Anti-infectives from Microbiota

The department of Prof Christine Beemelmanns focuses on the identification and functional analysis of novel anti-infective natural products from microbial communities. Co-cultivation studies as well as cell-based assays in combination with chemical-analytical and molecular-biological methods are used to evaluate and prioritize novel natural product producers. The department uses established and innovative metabolomic-, activity and genome-based methods to identify and determine the structure of the secreted natural products. Based on the isolated novel natural substances, the functional analysis and evaluation of their range of effects is carried out. This department is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).

Leader

Selected Publications

Raguž L,# Peng CC,# Rutaganira FUN, Krüger T, Stanisic A, Jautzus T, Kries H, Kniemeyer O, Brakhage A, King N, Beemelmanns C* (2022) Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosettaAngew Chem Int Ed, e202209105.

Raguž L, Peng CC, Kaiser M, Görls H, Beemelmanns C* (2022) A modular approach to the antifungal Sphingofungin family: Concise total synthesis of Sphingofungin A and C. Angew Chem Int Ed, e202112616

Guo H, Rischer M, Westermann M, Beemelmanns C* (2021) Two distinct bacterial biofilm components trigger metamorphosis in the colonial hydrozoan Hydractinia echinatamBio 12(3), e0040121.

Schalk F, Gostinčar C, Kreuzenbeck NB, Conlon BH, Sommerwerk E, Rabe P, Burkhardt I, Krüger T, Kniemeyer O, Brakhage AA, Gunde-Cimerman N, de Beer ZW, Dickschat JS, Poulsen M, Beemelmanns C* (2021) The termite fungal cultivar Termitomyces combines diverse enzymes and oxidative reactions for plant biomass conversion. mBio 12(3), e0355120.

Guo H, Schwitalla JW, Benndorf R, Baunach M, Steinbeck C, Görls H, de Beer ZW, Regestein L, Beemelmanns C* (2020) Gene cluster activation in a bacterial symbiont leads to halogenated angucyclic maduralactomycins and spirocyclic actinospirols. Org Lett 22(7), 2634-2638

Further Information

A current overview of the team and further information about the research group can be found on the HIPS page.

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