Michael A. Jarvis "Persistent Vector-based Vaccine Strategies for Infectious Disease & Cancer"

Michael Jarvis

Persistent vectors such as those based on cytomegalovirus (CMV) offer a novel vaccine platform capable of inducing immunity with immediate effector function localized to mucosal epithelium. CMV-based vectors represent a new class of persistent vaccine due to their ability to provide continuous, low level antigenic stimulation, resulting in high levels of durable T cell immunity that is shifted towards the effector (TEM) compartment – even following oral administration. These vaccines may therefore prove effective against infectious disease and cancers that are refractory to targeting by conventional vaccines. Recent studies in model systems show the efficacy of these vectors against simian immunodeficiency (SIV) and Ebola virus, as well as tetanus and prostate cancer. Remarkably, reuse of CMV is not prevented by prior immunity against the vector. This characteristic has led to the potential for development of ‘disseminating’ vaccines for use in wild animal populations to prevent transmission of diseases such as Ebola virus and bovine tuberculosis. The approach takes advantage of the ability of CMV to spread through its host population, even in the presence of pre-existing CMV immunity. Other studies are investigating the ability of TEM-biased responses induced by CMV to slow tumor progression, and to determine the role of T cell immunity in diseases that have historically been controlled by antibody-based vaccines.

  • Overview

    The "HZI Colloquium" is a scientific lecture series at the Helmholtz Centre for Infection Research in Braunschweig, organized to host internationally renowned experts from the field of infection research. Invited guest speakers present their current research activities to a scientific audience. The presentation is followed by an open discussion.
    We cordially invite interested scientists to take part in this colloquium.
    The HZI Colloquium takes place on Wednesdays, 5.15 p.m. to 6.30 p.m. in the Forum, X0.13.


    Date: 05.03.2014, 17:15

    Location

    Helmholtz-Zentrum für Infektionsforschung

    Building and room

    X0.13

    Speaker

    Michael A. Jarvis, PhD
    Lecturer & Director of Graduate Studies,
    School of Biomedical & Healthcare Sciences University of Plymouth

  • Directions

    How to find us in Braunschweig

    Lage des Helmholtz-Zentrums in der Stadt Braunschweig.

    Address

    Helmholtz Centre for Infection Research

    Inhoffenstraße 7

    38124 Braunschweig

    Car

    From Berlin/Wolfsburg/Helmstedt:

    • A2 till motorway interchange Wolfsburg/Königslutter > A39 direction Kreuz BS-Süd/Wolfenbüttel/Bad Harzburg
    • A39 till motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Celle/Hannover:

    • A2 till motorway interchange Kreuz BS Nord > A391 direction Kreuz BS Süd/Bad Harzburg/Wolfenbüttel
    • A391 motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Kassel/Salzgitter:

    • A7 till motorway interchange Kreuz Salzgitter > A39 direction Berlin/Braunschweig/Salzgitter
    • A39 till motorway interchange Kreuz BS-Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    Train

    Braunschweig Central Station has got two Intercity-Express-Lines, which are connecting Berlin-Braunschweig-Göttingen-Fulda-Frankfurt-Mannheim. 

    Two other Intercity-Lines are in direction to Leipzig, Halle, Magdeburg and Hannover, Bremen, Oldenburg, Bielefeld, Wuppertal and Köln.

    Here you'll get more information about the timetable.

    Bus or Tram

    Bus line 431 or Tram line 1 from central station to stop "Stöckheimer Markt". Turn left into "Mascheroder Weg" and after 500m turn right into "Inhoffenstraße". 

    Futher links:

    Braunschweig traffic corporation

    Electronic time table (EFA)

    Map provided by the city of Braunschweig

    Airplane

    Hannover Airport is about 60 minutes away from Braunschweig (60km). You can hourly take a train in direction of Braunschweig.

    From the International Airport Frankfurt you can reach Braunschweig in 180 minutes by train and it's about 350km away.

    Berlin's Airports Schönefeld and Tegel are 120 minutes away from Braunschweig (230km). A train in direction of Braunschweig leaves every hour.


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