The combination of incorrect and overly frequent application of antibiotics and insufficient hygiene measures in hospitals leads to a worldwide rise in the number of resistant germs for which ever less effective therapies exist. The scientists of the "Biogenic Nano-Therapeutics" group develop intelligent mechanisms of action and nano-systems that transport known antibiotics specifically to infected sites in the human body. In their work, they use modern biomimetic systems that utilise mechanisms found in nature or are derived from them. This allows for an effective control of pathogenic bacteria with minimal adverse effects. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Kuhn T, Koch M & Fuhrmann G* (2020) Probiomimetics—Novel Lactobacillus‐Mimicking Microparticles Show Anti‐Inflammatory and Barrier‐Protecting Effects in Gastrointestinal Models. Small, DOI: 0.1002/smll.202003158
Hoppstädter J, Dembek A, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer AK (2019) Toll-like receptor 2 release by macrophages: an anti-inflammatory program induced by glucocorticoids and lipopolysaccharide. Frontiers in Immunology 10:1634
Schulz E, Goes A, Panter F, Koch M, Garcia R, Müller R, Fuhrmann K & Fuhrmann G* (2018) Biocompatible bacteria-derived vesicles show inherent antimicrobial activity. Journal of Controlled Release 290:46
Frank J, Richter M, De Rossi C, Lehr CM, Fuhrmann K & Fuhrmann G* (2018) Extracellular vesicles protect glucuronidase model enzymes during freeze-drying. Scientific Reports 8:12377
Fuhrmann G, Chandrawati R et al. (2018) Engineering extracellular vesicles with the tools of enzyme prodrug therapy Advanced Materials DOI: 10.1002/adma.201706616
Fuhrmann K & Fuhrmann G* (2017) Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation Current Opinion in Colloid & Interface ScienceDOI:10.1016/j.cocis.2017.07.002
Fuhrmann G1, Herrmann I1 & Stevens MM (2015) Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges. Nano Today 10: 397-409 (1GF and IH with equal contribution) DOI:10.1016/j.nantod.2015.04.004
Fuhrmann G*, Serio A, Mazo M, Nair R & Stevens MM (2015), Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. Journal of Controlled Release 205: 35-44 (*GF co-corresponding author) DOI:10.1016/j.jconrel.2014.11.029
Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Zhang B, Yu H, Walde P, Schlüter AD, Gauthier MA & Leroux JC (2013) Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates. Nature Chemistry 5: 582–589. DOI:10.1038/nchem.1675
- This work was highlighted in Nature Chemistry News and Views (2013, 5:557–558), in Chemistry World (Hairy proteins survive stomach trip) and ETH Life (July 2013), and featured in Chimia, the magazine of the Swiss Chemical Society (Fuhrmannet al. (2013) 67:685–686).
Fuhrmann G & Leroux JC (2011) In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract. Proceedings of the National Academy of Sciences USA 108:9032-9037. DOI:10.1073/pnas.1100285108
- This work was highlighted in numerous daily newspapers in Germany, Switzerland and Austria, in coeliac disease fora, and in ETH Life (August 2011).
A current overview of the team and further information about the research group can be found on the HIPS page.