May 30 – June 1 2013

6th International Workshop “Interferon and Infection”


The 6th International Workshop “Interferon & Infection” will be held in Braunschweig, Germany, from May 30th to June 1st.


- Sensing mechanisms of IFN induction

- IFN in pathogenesis of cancer and infection

- Type III interferon

- Neurotropic virus infection and the IFN system

- Antiviral action


The final program is uploaded.


May 30 – June 1 2013


Forum X0.13


Talks: 15 minutes plus 5 minutes discussion

Keynote Lecture: 45 minutes plus 15 minutes discussion.
We are happy to announce that the keynote lecture will be held by Dr. Jacob Piehler.

Poster Session on Friday 31st, 2013, 12:30 - 14:30

Thursday, 30.05.2013

12:00 REGISTRATION, Forum of HZI

13:15 Hauser, Hansjoerg / HZI: WELCOME

Session: Sensing mechanisms of IFN Induction

Chair: to be defined


13:30 - 13:50 Heinrich, Julia / TWINCORE, Hannover
“Toll-like receptor and RIG-I like helicase crosstalk is essential for protection against vesicular stomatitis virus infection

13:50 - 14:10 Bauer, Jens / University of Duesseldorf
“Differential gene expression analysis of IFNβ+ vs. IFNβ- plasmacytoid dendritic cells ex vivo reveals different functional subsets”

14:10 - 14:30 Scheu, Stefanie / University of Duesseldorf
“Poly(I:C) sensitization induces a cytokine imprinting mechanism in dendritic cells and aggravates septic peritonitis”

14:30 - 15:00 Coffee Break

15:00 - 15:20 Schweizer, Matthias / University of Bern
“Homodimerisation-independent cleavage of dsRNA by Erns of pestiviruses”

15:20 - 15:40 Weber, Michaela / Philipps-University Marburg
"Activation of RIG-I by incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome”

15:40 - 16:00 Ruggli, Nicolas / Institute of Virology and Immunology, Mittelhäusern
“Sensing of infected cells in absence of virus particles by plasmacytoid dendritic cells is inhibited by the ribonuclease Erns of classical swine fever virus”

16:00 - 16:20 Rand, Ulfert / The University of Manchester
“Stochastic cell-to-cell variation of IFN induction and signalling tunes timing and quality of the antiviral response”

Session: IFN in pathogenesis of cancer and infection

Chair: to be defined


16:20 - 16:40 Jablonska-Koch, Jadwiga / HZI, Braunschweig
"Tumor angiogenesis and growth is regulated by tumor infiltrating neutrophils responsive to endogenous IFNb”

16:40 - 17:00 Frenz, Theresa / TWINCORE, Hannover
"Locally induced IFN-I balances cytokine responses and confers survival of vaccinia virus infection"

17:00 - 18:00 Transfer to Braunschweig

18:00 - 19:00 City Tour

19:00 - 23:00 Dinner in "Alte Waage"

Friday, 31.05.2013

Session: IFN in pathogenesis of cancer and infection (continued)

Chair: to be defined


9:00 - 9:20 Lienenklaus, Stefan / HZI, Braunschweig
“Visualizing the IFN-ß in vivo

9:20 - 9:40 Finsterbusch, Katja / HZI, Braunschweig
“IRF-5 controls VSV infection and pathogenesis in mice”

9:40 - 10:00 Resch, Theresa / Paul-Ehrlich-Institut, Langen
"Protection from poly(I:C)-induced liver damage requires type I IFN-dependent recruitment of myeloid supressor cells and IL-1RA expression “

10:00 - 10:20 Zielecki, Florian / Philipps-University Marburg
“Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to SARS-coronavirus”

 10:20 - 10:50 Coffee Break

Session: Type III Interferon

Chair: to be defined


10:50 - 11:10 Jorgensen, Sanne Ea / Aarhus University
“Biochemical aspects of an IFN-λ3 SNP and IFN-λ4”

11:10 - 11:30 Hermant, Pascale / Université Catholique de Louvain
Interferon Lambda and the liver paradox”

11:30 - 11:50 Mahlakoiv, Tanel / University Hospital Freiburg
Interferon lambda confers antiviral protection on the epithelium”

11:50 - 12:10 Soubies, Sébastien / University Hospital Freiburg
“Antiviral activity of interferon-lambda in chickens”

12:10 - 12:30 Rauch, Isabella / University of Vienna
"Analysis of IRF9-deficient mice suggests a contribution of IFN-III to DSS-induced colitis”

12:30 - 14:30 Lunch + POSTER SESSION


Session: Neurotropic virus infection and the IFN system

Chair: to be defined


14:30 -14:50 Nair, Sharmila / HZI, Braunschweig
“IRF-1 protects mice from lethal VSV Neuropathogenesis by type I IFN-independent local antiviral effects“

14:50 - 15:10 Detje, Claudia / TWINCORE, Hannover
“Non-redundant in vivo functions of IFN-beta protect against virus infection within the central nervous system”

15:10 - 15:30 Pfefferkorn, Cathleen / University Hospital Freiburg
“Identification of interferon-beta-producing cells upon viral infection of the brain”

15:30 - 15:50 Weber, Elvira / University of Umea
“Type I Interferon protects against lethal Langat Virus Infection”

15:50 - 16:20 Coffee Break

Session: Antiviral action

Chair: to be defined


16:20 - 16:40 Oeverby, Anna / University of Umea
“The antiviral protein viperin targets tick-borne encephalitis virus replication via ist radical SAM domain”

