Mathematical modeling of immunological synapse dynamics
Immunological synapse (IS) formation is one of the most important steps during adaptive immune responses. T cells interact with antigen presenting cells (APCs) in order to exchange information. During this process, molecular re-organization and pattern formation on the surface of both cells is observed. We have developed an agent-based model aiming to understand the localization mechanisms of different molecules. Microscopy data obtained by our collaborators in Oxford are used in order to validate and improve the model. Our model accurately reproduces the spatial behaviour of components of the immunological synapse and provides a framework for studying the role of central molecules and processes in IS formation.
Philippe Robert (former member), Michael Meyer-Hermann
Michael Dustin (Oxford University)
Siokis A, Robert PA, Demetriou P, Dustin ML, Meyer-Hermann M. F-actin driven CD28-CD80 localization in the immune synapse. Cell Reports 2018 Jul 31; 24(5): 1151-1162.
Siokis A, Robert PA, Meyer-Hermann M. Mathematical modelling of synaptic patterns. In: Baldari CT and Dustin ML (eds.), The Immune Synapse: Methods and Protocols. Methods Mol Biol 1584 (2017) 171-182.
Figge MT, Meyer-Hermann M. Geometrically re-patterned immunological synapses uncover formation mechanisms. PLoS Comput Biol 2 (2006) e171.
DFG, Human Frontier Science Program
- Systems Immunology- Prof. Dr. Michael Meyer-Hermann