Melanoma cell migration driven by WAVE complex (green) and actin filaments (red). Elapsing time is in minutes and seconds.
Various bacterial pathogens stimulate their hosts to engulf them during infection processes, allowing the bacteria to gain access to the host cell cytoplasm. This occurs through manipulation of dynamic, but force-bearing cellular protein scaffolds, allowing the pathogens to firmly adhere to, invade or spread within host cells. A protein complex termed WAVE complex that can bind to regulatory switches, so-called small GTPases, has been ascribed a key role in such processes.