6th International Workshop “Interferon and Infection”


  • Overview

    The 6th International Workshop “Interferon & Infection” will be held in Braunschweig, Germany, from May 30th to June 1st.


    - Sensing mechanisms of IFN induction

    - IFN in pathogenesis of cancer and infection

    - Type III interferon

    - Neurotropic virus infection and the IFN system

    - Antiviral action


    The final program is uploaded.

    Date: May 30 – June 1 2013


    Forum X0.13

  • Programme


    Talks: 15 minutes plus 5 minutes discussion

    Keynote Lecture: 45 minutes plus 15 minutes discussion.
    We are happy to announce that the keynote lecture will be held by Dr. Jacob Piehler.

    Poster Session on Friday 31st, 2013, 12:30 - 14:30

    Thursday, 30.05.2013

    12:00 REGISTRATION, Forum of HZI

    13:15 Hauser, Hansjoerg / HZI: WELCOME

    Session: Sensing mechanisms of IFN Induction

    Chair: to be defined


    13:30 - 13:50 Heinrich, Julia / TWINCORE, Hannover
    “Toll-like receptor and RIG-I like helicase crosstalk is essential for protection against vesicular stomatitis virus infection”

    13:50 - 14:10 Bauer, Jens / University of Duesseldorf
    “Differential gene expression analysis of IFNβ+ vs. IFNβ- plasmacytoid dendritic cells ex vivo reveals different functional subsets”

    14:10 - 14:30 Scheu, Stefanie / University of Duesseldorf
    “Poly(I:C) sensitization induces a cytokine imprinting mechanism in dendritic cells and aggravates septic peritonitis”

    14:30 - 15:00 Coffee Break

    15:00 - 15:20 Schweizer, Matthias / University of Bern
    “Homodimerisation-independent cleavage of dsRNA by Erns of pestiviruses”

    15:20 - 15:40 Weber, Michaela / Philipps-University Marburg
    "Activation of RIG-I by incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome”

    15:40 - 16:00 Ruggli, Nicolas / Institute of Virology and Immunology, Mittelhäusern
    “Sensing of infected cells in absence of virus particles by plasmacytoid dendritic cells is inhibited by the ribonuclease Erns of classical swine fever virus”

    16:00 - 16:20 Rand, Ulfert / The University of Manchester
    “Stochastic cell-to-cell variation of IFN induction and signalling tunes timing and quality of the antiviral response”

    Session: IFN in pathogenesis of cancer and infection

    Chair: to be defined


    16:20 - 16:40 Jablonska-Koch, Jadwiga / HZI, Braunschweig
    "Tumor angiogenesis and growth is regulated by tumor infiltrating neutrophils responsive to endogenous IFNb”

    16:40 - 17:00 Frenz, Theresa / TWINCORE, Hannover
    "Locally induced IFN-I balances cytokine responses and confers survival of vaccinia virus infection"

    17:00 - 18:00 Transfer to Braunschweig

    18:00 - 19:00 City Tour

    19:00 - 23:00 Dinner in "Alte Waage"

    Friday, 31.05.2013

    Session: IFN in pathogenesis of cancer and infection (continued)

    Chair: to be defined


    9:00 - 9:20 Lienenklaus, Stefan / HZI, Braunschweig
    “Visualizing the IFN-ß in vivo”

    9:20 - 9:40 Finsterbusch, Katja / HZI, Braunschweig
    “IRF-5 controls VSV infection and pathogenesis in mice”

    9:40 - 10:00 Resch, Theresa / Paul-Ehrlich-Institut, Langen
    "Protection from poly(I:C)-induced liver damage requires type I IFN-dependent recruitment of myeloid supressor cells and IL-1RA expression “

    10:00 - 10:20 Zielecki, Florian / Philipps-University Marburg
    “Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to SARS-coronavirus”

     10:20 - 10:50 Coffee Break

    Session: Type III Interferon

    Chair: to be defined


    10:50 - 11:10 Jorgensen, Sanne Ea / Aarhus University
    “Biochemical aspects of an IFN-λ3 SNP and IFN-λ4”

    11:10 - 11:30 Hermant, Pascale / Université Catholique de Louvain
    “Interferon Lambda and the liver paradox”

    11:30 - 11:50 Mahlakoiv, Tanel / University Hospital Freiburg
    “Interferon lambda confers antiviral protection on the epithelium”

    11:50 - 12:10 Soubies, Sébastien / University Hospital Freiburg
    “Antiviral activity of interferon-lambda in chickens”

    12:10 - 12:30 Rauch, Isabella / University of Vienna
    "Analysis of IRF9-deficient mice suggests a contribution of IFN-III to DSS-induced colitis”

    12:30 - 14:30 Lunch + POSTER SESSION


    Session: Neurotropic virus infection and the IFN system

    Chair: to be defined


    14:30 -14:50 Nair, Sharmila / HZI, Braunschweig
    “IRF-1 protects mice from lethal VSV Neuropathogenesis by type I IFN-independent local antiviral effects“

    14:50 - 15:10 Detje, Claudia / TWINCORE, Hannover
    “Non-redundant in vivo functions of IFN-beta protect against virus infection within the central nervous system”

    15:10 - 15:30 Pfefferkorn, Cathleen / University Hospital Freiburg
    “Identification of interferon-beta-producing cells upon viral infection of the brain”

    15:30 - 15:50 Weber, Elvira / University of Umea
    “Type I Interferon protects against lethal Langat Virus Infection”

    15:50 - 16:20 Coffee Break

    Session: Antiviral action

    Chair: to be defined


    16:20 - 16:40 Oeverby, Anna / University of Umea
    “The antiviral protein viperin targets tick-borne encephalitis virus replication via ist radical SAM domain”

