Molecular signatures determining pathogenicity and species transmission of influenza A viruses
Coordinator: Prof. Dr. Stephan Ludwig, University of Münster
Co-Coordinator: Prof. Dr. Klaus Schughart
The goal of the FluResearchNet consortium is to integrate all national expertises from basic and clinical virology as well as veterinary medicine for investigation of the zoonotic potential of influenza A virus in a network. The activities of the network are aimed to fight the burden of influenza epidemics in humans and animals to reduce the risk of future pandemic outbreaks. The network comprises thirteen projects and twentythree partners.
Project 7 - Host susceptibility to H1 and H9 influenza subtypes in mammalian species
Project leader: Prof. Dr. Klaus Schughart
Co-Project investigator: PD Dr. Gerd Sutter, Dr. Ralf Wagner, Paul Ehrlich Institute, Frankfurt
In this project, we aim to determine the genetic factors in mammalian species that influence host susceptibility to influenza A infections. The LD50, general patho-physiology, lung pathology, virus dissemination, and various aspects of the host immune response will be investigated in mouse strains after infection with two mouse adapted influenza A/H1N1 subtypes. Different inbred mouse strains as well as recombinant inbred strains of mice will be used to identify Mendelian and quantitative genetic traits of host susceptibility. These studies will provide new targets for prevention and therapy of influenza infections in humans and life stock.
In addition, we will aim to determine the zoonotic potential of circulating H9N2 subtypes from chicken. We will analyse virus isolates from partners at the National Reference Centres and collaborators in the US, China and India in mouse & human cell cultures for their potential to replicate and adapt to mammalian species.