Special Seminar: “Immune sensing of microbial threats- mechanisms and implications”

Leif Erik Sander

  • Overview

    The immune system protects us from infections, yet immune activation can cause serious damage to host tissues and thus has to be carefully dosed.Moreover, efficient host defense against various classes of pathogens requires very different responses.How does the immune system decide on the mode and strength of its responses? We have previously reported that immune cells can actively distinguish between viable and dead bacteria. Detection of bacterial viability, which is the quintessential basis for infectivity, triggers robust immune responses. These findings exemplify the immune system's inherent capacity to carefully scale the microbial threat. Consequently, immune responses are tailored to the microbial threat level. This type of immunological decision making is critically determined by the class and combination of immune receptors which are engaged. Yet the resulting responses also vary greatly between different cell types, and are strongly shaped by the local microenvironment. Thus, we believe that a series of checkpoints that integrate microbial and host signals dictates the immunological outcome of a microbial encounter. 

    Guests are welcome!
    Gäste sind herzlich willkommen!


    Date: 23.01.2014, 15:00

    Location

    Helmholtz-Centre for Infection Research

    Building and room

    Forum X0.13a

    Speaker

    Leif Erik Sander

    Charité University Hospital Berlin

    Host

    Dirk Heinz

  • Directions

    How to find us in Braunschweig

    Lage des Helmholtz-Zentrums in der Stadt Braunschweig.

    Address

    Helmholtz Centre for Infection Research

    Inhoffenstraße 7

    38124 Braunschweig

    Car

    From Berlin/Wolfsburg/Helmstedt:

    • A2 till motorway interchange Wolfsburg/Königslutter > A39 direction Kreuz BS-Süd/Wolfenbüttel/Bad Harzburg
    • A39 till motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Celle/Hannover:

    • A2 till motorway interchange Kreuz BS Nord > A391 direction Kreuz BS Süd/Bad Harzburg/Wolfenbüttel
    • A391 motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Kassel/Salzgitter:

    • A7 till motorway interchange Kreuz Salzgitter > A39 direction Berlin/Braunschweig/Salzgitter
    • A39 till motorway interchange Kreuz BS-Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    Train

    Braunschweig Central Station has got two Intercity-Express-Lines, which are connecting Berlin-Braunschweig-Göttingen-Fulda-Frankfurt-Mannheim. 

    Two other Intercity-Lines are in direction to Leipzig, Halle, Magdeburg and Hannover, Bremen, Oldenburg, Bielefeld, Wuppertal and Köln.

    Here you'll get more information about the timetable.

    Bus or Tram

    Bus line 431 or Tram line 1 from central station to stop "Stöckheimer Markt". Turn left into "Mascheroder Weg" and after 500m turn right into "Inhoffenstraße". 

    Futher links:

    Braunschweig traffic corporation

    Electronic time table (EFA)

    Map provided by the city of Braunschweig

    Airplane

    Hannover Airport is about 60 minutes away from Braunschweig (60km). You can hourly take a train in direction of Braunschweig.

    From the International Airport Frankfurt you can reach Braunschweig in 180 minutes by train and it's about 350km away.

    Berlin's Airports Schönefeld and Tegel are 120 minutes away from Braunschweig (230km). A train in direction of Braunschweig leaves every hour.


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