Doctoral Researcher (f/m/d): Systematic Characterization of Cytochalasan Activities on Actin Dynamics in Mammalian Cells
The Department of Cell Biology of Prof. Dr. Theresia Stradal at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany is offering a position as Doctoral Researcher (f/m/d).
Project embedded into the DFG-funded research unit ‘CytoLabs’, aiming at exploring and exploiting the activities of cytochalasans through a systematic and integrated, collaborative approach. Cytochalasans are biologically active fungal metabolites, which are best known to bind to actin, the main building block of the eukaryotic actin cytoskeleton. Cytochalasans thereby cause changes in cell morphology and motility, but also in trafficking and secretion. A multitude of studies have demonstrated that different cytochalasans can exert differential effects on actin and thus on whole cells. However, the molecular basis of these differences remain poorly defined, and are thus subject of this research project.
The candidate will work at the interface between the production and analysis of different cytochalasans from natural and synthetic sources. Thus, the candidate will have the challenging task to set up a systematic series of high content screening (HCS) microscopic assays to probe the different incoming cytochalasans for their effects on selected actin dynamics-mediated processes such as adhesion and migration in tissue-cultured cells. In addition, she/he will file the data and establish a detailed catalogue, systematically bringing together phenotypic effects with the origin, purity or purification protocols and structural features of respective cytochalasan.
- Master’s Degree in biology, or a related field within the life sciences
- Excellent English communication skills (written and spoken)
- Ability to work independently and as part of an international team
- Experience on tissue culture and state of the art wet lab techniques such as Western Blotting or molecular cloning
- An interest in chemistry is highly beneficial
- Publications in a peer reviewed Journal are advantageous
- The Project demands a well-structured and communicative working style
Equal Opportunities are part of our personnel policy. Qualified applicants with a disability will be given preference. The position is suitable for part-time employment.
Starting date: June 1st or later - Initial contract for 3 years
Salary: alike TVöD E13 (65%)
Probation period: 6 months
Published on: April 13th, 2021
Closing date: May 23rd, 2021
Applicants are required to complete the online application form here:
https://hzi.opencampus.net/ (Please select Job No. 50/2021).
For more details regarding the position, please contact Prof. Dr. Stradal via email: Theresia.Stradal@helmholtz-hzi.de. Further information about the institute and the research group of Prof. Dr. Stradal can be found on our website: https://www.helmholtz-hzi.de/en/research/research-topics/bacterial-and-viral-pathogens/cell-biology/
- Cell Biology- Prof. Dr. Theresia Stradal
Qualified applicants with a disability will be given preference.
The position is suitable for part-time employment.
Special preference toward women
Applications accepted until 2021-05-23
The HZI International Graduate School for Infection Research (GS-FIRE) provides an innovative structured PhD programme within the field of Infection Research.