS00954D

Kuhaudomlarp, S.; Siebs, E.; Shanina, E.; Topin, J.; Joachim, I.; da Silva Figueiredo Celestino Gomes, P.; Varrot, A.; Rognan, D.; Rademacher, C.; Imberty, A.*, Titz, A.* Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-binding Lectins. Angew. Chem. Int. Ed. Engl. 2021, 60(15), 8104-8114, DOI: 10.1002/anie.202013217

Sommer, R.; Wagner, S.; Rox, K.; Varrot, A.; Hauck, D.; Wamhoff, E.-C.; Schreiber, J.; Ryckmans, T.; Brunner, T.; Rademacher, C.; Hartmann, R. W.; Brönstrup, M.; Imberty, A.; Titz, A.* Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa. J. Am. Chem. Soc. 2018, 140(7), 2537-2545, DOI: 10.1021/jacs.7b11133

Wagner, S.; Hauck, D.; Hoffmann, M.; Sommer, R.; Joachim, I.; Müller, R.; Imberty, A.; Varrot, A.; Titz, A.* Covalent lectin inhibition and its application in bacterial biofilm imaging. Angew. Chem. Int. Ed. Engl. 2017, 56, 16559-16564. DOI: 10.1002/anie.201709368

Further Information

A current overview of the team and further information about the research group can be found on the HIPS page.

Bachelor & Master
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Video

  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

Audio Podcast

  • Widerspenstige Quellen für neue Antibiotika – eine neue Strategie um Bakterien neue Wirkstoffe zu entlockenSie sind winzig klein, lieben es warm und gelten unter wissenschaftlichen Insidern als neuer Stern am Antibiotikahimmel: Actinomyceten. Allerdings ist dieser Stern nicht sehr freigiebig mit seinen Produkten und wehrt sich beinahe schon zielstrebig gegen Versuche ihm neue Substanzen zu entlocken. Andriy Luzhetskyy hat einen Trick entwickelt, mit dem er die Abwehr der Actinomyceten unterwandern kann – und so neue Quellen für neuartige Antibiotika erschließt. Besuchen Sie ihn am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)…
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