SARS-CoV-2 / COVID-19

Since the end of 2019, a novel virus that can cause respiratory diseases and pneumonia has been spreading worldwide. The pathogen SARS-CoV-2 belongs to the coronavirus family and is closely related to the SARS virus, which caused a pandemic in 2002. Here we will keep you informed about current developments in research and provide answers to the most important questions.

An overview of selected recent publications on coronavirus SARS-CoV-2:

Peer-reviewed studies

  • Federico Bertoglio, Viola Fuhner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klunemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M. Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Margitta Scholz, Gustavo Marc¸ al Schmidt Garcia Moreira, Esther Veronika Wenzel, Giulio Russo, Hendrikus S.P. Garritsen, Sebastian Casu, Andreas Gerstner, Gunter Roth, Julia Adler, Jakob Trimpert, Andreas Hermann, Thomas Schirrmann, Stefan Dubel, André Frenzel, Joop Van den Heuvel, Luka  Čičin-Šain, Maren Schubert & Michael Hust. SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations. Cell Reports, July 2021, DOI: 10.1016/j.celrep.2021.109433
  • Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzmán, Gerd Sutter, Reinhold E Schmidt, Torsten Witte & Ulrich Kalinke. B cell depletion impairs vaccination-induced CD8+ T cell responses in a type I interferon-dependent manner. Annals of the Rheumatic Diseases, July 2021, DOI: 10.1136/annrheumdis-2021-220435
  • Chunlei Jiao, Sahil Sharma, Gaurav Dugar, Natalia L. Peeck, Thorsten Bischler, Franziska Wimmer, Yanying Yu, Lars Barquist, Christoph Schoen, Oliver Kurzai, Cynthia M. Sharma, Chase L. Beisel. Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9. Science, May 2021, DOI: 10.1126/science.abe7106
  • Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert & Michael Hust. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nature Communications, March 2021, DOI: 10.1038/s41467-021-21609-2
  • Matthias Becker, Monika Strengert, Daniel Junker, Philipp D. Kaiser, Tobias Kerrinnes, Bjoern Traenkle, Heiko Dinter, Julia Häring, Stéphane Ghozzi, Anne Zeck, Frank Weise, Andreas Peter, Sebastian Hörber, Simon Fink, Felix Ruoff, Alex Dulovic, Tamam Bakchoul, Armin Baillot, Stefan Lohse, Markus Cornberg, Thomas Illig, Jens Gottlieb, Sigrun Smola, André Karch, Klaus Berger, Hans-Georg Rammensee, Katja Schenke-Layland, Annika Nelde, Melanie Märklin, Jonas S. Heitmann, Juliane S. Walz, Markus Templin, Thomas O. Joos, Ulrich Rothbauer, Gérard Krause & Nicole Schneiderhan-Marra. Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity. Nature Communications, February 2021, DOI: 10.1038/s41467-021-20973-3
  • Nora Schmidt, Caleb A. Lareau, Hasmik Keshishian, Sabina Ganskih, Cornelius Schneider, Thomas Hennig, Randy Melanson, Simone Werner, Yuanjie Wei, Matthias Zimmer, Jens Ade, Luisa Kirschner, Sebastian Zielinski, Lars Dölken, Eric S. Lander, Neva Caliskan, Utz Fischer, Jörg Vogel, Steven A. Carr, Jochen Bodem & Mathias Munschauer. The SARS-CoV-2 RNAprotein interactome in infected human cells. Nature Microbiology, December 2020, DOI: 10.1038/s41564-020-00846-z
  • Andreas Ambrosch, Felix Rockmann, Frank Klawonn, Benedikt Lampl. Effect of a strict hygiene bundle for the prevention of nosocomialtransmission of SARS-CoV-2 in the hospital: a practical approach from the field. Journal of Infection and Public Health, December 2020, DOI: 10.1016/j.jiph.2020.10.005
  • Lara Marleen Fricke, Stephan Gloeckner, Maren Dreier, Berit Lange. Impact of non-pharmaceutical interventions targeted at COVID-19 pandemic on influenza burden – a systematic review. Journal of Infection, December 2020, DOI: 10.1016/j.jinf.2020.11.039
