Innate immunity supports the initiation of germinal centre reactions
The initiation of germinal centre reactions relies on B cells, having seen the native pathogen, and on interaction of B and T cells at the follicular border. However, in cooperation with the groups of Marie Kosco-Vilbois (Geneva, Switzerland) and Kai Toellner (Birmingham, UK), we have shown that factors associated with innate immunity are also critical for germinal centre formation. Toll-like-receptor 4 was required for the proper formation of the follicular dendritic cell network in B cell follicles and, thus, instrumental for B cell mutation and maturation. This finding contributes to medical research on poor immune responses, e.g. after vaccination of the elderly population.
Alexey Uvarovskii (since 2016 in Heidelberg), Jaber Dehghany, Michael Meyer-Hermann
Garin* A, Meyer-Hermann* M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner, K-M, Elson G, Kosco-Vilbois MH. Toll-Like Receptor 4 signaling by Follicular Dendritic Cells is pivotal for germinal center onset and affinity maturation, Immunity 33 (2010) 84-95. [*shared first author]
Meyer-Hermann M, Beyer T. The type of seeder cells determines the efficiency of germinal center reactions. Bull Math Biol 66 (2004) 125-141.
- Systems Immunology- Prof. Dr. Michael Meyer-Hermann