Molecular Mechanisms of Antigen Translocation in Adaptive Immunity and Viral Immune Evasion
Adaptive immunity plays an important role protecting vertebrates against a broad range of pathogens and cancer. The major histocompatibility complex (MHC) class I-dependent pathway of antigen presentation represents a sophisticated strategy to recognize and eliminate infected or malignantly transformed cells, taking advantage of the constant proteasomal turnover of the cellular proteome. The transporter associated with antigen processing (TAP) is a crucial component of this pathway, catalyzing the peptide translocation and loading of MHC I complexes in the ER-lumen. The peptide-loading complex (PLC) consists of the antigen ABC transport complex TAP1/2, MHC I heavy chain, 2- mircoblobulin, calreticulin, the disulfide isomerase ERp57, and the adapter protein tapasin. The molecular mechanism of the antigen translocation machinery, the structural organization of the macromolecular peptide-loading complex, and various modes of regulation by newly identified viral factor will be discussed.
Who is Robert Tampé?
• Full Professor & Director, Institute of Biochemistry, Biocenter.
• Guest Professor, University of California San Francisco (UCSF).
• Visiting Professor, iCeMS, Kyoto University, Japan.
• Coordinator, Research Center (SFB 807) Transport and Communication across Cell Membranes.
TWINCORE, Feodor-Lynen-Str. 7, 30625 Hannover, Lecture Hall
Prof. Dr. Robert Tampé
Prof. Dr. Ulrich Kalinke, Twincore