Manfred Lutz "Understanding Myeloid-Derived Suppressor Cell Functions: GM-CSF-Licensing and Mycobacterial Activation"

Manfred Lutz

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of myeloid cells with an immature phenotype and T cell-suppressive functions. Under steady-state conditions they are lacking the suppressive activity and are called immature myeloid cells (IMCs). In the mouse two major subsets have been defined: granulocytic and monocytic MDSCs. However, the difference of the latter subset to monocytes has not been defined yet. Our data suggest that GM-CSF "licensing" of monocytes marks their conversion to IMC in order to respond to further LPS/IFN-γ activation. MDSC activation can also strongly be induced by mycobacteria. Our results indicate new survival and immune escape strategies by Mtb by hiding in caveolae of MDSC but simultaneously expand and activate them for immune suppression of T cell responses.

  • Overview

    The "HZI Colloquium" is a scientific lecture series at the Helmholtz Centre for Infection Research in Braunschweig, organized to host internationally renowned experts from the field of infection research. Invited guest speakers present their current research activities to a scientific audience. The presentation is followed by an open discussion.
    We cordially invite interested scientists to take part in this colloquium.
    The HZI Colloquium takes place on Wednesdays, 5.15 p.m. to 6.30 p.m. in the Forum, X0.13.


    Date: 19.12.2012, 17:15

    Location

    Helmholtz Centre for Infection Research

    Building and room

    Forum, X1.04

    Speaker

    Manfred Lutz,
    University of Würzburg

     

    Host

    Jochen Hühn

  • Directions

    How to find us in Braunschweig

    Lage des Helmholtz-Zentrums in der Stadt Braunschweig.

    Address

    Helmholtz Centre for Infection Research

    Inhoffenstraße 7

    38124 Braunschweig

    Car

    From Berlin/Wolfsburg/Helmstedt:

    • A2 till motorway interchange Wolfsburg/Königslutter > A39 direction Kreuz BS-Süd/Wolfenbüttel/Bad Harzburg
    • A39 till motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Celle/Hannover:

    • A2 till motorway interchange Kreuz BS Nord > A391 direction Kreuz BS Süd/Bad Harzburg/Wolfenbüttel
    • A391 motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Kassel/Salzgitter:

    • A7 till motorway interchange Kreuz Salzgitter > A39 direction Berlin/Braunschweig/Salzgitter
    • A39 till motorway interchange Kreuz BS-Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    Train

    Braunschweig Central Station has got two Intercity-Express-Lines, which are connecting Berlin-Braunschweig-Göttingen-Fulda-Frankfurt-Mannheim. 

    Two other Intercity-Lines are in direction to Leipzig, Halle, Magdeburg and Hannover, Bremen, Oldenburg, Bielefeld, Wuppertal and Köln.

    Here you'll get more information about the timetable.

    Bus or Tram

    Bus line 431 or Tram line 1 from central station to stop "Stöckheimer Markt". Turn left into "Mascheroder Weg" and after 500m turn right into "Inhoffenstraße". 

    Futher links:

    Braunschweig traffic corporation

    Electronic time table (EFA)

    Map provided by the city of Braunschweig

    Airplane

    Hannover Airport is about 60 minutes away from Braunschweig (60km). You can hourly take a train in direction of Braunschweig.

    From the International Airport Frankfurt you can reach Braunschweig in 180 minutes by train and it's about 350km away.

    Berlin's Airports Schönefeld and Tegel are 120 minutes away from Braunschweig (230km). A train in direction of Braunschweig leaves every hour.


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Contact

  • Prof Jochen Hühn

    Jochen Hühn

    Head of Department

    +49 531 6181-3310

    +49 531 6181-3399

    Contact

Involved Groups