19.10.2021 17:00

HIPS Talk

PK/PD of Antimicrobial Agents and Antibiotic resistance: Beyond the MIC

Prof. Sandrine Marchand, Assoc. Prof. Frederic Tewes and Assoc. Prof. Julien Buyck, INSERM U1070 "Pharmacology of antimicrobial agents" – University of Poitiers, France, will give a presentation entitled “PK/PD of Antimicrobial Agents and Antibiotic resistance: Beyond the MIC”

    t It is commonly understood that one of the major causes of antibiotic resistance is the excessive but also inappropriate use of antibiotics, especially under-dosing that creates selection pressure leading to the emergence and development of resistant strains. Dosing regimen optimization is therefore important to obtain the best compromise between efficacy and toxicity, but also to prevent antibiotic resistance. Traditionally, antibiotic dosing regimen optimization relies on PK/PD (Pharmacokinetics/Pharmacodynamics) indexes derived from the minimum inhibitory concentration (MIC), distinguishing between time-dependent and concentration-dependent antibiotics (T>MIC, fAUC/MIC, Cmax/MIC). However, these traditional PK/PD approaches, based on MIC present serious limitations.

    The main approach of the U1070 unit to overcome the MIC limitation to use semi-mechanical PK/PD models, which is a recent development of PK/PD integrating the phenomena of bacterial susceptibility changes.

    Another approach used to avoid antibiotic resistance is to consider the infectious microenvironment. Bacteria behave significantly differently under standard laboratory conditions than they do in real-world infections. The infectious microenvironment can cause susceptible bacteria to lose their sensitivity to antibiotics, which can be assessed using molecular biology tools and relevant in vitro and in vivo models that resemble real infectious microenvironments.

    After a presentation of the unit, a description of the complementary (formulation, in vitro and in vivo PK/PD, PK/PD modelling and study of resistance mechanisms) and transversal (preclinical and clinical) skills of the unit will be proposed through a presentation of studies developed or in progress.

    The event will take place on Youtube: https://hips.saarland/youtube 

    Date

    19.10.2021 17:00

    Location

    Online on YouTube

    Speaker

    Pr. Sandrine Marchand studied Pharmacy at the University of Poitiers and obtained her Ph.D. in December 2001. She becomes assistant professor in 2001 at the faculty of Pharmacy (University of Poitiers). Since 2012, she is Professor in pharmacokinetics at the University of Poitiers and becomes in 2019 head of the department of Toxicology and Pharmacokinetics at the University Hospital of Poitiers. Sandrine Marchand is member for more than 15 years of the INSERM U1070 Research «Pharmacology of antimicrobial agents» a multidisciplinary group from the University of Poitiers, directed by Pr. William Couet and which works on antibiotics PK-PD with translational approaches. She is currently (co-)author of 84 articles, 4 book chapters and 1 patent. Her main research interest has been focusing for many years on antibiotics tissue distribution using microdialysis both in animals and humans. She is now conducting research on the disposition of antimicrobial agents alone or in combination after systemic administration or nebulization to improve the treatment of severe infections and limit resistances. She is also currently performing PK-PD in vivo studies in various infectious models both in mice and rats in the framework of various projects (IMI AB-direct, GNA-NOW, VLM…).

    More information:
    https://orcid.org/0000-0001-5279-6678
    https://phar.labo.univ-poitiers.fr/

    Dr. Frédéric Tewes is an associate professor at the University of Poitiers and is affiliated with the INSERM U1070 research unit "Pharmacology of antimicrobial agents" since 2005. He is (co-)author of 35 articles, 4 patents, and 2 book chapters. His research activities focus on antimicrobial delivery, formulation science, inhalation and development of in vitro and in vivo infectious models. Through his 4-year post-doc position in Anne Marie Healy's laboratory at Trinity College Dublin, he has acquired a good expertise in the field of spray-dried powders for inhalation and solid-state characterization. In 2016, he spent 7 months at the Smyth Lab at the University of Texas at Austin as a visiting professor, where he expanded his research on Pseudomonas aeruginosa lung biofilms, evaluation of in vivo models of chronic lung infection using an IVIS system, and animal dosing using a nose-only inhalation system. He has received funding from various agencies to progress his research (Euroregion grant, the French National Research Agency (ANR)).

    More information:
    https://orcid.org/0000-0002-7865-718X
    https://phar.labo.univ-poitiers.fr/

    Dr. Julien Buyck has been hired in 2016 as an associate Professor on a Join chair INSERM – University of Poitiers to develop the microbiology field of the INSERM U1070. He is (co-)author of 20 articles and 2 book chapters. He is familiar with in vitro assessment of antibiotics activity against Gram negative bacteria that he has developed during a first Postdoctoral fellow at University Catholique de Louvain in Brussels (Pr. Tulkens). During a second Post-doctoral fellow at Biozentrum of Basel, he acquired biomolecular skills to modify genome of bacteria. He is co-director of 2 PhD students and has been involved in European project as JPIAMR Co-Action, IMI2 GNA-NOW, and he is coordinator of « Nouvelle Aquitaine » project « PANAMA »

    More information:
    https://orcid.org/0000-0001-5279-6678
    https://phar.labo.univ-poitiers.fr/

    Host

    Prof. Dr. Claus-Michael Lehr

    Contact

    Referent: Sandrine Marchand

    Prof. Dr. Marchand

    Your referent on this HIPS TALK: Prof. Marchand © Universite de Poitiers

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