The role of the atypical NF-kB inhibitory protein IkBNS in effector cells
NF-kB is an important transcription factor for development and function of immune cells and is regulated by IkB proteins. IkBNS is an unusual IkB protein and functionally poorly characterized. During the 2nd funding period, we found that IkBNS-/- mice are resistant towards high-dose Listeria infection hinting towards alterations in innate immunity. Indeed, we found extraordinary high expression of IkBNS in innate immune cells using reporter mice. In the next funding period, we will decipher molecular and cellular functions of IkBNS in innate cells using newly established conditional knockout mice that are currently being characterized. This includes IkBNS-dependent leucocyte migration during Listeria infection and functional characterization of target genes and microRNAs.
- Immune Regulation- Prof. Dunja Bruder
- Systems-Oriented Immunology and Inflammation Research- Prof. Dr. Ingo Schmitz
DFG - German Research Foundation