  • T. Finkenzeller, A. Faltlhauser, K.-H. Dietl, C. Paetzel, N. Szczypien, F. Klawonn, K.-F. Bodmann, A. von Meyer. SARS-CoV-2-Antikörper bei Intensiv- und Klinikpersonal. Med Klin Intensivmed Notfmed, October 2020, DOI: 10.1007/s00063-020-00761-5
  • Thomas Günther, Manja Czech‐Sioli, Daniela Indenbirken, Alexis Robitaille, Peter Tenhaken, Martin Exner, Matthias Ottinger, Nicole Fischer, Adam Grundhoff, Melanie M Brinkmann. SARS‐CoV‐2 outbreak investigation in a German meat processing plant. EMBO Molecular Medicine, October 2020, DOI: 10.15252/emmm.202013296
  • Annika Nelde, Tatjana Bilich, Jonas S. Heitmann, Yacine Maringer, Helmut R. Salih, Malte Roerden, Maren Lübke, Jens Bauer, Jonas Rieth, Marcel Wacker, Andreas Peter, Sebastian Hörber, Bjoern Traenkle, Philipp D. Kaiser, Ulrich Rothbauer, Matthias Becker, Daniel Junker, Gérard Krause, Monika Strengert, Nicole Schneiderhan-Marra, Markus F. Templin, Thomas O. Joos, Daniel J. Kowalewski, Vlatka Stos-Zweifel, Michael Fehr, Armin Rabsteyn, Valbona Mirakaj, Julia Karbach, Elke Jäger, Michael Graf, Lena-Christin Gruber, David Rachfalski, Beate Preuß, Ilona Hagelstein, Melanie Märklin, Tamam Bakchoul, Cécile Gouttefangeas, Oliver Kohlbacher, Reinhild Klein, Stefan Stevanović, Hans-Georg Rammensee & Juliane S. Walz. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition. Nature Immunology, September 2020, DOI: 10.1038/s41590-020-00808-x
  •  Verena Haselmann, Mustafa K. Özçürümez, Frank Klawonn, Volker Ast, Catharina Gerhards, Romy Eichner, Victor Costina, Gerhard Dobler, Wolf-Jochen Geilenkeuser, Roman Wölfel, Michael Neumaier. Results of the first pilot external quality assessment (EQA) scheme for anti-SARS-CoV2-antibody testing. Clinical Chemistry and Laboratory Medicine, August 2020, DOI: 10.1515/cclm-2020-1183 
  • Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Martin Grasshoff, Theodore S. Kapellos, Michael Beckstette, Tal Pecht, Adem Saglam, Oliver Dietrich, Henrik E. Mei, Axel R. Schulz, Claudia Conrad, Désirée Kunkel, Ehsan Vafadarnejad, Cheng-Jian Xu, Arik Horne, Miriam Herbert, Anna Drews, Charlotte Thibeault, Moritz Pfeiffer, Stefan Hippenstiel, Andreas Hocke, Holger Müller-Redetzky, Katrin-Moira Heim, Felix Machleidt, Alexander Uhrig, Laure Bosquillon de Jarcy, Linda Jürgens, Miriam Stegemann, Christoph R. Glösenkamp, Hans-Dieter Volk, Christine Goffinet, Markus Landthaler, Emanuel Wyler, Philipp Georg, Maria Schneider, Chantip DangHeine, Nick Neuwinger, Kai Kappert, Rudolf Tauber, Victor Corman, Jan Raabe, Kim Melanie Kaiser, Michael To Vinh, Gereon Rieke, Christian Meisel, Thomas Ulas, Matthias Becker, Robert Geffers, Martin Witzenrath, Christian Drosten, Norbert Suttorp, Christof von Kalle, Florian Kurth, Kristian Händler, Joachim L. Schultze, Anna C. Aschenbrenner, Yang Li, Jacob Nattermann, Birgit Sawitzki, Antoine-Emmanuel Saliba, Leif Erik Sander. Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell, July 2020, DOI: 10.1016/j.cell.2020.08.001.
  • Daniel Hornuss, Berit Lange, Nils Schröter, Siegbert R. Rieg, Winfried Wincenz Kern, Dirk Wagner. Anosmia in COVID-19 patients. Clinical Microbiology and Infection, May 2020, DOI: 10.1016/j.cmi.2020.05.017.
  • Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Ute Curth, Christian Drosten, Lucie Sauerhering, Stephan Becker, Katharina Rox, Rolf Hilgenfeld. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science, April 2020, DOI: 10.1126/science.abb3405.05.