    16:40 - 17:00 Gad, Hans Henrik / Aarhus University
    “A novel role for OASL during viral infection”

    17:00 - 17:20 Kreit, Marguerite / Université Catholique de Louvain
    “Antiviral activity of murine Apolipoprotein L9”

    17:20 - 17:40 Randall, Rick / University of St Andrews
    “STAT2 deficiency and viral illness in humans”

    Keynote Lecture

    17:40 - 18:40 Piehler, Jacob / University of Osnabrueck
    “Assembly and dynamics of the type I interferon receptor: regulation of a family business”

    Saturday, 01.06.2013

    Session: Antiviral action (continued)

    Chair: to be defined


    9:00 -9:20 Patzina, Corinna / University Hospital Freiburg
    “A flexible loop in the IFN-induced human MxA as major determinant for ist antiviral specifity”

    9:20 - 9:40 Dornfeld, Dominik / University Hospital Freiburg
    “Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein”

    9:40 - 10:00 Nürnberger, Cindy / University Hospital Freiburg
    “The Mx system of wild-derived CAST/EiJ mice protects against Thogoto virus but not influenza A virus”

    10:00 - 10:20 Pavlovic, Jovan / University of Zurich
    “Role of GTP-mediated structural changes of MxA on ist antiviral function against influenza A”

    10:20 - 10:40 Schilling, Mirjam / University Hospital Freiburg
    “What is the role of human MxB in the IFN-induced antiviral host response?”


    10:40 - 11:10 Coffee Break


    11:10 - 11:30 Goodbourn, Steve / St. George's, University of London
    “Activation and inhibition of IG-I and mda-5 by paramyxoviruses”

    11:30 - 11:50 Schwerk, Johannes / HZI, Braunschweig
    “Murine gammaherpesvirus 68 latency is controlled by type I interferon signaling in vivo”

    11:50 - 12:10 van Kuppeveld, Frank / Utrecht University
    “Immune recognition of picornavirus RNAs and viral evasion strategies”

    12:10 - 12:30 Langereis, Martijn / Utrecht University
    “MDA5 localizes to stress granules but this localization is not required for the induction of type I interferon”

    12:30 - 12:50 Sparrer, Konstantin / Ludwig-Maximilians-Universität München
    “Measles virus V and C proteins tricking innate immunity“


    12:50 - 13:30 Lunch


    13:30 END OF WORKSHOP / Departure

  • Register

    Registration is free.

    Please register, if you wish to attend the lectures.

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  • Accommodation

    In case you are looking for accommodation we have a limited allocation of rooms in the following hotels.
    Please contact the hotel by yourself:

    Pentahotel [25 rooms]

    Augusstrasse 6-8
    38100 Braunschweig

    Arrival: 30.05.2013 - Departure: 01.06.2013

    Price/night incl. breakfast: Single room 99,- Euro, Double room: 116,- Euro

    Please contact the hotel by phone 01805-495 555 or +49 69 2566 99300 or email reservations.braunschweig@pentahotels.com, indicating the keyword “6th Int. Workshop Interferon & Infection”

    This offer expires on May 8, 2013, at the latest.


    Alternatively you may contact any other hotel of your choice. Please see http://www.braunschweig.de/english/touristservice/hotels/index.html

  • Directions

    How to find us in Braunschweig

    Lage des Helmholtz-Zentrums in der Stadt Braunschweig.


    Helmholtz Centre for Infection Research

    Inhoffenstraße 7

    38124 Braunschweig


    From Berlin/Wolfsburg/Helmstedt:

    • A2 till motorway interchange Wolfsburg/Königslutter > A39 direction Kreuz BS-Süd/Wolfenbüttel/Bad Harzburg
    • A39 till motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Celle/Hannover:

    • A2 till motorway interchange Kreuz BS Nord > A391 direction Kreuz BS Süd/Bad Harzburg/Wolfenbüttel
    • A391 motorway interchange Kreuz BS Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße

    From Kassel/Salzgitter:

    • A7 till motorway interchange Kreuz Salzgitter > A39 direction Berlin/Braunschweig/Salzgitter
    • A39 till motorway interchange Kreuz BS-Süd > A395 direction Wolfenbüttel
    • A395 till exit BS-Stöckheim > turn right into Mascheroder Weg
    • after 500m turn left into Inhoffenstraße


    Braunschweig Central Station has got two Intercity-Express-Lines, which are connecting Berlin-Braunschweig-Göttingen-Fulda-Frankfurt-Mannheim. 

    Two other Intercity-Lines are in direction to Leipzig, Halle, Magdeburg and Hannover, Bremen, Oldenburg, Bielefeld, Wuppertal and Köln.

    Here you'll get more information about the timetable.

    Bus or Tram

    Bus line 431 or Tram line 1 from central station to stop "Stöckheimer Markt". Turn left into "Mascheroder Weg" and after 500m turn right into "Inhoffenstraße". 

    Futher links:

    Braunschweig traffic corporation

    Electronic time table (EFA)

    Map provided by the city of Braunschweig


    Hannover Airport is about 60 minutes away from Braunschweig (60km). You can hourly take a train in direction of Braunschweig.

    From the International Airport Frankfurt you can reach Braunschweig in 180 minutes by train and it's about 350km away.

    Berlin's Airports Schönefeld and Tegel are 120 minutes away from Braunschweig (230km). A train in direction of Braunschweig leaves every hour.



  • Sylvia Richter

    Sylvia Richter

    Secretary of Department Gene Regulation and Differentiation

    +49 531 6181-5001

    +49 531 6181-5002


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