Research Projects (Third party funds)
- A combined in vitro and in silico analysis of microglia activation to assess the potential of the voltage-gated proton channel HVCN1 as a therapeutic target in Alzheimer’s disease
- A joint machine learning and modelling approach to explore the prognostic potential of inflammatory patterns in breast tissue
- A Method for Tracking CRISPR/Plasmidome Dynamics in Complex Bacterial Communities
- A quantitative concept of self-nonself distinction
- A signal integration model for thymic selection
- Advancement of the adjuvant c-di-AMP for its use in clinical phase 1 study in combination with a HCV vaccine antigen candidate
- Aging and Metabolic Programming
- Aging and Metabolic Programming: AMPRO
- Analysis of the mechanisms of action of anti-infectives : ANTI-INFEKTIVA
- Analysing influenza A virus-mediated changes in the reactivity of alveolar type II epithelial cells as an underlying mechanism of increased susceptibility to secondary pneumococcal infections : AECII AND COINFECTION
- Analysis of the role of trans-membrane molecules for T cell calcium dynamics
- Antibiotika-beladene Nanocarrier zur Therapeutischen Inhalation gegen Tuberkulose; Teilvorhaben: Optimierung der Wechselwirkungen mit dem Flüssigkeitsfilm der Lunge und Entwicklung einer Pulverformulierung zur Inhalation der Antibiotika-Nanocarrier Syste: ANTI-TB
- Self-medication with antimicrobials in urban and rural areas of Western India: A cross sectional study
- Antibiotics use in The Gambia
- BioBarriers
- Bioengineered microfluidic in vitro test system to study alveolar transport and clearance: LUNG-ON-A-CHIP
- Biogenic nano therapy for bacterial infections – extracellular vesicles as novel carriers for antibiotics, NanoMatFutur programme from the Federal Ministry for Research and Education (BMBF) : BEVA
- Broadly neutralizing antibodies
- Cellular Immune Responses in the Senescent and Unresponsive Immune System
- Characterization of CTLA4 trafficking and implications for its function
- Characterisation of the cGAS-mediated DNA-sensing signaling in HIV infected T-cells
- Characterization of the secretory glycoprotein 90K/LGALS3BP as an antiviral restriction factor
- ChilSFree-Studie (ongoing project): CHILSFREE
- Chronic Infections: Microbial Persistence and its Control: CRC900
- Collaborative Research Consortium CDInfect - Adaptation strategies of Clostridioides difficile during host infection: Structure and function of protein interaction networks required for infection with C. difficile
- Communities Allied in Infection coalition
- Design and synthesis of novel clostridial collagenase inhibitors
- Deutsches Ebola-Virus Konsortium: SORMAS
- Development of a prophylactic HCV vaccine candidate.
- Development of a sublingual mucosal immunization technology platform: MUCOVAC
- Development of novel compounds targeting Pseudonomas aeriginosa elastase LasB
- Development of novel inhibitors targeting the β-sliding clamp DnaN
- Development of potent inhibitors of the enzyme DXS for the treatment of important infections such as malaria and tuberculosis: DXS
- The role of astrocyte activation in neuropathological situations of viral infections: ABINEP
- Die Rolle der Proteintyrosinphosphatase PTP1B für die Funktion der Toll-like Rezeptoren TLR7 und TLR9: DFG BR3432/3-1
- The role of the atypical NF-κB inhibitory protein IκBNS in effector cells: SFB 854, TEILPROJEKT A23
- Differential equations, parameter fitting, and identifiability analysis
- Differential Multiplex Serology of vaccine-preventable diseases
- Discrete agent-based models
- Dissecting immune response to Ebola virus and identifying the fate decisive steps by modelling a cytokine network
- Dissection of formin functions in cell edge protrusion and migration
- Do germinal centres interact via their produced antibodies?