Preprints

  • Daniela Gornyk, Manuela Harries, Stephan Glöckner, Monika Strengert, Tobias Kerrinnes, Gerhard Bojara, Stefanie Castell, Kerstin Frank, Knut Gubbe, Jana-Kristin Heise, Pilar Hernandez, Oliver Kappert, Winfried Kern, Thomas Illig, Norman Klopp, Henrike Maaß, Julia Ortmann, Barbora Kessel, Gottfried Roller, Monike Schlüter, Torsten Tonn, Michael Ziemons, Yvonne Kemmling, Berit Lange, Gérard Krause. SARS-CoV-2 seroprevalence in Germany - a population based sequential study in five regions. medRxiv, May 2021, DOI: 10.1101/2021.05.04.21256597
  • Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Ulfert Rand, Thomas Klünemann, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, Susanne Zock-Emmenthal, Marlies Becker, Margitta Scholz, Gustavo Marçal Schmidt Garcia Moreira, Esther Veronika Wenzel, Giulio Russo, Hendrikus S.P. Garritsen, Sebastian Casu, Andreas Gerstner, Günter Roth, Andreas Hermann, Thomas Schirrmann, Stefan Dübel, André Frenzel, Joop Van den Heuvel, Luka Čičin-Šain, Maren Schubert, Michael Hust. A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to known RBD mutations. bioRxiv,  December2020, DOI: 10.1101/2020.12.03.409318
  • Simone Schmitt, Marcel Weber, Matthias Hillenbrand, Jemima Seidenberg, Andreas Zingg, Catherine Townsend, Barbara Eicher, Justina Rutkauskaite, Peggy Riese, Carlos A. Guzman, Karsten Fischer,  Christoph Esslinger. MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19. , bioRxiv, December 2020, DOI: 10.1101/2020.12.01.406934
  • Matthias Linden, Sebastian B. Mohr, Jonas Dehning, , Jan Mohring, Michael Meyer-Hermann, Iris Pigeot, Anita Schöbel, Viola Priesemann. Case numbers beyond contact tracing capacity are endangering the containment of COVID-19. Dtsch Arztebl Int; 117: 790–1, October 2020, DOI: 10.3238/arztebl.2020.0790
  • Arnab Bandyopadhyay, Marta Schips, Tanmay Mitra, Sahamoddin Khailaie, Sebastian Binder, Michael Meyer-Hermann. COVID-19 in Italy: targeted testing as a proxy of limited health care facilities and a key to reducing hospitalization rate and the death toll. medRxiv preprint, Oktober 2020, DOI: 10.1101/2020.10.12.20211169 
  •  Matthias Linden, Jonas Dehning, Sebastian B. Mohr, Jan Mohring, Michael Meyer-Hermann, Iris Pigeot, Anita Schöbel, Viola Priesemann. The foreshadow of a second wave: An analysis of current COVID-19 fatalities in Germany. arXiv preprint, October 2020, arXiv: 2010.05850
  • Teresa R. Wagner, Philipp D. Kaiser, Marius Gramlich, Matthias Becker, Bjoern Traenkle, Daniel Junker, Julia Haering, Alex Dulovic, Helen Schweizer, Stefan Nueske, Armin Scholz, Anne Zeck, Katja Schenke-Layland, Annika Nelde, Monika Strengert, Juliane S. Walz, Natalia Ruetalo, Michael Schindler, Nicole Schneiderhan-Marra, Ulrich Rothbauer. NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response. bioRxiv preprint, September 2020, DOI: 10.1101/2020.09.22.308338v3