16:40 - 17:00 Gad, Hans Henrik / Aarhus University
“A novel role for OASL during viral infection

17:00 - 17:20 Kreit, Marguerite / Université Catholique de Louvain
“Antiviral activity of murine Apolipoprotein L9”

17:20 - 17:40 Randall, Rick / University of St Andrews
“STAT2 deficiency and viral illness in humans”

Keynote Lecture

17:40 - 18:40 Piehler, Jacob / University of Osnabrueck
“Assembly and dynamics of the type I interferon receptor: regulation of a family business”

Saturday, 01.06.2013

Session: Antiviral action (continued)

Chair: to be defined


9:00 -9:20 Patzina, Corinna / University Hospital Freiburg
“A flexible loop in the IFN-induced human MxA as major determinant for ist antiviral specifity”

9:20 - 9:40 Dornfeld, Dominik / University Hospital Freiburg
“Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein”

9:40 - 10:00 Nürnberger, Cindy / University Hospital Freiburg
“The Mx system of wild-derived CAST/EiJ mice protects against Thogoto virus but not influenza A virus”

10:00 - 10:20 Pavlovic, Jovan / University of Zurich
“Role of GTP-mediated structural changes of MxA on ist antiviral function against influenza A”

10:20 - 10:40 Schilling, Mirjam / University Hospital Freiburg
“What is the role of human MxB in the IFN-induced antiviral host response?”


10:40 - 11:10 Coffee Break


11:10 - 11:30 Goodbourn, Steve / St. George's, University of London
“Activation and inhibition of IG-I and mda-5 by paramyxoviruses”

11:30 - 11:50 Schwerk, Johannes / HZI, Braunschweig
“Murine gammaherpesvirus 68 latency is controlled by type I interferon signaling in vivo

11:50 - 12:10 van Kuppeveld, Frank / Utrecht University
“Immune recognition of picornavirus RNAs and viral evasion strategies”

12:10 - 12:30 Langereis, Martijn / Utrecht University
“MDA5 localizes to stress granules but this localization is not required for the induction of type I interferon”

12:30 - 12:50 Sparrer, Konstantin / Ludwig-Maximilians-Universität München
“Measles virus V and C proteins tricking innate immunity


12:50 - 13:30 Lunch


13:30 END OF WORKSHOP / Departure

Registration is free.

Please register, if you wish to attend the lectures.

Personal data

Please complete the registration by pressing the Senden button. Within the next few minutes you will receive a confirmaion email. If you do not receive a confirmation email, please register again and check the email address field for potential spelling mistakes.

In case you are looking for accommodation we have a limited allocation of rooms in the following hotels.
Please contact the hotel by yourself:

Pentahotel [25 rooms]

Augusstrasse 6-8
38100 Braunschweig

Arrival: 30.05.2013 - Departure: 01.06.2013

Price/night incl. breakfast: Single room 99,- Euro, Double room: 116,- Euro

Please contact the hotel by phone 01805-495 555 or +49 69 2566 99300 or email, indicating the keyword “6th Int. Workshop Interferon & Infection”

This offer expires on May 8, 2013, at the latest.


Alternatively you may contact any other hotel of your choice. Please see

How to find us in Braunschweig

Lage des Helmholtz-Zentrums in der Stadt Braunschweig.


Helmholtz Centre for Infection Research

Inhoffenstraße 7

38124 Braunschweig


From Berlin/Wolfsburg/Helmstedt:

  • A2 till motorway interchange Wolfsburg/Königslutter > A39 direction Kreuz BS-Süd/Wolfenbüttel/Bad Harzburg
  • A39 till motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
  • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
  • after 500m turn left into Inhoffenstraße

From Celle/Hannover:

  • A2 till motorway interchange Kreuz BS Nord > A391 direction Kreuz BS Süd/Bad Harzburg/Wolfenbüttel
  • A391 motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
  • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
  • after 500m turn left into Inhoffenstraße

From Kassel/Salzgitter:

  • A7 till motorway interchange Kreuz Salzgitter > A39 direction Berlin/Braunschweig/Salzgitter
  • A39 till motorway interchange Kreuz BS-Süd > A395 direction Wolfenbüttel
  • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
  • after 500m turn left into Inhoffenstraße


Braunschweig Central Station has got two Intercity-Express-Lines, which are connecting Berlin-Braunschweig-Göttingen-Fulda-Frankfurt-Mannheim. 

Two other Intercity-Lines are in direction to Leipzig, Halle, Magdeburg and Hannover, Bremen, Oldenburg, Bielefeld, Wuppertal and Köln.

Here you'll get more information about the timetable.

Bus or Tram

Bus line 431 or Tram line 1 from central station to stop "Stöckheimer Markt". Turn left into "Mascheroder Weg" and after 500m turn right into "Inhoffenstraße". 

Futher links:

Braunschweig traffic corporation

Electronic time table (EFA)

Map provided by the city of Braunschweig


Hannover Airport is about 60 minutes away from Braunschweig (60km). You can hourly take a train in direction of Braunschweig.

From the International Airport Frankfurt you can reach Braunschweig in 180 minutes by train and it's about 350km away.

Berlin's Airports Schönefeld and Tegel are 120 minutes away from Braunschweig (230km). A train in direction of Braunschweig leaves every hour.



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