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Here you can find out more about the scientific results of the HZI in the research topics ”Bacterial and Viral Pathogens”, “Immune Response and Interventions” and “Anti-Infectives”.
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The coronaviruses are a family of viruses that includes a series of very different pathogens. These viruses usually infect mammals, rodents, and birds, but only few coronaviruses adapted to humans. They did this with great success: About one third of all typical "common colds" and some cases of diarrhoea as well are caused by these RNA Viruses, which are the largest of their kind. We have compiled more information about the coronaviruses for you.
With the pathogen SARS-CoV-2, a novel virus that can cause respiratory diseases and pneumonia has been spreading worldwide since the end of 2019. Here we will keep you informed about current developments in research and provide answers to the most important questions.
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Fusobacterium nucleatum is found in the human oral cavity and is an important component of an intact microflora in the mouth. However, it can also contribute to the development of periodontitis. And more importantly, the germ is also increasingly being found within the human body, namely on colon cancer cells and breast carcinomas. There, it appears to accelerate tumor growth and…
Autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis, in which the body's own immune system causes inflammation, are treated with drugs that remove a certain type of immune cells. These are the so-called B cells, whose most important role is the production of antibodies against pathogens, for example during an infection. However, patients under therapy are thus…
What was your first thought after you were told that you would receive the Foundation Award? This must be a joke! Normally, when someone calls and says that you have won something, they are mostly just phishing calls and it is better to hang up quickly. After a very nice conversation with the foundation's notary - Mr Burgemeister – I however was quickly convinced that I had indeed…
In the first step, the researchers isolated the genetic information of immune cells, which are producing anti-SARS-CoV-2 antibodies, from blood samples from local convalescent COVID-19 patients. From the collected antibody genes, they constructed a phage display library. Nearly 200 unique human antibodies binding to the Receptor Binding Domain (RBD) in the spike protein of…
Aus der MHH stammen Bioproben und Daten der „COVID-19-Kohorte“, die seit März 2020 von unterschiedlich stark am Coronavirus SARS-CoV-2 erkrankten Patientinnen und Patienten sowie Kontrollproben von Menschen mit anderen Atemwegserkrankungen aus verschiedenen MHH-Kliniken und dem Klinikum Region Hannover gesammelt und verglichen worden sind. Untergebracht ist die COVID-19-Biobank in der Hannover…