Research Projects (Third party funds)

Project

Mathematical modeling of immunological synapse dynamics

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Immunological synapse (IS) formation is one of the most important steps during adaptive immune responses. T cells interact with antigen presenting cells (APCs) in order to exchange information. During this process, molecular re-organization and pattern formation on the surface of both cells is observed. We have developed an agent-based model aiming to understand the localization mechanisms of different molecules. Microscopy data obtained by our collaborators in Oxford are used in order to validate and improve the model. Our model accurately reproduces the spatial behaviour of components of the immunological synapse and provides a framework for studying the role of central molecules and processes in IS formation.

Simm members

Philippe Robert (former member), Michael Meyer-Hermann

other collaborators

Michael Dustin (Oxford University)

Publications

Siokis A, Robert PA, Demetriou P, Dustin ML, Meyer-Hermann M. F-actin driven CD28-CD80 localization in the immune synapse. Cell Reports 2018 Jul 31; 24(5): 1151-1162.

Siokis A, Robert PA, Meyer-Hermann M. Mathematical modelling of synaptic patterns. In: Baldari CT and Dustin ML (eds.), The Immune Synapse: Methods and Protocols. Methods Mol Biol 1584 (2017) 171-182.

Figge MT, Meyer-Hermann M. Geometrically re-patterned immunological synapses uncover formation mechanisms. PLoS Comput Biol 2 (2006) e171.

Funding

DFG, Human Frontier Science Program

Groups

Funding agency

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