  • Thibaut Jombart, Stephane Ghozzi, Dirk Schumacher, Quentin Leclerc, Mark Jit, Stefan Flasche, Felix Greaves, Tom Ward, Rosalind M Eggo, Emily Nightingale, Sophie Meakin, Oliver J Brady, Centre for Mathematical Modelling of Infectious Diseases COVID-19 Working Group, Graham Medley, Michael Hohle, John Edmunds. Real-time monitoring of COVID-19 dynamics using automated trend fitting and anomaly detection. medRxiv preprint, September 2020, DOI: 10.1101/2020.09.02.20186502
  • Florian Dorn, Sahamoddin Khailaie, Marc Stoeckli, Sebastian, C Binder, Berit Lange, Stefan Lautenbacher, Andreas Peichl, Patrizio Vanella, Timo Wollmershaeuser, Clemens Fuest, Michael Meyer-Hermann. The Common Interests of Health Protection and the Economy: Evidence from Scenario Calculations of COVID-19 Containment Policies. medRxiv preprint, August 2020, DOI: 10.1101/2020.08.14.20175224
  • Ludwig Knabl, Tanmay Mitra, Janine Kimpel, Annika Roessler, Andre Volland, Andreas Walser, Hanno Ulmer, Lisa Pipperger, Sebastian C Binder, Lydia Riepler, Katie Bates, Arnab Bandyopadhyay, Marta Schips, Mrinalini Ranjan, Barbara Falkensammer, Wegene Borena, Michael Meyer-Hermann, Dorothee von Laer. High SARS-CoV-2 Seroprevalence in Children and Adults in the Austrian Ski Resort Ischgl. medRxiv preprint, August 2020, DOI: 10.1101/2020.08.20.20178533
  • M. Zeeshan Chaudhry, Kathrin Eschke, Martina Grashoff, Leila Abassi, Yeonsu Kim, Linda Brunotte, Stephan Ludwig, Željka Mačak Šafranko, Ivan-Christian Kurolt, Alemka Markotić, Andrea Kröger, Frank Klawonn and Luka Cicin-Sain. SARS-CoV-2 Quasispecies Mediate Rapid Virus Evolution and Adaptation. bioRxiv preprint, August 2020, DOI: 10.1101/2020.08.10.241414
  • Simon Fink, Felix Ruoff, Aaron Stahl, Matthias Becker, Philipp Kaiser, Bjoern Traenkle, Daniel Junker, Frank Weise Natalia Ruetalo, Sebastian Hoerber, Andreas Peter, Annika Nelde, Juliane Walz, G&eacuterard Krause, Katja Schenke-Layland, Thomas Joos Ulrich Rothbauer, Nicole Schneiderhan-Marra, Michael Schindler and Markus F Templin. A throughput serological Western blot system using whole virus lysate for the concomitant detection of antibodies against SARS-CoV-2 and human endemic Coronaviridae. medRxiv preprint, August 2020, DOI: 10.1101/2020.07.31.20165019
  • Nathalie Veronica Fernandez Villalobos, Joerdis Jennifer Ott, Carolina Judith Klett-Tammen, Annabelle Bockey, Patrizio Vanella, Gerard Krause, Berit Lange.Quantification of the association between predisposing health conditions, demographic, and behavioural factors with hospitalisation, intensive care unit admission, and death from COVID-19: a systematic review and meta-analysis. medRxiv preprint, August 2020, DOI: 10.1101/2020.07.30.20165050
  • Matthias Becker, Monika Strengert, Daniel Junker, Tobias Kerrinnes, Philipp D. Kaiser, Bjoern Traenkle, Heiko Dinter, Julia Haering, Anne Zeck, Frank Weise, Andreas Peter, Sebastian Hoerber, Simon Fink, Felix Ruoff, Tamam Bakchoul, Armin Baillot, Stefan Lohse, Markus Cornberg, Thomas Illig, Jens Gottlieb, Sigrun Smola, Andre Karch, Klaus Berger, Hans-Georg Rammensee, Katja Schenke-Layland, Annika Nelde, Melanie Maerklin, Jonas S. Heitmann, Juliane S. Walz, Markus F. Templin, Thomas O. Joos, Ulrich Rothbauer, Gerard Krause, Nicole Schneiderhan-Marra. Going beyond clinical routine in SARS-CoV-2 antibody testing - A multiplex corona virus antibody test for the evaluation of cross-reactivity to endemic coronavirus antigens. medRxiv preprint, July 2020, DOI: 10.1101/2020.07.17.20156000
