Reinhard Köster "Zebrafish as in vivo model to study differentiation, degeneration and inflammation in the central nervous system"

Reinhard Koester

The differentiation, function and pathological behavior of cells are ideally studied non-invasively in their natural environment - the organism itself. Zebrafish embryos are genetically tractable and nearly transparent allowing for in vivo time-lapse analysis of cellular interactions and cell biological events. The central nervous system and in particular the cerebellum is highly conserved between zebrafish and humans. This brain compartment controls balance, body posture and locomotion - behaviors that are easy to study across vertebrates. This allows us for revealing structure-function-behavior relations, which are severely affected in cerebellar neurodegenerative diseases. To provide an overview over the activities of my research group at the TU Braunschweig I will present summaries of our findings regarding molecular mechanisms of neuronal migration during cerebellar development. In addition, for elucidating cerebellar function we employ non-invasive optogenetic manipulations of neuronal physiology combined with simultaneous studies of behavioral performance. To understand cellular processes of neurodegeneration we genetically model neurodegenerative diseases that are used for both cell biological characterization and small compound analysis towards developing therapeutic approaches. Finally, to take advantage of the possibility to image highly motile cells in vivo, we are developing in vivo reporter strains for neutrophil, macrophage and microglia activity. These will be used to monitor host-pathogen interactions among cells of the innate immune system and the pathogen Chlostridium difficile. Interestingly, infections and inflammation have recently been associated with the initiation and progression of neurodegenerative diseases pointing at important interdependences between the immune and the nervous system for which zebrafish represents a powerful genetic model to dissect these highly dynamic events on a cellular and molecular level.

  • Overview

    The "HZI Colloquium" is a scientific lecture series at the Helmholtz Centre for Infection Research in Braunschweig, organized to host internationally renowned experts from the field of infection research. Invited guest speakers present their current research activities to a scientific audience. The presentation is followed by an open discussion.
    We cordially invite interested scientists to take part in this colloquium.
    The HZI Colloquium takes place on Wednesdays, 5.15 p.m. to 6.30 p.m. in the Forum, X0.13.


    Date: 14.08.2013, 17:15

    Location

    Helmholtz Centre for Infection Research

    Building and room

    X0.13

    Speaker

    Axel Haverich,
    Hannover Medical School

    Host

    Dirk Heinz

  • Directions

    How to find us in Braunschweig

    Lage des Helmholtz-Zentrums in der Stadt Braunschweig.

    Address

    Helmholtz Centre for Infection Research

    Inhoffenstraße 7

    38124 Braunschweig

    Car

    From Berlin/Wolfsburg/Helmstedt:

    • A2 till motorway interchange Wolfsburg/Königslutter > A39 direction Kreuz BS-Süd/Wolfenbüttel/Bad Harzburg
    • A39 till motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Celle/Hannover:

    • A2 till motorway interchange Kreuz BS Nord > A391 direction Kreuz BS Süd/Bad Harzburg/Wolfenbüttel
    • A391 motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Kassel/Salzgitter:

    • A7 till motorway interchange Kreuz Salzgitter > A39 direction Berlin/Braunschweig/Salzgitter
    • A39 till motorway interchange Kreuz BS-Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    Train

    Braunschweig Central Station has got two Intercity-Express-Lines, which are connecting Berlin-Braunschweig-Göttingen-Fulda-Frankfurt-Mannheim. 

    Two other Intercity-Lines are in direction to Leipzig, Halle, Magdeburg and Hannover, Bremen, Oldenburg, Bielefeld, Wuppertal and Köln.

    Here you'll get more information about the timetable.

    Bus or Tram

    Bus line 431 or Tram line 1 from central station to stop "Stöckheimer Markt". Turn left into "Mascheroder Weg" and after 500m turn right into "Inhoffenstraße". 

    Futher links:

    Braunschweig traffic corporation

    Electronic time table (EFA)

    Map provided by the city of Braunschweig

    Airplane

    Hannover Airport is about 60 minutes away from Braunschweig (60km). You can hourly take a train in direction of Braunschweig.

    From the International Airport Frankfurt you can reach Braunschweig in 180 minutes by train and it's about 350km away.

    Berlin's Airports Schönefeld and Tegel are 120 minutes away from Braunschweig (230km). A train in direction of Braunschweig leaves every hour.


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