Screening for Inhibitors of the NS2_3 Protease of the Hepatitis C Virus
The project was funded by the European Commission within the ERA-NET Rus program (November 2015 – October 2017). It aimed at directly acting inhibitors of Hepatitis C Virus (HCV) infections targeting the NS2_3 protease, which is essential for the infection process but not yet exploited as target of directly acting antivirals. The Rumanian coordinator of this project had developed a screening assay, which allowed the detection of the protease activity via reporter proteins. This assay was established in our laboratories. Our Russian partner chose 5.000 chemical compounds and made them available to us, so that we could use them in the screening campaign.
- Compound Profiling und Screening- Prof. Dr. Ursula Bilitewski