Stefan Ehlers "The granuloma in Mycobacterium tuberculosis infection: closed shop or dynamic host-pathogen collusion?"


  • Overview

    In recent years, an integrated view of tuberculosis pathogenesis has emerged in which the granuloma is viewed as part of the successful life cycle of M. tuberculosis (Mtb). This includes an evolutionary perspective that takes into account the mutual shaping of the tissue microenvironment, which concurrently allows propagation and transmission of Mtb, yet restricts tissue damage to safeguard survival of the host. In this “holistic” view of the Mtb life cycle, a focal accumulation of mononuclear cells in various states of differentiation, i.e. a granuloma, is not per se protective. As a consequence, to stop M. tuberculosis from multiplying and transmitting, simple imitation or augmentation of the natural and acquired host response to infection may not be sufficient. There is good evidence that T cell responses driven by Mtb can lead to tissue remodeling that allows Mtb to exit from the granulomatous lesion and spread into the environment. Adjunct immunomodulation may be useful to blunt this strategy in an attempt to contain the infection, prevent tissue necrosis and break the transmission cycle. In addition, innovative drug therapy needs to take into account both, the dynamic nature of the granuloma and the metabolic stress it imposes on Mtb.

    Date: 18.12.2012, 17:00


    Saarland University

    Building and room

    Bernd Eistert Lecture Hall


    Stefan Ehlers,
    University of Kiel


    Rolf Müller

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    The HIPS building is located at the east entrance on the main campus of Saarland University, which is situated outside the city centre of Saarbrücken, the state capital of Saarland. Saarland is located in the south-west of Germany, having common frontiers with Luxembourg and France.


    Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)
    Universitätscampus E8 1
    66123 Saarbrücken

    By car

    • from the north (Cologne/Trier) via the motorway A1/A8 to „Autobahnkreuz Neunkirchen“, take A6 to „Saarbrücken“
    • from the east (Kaiserslautern/Mannheim) via A6 to "Saarbrücken/Paris"
    • from the north-west from Luxembourg via A620 by-pass the city centre and follow A6 to „Mannheim“
    • from the west (Metz/Paris) and south-west (Strasbourg) via the A4/A320 (E50) follow A6 (E50) to „Mannheim“
    • to reach the campus from motorway A6: take exit no. 5 „St. Ingbert West/Universität“, follow „Universität Ost“, (ca. 6 km)

    By train

    (ICE/TGV and Intercity - Saarbrücken Central Station) you can reach the campus by local busses from the main train station (112, 124) and the city centre (101, 102, 109, 111) within 15 min 



  • Prof Dr Rolf Müller

    Rolf Müller

    Managing Director of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Head of the Department Microbial Natural Products

    +49 681 98806-3000

    +49 681 98806-3009


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