30.-31- August 2018

10. TWINCORE Symposium


From August 30th to 31st, 2018, international Infection researchers meet at TWINCORE for the tenth time.

This years topic: Frontiers in translational research.

For more information, please click here.
Registration is not necessary!

We are looking forward to welcoming you at TWINCORE!


30.-31- August 2018




  • Björn Thümler - Niedersächsischer Minister für Wissenschaft und Kultur, Hannover
  • Prof. Dr. Ralf Bartenschlager - Universität Heidelberg, Heidelberg
  • Dr. Ursula Buchholz - National Institute of Allergy and Infectious Diseases, NIH, Bethesda
  • Prof. Dr. Petra Dersch - Helmholtz-Zentrum für Infektionsforschung / TU Braunschweig, Braunschweig
  • Prof. Dr. Alain Filloux - Imperial College, London
  • Prof. Dr. Michael P. Manns - Medizinische Hochschule Hannover, Hannover
  • Prof. Dr. Michael Meyer-Hermann - Helmholtz-Zentrum für Infektionsforschung
  • Prof. Dr. Rolf Müller - Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS), Saarbrücken
  • Prof. Dr. Albert Osterhaus - Research Center for Emerging Infections and Zoonoses (RIZ), Hannover
  • Prof. Dr. Klaus Rajewsky - Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin
  • Prof. Dr. Charles M. Rice - Rockefeller University, New York
  • Prof. Dr. Helga Rübsamen-Schaeff - AiCuris Anti-Infective Cures GmbH, Wuppertal
  • Prof. Dr. Emmanuel Saliba - Helmholtz Institute for RNA-based Infection Research (HIRI), Würzburg
  • Prof. Dr. Eike Steinmann - Ruhr-Universität Bochum, Bochum
  • Prof. Dr. Jörg Vogel - Helmholtz Institute for RNA-based Infection Research (HIRI), Würzburg


08.15-09.00      Registration
09.00-09.05       Ulrich Kalinke
                               Begrüßung “10. TWINCORE-Symposium“
09.05-09.20       Minister Björn Thümler
                               Grußwort; Niedersächsisches Ministerium für Wissenschaft und
09.20-09.30       Christopher Baum
                               Grußwort; Präsident MHH
09.30-09.40       Dirk Heinz
                               Grußwort; Wissenschaftlicher Direktor HZI
09.40-10.00      Coffee break

TOPIC: Virology              Chair: Eike Steinmann

10.00-10.20       Michael P. Manns
                               Medical challenges in viral hepatitis
10.20-10.50       Ralf Bartenschlager
                               Hepatitis C virus research: Challenges and opportunities
                               beyond antiviral therapy
10.50-11.15       Eike Steinmann
                               Hepatitis E virus: Principles of replication, resistance, and
                               chronic persistence
11.15-11.45      Coffee break
11.45-12.15       Charles M. Rice
                               Diverse and unexpected strategies of host antiviral immunity
12.15-12.30       Michael Ott
                               Beyond hepatitis C - novel concepts to treat liver fibrosis
12.30-12.40       Gisa Gerold
                               Protein complexes as entry ports into cells: Lessons learned
                               from hepatitis C virus
12.40-13.40       Lunch

TOPIC: Immunology                                   Chair: Jan Buer

13.40-13.55       Reinhold Förster
13.55-14.05       Christine Goffinet
                               Innate sensing and restriction of HIV-1 in T-cells
14.05-14.15       Ulrich Kalinke
                               Hepatocytes are key innate effector cells during enterovirus
14.15-14.30       Tim Sparwasser
                               Metabolic programs controlling immune cell function
14.30-15.00      Coffee break

TOPIC: Bacteriology                 Chair: Alain Filloux

15.00-15.30       Alain Filloux
                               The type VI secretion system: A bacterial killing machine
15.30-15.45       Susanne Häußler
                               tRNA modifications in Pseudomonas aeruginosa
15.45-16.00       Petra Dersch
                               RNA-based virulence strategies of enteric pathogens as
                               potential drug targets
16.00-17.00       Honours for Dieter Bitter-Suermann and Rudi Balling
17.00                    Barbecue, live music


TOPIC: Natural Compounds                       Chair: Rolf Müller

09.00-09.20       Rolf Müller
                               Discovery and development of antibiotics from bacterial
                               natural products
09.20-09.45       Helga Rübsamen-Schaeff
                               PREVYMIS™ (Letermovir), a novel drug for prophylaxis of HCMV
                               reactivation in stem cell recipients - from bench to bedside
09.45-10.00       Luka Cicin-Sain
                               Understanding T cell responses to CMV infection
10.00-10.30      Coffee break

TOPIC: Vaccination                                    Chair: Albert Osterhaus

10.30-11.00       Albert Osterhaus
                               From virus discovery to intervention strategy
11.00-11.15       Michael Meyer-Hermann
                               How to generate optimal antibodies in in silico germinal centres
11.15-11.40       Ursula Buchholz
                               Progress in the development of pediatric live-attenuated
                               respiratory syncytial virus vaccines
11.40-11.55       Thomas Pietschmann
                               Genetic determinants of severe respiratory syncytial virus
                               infection in infants
11.55-12.15       Emmanuel Saliba
                               Single-cell RNA-seq reveals the complexity and heterogeneity of
                               infection processes
12.15-13.15       Lunch

TOPIC: Monitoring                                      Chair: Ulrich Kalinke

13.15-13.25       Frank Pessler
                               IL8 and IL18 as predictive biomarkers for the immune response
                               to influenza vaccination among elderly individuals
13.25-13.40       Gérard Krause
                               Differential serology – biomarker for evaluation of vaccination
13.40-14.00       Jörg Vogel
                               Towards precision editing of the human microbiota
14.00                   Closure

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