Drug Delivery

This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Drug Delivery” on techniques for the correct distribution of novel drugs.


Selected Publications

Kuehn A, Kletting S, Souza Carvalho-Wodarz C de, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N, Lehr CM (2016) Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier. ALTEX 33251–260

Susewind J, Souza Carvalho-Wodarz C de, Repnik U, Collnot EM, Schneider-Daum N, Griffiths GW, Lehr CM (2016) A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials. Nanotoxicology 10: 53–62

Raber AS, Mittal A, Schäfer J, Bakowsky U, Reichrath J, Vogt T, Schaefer UF, Hansen S, Lehr CM (2014) Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm J Control Release 179: 25–32

Mittal A, Schulze K, Ebensen T, Weißmann S, Hansen S, Lehr CM, Guzmán CA (2015) Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation. Nanomedicine 11: 147–154

Herd H, Daum N, Jones AT, Huwer H, Ghandehari H, Lehr CM (2013) Nanoparticle geometry and surface orientation influence mode of cellular uptake. ACS Nano 7: 1961–1973

Mahiny AJ, Dewerth A, Mays LE, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch DM, Reautschnig P, Surapolchai P, Zeyer F, Schams A, Carevic M, Bakele M, Griese M, Schwab M, Nurnberg B, Beer-Hammer S, Handgretinger R, Hartl D, Lehr CM, Kormann MSD (2015) In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. Nat Biotechnol 33584–586; connected patent: Kormann M, Mays L, Loretz B, Malaeksefat E, Lehr CM (2014) Permanent gene-correction by means of nucleotide-modified mRNA; Priority:  DE 10 2013 111 099 and PCT/EP2014/071343

Graef F, Vukosavljevic B, Michel JP, Wirth M, Ries O, De Rossi C, Windbergs M, Rosilio V, Ducho C, Gordon S, Lehr CM (2016) The bacterial cell envelope as delimiter of anti-infective bioavailability – An in vitro permeation model of the Gram-negative bacterial inner membrane. J Control Rel 243214–224


Full publications list of Claus-Michael Lehr

(PDF) Full publications list of Claus-Michael Lehr

(PDF) Claus-Michael Lehr - 10 most cited papers


Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!


  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

Audio Podcast

  • Kleine Teile – große Wirkung: Pharmazeuten des HIPS schleusen Medikamente zielsicher durch den Körper Wie kommt ein Medikament dahin, wo es wirken soll? Das ist eine der zentralen Fragen bei der Entwicklung neuer Wirkstoffe. Denn es reicht nicht, ein tolles neues Medikament gegen Darminfektionen im Reagenzglas zu haben – es muss auch dort hin gelangen, wo die Krankheit stattfindet. Mit Transportmolekülen schleusen die Pharmazeuten des HZI diese Wirkstoffe durch unseren Körper – über Barrieren, durch passende Lücken und an gefährlichen Stellen vorbei. Besuchen Sie Claus-Michael Lehr und Brigitta Loretz am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)…
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