Biogenic Nanotherapeutics

The combination of incorrect and overly frequent application of antibiotics and insufficient hygiene measures in hospitals leads to a worldwide rise in the number of resistant germs for which ever less effective therapies exist. The scientists of the "Biogenic Nano-Therapeutics" group develop intelligent mechanisms of action and nano-systems that transport known antibiotics specifically to infected sites in the human body. In their work, they use modern biomimetic systems that utilise mechanisms found in nature or are derived from them. This allows for an effective control of pathogenic bacteria with minimal adverse effects.

Leader

Selected Publications

Fuhrmann G, Chandrawati R et al. (2018) Engineering extracellular vesicles with the tools of enzyme prodrug therapy Advanced Materials  DOI: 10.1002/adma.201706616


Fuhrmann K & Fuhrmann G* (2017) Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation Current Opinion in Colloid & Interface Science DOI:10.1016/j.cocis.2017.07.002

Fuhrmann G1, Herrmann I1 & Stevens MM (2015) Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges. Nano Today 10: 397-409 (1GF and IH with equal contribution) DOI:10.1016/j.nantod.2015.04.004

Fuhrmann G*, Serio A, Mazo M, Nair R & Stevens MM (2015), Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. Journal of Controlled Release 205: 35-44 (*GF co-corresponding author) DOI:10.1016/j.jconrel.2014.11.029

Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Zhang B, Yu H, Walde P, Schlüter AD, Gauthier MA & Leroux JC (2013) Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates. Nature Chemistry 5: 582–589. DOI:10.1038/nchem.1675

  • This work was highlighted in Nature Chemistry News and Views (2013, 5:557–558), in Chemistry World (Hairy proteins survive stomach trip) and ETH Life (July 2013), and featured in Chimia, the magazine of the Swiss Chemical Society (Fuhrmann et al. (2013) 67:685–686).

Fuhrmann G & Leroux JC (2011) In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract. Proceedings of the National Academy of Sciences USA 108:9032-9037. DOI:10.1073/pnas.1100285108

  • This work was highlighted in numerous daily newspapers in Germany, Switzerland and Austria, in coeliac disease fora, and in ETH Life (August 2011).

Full Publicationlist

Video

  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

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