Signal Specific Activation of NF-kB in Immunity and Lymphomagenesis
“Signal Specific Activation of NF-kB in Immunity and Lymphomagenesis”
NF-kB transcription factors are master regulators of normal and pathological immune cell function. Their controlled activation is essential for regulated immunity, while deregulated NF-kB activity contributes to a wide variety of inflammatory diseases and cancer. This seminar will discuss signal transduction pathways that activate NF-kB downstream of distinct immunoreceptors by focusing on the two proteins Bcl10 and Malt1. Both molecules were originally isolated from recurrent chromosomal translocations in B cell lymphomas. These two proteins form a signaling complex that can receive various physiological inputs from innate and adaptive immune cell receptors. Bcl10 and Malt1 couple these upstream stimuli to the classical IKK dependent NF-kB pathway to mediate context dependent immune cell activation. However, overexpression of Bcl10 or Malt1 in lymphoma leads to abberrant NF-kB activation and promotes tumorigenesis by inducing constitutive survival and proliferation signals. Results from the analysis of various mouse models with mutations in the Bcl10/ Malt1 signaling cascade will be presented.
Forum, room X1.04
Dr. Jürgen Ruland, TU München