HIPS Talk: "Synthetic vaccine nanocarriers mimicking structure and function of pathogens"
Micro- and nanoparticulate encapsulation strategies have attracted attention to solve anumber of challenges in the biomedical field, e.g. for drug delivery or as building blocks intissue engineering. We hypothesize that, compared to solid matrix particles such as PLGAmicrospheres, porous, fully-hydrated particles are hypothesized to have superiorproperties for several applications. Hydrated particles allow in and outwards diffusion ofwater as well as reactants and reaction products.
In view of these considerations we are evaluating self-assembly strategies to design nano-and microparticulate systems that target immune cells to delivery vaccine antigens andstimulatory cues that shape the magnitude and type of immune response. Inspired bynature, the systems we design mimic the structure and function of pathogens, therebysimulating natural infection. Here we present the bottom-up approach, using Layer-byLayer (LbL) self-assembly of polyelectrolytes onto a sacrificial template, that we havefollowed in our research group the past years starting from simple laboratory bench experiments towards delivery systems that are non-toxic, have excellent performance in in vivo models for cancer and viral infection. Finally, our recent advances will be shown how we translate this know-how to design similar carriers that can be produced on an industrial relevant scale.
Universität des Saarlandes
Building and room
Blg C4 3, Kleiner Hörsaal der Anorganischen Chemie
Prof. Dr. Bruno De Geest,
Biopharmaceutical Technology, Ghent University
Prof. Dr. Claus-Michael Lehr
How to find us in Saarbrücken
The HIPS building is located at the east entrance on the main campus of Saarland University, which is situated outside the city centre of Saarbrücken, the state capital of Saarland. Saarland is located in the south-west of Germany, having common frontiers with Luxembourg and France.
Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)
Universitätscampus E8 1
- from the north (Cologne/Trier) via the motorway A1/A8 to „Autobahnkreuz Neunkirchen“, take A6 to „Saarbrücken“
- from the east (Kaiserslautern/Mannheim) via A6 to "Saarbrücken/Paris"
- from the north-west from Luxembourg via A620 by-pass the city centre and follow A6 to „Mannheim“
- from the west (Metz/Paris) and south-west (Strasbourg) via the A4/A320 (E50) follow A6 (E50) to „Mannheim“
- to reach the campus from motorway A6: take exit no. 5 „St. Ingbert West/Universität“, follow „Universität Ost“, (ca. 6 km)
(ICE/TGV and Intercity - Saarbrücken Central Station) you can reach the campus by local busses from the main train station (112, 124) and the city centre (101, 102, 109, 111) within 15 min
- HIPS at UdS Campus (pdf, 137 kB)