  • Thomas Guenther, Manja Czech-Sioli, Daniela Indenbirken, Alexis Robitailles, Peter Tenhaken, Martin Exner, Matthias Ottinger, Nicole Fischer, Adam Grundhoff, Melanie Brinkmann. Investigation of a superspreading event preceding the largest meat processing plant-related SARS-Coronavirus 2 outbreak in Germany. SSRN preprint, July 2020, DOI: 10.2139/ssrn.3654517
  • Rebecca Moeller, Francisco J. Zapatero Belinchon, Lisa Lasswitz, Jared Kirui, Graham Brogden, Antonia P. Gunesch, Thomas Pietschmann, Dominic Wichmann, Stefan Kluge, Gisa Gerold. Effect of statins on SARS-CoV-2 infection. medRxiv preprint, July 2020, DOI: 10.1101/2020.07.13.20152272
  • Nora Schmidt, Caleb A. Lareau, Hasmik Keshishian, Randy Melanson, Matthias Zimmer, Luisa Kirschner, Jens Ade, Simone Werner, Neva Caliskan, Eric S. Lander, Jörg Vogel, Steven A. Carr, Jochen Bodem, Mathias Munschauer. A direct RNA-protein interaction atlas of the SARS-CoV-2 RNA in infected human cells. bioRxiv preprint, July 2020, DOI: 10.1101/2020.07.15.204404
  • Claudia Pommerenke, Ulfert Rand, C. Uphoff, Stefan Nagel, Margarete Zaborski, Vivian Hauer, Maren Kaufmann, Corinna Meyer, Sabine A. Denkmann, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Zeljka Macak Safranko, Ivan-Christian Kurolt, Alemka Markotic, Linda Brunotte, Stephan Ludwig, Luka Cicin-Sain, Laura Steenpaß. Screening and testing for a suitable untransfected cell line for SARS-CoV-2 studies. bioRxiv preprint, July 2020, DOI: 10.1101/2020.07.09.195040
  • Khailaie Sahamoddin, Mitra Tanmay, Bandyopadhyay Arnab, Schips Marta, Mascheroni Pietro, Vanella Patrizio, Lange Berit, Binder Sebastian, Meyer-Hermann Michael: Estimate of the development of the epidemic reproduction number Rt from Coronavirus SARS-CoV-2 case data and implications for political measures based on prognostics. medRxiv preprint, June 2020, DOI: 10.1101/2020.04.04.20053637.
  • Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert, Michael Hust. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. bioRxiv preprint, June 2020, DOI: 10.1101/2020.06.05.135921
  • Stephan Glöckner, Gérard Krause, Michael Höhle. Now-casting the COVID-19 epidemic: The use case of Japan. medRxiv preprint, March 2020, DOI: 10.1101/2020.03.18.20037473

Coronavirus

The coronaviruses are a family of viruses that includes a series of very different pathogens. These viruses usually infect mammals, rodents, and birds, but only few coronaviruses adapted to humans. They did this with great success: About one third of all typical "common colds" and some cases of diarrhoea as well are caused by these RNA Viruses, which are the largest of their kind. [more]

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