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2020-01-03
“Mupirocin is a highly effective antibiotic against methicillin-resistant Staphylococcus aureus (MRSA). However, this drug is rapidly inactivated by proteins in the blood and, therefore, can only be used for local application,” says Prof Eva Medina, head of the research group “Infection Immunology” at the HZI. Previous investigations have already shown that mupirocin can be…
2019-12-16
Antibiotic resistance occurs naturally in bacteria as a mechanism to defend themselves and survive in the course of evolution. However, due to the large-scale and often erroneous use of antibiotic drugs, antibiotic resistant pathogens are becoming more widespread. Infections with multi-resistant pathogens that can withstand several types of antibiotics are frequently difficult to…
2019-12-12
PRF causes the ribosome to "slip" during translation and change the reading frame to produce a different protein. PRF is used, for example, by viruses that have to produce different proteins with a very limited number of mRNAs in order to multiply. “PRF is not a random event, but determined by RNA motifs and external factors. Certain RNA motifs that favor PRF were already known.…
2019-12-10
CRISPR is a word on everyone’s lips at the moment. Although it sounds somewhat crispy and delicious, it is in fact inedible – it is actually one of the most promising tools of genetic engineering. CRISPR stands for “Clustered Regularly Interspaced Short Palindromic Repeats”. These short DNA segments in the genome of bacteria are named after their regular pattern of repeating and…
2019-12-09
Tuberculosis and malaria, along with AIDS, are the three major infectious diseases. Tuberculosis is one of the ten most common causes of death worldwide; in 2017 alone, ten million contracted the disease and 1.6 million died. Only increased efforts will make it possible to reduce the spread of the deadliest poverty-associated diseases. The new collaboration between the Helmholtz…
