Drug Delivery

While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Drug Delivery” on techniques for the correct distribution of novel drugs. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).

Leader

Selected Publications

Costa, A., de Souza Carvalho-Wodarz, C., Seabra, V., Sarmento, B., Lehr, C.-M. Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier (2019) Acta Biomaterialia, 91, pp. 235-247.

Christmann, R., Thomas, C., Jager, N., Raber, A.S., Loretz, B., Schaefer, U.F., Tschernig, T., Vogt, T., Lehr, C.-M. Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata (2019) Journal of Investigative Dermatology.

Graef, F., Vukosavljevic, B., Michel, J.-P., Wirth, M., Ries, O., De Rossi, C., Windbergs, M., Rosilio, V., Ducho, C., Gordon, S., Lehr, C.-M. The bacterial cell envelope as delimiter of anti-infective bioavailability – An in vitro permeation model of the Gram-negative bacterial inner membrane (2016) Journal of Controlled Release, 243, pp. 214-224.

Mahiny, A.J., Dewerth, A., Mays, L.E., Alkhaled, M., Mothes, B., Malaeksefat, E., Loretz, B., Rottenberger, J., Brosch, D.M., Reautschnig, P., Surapolchai, P., Zeyer, F., Schams, A., Carevic, M., Bakele, M., Griese, M., Schwab, M., Nürnberg, B., Beer-Hammer, S., Handgretinger, R., Hartl, D., Lehr, C.-M., Kormann, M.S.D. In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency (2015) Nature Biotechnology, 33 (6), pp. 584-586.

Mittal, A., Schulze, K., Ebensen, T., Weißmann, S., Hansen, S., Lehr, C.M., Guzmán, C.A. Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation (2015) Nanomedicine: Nanotechnology, Biology, and Medicine, 11 (1), pp. 147-154.

Publications

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Video

  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

Audio Podcast

  • Kleine Teile – große Wirkung: Pharmazeuten des HIPS schleusen Medikamente zielsicher durch den Körper Wie kommt ein Medikament dahin, wo es wirken soll? Das ist eine der zentralen Fragen bei der Entwicklung neuer Wirkstoffe. Denn es reicht nicht, ein tolles neues Medikament gegen Darminfektionen im Reagenzglas zu haben – es muss auch dort hin gelangen, wo die Krankheit stattfindet. Mit Transportmolekülen schleusen die Pharmazeuten des HZI diese Wirkstoffe durch unseren Körper – über Barrieren, durch passende Lücken und an gefährlichen Stellen vorbei. Besuchen Sie Claus-Michael Lehr und Brigitta Loretz am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)…
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