- DrugBioTune - Process and target directed exploitation of catalytic and regulatory plasticity of drug biosynthetic pathways: INFECTCONTROL2020
- Dynamics of influenza A virus defective interfering particle replication – from single cells and tissues to the host level: DIA_TIP
- A novel approach for eradicating HIV
- A study to prevent infectious diseases in children (project concluded): KRAKI
- Impact of acute influenza infection on cancer development
- Impact of viral virulence on neuro-invasion and neuro-pathology caused by tick-borne encephaltitis virus infection: TBENAGER
- Developing Leads to Shorten Duration of TB Chemotherapy: SHORTEN TB
- Development of potent inhibitors of the RNA polymerase for the treatment of bacterial infections: RNAP
- Development of molecules that interfere with the PQS quorum sensing communication system in Pseudomonas aeruginosa: PQS QUORUM SENSING COMMUNICATION SYSTEM
- Epidemiology of chronic HBV infection among different high risk groups in Rwanda and mortality of HBV-HIV co-infected persons: SEROPREVALENCE HBV RWANDA
- Epidemiological study on app-based reporting of adverse events following influenza vaccination : SAFEVAC
- Epidemiology of hepatitis E virus infection in EU/EEA countries (ongoing project)
- eResearch Tool PIA-App: PIA
- European Vaccine Research and Development Infrastructure: TRANSVAC2
- Evaluation of an innovative differential serology for hepatitis A serodiagnosis, and a seroprevalence study in children and adolescents, up to 11 years following the introduction of universal mass vaccination with a single dose in Bogotá, Colombia.: HAV&HEV-CO
- Evaluation of the Tuberculosis Surveillance System in Ghana using a Capture-Recapture Design
- Evaluation of case definitions in West Africa
- Events controlling germinal centre onset
- Exploring the energy-coupling factor (ECF) transporters as a novel antibiotic target: ECF
- Functional role of neuronal aging on neuron-Tcell interaction during viral CNS infection: SFB854
- Functional peptides implicated in the virulence of the enteric pathogen Yersinia pseudotuberculosis: SPP 2002
- Genetic engineering of chimeric antigen receptor (CAR) T cells for immunotherapy in cancer and infection: CART
- GenomeNet: A deep neural network for genomic modelling, semi-supervised classification and imputation
- GMP production and safety evaluation of the adjuvant c-di-AMP in a context of a therapeutic hepatitis B Vaccine
- Golden Mycological Triangle: GOMYTRI
- Graduate School Protein Complex Assembly (PROCOMPAS): Maturation of nitrite reductase NirS through interaction with NirF and NirN
- Heidelberg – Göttingen – Hannover - Medical Informatics: HIGHMED
- Helmholtz-Alberta Initiative – Infectious Disease Research: HAI-IDR
- Helmholtz Drug Research Initiative: DRUG RESEARCH
- Heterologous expression of antibiotic gene cluster
- HEV vaccinology
- HiGHmed (Heidelberg-Göttingen-Hannover Medizininformatik)
- How are regulatory T cells maintained in the immune system?
- How does ageing affect the immune response to influenza infections?
- Human mucosal-associated invariant T (MAIT) cells in age-associated Clostridioides difficile infections : ESF-GS ABINEP / TEILPROJEKT M3.P6
- Hygiene and Behaviour Infectious Diseases Survey (ongoing project): HABIDS
- Identification and characterization of natural products with activities against tuberculosis
- iMed Challenge
- Immune mediators of cytomegalovirus latency
- Immunology & Inflammation: Interactions of amyloid-beta with the neurotrophin receptor p75ntr mediate dendritic spine alterations
- Individualized Vaccination : I.VACC
- Inducing synchrony of coupled excitable cells by noise
- Inflammation signals in type 2 diabetes
- INFRAFONTIER2020 - Towards enduring mouse resources and services advancing research into human health and disease: INFRAFRONTIER2020
- Innate immunity supports the initiation of germinal centre reactions
- Innovative hit-identification strategies: HIT ID
- Innovative microbial resources for new anti-infectives
- Integrated DZIF Infection Cohort within the German National Cohort: ZIFCO
- Interaction of microbiota and immune system
- Investigating bottromycin biosynthesis by X-ray crystallography and in vitro engineering of the pathway: BOTSYN-PE
- Jamming of phosphorylated τ-proteins leads to the formation of τ -tangles creating a feedback of disruption in cellular transport machinery
- Climate change and its effects on vector-borne Lyme disease Borreliosis: HI-CAM
- Lack of class switching in Germinal Centers
- Long-term effects of preceding influenza A virus infection on myeloid cells along the lung-bone marrow-axis.
- Lattice-free agent-based models and Delaunay-Object-Dynamics
- Learning structures in the CRISPR-Cas system using deep learning architectures
- Lipid-based therapeutics for liver fibrosis and their impact on extracellular vesicles, Phospholipid Research Centre Heidelberg
- Blood self-collection in epidemiologic research: Feasibility and acceptance of a novel DBS-technology-based device (ongoing project)
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